(13 nodes) PIN-like domain superfamily network (Gasterosteus aculeatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	G3NEX7_GASAC	XPGN domain-containing protein. (570 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
	G3NBZ1_GASAC	Exonuclease 1. (770 aa)
	G3NRP4_GASAC	Uncharacterized protein. (636 aa)
	G3QB68_GASAC	SMG6 nonsense mediated mRNA decay factor. (1292 aa)
	G3PUJ0_GASAC	Family with sequence similarity 120B. (644 aa)
	G3PT40_GASAC	Zgc:110269. (375 aa)
	G3PRD1_GASAC	Excision repair cross-complementation group 5. (1122 aa)
	G3P8N7_GASAC	Family with sequence similarity 120C. (907 aa)
	G3P5Z3_GASAC	DIS3 exosome endoribonuclease and 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (973 aa)
	GEN1	GEN1 Holliday junction 5' flap endonuclease. (460 aa)
	G3NQM0_GASAC	FCF1 rRNA-processing protein. (198 aa)
	G3NEZ9_GASAC	UTP23 small subunit processome component. (249 aa)

Your Current Organism:

Gasterosteus aculeatus

NCBI taxonomy Id: 69293
Other names: G. aculeatus, three spined stickleback, three-spined stickleback

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FEN1	G3NBZ1_GASAC	ENSGACP00000002941	ENSGACP00000002840	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Exonuclease 1.	0.884
FEN1	G3NEX7_GASAC	ENSGACP00000002941	ENSGACP00000003878	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	XPGN domain-containing protein.	0.600
FEN1	G3NRP4_GASAC	ENSGACP00000002941	ENSGACP00000008011	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.600
FEN1	G3PRD1_GASAC	ENSGACP00000002941	ENSGACP00000020166	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Excision repair cross-complementation group 5.	0.496
FEN1	G3PT40_GASAC	ENSGACP00000002941	ENSGACP00000020776	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Zgc:110269.	0.850
FEN1	G3PUJ0_GASAC	ENSGACP00000002941	ENSGACP00000021277	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Family with sequence similarity 120B.	0.600
FEN1	GEN1	ENSGACP00000002941	ENSGACP00000011702	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	GEN1 Holliday junction 5' flap endonuclease.	0.813
G3NBZ1_GASAC	FEN1	ENSGACP00000002840	ENSGACP00000002941	Exonuclease 1.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.884
G3NBZ1_GASAC	G3NEX7_GASAC	ENSGACP00000002840	ENSGACP00000003878	Exonuclease 1.	XPGN domain-containing protein.	0.586
G3NBZ1_GASAC	G3NRP4_GASAC	ENSGACP00000002840	ENSGACP00000008011	Exonuclease 1.	Uncharacterized protein.	0.586
G3NBZ1_GASAC	G3PRD1_GASAC	ENSGACP00000002840	ENSGACP00000020166	Exonuclease 1.	Excision repair cross-complementation group 5.	0.457
G3NBZ1_GASAC	G3PT40_GASAC	ENSGACP00000002840	ENSGACP00000020776	Exonuclease 1.	Zgc:110269.	0.882
G3NBZ1_GASAC	G3PUJ0_GASAC	ENSGACP00000002840	ENSGACP00000021277	Exonuclease 1.	Family with sequence similarity 120B.	0.586
G3NBZ1_GASAC	GEN1	ENSGACP00000002840	ENSGACP00000011702	Exonuclease 1.	GEN1 Holliday junction 5' flap endonuclease.	0.784
G3NEX7_GASAC	FEN1	ENSGACP00000003878	ENSGACP00000002941	XPGN domain-containing protein.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.600
G3NEX7_GASAC	G3NBZ1_GASAC	ENSGACP00000003878	ENSGACP00000002840	XPGN domain-containing protein.	Exonuclease 1.	0.586
G3NEX7_GASAC	G3PRD1_GASAC	ENSGACP00000003878	ENSGACP00000020166	XPGN domain-containing protein.	Excision repair cross-complementation group 5.	0.515
G3NEX7_GASAC	G3PT40_GASAC	ENSGACP00000003878	ENSGACP00000020776	XPGN domain-containing protein.	Zgc:110269.	0.600
G3NEX7_GASAC	GEN1	ENSGACP00000003878	ENSGACP00000011702	XPGN domain-containing protein.	GEN1 Holliday junction 5' flap endonuclease.	0.516
G3NEZ9_GASAC	G3NQM0_GASAC	ENSGACP00000003900	ENSGACP00000007636	UTP23 small subunit processome component.	FCF1 rRNA-processing protein.	0.916