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soj_1 soj_1 hypBA1_3 hypBA1_3 rplY rplY gntK_1 gntK_1 ispE ispE hrpB_1 hrpB_1 hemA hemA recR recR KJL41434.1 KJL41434.1 KJL41512.1 KJL41512.1 rplL rplL rplJ rplJ KJL41548.1 KJL41548.1 rplA rplA rplK rplK KJL41611.1 KJL41611.1 gntK_2 gntK_2 KJL41143.1 KJL41143.1 bcpA_2 bcpA_2 recQ_2 recQ_2 pglD pglD KJL40694.1 KJL40694.1 rpsL rpsL rpsG rpsG rpsJ rpsJ rplC rplC rplD rplD rplW rplW rplB rplB rpsS rpsS rplV rplV rpsC rpsC rplP rplP rpmC rpmC rpsQ rpsQ rplN rplN rplX rplX rplE rplE rpsH rpsH rplF rplF rplR rplR rpsE rpsE rpmD rpmD rplO rplO rpmJ rpmJ rpsM rpsM rpsK rpsK rplQ rplQ rplM rplM rpsI rpsI mshD_6 mshD_6 pbsA1 pbsA1 rpsN rpsN rpmG2 rpmG2 rpmB rpmB KJL40207.1 KJL40207.1 bkdA_1 bkdA_1 dnaB dnaB rplI rplI rpsR1 rpsR1 rpsF rpsF KJL40286.1 KJL40286.1 spo0C spo0C soj_3 soj_3 rpmH rpmH gyrB_1 gyrB_1 gyrA_1 gyrA_1 rpmE2 rpmE2 bkdA_2 bkdA_2 priA_2 priA_2 rpsD rpsD rarA rarA KJL39706.1 KJL39706.1 gyrA_2 gyrA_2 gyrB_2 gyrB_2 dnaG dnaG recO recO rpsT rpsT yedK yedK nadD nadD rpmA rpmA rplU rplU paiB paiB KJL45879.1 KJL45879.1 clpS clpS KJL45767.1 KJL45767.1 KJL45707.1 KJL45707.1 KJL45586.1 KJL45586.1 hpaIIM hpaIIM KJL45597.1 KJL45597.1 KJL45441.1 KJL45441.1 ribF ribF KJL44610.1 KJL44610.1 phr phr KJL44425.1 KJL44425.1 rplT rplT rpmI rpmI miaA miaA KJL44307.1 KJL44307.1 rpsO rpsO KJL44364.1 KJL44364.1 KJL44096.1 KJL44096.1 KJL43864.1 KJL43864.1 recQ_1 recQ_1 KJL43654.1 KJL43654.1 hypBA1_1 hypBA1_1 hypBA1_2 hypBA1_2 rpsB rpsB rplS rplS rimM rimM rpsP rpsP smc_2 smc_2 rpmF rpmF KJL43453.1 KJL43453.1 KJL43460.1 KJL43460.1 KJL43143.1 KJL43143.1 KJL43152.1 KJL43152.1 uox uox KJL43225.1 KJL43225.1 prpB_1 prpB_1 KJL42860.1 KJL42860.1 KJL42436.1 KJL42436.1 bcpA_1 bcpA_1 parA parA nnr_3 nnr_3 KJL42548.1 KJL42548.1 KJL42582.1 KJL42582.1 rlp2 rlp2 KJL41809.1 KJL41809.1 KJL41803.1 KJL41803.1 prpB_2 prpB_2 yfeX yfeX sirB sirB
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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soj_1Sporulation initiation inhibitor protein Soj. (294 aa)
hypBA1_3Non-reducing end beta-L-arabinofuranosidase. (663 aa)
rplY50S ribosomal protein L25; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (214 aa)
gntK_1Thermoresistant gluconokinase. (170 aa)
ispE4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (308 aa)
hrpB_1ATP-dependent RNA helicase HrpB. (1314 aa)
hemAGlutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (415 aa)
recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (197 aa)
KJL41434.1Cation efflux family protein. (220 aa)
KJL41512.1Hypothetical protein. (505 aa)
rplL50S ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (128 aa)
rplJ50S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (171 aa)
KJL41548.1Putative pterin-4-alpha-carbinolamine dehydratase. (211 aa)
rplA50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (230 aa)
rplK50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (143 aa)
KJL41611.16-pyruvoyl tetrahydropterin synthase. (131 aa)
gntK_2Thermoresistant gluconokinase. (167 aa)
KJL41143.1Hypothetical protein. (223 aa)
bcpA_2Carboxyvinyl-carboxyphosphonate phosphorylmutase. (268 aa)
recQ_2ATP-dependent DNA helicase RecQ. (713 aa)
pglDUDP-N-acetylbacillosamine N-acetyltransferase. (135 aa)
KJL40694.1Hypothetical protein. (113 aa)
rpsL30S ribosomal protein S12; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. (122 aa)
rpsG30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
rpsJ30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
rplC50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (219 aa)
rplD50S ribosomal protein L4; Forms part of the polypeptide exit tunnel. (220 aa)
rplW50S ribosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (99 aa)
rplB50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (279 aa)
rpsS30S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (93 aa)
rplV50S ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (132 aa)
rpsC30S ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (260 aa)
rplP50S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (139 aa)
rpmC50S ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (104 aa)
rpsQ30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (110 aa)
rplN50S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rplX50S ribosomal protein L24; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. (119 aa)
rplE50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (196 aa)
rpsH30S ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa)
rplF50S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (178 aa)
rplR50S ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (119 aa)
rpsE30S ribosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (229 aa)
rpmD50S ribosomal protein L30. (61 aa)
rplO50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (203 aa)
rpmJ50S ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family. (38 aa)
rpsM30S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (124 aa)
rpsK30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (132 aa)
rplQ50S ribosomal protein L17. (182 aa)
rplM50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (148 aa)
rpsI30S ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (158 aa)
mshD_6Mycothiol acetyltransferase. (167 aa)
pbsA1Heme oxygenase 1. (220 aa)
rpsN30S ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (101 aa)
rpmG250S ribosomal protein L33 2; Belongs to the bacterial ribosomal protein bL33 family. (56 aa)
rpmB50S ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family. (78 aa)
KJL40207.1Putative 3-methyladenine DNA glycosylase; Belongs to the DNA glycosylase MPG family. (225 aa)
bkdA_13-methyl-2-oxobutanoate dehydrogenase subunit alpha. (376 aa)
dnaBReplicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (467 aa)
rplI50S ribosomal protein L9; Binds to the 23S rRNA. (150 aa)
rpsR130S ribosomal protein S18 1; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (84 aa)
rpsF30S ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (122 aa)
KJL40286.1Hypothetical protein. (746 aa)
spo0CChromosome-partitioning protein Spo0J; Belongs to the ParB family. (329 aa)
soj_3Sporulation initiation inhibitor protein Soj. (422 aa)
rpmH50S ribosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family. (45 aa)
gyrB_1DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (680 aa)
gyrA_1DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (881 aa)
rpmE250S ribosomal protein L31 type B. (84 aa)
bkdA_23-methyl-2-oxobutanoate dehydrogenase subunit alpha. (374 aa)
priA_2Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (673 aa)
rpsD30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (209 aa)
rarAReplication-associated recombination protein A. (448 aa)
KJL39706.1Hypothetical protein. (546 aa)
gyrA_2DNA gyrase subunit A. (819 aa)
gyrB_2DNA gyrase subunit B. (682 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (621 aa)
recODNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. (223 aa)
rpsT30S ribosomal protein S20; Binds directly to 16S ribosomal RNA. (86 aa)
yedKPutative SOS response-associated peptidase YedK; Belongs to the SOS response-associated peptidase family. (237 aa)
nadDNicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (187 aa)
rpmA50S ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family. (85 aa)
rplU50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (102 aa)
paiBProtease synthase and sporulation protein PAI 2. (213 aa)
KJL45879.1Integrase core domain protein. (369 aa)
clpSATP-dependent Clp protease adapter protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. (100 aa)
KJL45767.1Hypothetical protein; MT-A70. (295 aa)
KJL45707.1Hypothetical protein. (227 aa)
KJL45586.1Hypothetical protein. (273 aa)
hpaIIMModification methylase HpaII. (245 aa)
KJL45597.1Hypothetical protein. (252 aa)
KJL45441.1Eukaryotic DNA topoisomerase I, catalytic core. (325 aa)
ribFRiboflavin biosynthesis protein RibF; Belongs to the ribF family. (323 aa)
KJL44610.1Prephenate dehydrogenase. (224 aa)
phrDeoxyribodipyrimidine photo-lyase; Belongs to the DNA photolyase family. (451 aa)
KJL44425.1NADP oxidoreductase coenzyme F420-dependent. (191 aa)
rplT50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (127 aa)
rpmI50S ribosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family. (64 aa)
miaAtRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (314 aa)
KJL44307.1Thioredoxin. (145 aa)
rpsO30S ribosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (89 aa)
KJL44364.1Hypothetical protein. (238 aa)
KJL44096.1Hypothetical protein. (108 aa)
KJL43864.1N(G),N(G)-dimethylarginine dimethylaminohydrolase. (254 aa)
recQ_1ATP-dependent DNA helicase RecQ. (679 aa)
KJL43654.1Cadherin-like beta sandwich domain protein. (1396 aa)
hypBA1_1Non-reducing end beta-L-arabinofuranosidase. (766 aa)
hypBA1_2Non-reducing end beta-L-arabinofuranosidase. (649 aa)
rpsB30S ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (304 aa)
rplS50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (116 aa)
rimMRibosome maturation factor RimM; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. (216 aa)
rpsP30S ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. (143 aa)
smc_2Chromosome partition protein Smc; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1202 aa)
rpmF50S ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family. (69 aa)
KJL43453.1Alpha-L-fucosidase. (447 aa)
KJL43460.1Alpha-L-fucosidase. (421 aa)
KJL43143.1Hypothetical protein. (436 aa)
KJL43152.1OHCU decarboxylase. (165 aa)
uoxUricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. (299 aa)
KJL43225.1Polyketide cyclase / dehydrase and lipid transport. (151 aa)
prpB_1Methylisocitrate lyase. (299 aa)
KJL42860.1HhH-GPD superfamily base excision DNA repair protein. (194 aa)
KJL42436.130S ribosomal protein S1 homolog. (482 aa)
bcpA_1Carboxyvinyl-carboxyphosphonate phosphorylmutase. (258 aa)
parAChromosome partitioning protein ParA. (269 aa)
nnr_3Bifunctional NAD(P)H-hydrate repair enzyme Nnr; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX; Belongs to the NnrE/AIBP family. (255 aa)
KJL42548.1NADP oxidoreductase coenzyme F420-dependent. (242 aa)
KJL42582.1Acetyltransferase (GNAT) family protein. (144 aa)
rlp2Ribulose bisphosphate carboxylase-like protein 2; Belongs to the RuBisCO large chain family. (423 aa)
KJL41809.1Amidinotransferase. (294 aa)
KJL41803.1Hypothetical protein. (183 aa)
prpB_2Methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. (299 aa)
yfeXPutative deferrochelatase/peroxidase YfeX. (320 aa)
sirBSirohydrochlorin ferrochelatase. (229 aa)
Your Current Organism:
Microbacterium trichothecenolyticum
NCBI taxonomy Id: 69370
Other names: ATCC 51475, Aureibacterium trichothecenolyticum, Aureobacterium trichothecenolyticum, CIP 103817, DSM 8608, IFO 15077, LMG 16696, LMG:16696, M. trichothecenolyticum, Microbacterium sp. BDR3P1B1, NBRC 15077
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