(109 nodes) Innate immune response network (Ixodes scapularis)

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Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ISCW002113	Antimicrobial peptide microplusin; Has bacteriostatic activity against Gram-positive bacteria, but not against Gram-negative bacteria. Has fungistatic activity against some but not all fungi. Binds and sequesters copper and iron ions. Copper-chelating is crucial for antimicrobial activity against M.luteus (By similarity). (107 aa)
	B7QNV0_IXOSC	Uncharacterized protein. (887 aa)
	B7QN98_IXOSC	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (266 aa)
	B7QN97_IXOSC	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (278 aa)
	B7QMK6_IXOSC	RING-type domain-containing protein. (390 aa)
	B7QMC8_IXOSC	Alpha-macroglobulin, putative (Fragment). (1092 aa)
	B7QJT0_IXOSC	Rho guanine nucleotide exchange factor, putative (Fragment). (572 aa)
	B7QJI7_IXOSC	Serine/threonine protein kinase, putative; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (577 aa)
	B7QJF3_IXOSC	Protein-glutamine gamma-glutamyltransferase, putative. (688 aa)
	B7QJ81_IXOSC	Eph receptor tyrosine kinase, putative. (902 aa)
	B7QHS0_IXOSC	Flotillin, putative; Belongs to the band 7/mec-2 family. Flotillin subfamily. (399 aa)
	B7QHN6_IXOSC	Caspase-2, putative (Fragment); Belongs to the peptidase C14A family. (299 aa)
	B7QGL7_IXOSC	DUF4203 domain-containing protein. (326 aa)
	B7QGK4_IXOSC	WD-repeat protein, putative (Fragment). (590 aa)
	B7QFC1_IXOSC	Spatzle alternatively spliced isoform 11.27, putative. (155 aa)
	B7QF75_IXOSC	GTPase binding protein, putative. (479 aa)
	B7QDN8_IXOSC	Sptzle 1B, putative. (191 aa)
	B7QC27_IXOSC	Peptidoglycan-recognition protein; Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. (197 aa)
	B7QAL6_IXOSC	Tnf receptor associated factor, putative. (419 aa)
	B7Q9T0_IXOSC	Collybistin, putative. (963 aa)
	B7Q9E4_IXOSC	Uncharacterized protein. (525 aa)
	B7Q941_IXOSC	TPIP alpha lipid phosphatase, putative. (363 aa)
	B7Q8J3_IXOSC	Uncharacterized protein. (326 aa)
	B7Q8J1_IXOSC	Uncharacterized protein. (233 aa)
	B7Q7X6_IXOSC	LAM_G_DOMAIN domain-containing protein. (372 aa)
	B7Q7X5_IXOSC	Laminin alpha-4 chain, putative. (807 aa)
	B7Q7F3_IXOSC	Adenosine deaminase acting on RNA (Adar)-1, putative. (503 aa)
	B7Q6S4_IXOSC	Prostate-specific transglutaminase, putative. (240 aa)
	B7Q6S3_IXOSC	Uncharacterized protein. (248 aa)
	B7Q6P7_IXOSC	COE1_DBD domain-containing protein. (238 aa)
	B7Q6P5_IXOSC	IPT/TIG domaincontaining protein. (619 aa)
	B7Q609_IXOSC	Cytoplasmic dynein heavy chain, putative (Fragment). (2827 aa)
	B7Q5P0_IXOSC	Cdc42 protein, putative. (202 aa)
	B7Q5J1_IXOSC	Peptidoglycan recognition protein, putative. (131 aa)
	B7Q3E7_IXOSC	Protein pellino, putative (Fragment). (391 aa)
	B7Q2Y0_IXOSC	Tyrosine-protein kinase. (457 aa)
	B7Q216_IXOSC	Tyrosine kinase, putative (Fragment). (1201 aa)
	B7Q1Z8_IXOSC	Neuronal cell adhesion molecule, putative. (1224 aa)
	B7Q1P4_IXOSC	Shc transforming protein, putative (Fragment). (461 aa)
	B7Q1E2_IXOSC	Thioester-containing protein, putative. (1475 aa)
	B7Q122_IXOSC	Mitogen-activated protein kinase. (411 aa)
	B7Q0A8_IXOSC	Myd88, putative. (364 aa)
	B7PZS1_IXOSC	Uncharacterized protein. (234 aa)
	B7PZM8_IXOSC	Rhogtpase, putative. (535 aa)
	B7PZ38_IXOSC	Prostate-specific transglutaminase, putative. (219 aa)
	B7PYZ8_IXOSC	Intermediate in Toll signal transduction pathway, putative. (466 aa)
	B7PWL2_IXOSC	F-spondin, putative (Fragment). (146 aa)
	B7PWC4_IXOSC	Poly [ADP-ribose] polymerase. (963 aa)
	B7PVJ6_IXOSC	Mitogen-activated protein kinase kinase MKK4, putative. (364 aa)
	B7PVH4_IXOSC	Tyrosine-protein kinase. (467 aa)
	B7PUZ1_IXOSC	Secreted protein, putative. (315 aa)
	B7PUU6_IXOSC	Toll, putative (Fragment). (436 aa)
	B7PUU5_IXOSC	Toll, putative. (250 aa)
	B7PUU4_IXOSC	Toll, putative. (421 aa)
	B7PUN2_IXOSC	TPR repeatcontaining protein C12orf30 (p120) family protein. (512 aa)
	B7PU24_IXOSC	Alpha-2-macroglobulin, putative (Fragment). (413 aa)
	B7PTW3_IXOSC	Werner helicase interacting protein, putative. (400 aa)
	B7PTW1_IXOSC	Ccaat/enhancer binding protein gamma, putative (Fragment). (136 aa)
	B7PTQ5_IXOSC	Cyclin T-dependent kinase CDK9, putative; Belongs to the protein kinase superfamily. (454 aa)
	B7PSP3_IXOSC	Non-specific protein-tyrosine kinase. (674 aa)
	B7PSF8_IXOSC	Hemocyte protein-glutamine gamma-glutamyltransferase, putative (Fragment). (655 aa)
	B7PSF5_IXOSC	Keratinocyte transglutaminase, putative. (260 aa)
	B7PRT0_IXOSC	MORN repeatcontaining protein. (567 aa)
	B7PR09_IXOSC	Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (860 aa)
	B7PQ56_IXOSC	Spaetzle domain-containing protein. (228 aa)
	B7PQ42_IXOSC	Spatzle 6, putative. (95 aa)
	B7PP03_IXOSC	Laminin subunit beta-1, putative (Fragment). (188 aa)
	B7PNJ7_IXOSC	RAB-20, putative. (215 aa)
	B7PNC7_IXOSC	Ephrin, putative (Fragment); Belongs to the ephrin family. (164 aa)
	B7PN98_IXOSC	RING-type domain-containing protein. (313 aa)
	B7PN45_IXOSC	Laminin alpha-1, 2 chain, putative. (615 aa)
	B7PN44_IXOSC	Netrin-4, putative. (370 aa)
	B7PLQ8_IXOSC	CCDC92 domain-containing protein. (324 aa)
	B7PL19_IXOSC	Tyrosine-protein kinase. (447 aa)
	B7PKS1_IXOSC	Receptor protein-tyrosine kinase. (1083 aa)
	B7PKK5_IXOSC	GTPase Rho, putative. (82 aa)
	B7PK63_IXOSC	Uncharacterized protein. (764 aa)
	B7PJX1_IXOSC	TIR domain-containing protein. (542 aa)
	B7PJE7_IXOSC	Uncharacterized protein. (222 aa)
	B7PJE4_IXOSC	Protein-glutamine gamma-glutamyltransferase, putative (Fragment). (358 aa)
	B7PIR9_IXOSC	Spaetzle domain-containing protein. (244 aa)
	B7PI18_IXOSC	Alpha-macroglobulin, putative. (1040 aa)
	B7PHY7_IXOSC	Cdc42 protein, putative. (191 aa)
	B7PH66_IXOSC	GTPase Rho, putative. (192 aa)
	B7PH65_IXOSC	GTPase Rho, putative (Fragment). (205 aa)
	B7PH64_IXOSC	Cdc42 protein, putative. (201 aa)
	B7PGK0_IXOSC	Toll, putative. (750 aa)
	B7PF32_IXOSC	Uncharacterized protein. (566 aa)
	B7PER7_IXOSC	Peptidoglycan recognition protein, putative (Fragment). (199 aa)
	B7PEN5_IXOSC	Uncharacterized protein. (246 aa)
	B7PE84_IXOSC	Uncharacterized protein. (188 aa)
	B7PCZ6_IXOSC	Uncharacterized protein. (1472 aa)
	B7PCX4_IXOSC	Peptidoglycan recognition protein, putative (Fragment). (105 aa)
	B7PC36_IXOSC	Spatzle, putative. (550 aa)
	B7PBR2_IXOSC	Protein kinase, putative. (455 aa)
	B7PBP3_IXOSC	TOLLIP protein, putative. (193 aa)
	B7PA88_IXOSC	Poly [ADP-ribose] polymerase. (485 aa)
	B7P9I4_IXOSC	Cyclin-dependent kinase 5 activator, putative. (282 aa)
	B7P995_IXOSC	Mucosa-associated lymphoid tissue lymphoma translocation protein, putative. (512 aa)
	B7P8X6_IXOSC	Cdc42 protein, putative (Fragment). (238 aa)
	B7P8T7_IXOSC	Suppressor of potassium transport defect, putative. (609 aa)
	B7P5M3_IXOSC	Hemolin, putative. (270 aa)
	B7P4P0_IXOSC	Activated met oncogene, putative. (611 aa)
	B7P466_IXOSC	Serine-threonine protein kinase, plant-type, putative. (788 aa)
	B7P3R4_IXOSC	Zeta-associated protein Zap-70, putative. (207 aa)
	B7P264_IXOSC	Guanine nucleotide exchange factor, putative. (1373 aa)
	B7P1J6_IXOSC	GTPase Rho, putative. (228 aa)
	B7P0V3_IXOSC	Embryonic polarity dorsal, putative. (370 aa)
	B7P0S1_IXOSC	Rac3A protein, putative (Fragment). (189 aa)

Your Current Organism:

Ixodes scapularis

NCBI taxonomy Id: 6945
Other names: I. scapularis, Ixodes dammini, Ixodes sp. DNAS-303-249710, black-legged tick, blacklegged tick, deer tick, shoulder tick

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B7P0S1_IXOSC	B7P1J6_IXOSC	B7P0S1	B7P1J6	Rac3A protein, putative (Fragment).	GTPase Rho, putative.	0.545
B7P0S1_IXOSC	B7P264_IXOSC	B7P0S1	B7P264	Rac3A protein, putative (Fragment).	Guanine nucleotide exchange factor, putative.	0.400
B7P0S1_IXOSC	B7P8X6_IXOSC	B7P0S1	B7P8X6	Rac3A protein, putative (Fragment).	Cdc42 protein, putative (Fragment).	0.517
B7P0S1_IXOSC	B7PH64_IXOSC	B7P0S1	B7PH64	Rac3A protein, putative (Fragment).	Cdc42 protein, putative.	0.554
B7P0S1_IXOSC	B7PH65_IXOSC	B7P0S1	B7PH65	Rac3A protein, putative (Fragment).	GTPase Rho, putative (Fragment).	0.539
B7P0S1_IXOSC	B7PH66_IXOSC	B7P0S1	B7PH66	Rac3A protein, putative (Fragment).	GTPase Rho, putative.	0.731
B7P0S1_IXOSC	B7PKK5_IXOSC	B7P0S1	B7PKK5	Rac3A protein, putative (Fragment).	GTPase Rho, putative.	0.543
B7P0S1_IXOSC	B7PL19_IXOSC	B7P0S1	B7PL19	Rac3A protein, putative (Fragment).	Tyrosine-protein kinase.	0.505
B7P0S1_IXOSC	B7PNC7_IXOSC	B7P0S1	B7PNC7	Rac3A protein, putative (Fragment).	Ephrin, putative (Fragment); Belongs to the ephrin family.	0.439
B7P0S1_IXOSC	B7PR09_IXOSC	B7P0S1	B7PR09	Rac3A protein, putative (Fragment).	Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family.	0.485
B7P0S1_IXOSC	B7PRT0_IXOSC	B7P0S1	B7PRT0	Rac3A protein, putative (Fragment).	MORN repeatcontaining protein.	0.425
B7P0S1_IXOSC	B7PSP3_IXOSC	B7P0S1	B7PSP3	Rac3A protein, putative (Fragment).	Non-specific protein-tyrosine kinase.	0.482
B7P0S1_IXOSC	B7PVH4_IXOSC	B7P0S1	B7PVH4	Rac3A protein, putative (Fragment).	Tyrosine-protein kinase.	0.505
B7P0S1_IXOSC	B7Q122_IXOSC	B7P0S1	B7Q122	Rac3A protein, putative (Fragment).	Mitogen-activated protein kinase.	0.970
B7P0S1_IXOSC	B7Q1P4_IXOSC	B7P0S1	B7Q1P4	Rac3A protein, putative (Fragment).	Shc transforming protein, putative (Fragment).	0.413
B7P0S1_IXOSC	B7Q5P0_IXOSC	B7P0S1	B7Q5P0	Rac3A protein, putative (Fragment).	Cdc42 protein, putative.	0.902
B7P0S1_IXOSC	B7Q9T0_IXOSC	B7P0S1	B7Q9T0	Rac3A protein, putative (Fragment).	Collybistin, putative.	0.819
B7P0S1_IXOSC	B7QJ81_IXOSC	B7P0S1	B7QJ81	Rac3A protein, putative (Fragment).	Eph receptor tyrosine kinase, putative.	0.532
B7P0S1_IXOSC	B7QJI7_IXOSC	B7P0S1	B7QJI7	Rac3A protein, putative (Fragment).	Serine/threonine protein kinase, putative; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.629
B7P0S1_IXOSC	B7QJT0_IXOSC	B7P0S1	B7QJT0	Rac3A protein, putative (Fragment).	Rho guanine nucleotide exchange factor, putative (Fragment).	0.841