50 items (Gasterosteus aculeatus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	G3PH51_GASAC	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1379 aa)
	G3PI70_GASAC	Sprouty related EVH1 domain containing 3. (411 aa)
	G3PK56_GASAC	LIM homeobox 1a. (407 aa)
	G3PK82_GASAC	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (367 aa)
	G3PKP6_GASAC	Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (323 aa)
	G3PL07_GASAC	T-cell acute lymphocytic leukemia 1. (352 aa)
	G3PNT4_GASAC	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (368 aa)
	il1b	Interleukin-1. (262 aa)
	KLF7	Kruppel like factor 7. (305 aa)
	G3PR23_GASAC	Protein kinase X-linked. (303 aa)
	G3P7A3_GASAC	Tumor necrosis factor receptor superfamily, member 1a. (394 aa)
	G3PT67_GASAC	Uncharacterized protein. (435 aa)
	G3PZ53_GASAC	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1365 aa)
	G3Q0V0_GASAC	Apolipoprotein L, 1. (354 aa)
	G3Q4G0_GASAC	COMM domain containing 5. (211 aa)
	MAFG	MAF bZIP transcription factor G. (163 aa)
	G3Q7Y8_GASAC	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
	G3Q821_GASAC	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (721 aa)
	G3Q8B3_GASAC	Uncharacterized protein. (149 aa)
	G3Q8F5_GASAC	B-cell translocation gene 1, anti-proliferative. (137 aa)
	G3QAT5_GASAC	F11 receptor, tandem duplicate 1. (302 aa)
	G3PRQ0_GASAC	Homeobox domain-containing protein. (274 aa)
	G3P7X5_GASAC	Bone morphogenetic protein 4. (403 aa)
	G3PAM7_GASAC	NK6 homeobox 3. (264 aa)
	G3PC66_GASAC	Abelson helper integration site 1. (963 aa)
	G3PDG4_GASAC	CCAAT enhancer binding protein beta. (284 aa)
	G3PDV1_GASAC	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (672 aa)
	G3NHJ2_GASAC	CP2 domain-containing protein. (610 aa)
	G3NBU9_GASAC	Vinculin b. (1065 aa)
	G3NBR2_GASAC	Kruppel-like factor 7b. (276 aa)
	G3NAF5_GASAC	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (117 aa)
	G3N6K3_GASAC	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (395 aa)
	G3NU32_GASAC	Vinculin a. (1127 aa)
	PTCH1	Patched 1. (1032 aa)
	G3NVZ9_GASAC	Keratinocyte differentiation factor 1a. (257 aa)
	G3NXI2_GASAC	ERBB receptor feedback inhibitor 1a. (223 aa)
	G3NYK7_GASAC	Uncharacterized protein. (2199 aa)
	G3NZQ3_GASAC	Frizzled related protein. (315 aa)
	G3P1A4_GASAC	Forkhead box N1. (496 aa)
	G3P246_GASAC	Grainyhead-like transcription factor 1. (607 aa)
	G3P517_GASAC	Bone morphogenetic protein 16. (424 aa)
	G3P6Q0_GASAC	Inhibitor of DNA binding 1, HLH protein. (132 aa)
	G3NPU4_GASAC	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (199 aa)
	G3NRM9_GASAC	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1635 aa)
	G3NT26_GASAC	Uncharacterized protein. (214 aa)
	G3NTK8_GASAC	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (672 aa)
	G3NPJ1_GASAC	Adherens junctions associated protein 1. (386 aa)
	G3NJI7_GASAC	KRIT1 ankyrin repeat containing. (742 aa)
	G3NHT4_GASAC	Ets variant 4. (508 aa)
	G3NHP2_GASAC	Grainyhead-like transcription factor 2b. (625 aa)

Your Current Organism:

Gasterosteus aculeatus

NCBI taxonomy Id: 69293
Other names: G. aculeatus, three spined stickleback, three-spined stickleback

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
G3N6K3_GASAC	G3PT67_GASAC	ENSGACP00000000928	ENSGACP00000020803	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family.	Uncharacterized protein.	0.910
G3NAF5_GASAC	G3NYK7_GASAC	ENSGACP00000002300	ENSGACP00000010428	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.453
G3NAF5_GASAC	G3PDG4_GASAC	ENSGACP00000002300	ENSGACP00000015638	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	CCAAT enhancer binding protein beta.	0.423
G3NAF5_GASAC	G3PH51_GASAC	ENSGACP00000002300	ENSGACP00000016926	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.598
G3NAF5_GASAC	G3PT67_GASAC	ENSGACP00000002300	ENSGACP00000020803	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.412
G3NAF5_GASAC	G3PZ53_GASAC	ENSGACP00000002300	ENSGACP00000022893	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.598
G3NAF5_GASAC	il1b	ENSGACP00000002300	ENSGACP00000019287	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Interleukin-1.	0.518
G3NBR2_GASAC	G3PR23_GASAC	ENSGACP00000002759	ENSGACP00000020058	Kruppel-like factor 7b.	Protein kinase X-linked.	0.432
G3NBR2_GASAC	G3Q821_GASAC	ENSGACP00000002759	ENSGACP00000026035	Kruppel-like factor 7b.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.424
G3NBR2_GASAC	KLF7	ENSGACP00000002759	ENSGACP00000019435	Kruppel-like factor 7b.	Kruppel like factor 7.	0.460
G3NBU9_GASAC	G3PDV1_GASAC	ENSGACP00000002797	ENSGACP00000015775	Vinculin b.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.731
G3NHT4_GASAC	G3P6Q0_GASAC	ENSGACP00000004894	ENSGACP00000013273	Ets variant 4.	Inhibitor of DNA binding 1, HLH protein.	0.505
G3NJI7_GASAC	G3PDV1_GASAC	ENSGACP00000005498	ENSGACP00000015775	KRIT1 ankyrin repeat containing.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.420
G3NPU4_GASAC	G3PC66_GASAC	ENSGACP00000007359	ENSGACP00000015190	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Abelson helper integration site 1.	0.450
G3NPU4_GASAC	G3PDV1_GASAC	ENSGACP00000007359	ENSGACP00000015775	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.751
G3NPU4_GASAC	G3QAT5_GASAC	ENSGACP00000007359	ENSGACP00000027001	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	F11 receptor, tandem duplicate 1.	0.561
G3NPU4_GASAC	il1b	ENSGACP00000007359	ENSGACP00000019287	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Interleukin-1.	0.514
G3NRM9_GASAC	G3PDG4_GASAC	ENSGACP00000007996	ENSGACP00000015638	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	CCAAT enhancer binding protein beta.	0.556
G3NRM9_GASAC	G3Q0V0_GASAC	ENSGACP00000007996	ENSGACP00000023495	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Apolipoprotein L, 1.	0.486
G3NU32_GASAC	G3PDV1_GASAC	ENSGACP00000008850	ENSGACP00000015775	Vinculin a.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.737