(19 nodes) Thyroid gland development network (Gasterosteus aculeatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	G3NCX7_GASAC	Paired box 2b. (290 aa)
	G3Q958_GASAC	MADS-box domain-containing protein. (473 aa)
	G3Q7P9_GASAC	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1204 aa)
	G3Q3B7_GASAC	NK2 homeobox 5. (315 aa)
	EDNRA	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family. (336 aa)
	G3PWX5_GASAC	Paired box 8. (464 aa)
	G3PVN5_GASAC	Heart and neural crest derivatives expressed 2. (247 aa)
	G3PUG8_GASAC	Paired box 5. (427 aa)
	G3PRQ0_GASAC	Homeobox domain-containing protein. (274 aa)
	G3PLM1_GASAC	Vascular endothelial growth factor Aa; Belongs to the PDGF/VEGF growth factor family. (189 aa)
	G3PL07_GASAC	T-cell acute lymphocytic leukemia 1. (352 aa)
	G3P5W0_GASAC	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (280 aa)
	G3P0K3_GASAC	Paired box 2a. (457 aa)
	G3NXB9_GASAC	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1248 aa)
	G3NM34_GASAC	MNNL domain-containing protein. (137 aa)
	G3NKR8_GASAC	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1219 aa)
	G3NI51_GASAC	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
	SRF	Serum response factor. (507 aa)
	G3NHB3_GASAC	Homeobox domain-containing protein. (169 aa)

Your Current Organism:

Gasterosteus aculeatus

NCBI taxonomy Id: 69293
Other names: G. aculeatus, three spined stickleback, three-spined stickleback

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
G3NHB3_GASAC	G3PL07_GASAC	ENSGACP00000004721	ENSGACP00000018287	Homeobox domain-containing protein.	T-cell acute lymphocytic leukemia 1.	0.463
G3NHB3_GASAC	G3PVN5_GASAC	ENSGACP00000004721	ENSGACP00000021674	Homeobox domain-containing protein.	Heart and neural crest derivatives expressed 2.	0.463
G3NHB3_GASAC	G3Q958_GASAC	ENSGACP00000004721	ENSGACP00000026422	Homeobox domain-containing protein.	MADS-box domain-containing protein.	0.624
G3NHB3_GASAC	SRF	ENSGACP00000004721	ENSGACP00000004953	Homeobox domain-containing protein.	Serum response factor.	0.624
G3NI51_GASAC	G3PVN5_GASAC	ENSGACP00000005011	ENSGACP00000021674	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Heart and neural crest derivatives expressed 2.	0.429
G3NKR8_GASAC	G3NXB9_GASAC	ENSGACP00000005931	ENSGACP00000009988	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.623
G3NXB9_GASAC	G3NKR8_GASAC	ENSGACP00000009988	ENSGACP00000005931	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.623
G3NXB9_GASAC	G3Q7P9_GASAC	ENSGACP00000009988	ENSGACP00000025909	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.624
G3PL07_GASAC	G3NHB3_GASAC	ENSGACP00000018287	ENSGACP00000004721	T-cell acute lymphocytic leukemia 1.	Homeobox domain-containing protein.	0.463
G3PVN5_GASAC	G3NHB3_GASAC	ENSGACP00000021674	ENSGACP00000004721	Heart and neural crest derivatives expressed 2.	Homeobox domain-containing protein.	0.463
G3PVN5_GASAC	G3NI51_GASAC	ENSGACP00000021674	ENSGACP00000005011	Heart and neural crest derivatives expressed 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.429
G3PVN5_GASAC	G3Q3B7_GASAC	ENSGACP00000021674	ENSGACP00000024369	Heart and neural crest derivatives expressed 2.	NK2 homeobox 5.	0.832
G3Q3B7_GASAC	G3PVN5_GASAC	ENSGACP00000024369	ENSGACP00000021674	NK2 homeobox 5.	Heart and neural crest derivatives expressed 2.	0.832
G3Q3B7_GASAC	G3Q958_GASAC	ENSGACP00000024369	ENSGACP00000026422	NK2 homeobox 5.	MADS-box domain-containing protein.	0.527
G3Q3B7_GASAC	SRF	ENSGACP00000024369	ENSGACP00000004953	NK2 homeobox 5.	Serum response factor.	0.584
G3Q7P9_GASAC	G3NXB9_GASAC	ENSGACP00000025909	ENSGACP00000009988	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.624
G3Q958_GASAC	G3NHB3_GASAC	ENSGACP00000026422	ENSGACP00000004721	MADS-box domain-containing protein.	Homeobox domain-containing protein.	0.624
G3Q958_GASAC	G3Q3B7_GASAC	ENSGACP00000026422	ENSGACP00000024369	MADS-box domain-containing protein.	NK2 homeobox 5.	0.527
G3Q958_GASAC	SRF	ENSGACP00000026422	ENSGACP00000004953	MADS-box domain-containing protein.	Serum response factor.	0.847
SRF	G3NHB3_GASAC	ENSGACP00000004953	ENSGACP00000004721	Serum response factor.	Homeobox domain-containing protein.	0.624