(56 nodes) Cytosolic transport network (Ixodes scapularis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	B7PTH1_IXOSC	Ankyrin repeat containing protein. (570 aa)
	B7P149_IXOSC	Protein SYS1 homolog; Involved in protein trafficking. Belongs to the SYS1 family. (156 aa)
	B7P164_IXOSC	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. (182 aa)
	B7P1I8_IXOSC	Neutral sphingomyelinase (N-smase) activation associated factor FAN, putative (Fragment). (1378 aa)
	B7P1I9_IXOSC	Uncharacterized protein. (207 aa)
	B7P1K8_IXOSC	Vacuolar protein-sorting protein, putative. (605 aa)
	B7P269_IXOSC	WD domain, Gbeta repeat-containing protein. (714 aa)
	B7P2L0_IXOSC	Sorting nexin; Involved in several stages of intracellular trafficking. (408 aa)
	B7P4F9_IXOSC	RIC1 domain-containing protein. (328 aa)
	B7P4G0_IXOSC	RIC1 domain-containing protein. (878 aa)
	B7P4P6_IXOSC	V-SNARE, putative. (217 aa)
	B7P6H1_IXOSC	FABD domain-containing protein. (766 aa)
	B7P6H2_IXOSC	Tyrosine-protein kinase. (464 aa)
	B7P710_IXOSC	Sorting nexin, putative. (166 aa)
	B7P746_IXOSC	Uncharacterized protein. (495 aa)
	B7P7A2_IXOSC	Syntaxin, putative; Belongs to the syntaxin family. (247 aa)
	B7P8U5_IXOSC	Nuclear pore complex protein nup155, putative (Fragment). (1118 aa)
	B7PCX5_IXOSC	Hepatocyte growth factor-regulated tyrosine kinase substrate, putative. (392 aa)
	B7PE91_IXOSC	Sorting nexin, putative. (498 aa)
	B7PET6_IXOSC	Coiled-coil domain-containing protein, putative (Fragment). (808 aa)
	B7PEY2_IXOSC	Sorting nexin, putative. (279 aa)
	B7PGD2_IXOSC	Tyrosine protein phosphatase non-receptor type, putative. (1400 aa)
	B7PGM1_IXOSC	Cxyorf1, putative. (103 aa)
	B7PJL0_IXOSC	Regulator of G protein signaling, putative (Fragment). (1065 aa)
	B7PJL2_IXOSC	Regulator of g protein signaling, putative. (104 aa)
	B7PJP1_IXOSC	Vesicle transport protein; May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex. Belongs to the SFT2 family. (209 aa)
	B7PK70_IXOSC	Vacuolar membrane protein pep18, putative. (911 aa)
	B7PKH1_IXOSC	Cornichon, putative (Fragment). (261 aa)
	B7PM87_IXOSC	Uncharacterized protein. (545 aa)
	B7PMP6_IXOSC	AP-3 complex subunit delta-1, putative (Fragment). (925 aa)
	B7PNB8_IXOSC	Golgi vesicular membrane trafficking protein p18, putative. (140 aa)
	B7PQ07_IXOSC	H(Beta)58 protein, putative. (315 aa)
	B7PQM6_IXOSC	Ptm1, putative. (461 aa)
	B7PRS3_IXOSC	PQ-loop repeat-containing protein, putative. (243 aa)
	B7PRT0_IXOSC	MORN repeatcontaining protein. (567 aa)
	B7PWV4_IXOSC	RAB GTPase-activating protein, putative. (675 aa)
	B7PXU4_IXOSC	Vacuolar protein-sorting protein, putative. (839 aa)
	B7PYM8_IXOSC	HEAT repeat-containing protein 5B, putative. (2074 aa)
	B7PZN7_IXOSC	Protein dopey-1, putative. (2149 aa)
	B7Q243_IXOSC	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (358 aa)
	B7Q267_IXOSC	Osmotic avoidance abnormal protein, putative (Fragment); Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (426 aa)
	B7Q2Q5_IXOSC	Uncharacterized protein. (108 aa)
	B7Q3G2_IXOSC	Vasodilator-stimulated phosphoprotein, putative. (334 aa)
	B7Q4Q5_IXOSC	Vesicle transport protein GOT1B, putative. (140 aa)
	B7Q5G7_IXOSC	Vacuolar protein-sorting protein, putative. (844 aa)
	B7Q6A0_IXOSC	RNA binding motif-containing protein, putative (Fragment). (81 aa)
	B7Q7R1_IXOSC	RAS-related protein, putative. (208 aa)
	B7Q7T3_IXOSC	Granulocyte macrophage csf signaling molecule, putative (Fragment). (128 aa)
	B7Q8G5_IXOSC	Uncharacterized protein. (381 aa)
	B7Q8P2_IXOSC	Sorting nexin, putative (Fragment). (393 aa)
	B7QAK6_IXOSC	PH domain-containing protein. (242 aa)
	B7QCR5_IXOSC	Hyaluronan mediated motility receptor, putative (Fragment). (709 aa)
	B7QFX7_IXOSC	RAB-9 and, putative. (204 aa)
	B7QGJ2_IXOSC	Uncharacterized protein. (2382 aa)
	B7QHS7_IXOSC	RAS-related protein, putative (Fragment). (218 aa)
	B7QLI1_IXOSC	Vacuolar sorting protein, putative (Fragment). (738 aa)

Your Current Organism:

Ixodes scapularis

NCBI taxonomy Id: 6945
Other names: I. scapularis, Ixodes dammini, Ixodes sp. DNAS-303-249710, black-legged tick, blacklegged tick, deer tick, shoulder tick

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B7P149_IXOSC	B7P1K8_IXOSC	B7P149	B7P1K8	Protein SYS1 homolog; Involved in protein trafficking. Belongs to the SYS1 family.	Vacuolar protein-sorting protein, putative.	0.619
B7P149_IXOSC	B7P4F9_IXOSC	B7P149	B7P4F9	Protein SYS1 homolog; Involved in protein trafficking. Belongs to the SYS1 family.	RIC1 domain-containing protein.	0.497
B7P149_IXOSC	B7P4G0_IXOSC	B7P149	B7P4G0	Protein SYS1 homolog; Involved in protein trafficking. Belongs to the SYS1 family.	RIC1 domain-containing protein.	0.497
B7P149_IXOSC	B7P4P6_IXOSC	B7P149	B7P4P6	Protein SYS1 homolog; Involved in protein trafficking. Belongs to the SYS1 family.	V-SNARE, putative.	0.531
B7P149_IXOSC	B7PXU4_IXOSC	B7P149	B7PXU4	Protein SYS1 homolog; Involved in protein trafficking. Belongs to the SYS1 family.	Vacuolar protein-sorting protein, putative.	0.536
B7P149_IXOSC	B7Q5G7_IXOSC	B7P149	B7Q5G7	Protein SYS1 homolog; Involved in protein trafficking. Belongs to the SYS1 family.	Vacuolar protein-sorting protein, putative.	0.528
B7P149_IXOSC	B7Q7R1_IXOSC	B7P149	B7Q7R1	Protein SYS1 homolog; Involved in protein trafficking. Belongs to the SYS1 family.	RAS-related protein, putative.	0.538
B7P149_IXOSC	B7QCR5_IXOSC	B7P149	B7QCR5	Protein SYS1 homolog; Involved in protein trafficking. Belongs to the SYS1 family.	Hyaluronan mediated motility receptor, putative (Fragment).	0.527
B7P164_IXOSC	B7P2L0_IXOSC	B7P164	B7P2L0	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.	Sorting nexin; Involved in several stages of intracellular trafficking.	0.730
B7P164_IXOSC	B7P710_IXOSC	B7P164	B7P710	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.	Sorting nexin, putative.	0.950
B7P164_IXOSC	B7P7A2_IXOSC	B7P164	B7P7A2	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.	Syntaxin, putative; Belongs to the syntaxin family.	0.407
B7P164_IXOSC	B7PCX5_IXOSC	B7P164	B7PCX5	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.	Hepatocyte growth factor-regulated tyrosine kinase substrate, putative.	0.404
B7P164_IXOSC	B7PE91_IXOSC	B7P164	B7PE91	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.	Sorting nexin, putative.	0.690
B7P164_IXOSC	B7PGM1_IXOSC	B7P164	B7PGM1	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.	Cxyorf1, putative.	0.420
B7P164_IXOSC	B7PQ07_IXOSC	B7P164	B7PQ07	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.	H(Beta)58 protein, putative.	0.999
B7P164_IXOSC	B7PTH1_IXOSC	B7P164	B7PTH1	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.	Ankyrin repeat containing protein.	0.435
B7P164_IXOSC	B7PXU4_IXOSC	B7P164	B7PXU4	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.	Vacuolar protein-sorting protein, putative.	0.565
B7P164_IXOSC	B7Q7R1_IXOSC	B7P164	B7Q7R1	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.	RAS-related protein, putative.	0.452
B7P164_IXOSC	B7Q8P2_IXOSC	B7P164	B7Q8P2	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.	Sorting nexin, putative (Fragment).	0.985
B7P164_IXOSC	B7QFX7_IXOSC	B7P164	B7QFX7	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.	RAB-9 and, putative.	0.472