(42 nodes) Mixed, incl. IGF1R signaling cascade, and Transmembrane receptor protein tyrosine kinase activity network (Ixodes scapularis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	B7P0R2_IXOSC	C. elegans sem-5, putative. (211 aa)
	B7P1T5_IXOSC	Fibroblast growth factor superfamily protein; Belongs to the heparin-binding growth factors family. (180 aa)
	B7P3R4_IXOSC	Zeta-associated protein Zap-70, putative. (207 aa)
	B7P4P0_IXOSC	Activated met oncogene, putative. (611 aa)
	B7P719_IXOSC	Ras GTP exchange factor, putative. (1093 aa)
	B7P739_IXOSC	Uncharacterized protein. (269 aa)
	B7P7A9_IXOSC	Growth factor receptor-bound protein, putative (Fragment). (358 aa)
	B7P8S6_IXOSC	Protein kinase domaincontaining protein. (797 aa)
	B7P8W3_IXOSC	Tyrosine protein kinase family protein. (251 aa)
	B7PB23_IXOSC	Grb2 associated binder (Gab), putative. (721 aa)
	B7PDB9_IXOSC	Uncharacterized protein. (451 aa)
	B7PEL7_IXOSC	Signal transduction protein lnk-realted, putative. (553 aa)
	B7PHT1_IXOSC	Uncharacterized protein. (655 aa)
	B7PI55_IXOSC	Tyrosine-protein phosphatase domain-containing protein. (153 aa)
	B7PIC9_IXOSC	Proto-oncogene receptor tyrosine protein kinase ret, putative; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1153 aa)
	B7PQ59_IXOSC	Ras GTP exchange factor, son of sevenless, putative (Fragment). (1034 aa)
	B7PQH3_IXOSC	Pkinase_Tyr domain-containing protein. (67 aa)
	B7PVA5_IXOSC	Protein kinase domain-containing protein. (63 aa)
	B7PVG9_IXOSC	Docking protein, putative (Fragment). (269 aa)
	B7PVJ1_IXOSC	Pkinase_Tyr domain-containing protein. (375 aa)
	B7PWS2_IXOSC	Ras guanine nucleotide releasing factor, putative. (77 aa)
	B7PWV3_IXOSC	E3 ubiquitin ligase, putative. (459 aa)
	B7PX34_IXOSC	Transposable element tc1 transposase, putative. (325 aa)
	B7PXH9_IXOSC	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (153 aa)
	B7PZY6_IXOSC	Uncharacterized protein. (299 aa)
	B7Q054_IXOSC	Lysophosphatidic acid acyltransferase endophilin, putative. (350 aa)
	B7Q1G0_IXOSC	Variant sh3 domaincontaining protein. (690 aa)
	B7Q1P4_IXOSC	Shc transforming protein, putative (Fragment). (461 aa)
	B7Q2R0_IXOSC	Adaptor protein Crk, putative (Fragment). (310 aa)
	B7Q4T8_IXOSC	SP-RING-type domain-containing protein. (851 aa)
	B7Q655_IXOSC	Receptor protein-tyrosine kinase. (982 aa)
	B7Q6C7_IXOSC	RAS related protein, putative (Fragment). (189 aa)
	B7QCJ2_IXOSC	Growth factor receptor-bound protein, putative. (203 aa)
	B7QF55_IXOSC	Protein tyrosine phosphatase, putative (Fragment). (556 aa)
	B7QFM4_IXOSC	IRS-type PTB domain-containing protein. (282 aa)
	B7QI65_IXOSC	Uncharacterized protein. (100 aa)
	B7QJT0_IXOSC	Rho guanine nucleotide exchange factor, putative (Fragment). (572 aa)
	B7QKE9_IXOSC	Guanine-nucleotide exchange factor c3g, putative. (1071 aa)
	B7QLJ9_IXOSC	Tyrosine kinase receptor, putative (Fragment). (141 aa)
	B7QM19_IXOSC	Tyrosine-protein kinase receptor. (1458 aa)
	B7QMP5_IXOSC	Suc1-associated neurotrophic factor target, putative. (251 aa)
	B7QN45_IXOSC	Tyrosine kinase receptor, putative (Fragment). (288 aa)

Your Current Organism:

Ixodes scapularis

NCBI taxonomy Id: 6945
Other names: I. scapularis, Ixodes dammini, Ixodes sp. DNAS-303-249710, black-legged tick, blacklegged tick, deer tick, shoulder tick

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B7P0R2_IXOSC	B7P1T5_IXOSC	B7P0R2	B7P1T5	C. elegans sem-5, putative.	Fibroblast growth factor superfamily protein; Belongs to the heparin-binding growth factors family.	0.451
B7P0R2_IXOSC	B7P3R4_IXOSC	B7P0R2	B7P3R4	C. elegans sem-5, putative.	Zeta-associated protein Zap-70, putative.	0.775
B7P0R2_IXOSC	B7P4P0_IXOSC	B7P0R2	B7P4P0	C. elegans sem-5, putative.	Activated met oncogene, putative.	0.513
B7P0R2_IXOSC	B7P719_IXOSC	B7P0R2	B7P719	C. elegans sem-5, putative.	Ras GTP exchange factor, putative.	0.869
B7P0R2_IXOSC	B7P739_IXOSC	B7P0R2	B7P739	C. elegans sem-5, putative.	Uncharacterized protein.	0.591
B7P0R2_IXOSC	B7P7A9_IXOSC	B7P0R2	B7P7A9	C. elegans sem-5, putative.	Growth factor receptor-bound protein, putative (Fragment).	0.626
B7P0R2_IXOSC	B7P8S6_IXOSC	B7P0R2	B7P8S6	C. elegans sem-5, putative.	Protein kinase domaincontaining protein.	0.993
B7P0R2_IXOSC	B7P8W3_IXOSC	B7P0R2	B7P8W3	C. elegans sem-5, putative.	Tyrosine protein kinase family protein.	0.454
B7P0R2_IXOSC	B7PB23_IXOSC	B7P0R2	B7PB23	C. elegans sem-5, putative.	Grb2 associated binder (Gab), putative.	0.983
B7P0R2_IXOSC	B7PDB9_IXOSC	B7P0R2	B7PDB9	C. elegans sem-5, putative.	Uncharacterized protein.	0.598
B7P0R2_IXOSC	B7PEL7_IXOSC	B7P0R2	B7PEL7	C. elegans sem-5, putative.	Signal transduction protein lnk-realted, putative.	0.768
B7P0R2_IXOSC	B7PHT1_IXOSC	B7P0R2	B7PHT1	C. elegans sem-5, putative.	Uncharacterized protein.	0.598
B7P0R2_IXOSC	B7PI55_IXOSC	B7P0R2	B7PI55	C. elegans sem-5, putative.	Tyrosine-protein phosphatase domain-containing protein.	0.479
B7P0R2_IXOSC	B7PIC9_IXOSC	B7P0R2	B7PIC9	C. elegans sem-5, putative.	Proto-oncogene receptor tyrosine protein kinase ret, putative; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.598
B7P0R2_IXOSC	B7PQ59_IXOSC	B7P0R2	B7PQ59	C. elegans sem-5, putative.	Ras GTP exchange factor, son of sevenless, putative (Fragment).	0.999
B7P0R2_IXOSC	B7PQH3_IXOSC	B7P0R2	B7PQH3	C. elegans sem-5, putative.	Pkinase_Tyr domain-containing protein.	0.570
B7P0R2_IXOSC	B7PVA5_IXOSC	B7P0R2	B7PVA5	C. elegans sem-5, putative.	Protein kinase domain-containing protein.	0.598
B7P0R2_IXOSC	B7PVG9_IXOSC	B7P0R2	B7PVG9	C. elegans sem-5, putative.	Docking protein, putative (Fragment).	0.638
B7P0R2_IXOSC	B7PVJ1_IXOSC	B7P0R2	B7PVJ1	C. elegans sem-5, putative.	Pkinase_Tyr domain-containing protein.	0.598
B7P0R2_IXOSC	B7PWS2_IXOSC	B7P0R2	B7PWS2	C. elegans sem-5, putative.	Ras guanine nucleotide releasing factor, putative.	0.869