(55 nodes) Pancreas development network (Gasterosteus aculeatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	G3P730_GASAC	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (379 aa)
	G3P8L8_GASAC	ISL LIM homeobox 2a. (359 aa)
	G3PAR7_GASAC	HNF1 homeobox Ba. (560 aa)
	G3PAT8_GASAC	Insulin-like growth factor 2b. (214 aa)
	G3PBR2_GASAC	Achaete-scute family bHLH transcription factor 1b. (172 aa)
	G3PC89_GASAC	Fat storage inducing transmembrane protein 2. (257 aa)
	G3NAF5_GASAC	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (117 aa)
	G3NBG7_GASAC	RNA-binding region (RNP1, RRM) containing 3. (517 aa)
	G3NBH9_GASAC	Neurogenic differentiation factor. (340 aa)
	G3ND47_GASAC	Uncharacterized protein. (434 aa)
	G3Q8E0_GASAC	Uncharacterized protein. (216 aa)
	G3Q821_GASAC	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (721 aa)
	G3Q7X1_GASAC	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (371 aa)
	G3Q786_GASAC	Neuron navigator 3. (2299 aa)
	G3Q3T2_GASAC	Selenoprotein H. (151 aa)
	G3Q170_GASAC	Wolfram syndrome 1b (wolframin). (868 aa)
	G3PXD4_GASAC	Regulatory factor X, 3 (influences HLA class II expression). (761 aa)
	ISL2	ISL LIM homeobox 2b. (361 aa)
	G3PUD0_GASAC	Notch receptor 1a. (2434 aa)
	G3PU90_GASAC	Wolfram syndrome 1a (wolframin). (802 aa)
	G3PU68_GASAC	Paired box 6b. (439 aa)
	G3PT87_GASAC	Betaine-homocysteine methyltransferase; Involved in the regulation of homocysteine metabolism. (399 aa)
	G3PRQ0_GASAC	Homeobox domain-containing protein. (274 aa)
	G3PRP1_GASAC	Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. (486 aa)
	G3PPG3_GASAC	Pancreas associated transcription factor 1a. (275 aa)
	G3PMZ5_GASAC	Zgc:153993. (205 aa)
	G3PLH6_GASAC	Notch receptor 1b. (2478 aa)
	G3PJG9_GASAC	NK6 homeobox 1. (297 aa)
	G3PH31_GASAC	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (423 aa)
	G3PGY8_GASAC	UTP25 small subunit processor component. (756 aa)
	G3PGQ4_GASAC	HNF1 homeobox a. (564 aa)
	G3PFY2_GASAC	Bone morphogenetic protein 2b. (422 aa)
	G3PES7_GASAC	Uncharacterized protein. (171 aa)
	G3PEN8_GASAC	Yes-associated protein 1. (443 aa)
	G3NRP8_GASAC	Hcy-binding domain-containing protein; Involved in the regulation of homocysteine metabolism. (401 aa)
	G3NQW0_GASAC	Regulatory factor X, 6. (862 aa)
	G3NKH3_GASAC	Eukaryotic translation initiation factor 2-alpha kinase 3. (994 aa)
	SRP54	Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa)
	G3NIJ7_GASAC	Motor neuron and pancreas homeobox 1. (309 aa)
	G3NIG1_GASAC	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (413 aa)
	G3NIC0_GASAC	ISL LIM homeobox 1. (351 aa)
	MYO1D	Myosin ID; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1016 aa)
	G3NGP8_GASAC	Fibroblast growth factor receptor. (709 aa)
	G3NFF0_GASAC	Pancreatic and duodenal homeobox 1. (252 aa)
	G3NEF0_GASAC	NK6 homeobox 2. (270 aa)
	IKZF5	IKAROS family zinc finger 5. (418 aa)
	G3NTV3_GASAC	CDK5 regulatory subunit associated protein 1-like 1. (518 aa)
	G3NV97_GASAC	NK2 homeobox 2a. (273 aa)
	G3NVC2_GASAC	Insulinoma-associated 1b. (452 aa)
	G3NXT1_GASAC	T-box transcription factor Ta. (429 aa)
	G3P1Y2_GASAC	Spliceosome associated factor 3, U4/U6 recycling protein. (901 aa)
	G3P2G0_GASAC	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (778 aa)
	G3P2X0_GASAC	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1509 aa)
	G3P5G0_GASAC	IKAROS family zinc finger 5. (429 aa)
	G3P6A1_GASAC	Hcy-binding domain-containing protein; Involved in the regulation of homocysteine metabolism. (370 aa)

Your Current Organism:

Gasterosteus aculeatus

NCBI taxonomy Id: 69293
Other names: G. aculeatus, three spined stickleback, three-spined stickleback

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
G3NAF5_GASAC	G3NBH9_GASAC	ENSGACP00000002300	ENSGACP00000002676	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Neurogenic differentiation factor.	0.419
G3NAF5_GASAC	G3ND47_GASAC	ENSGACP00000002300	ENSGACP00000003247	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.588
G3NAF5_GASAC	G3NFF0_GASAC	ENSGACP00000002300	ENSGACP00000004052	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Pancreatic and duodenal homeobox 1.	0.773
G3NAF5_GASAC	G3NGP8_GASAC	ENSGACP00000002300	ENSGACP00000004504	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Fibroblast growth factor receptor.	0.856
G3NAF5_GASAC	G3NIJ7_GASAC	ENSGACP00000002300	ENSGACP00000005157	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Motor neuron and pancreas homeobox 1.	0.426
G3NAF5_GASAC	G3NQW0_GASAC	ENSGACP00000002300	ENSGACP00000007726	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Regulatory factor X, 6.	0.663
G3NAF5_GASAC	G3NV97_GASAC	ENSGACP00000002300	ENSGACP00000009266	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	NK2 homeobox 2a.	0.661
G3NAF5_GASAC	G3P2G0_GASAC	ENSGACP00000002300	ENSGACP00000011783	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.	0.808
G3NAF5_GASAC	G3PAT8_GASAC	ENSGACP00000002300	ENSGACP00000014712	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin-like growth factor 2b.	0.893
G3NAF5_GASAC	G3PJG9_GASAC	ENSGACP00000002300	ENSGACP00000017749	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	NK6 homeobox 1.	0.449
G3NAF5_GASAC	G3PLH6_GASAC	ENSGACP00000002300	ENSGACP00000018457	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Notch receptor 1b.	0.420
G3NAF5_GASAC	G3PPG3_GASAC	ENSGACP00000002300	ENSGACP00000019497	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Pancreas associated transcription factor 1a.	0.646
G3NAF5_GASAC	G3PU68_GASAC	ENSGACP00000002300	ENSGACP00000021155	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Paired box 6b.	0.612
G3NAF5_GASAC	G3PUD0_GASAC	ENSGACP00000002300	ENSGACP00000021217	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Notch receptor 1a.	0.485
G3NAF5_GASAC	G3PXD4_GASAC	ENSGACP00000002300	ENSGACP00000022273	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Regulatory factor X, 3 (influences HLA class II expression).	0.469
G3NAF5_GASAC	G3Q8E0_GASAC	ENSGACP00000002300	ENSGACP00000026154	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.588
G3NBH9_GASAC	G3NAF5_GASAC	ENSGACP00000002676	ENSGACP00000002300	Neurogenic differentiation factor.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.419
G3NBH9_GASAC	G3ND47_GASAC	ENSGACP00000002676	ENSGACP00000003247	Neurogenic differentiation factor.	Uncharacterized protein.	0.431
G3NBH9_GASAC	G3NQW0_GASAC	ENSGACP00000002676	ENSGACP00000007726	Neurogenic differentiation factor.	Regulatory factor X, 6.	0.420
G3NBH9_GASAC	G3NV97_GASAC	ENSGACP00000002676	ENSGACP00000009266	Neurogenic differentiation factor.	NK2 homeobox 2a.	0.717