(27 nodes) Endocrine pancreas development network (Gasterosteus aculeatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	G3NIJ7_GASAC	Motor neuron and pancreas homeobox 1. (309 aa)
	G3NIG1_GASAC	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (413 aa)
	G3NFF0_GASAC	Pancreatic and duodenal homeobox 1. (252 aa)
	G3NEF0_GASAC	NK6 homeobox 2. (270 aa)
	G3ND47_GASAC	Uncharacterized protein. (434 aa)
	G3NBH9_GASAC	Neurogenic differentiation factor. (340 aa)
	G3NAF5_GASAC	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (117 aa)
	G3NVC2_GASAC	Insulinoma-associated 1b. (452 aa)
	G3P6A1_GASAC	Hcy-binding domain-containing protein; Involved in the regulation of homocysteine metabolism. (370 aa)
	G3P730_GASAC	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (379 aa)
	G3NKH3_GASAC	Eukaryotic translation initiation factor 2-alpha kinase 3. (994 aa)
	G3PAR7_GASAC	HNF1 homeobox Ba. (560 aa)
	G3PBR2_GASAC	Achaete-scute family bHLH transcription factor 1b. (172 aa)
	G3PC89_GASAC	Fat storage inducing transmembrane protein 2. (257 aa)
	G3PES7_GASAC	Uncharacterized protein. (171 aa)
	G3PJG9_GASAC	NK6 homeobox 1. (297 aa)
	G3PMZ5_GASAC	Zgc:153993. (205 aa)
	G3PT87_GASAC	Betaine-homocysteine methyltransferase; Involved in the regulation of homocysteine metabolism. (399 aa)
	G3PU68_GASAC	Paired box 6b. (439 aa)
	G3PXD4_GASAC	Regulatory factor X, 3 (influences HLA class II expression). (761 aa)
	G3Q7X1_GASAC	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (371 aa)
	G3Q821_GASAC	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (721 aa)
	G3Q8E0_GASAC	Uncharacterized protein. (216 aa)
	G3NQW0_GASAC	Regulatory factor X, 6. (862 aa)
	G3NRP8_GASAC	Hcy-binding domain-containing protein; Involved in the regulation of homocysteine metabolism. (401 aa)
	G3NTV3_GASAC	CDK5 regulatory subunit associated protein 1-like 1. (518 aa)
	G3NV97_GASAC	NK2 homeobox 2a. (273 aa)

Your Current Organism:

Gasterosteus aculeatus

NCBI taxonomy Id: 69293
Other names: G. aculeatus, three spined stickleback, three-spined stickleback

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
G3NAF5_GASAC	G3NBH9_GASAC	ENSGACP00000002300	ENSGACP00000002676	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Neurogenic differentiation factor.	0.419
G3NAF5_GASAC	G3ND47_GASAC	ENSGACP00000002300	ENSGACP00000003247	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.588
G3NAF5_GASAC	G3NFF0_GASAC	ENSGACP00000002300	ENSGACP00000004052	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Pancreatic and duodenal homeobox 1.	0.773
G3NAF5_GASAC	G3NIJ7_GASAC	ENSGACP00000002300	ENSGACP00000005157	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Motor neuron and pancreas homeobox 1.	0.426
G3NAF5_GASAC	G3NQW0_GASAC	ENSGACP00000002300	ENSGACP00000007726	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Regulatory factor X, 6.	0.663
G3NAF5_GASAC	G3NV97_GASAC	ENSGACP00000002300	ENSGACP00000009266	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	NK2 homeobox 2a.	0.661
G3NAF5_GASAC	G3PJG9_GASAC	ENSGACP00000002300	ENSGACP00000017749	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	NK6 homeobox 1.	0.449
G3NAF5_GASAC	G3PU68_GASAC	ENSGACP00000002300	ENSGACP00000021155	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Paired box 6b.	0.612
G3NAF5_GASAC	G3PXD4_GASAC	ENSGACP00000002300	ENSGACP00000022273	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Regulatory factor X, 3 (influences HLA class II expression).	0.469
G3NAF5_GASAC	G3Q8E0_GASAC	ENSGACP00000002300	ENSGACP00000026154	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.588
G3NBH9_GASAC	G3NAF5_GASAC	ENSGACP00000002676	ENSGACP00000002300	Neurogenic differentiation factor.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.419
G3NBH9_GASAC	G3ND47_GASAC	ENSGACP00000002676	ENSGACP00000003247	Neurogenic differentiation factor.	Uncharacterized protein.	0.431
G3NBH9_GASAC	G3NQW0_GASAC	ENSGACP00000002676	ENSGACP00000007726	Neurogenic differentiation factor.	Regulatory factor X, 6.	0.420
G3NBH9_GASAC	G3NV97_GASAC	ENSGACP00000002676	ENSGACP00000009266	Neurogenic differentiation factor.	NK2 homeobox 2a.	0.717
G3NBH9_GASAC	G3NVC2_GASAC	ENSGACP00000002676	ENSGACP00000009291	Neurogenic differentiation factor.	Insulinoma-associated 1b.	0.629
G3NBH9_GASAC	G3PJG9_GASAC	ENSGACP00000002676	ENSGACP00000017749	Neurogenic differentiation factor.	NK6 homeobox 1.	0.459
G3NBH9_GASAC	G3PU68_GASAC	ENSGACP00000002676	ENSGACP00000021155	Neurogenic differentiation factor.	Paired box 6b.	0.446
G3NBH9_GASAC	G3Q8E0_GASAC	ENSGACP00000002676	ENSGACP00000026154	Neurogenic differentiation factor.	Uncharacterized protein.	0.431
G3ND47_GASAC	G3NAF5_GASAC	ENSGACP00000003247	ENSGACP00000002300	Uncharacterized protein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.588
G3ND47_GASAC	G3NBH9_GASAC	ENSGACP00000003247	ENSGACP00000002676	Uncharacterized protein.	Neurogenic differentiation factor.	0.431