(54 nodes) TCR signaling network (Gasterosteus aculeatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	G3NZ03_GASAC	Caspase recruitment domain family, member 11. (1146 aa)
	PAK3	Non-specific serine/threonine protein kinase. (578 aa)
	G3QA52_GASAC	Ubiquitin B. (611 aa)
	G3QA00_GASAC	Spinster homolog 3 (Drosophila). (479 aa)
	G3Q9I4_GASAC	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa)
	G3Q7W3_GASAC	Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. (750 aa)
	G3Q4R3_GASAC	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (149 aa)
	G3Q3J0_GASAC	Tyrosine-protein kinase. (613 aa)
	G3Q1D2_GASAC	F-box and WD repeat domain containing 11a. (539 aa)
	G3PFQ1_GASAC	Ig-like domain-containing protein. (286 aa)
	G3PG25_GASAC	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (316 aa)
	G3PIJ0_GASAC	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (570 aa)
	G3PIU6_GASAC	Non-specific serine/threonine protein kinase. (563 aa)
	G3PKS0_GASAC	MALT paracaspase 1. (723 aa)
	G3PNI1_GASAC	GRB2 related adaptor protein 2a. (325 aa)
	CSK	Tyrosine-protein kinase. (450 aa)
	G3PQ99_GASAC	Spinster homolog 1 (Drosophila). (488 aa)
	G3PRT1_GASAC	Protein kinase domain-containing protein. (443 aa)
	G3PU63_GASAC	Receptor-interacting serine-threonine kinase 2. (590 aa)
	G3PYF8_GASAC	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (574 aa)
	G3PZ17_GASAC	Uncharacterized protein. (388 aa)
	G3N5Q3_GASAC	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1263 aa)
	G3NBB2_GASAC	Protein kinase domain-containing protein. (584 aa)
	G3NGQ7_GASAC	Phosphoprotein membrane anchor with glycosphingolipid microdomains 1. (452 aa)
	G3NI44_GASAC	Immunoglobulin superfamily, member 3. (1192 aa)
	G3NI48_GASAC	Zgc:91849. (983 aa)
	G3NI52_GASAC	Inositol polyphosphate-5-phosphatase D. (868 aa)
	G3NI55_GASAC	Uncharacterized protein. (71 aa)
	G3NJC9_GASAC	Inhibitor of nuclear factor kappa B kinase subunit beta. (742 aa)
	G3NJL3_GASAC	Protein kinase domain-containing protein. (762 aa)
	G3NLI8_GASAC	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1281 aa)
	G3NLX7_GASAC	Uncharacterized protein. (802 aa)
	G3NMZ6_GASAC	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. (314 aa)
	G3NNT3_GASAC	Uncharacterized protein. (137 aa)
	G3NNU1_GASAC	IGv domain-containing protein. (132 aa)
	CD3D	Uncharacterized protein. (152 aa)
	G3NRZ9_GASAC	Ig_4 domain-containing protein. (175 aa)
	G3NSE7_GASAC	Mitogen-activated protein kinase kinase kinase 7. (602 aa)
	G3NTV9_GASAC	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (721 aa)
	G3NU66_GASAC	Component of inhibitor of nuclear factor kappa B kinase complex. (760 aa)
	G3NZ68_GASAC	Ubiquitin A-52 residue ribosomal protein fusion product 1. (130 aa)
	G3P0R0_GASAC	SH3 domain-containing protein. (488 aa)
	G3P2J8_GASAC	3-phosphoinositide dependent protein kinase 1b. (565 aa)
	G3P3P1_GASAC	Uncharacterized protein. (281 aa)
	G3P3R3_GASAC	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (414 aa)
	G3P5R0_GASAC	Tyrosine-protein kinase. (449 aa)
	G3P6I0_GASAC	C2 tensin-type domain-containing protein. (213 aa)
	PAK2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (498 aa)
	G3P9Z1_GASAC	MALT paracaspase 3. (342 aa)
	G3PAF6_GASAC	Tyrosine-protein phosphatase domain-containing protein. (125 aa)
	G3PAN1_GASAC	Non-specific serine/threonine protein kinase. (539 aa)
	G3PCG6_GASAC	Ribosomal protein S27a. (158 aa)
	UBE2N	Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
	G3PE27_GASAC	KxDL motif containing 1. (184 aa)

Your Current Organism:

Gasterosteus aculeatus

NCBI taxonomy Id: 69293
Other names: G. aculeatus, three spined stickleback, three-spined stickleback

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD3D	CSK	ENSGACP00000008114	ENSGACP00000019367	Uncharacterized protein.	Tyrosine-protein kinase.	0.704
CD3D	G3N5Q3_GASAC	ENSGACP00000008114	ENSGACP00000000627	Uncharacterized protein.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.561
CD3D	G3NBB2_GASAC	ENSGACP00000008114	ENSGACP00000002608	Uncharacterized protein.	Protein kinase domain-containing protein.	0.653
CD3D	G3NGQ7_GASAC	ENSGACP00000008114	ENSGACP00000004513	Uncharacterized protein.	Phosphoprotein membrane anchor with glycosphingolipid microdomains 1.	0.674
CD3D	G3NLI8_GASAC	ENSGACP00000008114	ENSGACP00000006201	Uncharacterized protein.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.538
CD3D	G3NLX7_GASAC	ENSGACP00000008114	ENSGACP00000006340	Uncharacterized protein.	Uncharacterized protein.	0.666
CD3D	G3NNT3_GASAC	ENSGACP00000008114	ENSGACP00000006997	Uncharacterized protein.	Uncharacterized protein.	0.787
CD3D	G3NNU1_GASAC	ENSGACP00000008114	ENSGACP00000007005	Uncharacterized protein.	IGv domain-containing protein.	0.810
CD3D	G3NRZ9_GASAC	ENSGACP00000008114	ENSGACP00000008116	Uncharacterized protein.	Ig_4 domain-containing protein.	0.999
CD3D	G3NSE7_GASAC	ENSGACP00000008114	ENSGACP00000008264	Uncharacterized protein.	Mitogen-activated protein kinase kinase kinase 7.	0.648
CD3D	G3NZ03_GASAC	ENSGACP00000008114	ENSGACP00000010574	Uncharacterized protein.	Caspase recruitment domain family, member 11.	0.429
CD3D	G3NZ68_GASAC	ENSGACP00000008114	ENSGACP00000010640	Uncharacterized protein.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.400
CD3D	G3P0R0_GASAC	ENSGACP00000008114	ENSGACP00000011183	Uncharacterized protein.	SH3 domain-containing protein.	0.513
CD3D	G3P5R0_GASAC	ENSGACP00000008114	ENSGACP00000012933	Uncharacterized protein.	Tyrosine-protein kinase.	0.734
CD3D	G3PAF6_GASAC	ENSGACP00000008114	ENSGACP00000014580	Uncharacterized protein.	Tyrosine-protein phosphatase domain-containing protein.	0.709
CD3D	G3PFQ1_GASAC	ENSGACP00000008114	ENSGACP00000016425	Uncharacterized protein.	Ig-like domain-containing protein.	0.804
CD3D	G3PNI1_GASAC	ENSGACP00000008114	ENSGACP00000019164	Uncharacterized protein.	GRB2 related adaptor protein 2a.	0.814
CD3D	G3PRT1_GASAC	ENSGACP00000008114	ENSGACP00000020317	Uncharacterized protein.	Protein kinase domain-containing protein.	0.648
CD3D	G3PU63_GASAC	ENSGACP00000008114	ENSGACP00000021150	Uncharacterized protein.	Receptor-interacting serine-threonine kinase 2.	0.648
CD3D	G3PZ17_GASAC	ENSGACP00000008114	ENSGACP00000022857	Uncharacterized protein.	Uncharacterized protein.	0.417