(107 nodes) Mixed, incl. Transmembrane receptor protein tyrosine kinase signaling pathway, and MAPK cascade network (Ixodes scapularis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	B7P0R2_IXOSC	C. elegans sem-5, putative. (211 aa)
	B7P0Z3_IXOSC	Uncharacterized protein. (544 aa)
	B7P1T5_IXOSC	Fibroblast growth factor superfamily protein; Belongs to the heparin-binding growth factors family. (180 aa)
	B7P3R2_IXOSC	Transcription factor Ap-1, putative. (235 aa)
	B7P3R4_IXOSC	Zeta-associated protein Zap-70, putative. (207 aa)
	B7P4P0_IXOSC	Activated met oncogene, putative. (611 aa)
	B7P4S6_IXOSC	DNA-binding protein, putative (Fragment). (359 aa)
	B7P696_IXOSC	Sensory transduction histidine kinase, putative (Fragment). (158 aa)
	B7P6Y3_IXOSC	MAP kinase-activated protein kinase, putative; Belongs to the protein kinase superfamily. (467 aa)
	B7P719_IXOSC	Ras GTP exchange factor, putative. (1093 aa)
	B7P739_IXOSC	Uncharacterized protein. (269 aa)
	B7P7A9_IXOSC	Growth factor receptor-bound protein, putative (Fragment). (358 aa)
	B7P838_IXOSC	Uncharacterized protein. (225 aa)
	B7P8S6_IXOSC	Protein kinase domaincontaining protein. (797 aa)
	B7P8W2_IXOSC	Nerve growth factor receptor TRKA, putative. (368 aa)
	B7P8W3_IXOSC	Tyrosine protein kinase family protein. (251 aa)
	B7P9M2_IXOSC	Kinase suppressor of Ras (KSR), putative (Fragment). (916 aa)
	B7PAJ0_IXOSC	Serine/threonine protein kinase, putative (Fragment); Belongs to the protein kinase superfamily. (306 aa)
	B7PAS3_IXOSC	Receptor protein tyrosine phosphatase, putative (Fragment). (1055 aa)
	B7PB23_IXOSC	Grb2 associated binder (Gab), putative. (721 aa)
	B7PB24_IXOSC	PP2C, putative. (347 aa)
	B7PB40_IXOSC	Mitogen-activated protein kinase kinase MKK4, putative; Belongs to the protein kinase superfamily. (344 aa)
	B7PCV1_IXOSC	WH2 domain-containing protein. (1326 aa)
	B7PDB9_IXOSC	Uncharacterized protein. (451 aa)
	B7PEL7_IXOSC	Signal transduction protein lnk-realted, putative. (553 aa)
	B7PHT1_IXOSC	Uncharacterized protein. (655 aa)
	B7PI23_IXOSC	FERM domain-containing protein, putative. (575 aa)
	B7PI55_IXOSC	Tyrosine-protein phosphatase domain-containing protein. (153 aa)
	B7PI92_IXOSC	Non-specific serine/threonine protein kinase. (420 aa)
	B7PIC9_IXOSC	Proto-oncogene receptor tyrosine protein kinase ret, putative; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1153 aa)
	B7PIM6_IXOSC	Protein-tyrosine phosphatase, putative (Fragment). (440 aa)
	B7PJL0_IXOSC	Regulator of G protein signaling, putative (Fragment). (1065 aa)
	B7PJL2_IXOSC	Regulator of g protein signaling, putative. (104 aa)
	B7PJL5_IXOSC	Uncharacterized protein. (1052 aa)
	B7PKP4_IXOSC	Phosphatase, putative. (463 aa)
	B7PLZ0_IXOSC	Serine/threonine protein kinase, putative (Fragment). (168 aa)
	B7PN38_IXOSC	Uncharacterized protein. (114 aa)
	B7PND3_IXOSC	Mitogen activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative. (1000 aa)
	B7PNJ8_IXOSC	Low-density lipoprotein receptor, putative. (1753 aa)
	B7PP39_IXOSC	Receptor tyrosine phosphatase type r2b, putative. (434 aa)
	B7PP73_IXOSC	Mitogen-activated protein kinase kinase MKK4, putative (Fragment); Belongs to the protein kinase superfamily. (385 aa)
	B7PPF1_IXOSC	GTP-binding protein Rhes, putative (Fragment). (209 aa)
	B7PQ59_IXOSC	Ras GTP exchange factor, son of sevenless, putative (Fragment). (1034 aa)
	B7PQH3_IXOSC	Pkinase_Tyr domain-containing protein. (67 aa)
	B7PS40_IXOSC	Sprouty, putative. (189 aa)
	B7PSP3_IXOSC	Non-specific protein-tyrosine kinase. (674 aa)
	B7PUJ4_IXOSC	Protein kinase C, putative. (204 aa)
	B7PVA5_IXOSC	Protein kinase domain-containing protein. (63 aa)
	B7PVG9_IXOSC	Docking protein, putative (Fragment). (269 aa)
	B7PVJ1_IXOSC	Pkinase_Tyr domain-containing protein. (375 aa)
	B7PVJ6_IXOSC	Mitogen-activated protein kinase kinase MKK4, putative. (364 aa)
	B7PVL6_IXOSC	Jnk interacting protein, putative. (355 aa)
	B7PWD2_IXOSC	Ubiquitin family protein. (791 aa)
	B7PWS2_IXOSC	Ras guanine nucleotide releasing factor, putative. (77 aa)
	B7PWV3_IXOSC	E3 ubiquitin ligase, putative. (459 aa)
	B7PX24_IXOSC	CRAL-TRIO domain-containing protein. (227 aa)
	B7PX34_IXOSC	Transposable element tc1 transposase, putative. (325 aa)
	B7PXH9_IXOSC	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (153 aa)
	B7PZC5_IXOSC	Phosphotyrosyl phosphatase, putative. (407 aa)
	B7PZC9_IXOSC	Protein 4.1G, putative. (365 aa)
	B7PZY6_IXOSC	Uncharacterized protein. (299 aa)
	B7Q054_IXOSC	Lysophosphatidic acid acyltransferase endophilin, putative. (350 aa)
	B7Q0E2_IXOSC	Cyclic-AMP-dependent transcription factor atf2, putative. (534 aa)
	B7Q0T5_IXOSC	Mitogen activated protein kinase kinase kinase 1, MAPKKK1, MEKK1, putative (Fragment). (1477 aa)
	B7Q122_IXOSC	Mitogen-activated protein kinase. (411 aa)
	B7Q1G0_IXOSC	Variant sh3 domaincontaining protein. (690 aa)
	B7Q1P4_IXOSC	Shc transforming protein, putative (Fragment). (461 aa)
	B7Q2R0_IXOSC	Adaptor protein Crk, putative (Fragment). (310 aa)
	B7Q3W1_IXOSC	Brca1-associated protein, putative. (591 aa)
	B7Q4T8_IXOSC	SP-RING-type domain-containing protein. (851 aa)
	B7Q557_IXOSC	Protein fosB, putative. (375 aa)
	B7Q5I4_IXOSC	Multifunctional chaperone, putative; Belongs to the 14-3-3 family. (258 aa)
	B7Q5K7_IXOSC	Uncharacterized protein. (413 aa)
	B7Q655_IXOSC	Receptor protein-tyrosine kinase. (982 aa)
	B7Q680_IXOSC	MAP kinase phosphatase 5, putative. (428 aa)
	B7Q6C7_IXOSC	RAS related protein, putative (Fragment). (189 aa)
	B7Q6W4_IXOSC	Uncharacterized protein. (234 aa)
	B7Q903_IXOSC	Pole hole family protein. (667 aa)
	B7QA36_IXOSC	RAS-related protein, putative. (184 aa)
	B7QCG1_IXOSC	cGMP-dependent protein kinase, putative. (283 aa)
	B7QCJ2_IXOSC	Growth factor receptor-bound protein, putative. (203 aa)
	B7QE69_IXOSC	Vh5 dual specificity phosphatase, putative. (392 aa)
	B7QEI6_IXOSC	Dual specificity protein phosphatase, putative (Fragment). (116 aa)
	B7QF55_IXOSC	Protein tyrosine phosphatase, putative (Fragment). (556 aa)
	B7QFM0_IXOSC	Tyrosine kinase, putative. (442 aa)
	B7QFM4_IXOSC	IRS-type PTB domain-containing protein. (282 aa)
	B7QFX4_IXOSC	Mitogen-activated protein kinase. (359 aa)
	B7QGJ2_IXOSC	Uncharacterized protein. (2382 aa)
	B7QGQ3_IXOSC	143-3 isoform A isoform 2 family protein; Belongs to the 14-3-3 family. (101 aa)
	B7QGX7_IXOSC	KA1 domain-containing protein. (356 aa)
	B7QGX8_IXOSC	Serine/threonine protein kinase, putative (Fragment). (492 aa)
	B7QI65_IXOSC	Uncharacterized protein. (100 aa)
	B7QI78_IXOSC	Uncharacterized protein. (36 aa)
	B7QIB7_IXOSC	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (384 aa)
	B7QIQ5_IXOSC	Kinase suppressor of Ras (KSR), putative. (686 aa)
	B7QJQ8_IXOSC	Protein-tyrosine phosphatase n9, putative. (100 aa)
	B7QJT0_IXOSC	Rho guanine nucleotide exchange factor, putative (Fragment). (572 aa)
	B7QKE9_IXOSC	Guanine-nucleotide exchange factor c3g, putative. (1071 aa)
	B7QKV7_IXOSC	Non-specific serine/threonine protein kinase. (841 aa)
	B7QLJ9_IXOSC	Tyrosine kinase receptor, putative (Fragment). (141 aa)
	B7QLP3_IXOSC	Cyclic AMP-dependent transcription factor ATF-3, putative. (182 aa)
	B7QLZ3_IXOSC	Mitogen-activated protein kinase kinase MKK4, putative (Fragment); Belongs to the protein kinase superfamily. (344 aa)
	B7QM19_IXOSC	Tyrosine-protein kinase receptor. (1458 aa)
	B7QMP5_IXOSC	Suc1-associated neurotrophic factor target, putative. (251 aa)
	B7QMZ1_IXOSC	LIM domain kinase 2, putative. (202 aa)
	B7QMZ2_IXOSC	Lim-kinase1, putative. (162 aa)
	B7QN45_IXOSC	Tyrosine kinase receptor, putative (Fragment). (288 aa)

Your Current Organism:

Ixodes scapularis

NCBI taxonomy Id: 6945
Other names: I. scapularis, Ixodes dammini, Ixodes sp. DNAS-303-249710, black-legged tick, blacklegged tick, deer tick, shoulder tick

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B7P0R2_IXOSC	B7P1T5_IXOSC	B7P0R2	B7P1T5	C. elegans sem-5, putative.	Fibroblast growth factor superfamily protein; Belongs to the heparin-binding growth factors family.	0.451
B7P0R2_IXOSC	B7P3R4_IXOSC	B7P0R2	B7P3R4	C. elegans sem-5, putative.	Zeta-associated protein Zap-70, putative.	0.775
B7P0R2_IXOSC	B7P4P0_IXOSC	B7P0R2	B7P4P0	C. elegans sem-5, putative.	Activated met oncogene, putative.	0.513
B7P0R2_IXOSC	B7P719_IXOSC	B7P0R2	B7P719	C. elegans sem-5, putative.	Ras GTP exchange factor, putative.	0.869
B7P0R2_IXOSC	B7P739_IXOSC	B7P0R2	B7P739	C. elegans sem-5, putative.	Uncharacterized protein.	0.591
B7P0R2_IXOSC	B7P7A9_IXOSC	B7P0R2	B7P7A9	C. elegans sem-5, putative.	Growth factor receptor-bound protein, putative (Fragment).	0.626
B7P0R2_IXOSC	B7P838_IXOSC	B7P0R2	B7P838	C. elegans sem-5, putative.	Uncharacterized protein.	0.464
B7P0R2_IXOSC	B7P8S6_IXOSC	B7P0R2	B7P8S6	C. elegans sem-5, putative.	Protein kinase domaincontaining protein.	0.993
B7P0R2_IXOSC	B7P8W2_IXOSC	B7P0R2	B7P8W2	C. elegans sem-5, putative.	Nerve growth factor receptor TRKA, putative.	0.454
B7P0R2_IXOSC	B7P8W3_IXOSC	B7P0R2	B7P8W3	C. elegans sem-5, putative.	Tyrosine protein kinase family protein.	0.454
B7P0R2_IXOSC	B7P9M2_IXOSC	B7P0R2	B7P9M2	C. elegans sem-5, putative.	Kinase suppressor of Ras (KSR), putative (Fragment).	0.585
B7P0R2_IXOSC	B7PAS3_IXOSC	B7P0R2	B7PAS3	C. elegans sem-5, putative.	Receptor protein tyrosine phosphatase, putative (Fragment).	0.481
B7P0R2_IXOSC	B7PB23_IXOSC	B7P0R2	B7PB23	C. elegans sem-5, putative.	Grb2 associated binder (Gab), putative.	0.983
B7P0R2_IXOSC	B7PCV1_IXOSC	B7P0R2	B7PCV1	C. elegans sem-5, putative.	WH2 domain-containing protein.	0.598
B7P0R2_IXOSC	B7PDB9_IXOSC	B7P0R2	B7PDB9	C. elegans sem-5, putative.	Uncharacterized protein.	0.598
B7P0R2_IXOSC	B7PEL7_IXOSC	B7P0R2	B7PEL7	C. elegans sem-5, putative.	Signal transduction protein lnk-realted, putative.	0.768
B7P0R2_IXOSC	B7PHT1_IXOSC	B7P0R2	B7PHT1	C. elegans sem-5, putative.	Uncharacterized protein.	0.598
B7P0R2_IXOSC	B7PI55_IXOSC	B7P0R2	B7PI55	C. elegans sem-5, putative.	Tyrosine-protein phosphatase domain-containing protein.	0.479
B7P0R2_IXOSC	B7PIC9_IXOSC	B7P0R2	B7PIC9	C. elegans sem-5, putative.	Proto-oncogene receptor tyrosine protein kinase ret, putative; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.598
B7P0R2_IXOSC	B7PIM6_IXOSC	B7P0R2	B7PIM6	C. elegans sem-5, putative.	Protein-tyrosine phosphatase, putative (Fragment).	0.509