(32 nodes) Positive regulation of peptidase activity network (Ixodes scapularis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	B7QLC7_IXOSC	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (766 aa)
	B7QLA1_IXOSC	Granulin, putative (Fragment). (163 aa)
	B7QL13_IXOSC	Granulin, putative. (826 aa)
	B7QHN6_IXOSC	Caspase-2, putative (Fragment); Belongs to the peptidase C14A family. (299 aa)
	B7QGL7_IXOSC	DUF4203 domain-containing protein. (326 aa)
	B7P2C6_IXOSC	Legumain, putative. (446 aa)
	B7P5Y4_IXOSC	Uncharacterized protein. (180 aa)
	B7P6Q1_IXOSC	Granulin, putative (Fragment). (529 aa)
	B7P744_IXOSC	Cullin, putative; Belongs to the cullin family. (188 aa)
	B7P815_IXOSC	Granulin, putative (Fragment). (146 aa)
	B7P844_IXOSC	Aspartate beta-hydroxylase domain-containing protein, putative. (246 aa)
	B7P899_IXOSC	Ribonucleoside-diphosphate reductase large chain, putative (Fragment). (382 aa)
	B7P995_IXOSC	Mucosa-associated lymphoid tissue lymphoma translocation protein, putative. (512 aa)
	B7P9J7_IXOSC	GRAM domain-containing protein. (319 aa)
	B7PB91_IXOSC	Asparaginyl peptidase, putative. (151 aa)
	B7PC77_IXOSC	Ring canal protein, putative (Fragment). (582 aa)
	B7PCI3_IXOSC	Ribonucleotide reductase, beta subunit, putative. (376 aa)
	B7PJX6_IXOSC	Octopamine receptor oamb, putative; Belongs to the G-protein coupled receptor 1 family. (451 aa)
	B7PKN7_IXOSC	GMP synthase, putative (Fragment). (696 aa)
	B7PN13_IXOSC	SCF ubiquitin ligase, Rbx1 component, putative. (116 aa)
	B7PT26_IXOSC	Uncharacterized protein. (822 aa)
	B7PZV8_IXOSC	Serine protease, putative. (160 aa)
	B7Q113_IXOSC	Electron transfer flavoprotein, beta subunit, putative. (177 aa)
	B7Q1Z3_IXOSC	Serine/threonine protein kinase, putative. (327 aa)
	B7QA28_IXOSC	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (138 aa)
	B7Q8R1_IXOSC	Adhesion regulating molecule, putative (Fragment). (336 aa)
	B7Q690_IXOSC	Serine/threonine protein kinase, putative (Fragment). (473 aa)
	B7Q5P1_IXOSC	Succinate-CoA ligase subunit beta. (425 aa)
	B7Q420_IXOSC	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (779 aa)
	B7Q408_IXOSC	Proteasome activator complex subunit, putative. (1849 aa)
	B7Q3C2_IXOSC	Neuroendocrine protein 7b2, putative. (201 aa)
	B7Q3H4_IXOSC	Autoantigen, putative (Fragment). (128 aa)

Your Current Organism:

Ixodes scapularis

NCBI taxonomy Id: 6945
Other names: I. scapularis, Ixodes dammini, Ixodes sp. DNAS-303-249710, black-legged tick, blacklegged tick, deer tick, shoulder tick

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B7P5Y4_IXOSC	B7P744_IXOSC	B7P5Y4	B7P744	Uncharacterized protein.	Cullin, putative; Belongs to the cullin family.	0.450
B7P5Y4_IXOSC	B7QHN6_IXOSC	B7P5Y4	B7QHN6	Uncharacterized protein.	Caspase-2, putative (Fragment); Belongs to the peptidase C14A family.	0.433
B7P744_IXOSC	B7P5Y4_IXOSC	B7P744	B7P5Y4	Cullin, putative; Belongs to the cullin family.	Uncharacterized protein.	0.450
B7P744_IXOSC	B7PC77_IXOSC	B7P744	B7PC77	Cullin, putative; Belongs to the cullin family.	Ring canal protein, putative (Fragment).	0.991
B7P744_IXOSC	B7PN13_IXOSC	B7P744	B7PN13	Cullin, putative; Belongs to the cullin family.	SCF ubiquitin ligase, Rbx1 component, putative.	0.986
B7P744_IXOSC	B7Q1Z3_IXOSC	B7P744	B7Q1Z3	Cullin, putative; Belongs to the cullin family.	Serine/threonine protein kinase, putative.	0.421
B7P744_IXOSC	B7Q3H4_IXOSC	B7P744	B7Q3H4	Cullin, putative; Belongs to the cullin family.	Autoantigen, putative (Fragment).	0.612
B7P744_IXOSC	B7Q408_IXOSC	B7P744	B7Q408	Cullin, putative; Belongs to the cullin family.	Proteasome activator complex subunit, putative.	0.630
B7P899_IXOSC	B7PCI3_IXOSC	B7P899	B7PCI3	Ribonucleoside-diphosphate reductase large chain, putative (Fragment).	Ribonucleotide reductase, beta subunit, putative.	0.951
B7P899_IXOSC	B7PKN7_IXOSC	B7P899	B7PKN7	Ribonucleoside-diphosphate reductase large chain, putative (Fragment).	GMP synthase, putative (Fragment).	0.534
B7P899_IXOSC	B7Q420_IXOSC	B7P899	B7Q420	Ribonucleoside-diphosphate reductase large chain, putative (Fragment).	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.561
B7P899_IXOSC	B7QLC7_IXOSC	B7P899	B7QLC7	Ribonucleoside-diphosphate reductase large chain, putative (Fragment).	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.563
B7PC77_IXOSC	B7P744_IXOSC	B7PC77	B7P744	Ring canal protein, putative (Fragment).	Cullin, putative; Belongs to the cullin family.	0.991
B7PC77_IXOSC	B7PN13_IXOSC	B7PC77	B7PN13	Ring canal protein, putative (Fragment).	SCF ubiquitin ligase, Rbx1 component, putative.	0.924
B7PCI3_IXOSC	B7P899_IXOSC	B7PCI3	B7P899	Ribonucleotide reductase, beta subunit, putative.	Ribonucleoside-diphosphate reductase large chain, putative (Fragment).	0.951
B7PCI3_IXOSC	B7Q420_IXOSC	B7PCI3	B7Q420	Ribonucleotide reductase, beta subunit, putative.	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.997
B7PCI3_IXOSC	B7Q5P1_IXOSC	B7PCI3	B7Q5P1	Ribonucleotide reductase, beta subunit, putative.	Succinate-CoA ligase subunit beta.	0.506
B7PCI3_IXOSC	B7QLC7_IXOSC	B7PCI3	B7QLC7	Ribonucleotide reductase, beta subunit, putative.	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.997
B7PKN7_IXOSC	B7P899_IXOSC	B7PKN7	B7P899	GMP synthase, putative (Fragment).	Ribonucleoside-diphosphate reductase large chain, putative (Fragment).	0.534
B7PKN7_IXOSC	B7Q420_IXOSC	B7PKN7	B7Q420	GMP synthase, putative (Fragment).	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.534