(13 nodes) Receptor tyrosine kinase binding, and GRB2 events in EGFR signaling network (Ixodes scapularis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	B7P0R2_IXOSC	C. elegans sem-5, putative. (211 aa)
	B7P8S6_IXOSC	Protein kinase domaincontaining protein. (797 aa)
	B7PB23_IXOSC	Grb2 associated binder (Gab), putative. (721 aa)
	B7PQ59_IXOSC	Ras GTP exchange factor, son of sevenless, putative (Fragment). (1034 aa)
	B7PWV3_IXOSC	E3 ubiquitin ligase, putative. (459 aa)
	B7Q054_IXOSC	Lysophosphatidic acid acyltransferase endophilin, putative. (350 aa)
	B7Q1G0_IXOSC	Variant sh3 domaincontaining protein. (690 aa)
	B7Q1P4_IXOSC	Shc transforming protein, putative (Fragment). (461 aa)
	B7Q2R0_IXOSC	Adaptor protein Crk, putative (Fragment). (310 aa)
	B7Q655_IXOSC	Receptor protein-tyrosine kinase. (982 aa)
	B7QF55_IXOSC	Protein tyrosine phosphatase, putative (Fragment). (556 aa)
	B7QKE9_IXOSC	Guanine-nucleotide exchange factor c3g, putative. (1071 aa)
	B7QMP5_IXOSC	Suc1-associated neurotrophic factor target, putative. (251 aa)

Your Current Organism:

Ixodes scapularis

NCBI taxonomy Id: 6945
Other names: I. scapularis, Ixodes dammini, Ixodes sp. DNAS-303-249710, black-legged tick, blacklegged tick, deer tick, shoulder tick

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B7P0R2_IXOSC	B7P8S6_IXOSC	B7P0R2	B7P8S6	C. elegans sem-5, putative.	Protein kinase domaincontaining protein.	0.993
B7P0R2_IXOSC	B7PB23_IXOSC	B7P0R2	B7PB23	C. elegans sem-5, putative.	Grb2 associated binder (Gab), putative.	0.983
B7P0R2_IXOSC	B7PQ59_IXOSC	B7P0R2	B7PQ59	C. elegans sem-5, putative.	Ras GTP exchange factor, son of sevenless, putative (Fragment).	0.999
B7P0R2_IXOSC	B7PWV3_IXOSC	B7P0R2	B7PWV3	C. elegans sem-5, putative.	E3 ubiquitin ligase, putative.	0.987
B7P0R2_IXOSC	B7Q054_IXOSC	B7P0R2	B7Q054	C. elegans sem-5, putative.	Lysophosphatidic acid acyltransferase endophilin, putative.	0.626
B7P0R2_IXOSC	B7Q1G0_IXOSC	B7P0R2	B7Q1G0	C. elegans sem-5, putative.	Variant sh3 domaincontaining protein.	0.774
B7P0R2_IXOSC	B7Q1P4_IXOSC	B7P0R2	B7Q1P4	C. elegans sem-5, putative.	Shc transforming protein, putative (Fragment).	0.983
B7P0R2_IXOSC	B7Q2R0_IXOSC	B7P0R2	B7Q2R0	C. elegans sem-5, putative.	Adaptor protein Crk, putative (Fragment).	0.883
B7P0R2_IXOSC	B7Q655_IXOSC	B7P0R2	B7Q655	C. elegans sem-5, putative.	Receptor protein-tyrosine kinase.	0.998
B7P0R2_IXOSC	B7QF55_IXOSC	B7P0R2	B7QF55	C. elegans sem-5, putative.	Protein tyrosine phosphatase, putative (Fragment).	0.977
B7P0R2_IXOSC	B7QKE9_IXOSC	B7P0R2	B7QKE9	C. elegans sem-5, putative.	Guanine-nucleotide exchange factor c3g, putative.	0.912
B7P0R2_IXOSC	B7QMP5_IXOSC	B7P0R2	B7QMP5	C. elegans sem-5, putative.	Suc1-associated neurotrophic factor target, putative.	0.929
B7P8S6_IXOSC	B7P0R2_IXOSC	B7P8S6	B7P0R2	Protein kinase domaincontaining protein.	C. elegans sem-5, putative.	0.993
B7P8S6_IXOSC	B7PB23_IXOSC	B7P8S6	B7PB23	Protein kinase domaincontaining protein.	Grb2 associated binder (Gab), putative.	0.989
B7P8S6_IXOSC	B7PQ59_IXOSC	B7P8S6	B7PQ59	Protein kinase domaincontaining protein.	Ras GTP exchange factor, son of sevenless, putative (Fragment).	0.700
B7P8S6_IXOSC	B7PWV3_IXOSC	B7P8S6	B7PWV3	Protein kinase domaincontaining protein.	E3 ubiquitin ligase, putative.	0.999
B7P8S6_IXOSC	B7Q054_IXOSC	B7P8S6	B7Q054	Protein kinase domaincontaining protein.	Lysophosphatidic acid acyltransferase endophilin, putative.	0.934
B7P8S6_IXOSC	B7Q1G0_IXOSC	B7P8S6	B7Q1G0	Protein kinase domaincontaining protein.	Variant sh3 domaincontaining protein.	0.937
B7P8S6_IXOSC	B7Q1P4_IXOSC	B7P8S6	B7Q1P4	Protein kinase domaincontaining protein.	Shc transforming protein, putative (Fragment).	0.966
B7P8S6_IXOSC	B7Q2R0_IXOSC	B7P8S6	B7Q2R0	Protein kinase domaincontaining protein.	Adaptor protein Crk, putative (Fragment).	0.942