(23 nodes) RHO GTPases Activate WASPs and WAVEs, and Musculoskeletal movement network (Ixodes scapularis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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Your Input:
	B7P207_IXOSC	Uncharacterized protein. (235 aa)
	B7P350_IXOSC	Myosin I, putative; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (87 aa)
	B7P5Z5_IXOSC	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (387 aa)
	B7P7F6_IXOSC	Stac, putative. (425 aa)
	B7P7H6_IXOSC	SH3 domain-containing protein. (172 aa)
	B7PCP7_IXOSC	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (156 aa)
	B7PG18_IXOSC	DUF2013 domain-containing protein. (418 aa)
	B7PGY1_IXOSC	WH2 motif domaincontaining protein. (855 aa)
	B7PSM1_IXOSC	WH2 domain-containing protein. (476 aa)
	B7PT90_IXOSC	Wiskott-aldrich syndrome protein, putative (Fragment). (476 aa)
	B7PTC7_IXOSC	Uncharacterized protein. (121 aa)
	B7Q0Z5_IXOSC	Membrane-associated protein Hem, putative. (1127 aa)
	B7Q261_IXOSC	Cyfip2 protein, putative. (277 aa)
	B7Q262_IXOSC	Cytoplasmic FMR1interacting protein, putative. (220 aa)
	B7Q3I1_IXOSC	Secernin, putative (Fragment). (98 aa)
	B7Q740_IXOSC	WD_REPEATS_REGION domain-containing protein. (355 aa)
	B7QB42_IXOSC	Arp2/3 complex 21 kD subunit, putative (Fragment). (177 aa)
	B7QDB0_IXOSC	Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (164 aa)
	B7QEI4_IXOSC	Uncharacterized protein. (581 aa)
	B7QF00_IXOSC	Myosin, putative; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1026 aa)
	B7QGL0_IXOSC	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
	B7QIL2_IXOSC	Dreadlocks/dock, putative (Fragment). (372 aa)
	Q4PMA3_IXOSC	Uncharacterized protein. (76 aa)

Your Current Organism:

Ixodes scapularis

NCBI taxonomy Id: 6945
Other names: I. scapularis, Ixodes dammini, Ixodes sp. DNAS-303-249710, black-legged tick, blacklegged tick, deer tick, shoulder tick

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B7P207_IXOSC	B7P5Z5_IXOSC	B7P207	B7P5Z5	Uncharacterized protein.	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	0.695
B7P207_IXOSC	B7P7F6_IXOSC	B7P207	B7P7F6	Uncharacterized protein.	Stac, putative.	0.750
B7P207_IXOSC	B7PCP7_IXOSC	B7P207	B7PCP7	Uncharacterized protein.	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.	0.675
B7P207_IXOSC	B7PG18_IXOSC	B7P207	B7PG18	Uncharacterized protein.	DUF2013 domain-containing protein.	0.558
B7P207_IXOSC	B7PGY1_IXOSC	B7P207	B7PGY1	Uncharacterized protein.	WH2 motif domaincontaining protein.	0.525
B7P207_IXOSC	B7PSM1_IXOSC	B7P207	B7PSM1	Uncharacterized protein.	WH2 domain-containing protein.	0.403
B7P207_IXOSC	B7PT90_IXOSC	B7P207	B7PT90	Uncharacterized protein.	Wiskott-aldrich syndrome protein, putative (Fragment).	0.525
B7P207_IXOSC	B7PTC7_IXOSC	B7P207	B7PTC7	Uncharacterized protein.	Uncharacterized protein.	0.403
B7P207_IXOSC	B7Q0Z5_IXOSC	B7P207	B7Q0Z5	Uncharacterized protein.	Membrane-associated protein Hem, putative.	0.445
B7P207_IXOSC	B7Q3I1_IXOSC	B7P207	B7Q3I1	Uncharacterized protein.	Secernin, putative (Fragment).	0.588
B7P207_IXOSC	B7Q740_IXOSC	B7P207	B7Q740	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.697
B7P207_IXOSC	B7QB42_IXOSC	B7P207	B7QB42	Uncharacterized protein.	Arp2/3 complex 21 kD subunit, putative (Fragment).	0.675
B7P207_IXOSC	B7QDB0_IXOSC	B7P207	B7QDB0	Uncharacterized protein.	Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family.	0.676
B7P207_IXOSC	B7QGL0_IXOSC	B7P207	B7QGL0	Uncharacterized protein.	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.645
B7P207_IXOSC	Q4PMA3_IXOSC	B7P207	Q4PMA3	Uncharacterized protein.	Uncharacterized protein.	0.408
B7P350_IXOSC	B7P5Z5_IXOSC	B7P350	B7P5Z5	Myosin I, putative; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	0.448
B7P350_IXOSC	B7PGY1_IXOSC	B7P350	B7PGY1	Myosin I, putative; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	WH2 motif domaincontaining protein.	0.658
B7P350_IXOSC	B7PT90_IXOSC	B7P350	B7PT90	Myosin I, putative; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Wiskott-aldrich syndrome protein, putative (Fragment).	0.658
B7P5Z5_IXOSC	B7P207_IXOSC	B7P5Z5	B7P207	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	Uncharacterized protein.	0.695
B7P5Z5_IXOSC	B7P350_IXOSC	B7P5Z5	B7P350	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	Myosin I, putative; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.448