(18 nodes) Positive regulation of receptor-mediated endocytosis network (Ixodes scapularis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	B7QI18_IXOSC	RAB GDP/GTP exchange factor, putative. (989 aa)
	B7P0R2_IXOSC	C. elegans sem-5, putative. (211 aa)
	B7P0V4_IXOSC	Cortactin, putative. (599 aa)
	B7P6Q5_IXOSC	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1109 aa)
	B7PEM1_IXOSC	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (556 aa)
	B7PH72_IXOSC	Uncharacterized protein. (813 aa)
	B7PMB5_IXOSC	Phosphatidylinositol-binding clathrin assembly protein, putative. (821 aa)
	B7PWH7_IXOSC	E3 ubiquitin-protein ligase. (946 aa)
	B7PWS6_IXOSC	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
	B7PWV3_IXOSC	E3 ubiquitin ligase, putative. (459 aa)
	B7PZA9_IXOSC	P63, Putative. (472 aa)
	B7Q1G0_IXOSC	Variant sh3 domaincontaining protein. (690 aa)
	B7Q6G3_IXOSC	Gremlin-1, putative. (170 aa)
	B7Q7G5_IXOSC	Protein kinase C alpha binding protein, putative. (189 aa)
	B7Q7T2_IXOSC	MIT domain-containing protein. (417 aa)
	B7Q8Q0_IXOSC	Ubiquitin protein ligase, putative. (972 aa)
	B7QI66_IXOSC	Ldl receptor adaptor protein, putative. (250 aa)
	B7QNY3_IXOSC	Rho GTPase-activating protein, putative. (790 aa)

Your Current Organism:

Ixodes scapularis

NCBI taxonomy Id: 6945
Other names: I. scapularis, Ixodes dammini, Ixodes sp. DNAS-303-249710, black-legged tick, blacklegged tick, deer tick, shoulder tick

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B7P0R2_IXOSC	B7PWH7_IXOSC	B7P0R2	B7PWH7	C. elegans sem-5, putative.	E3 ubiquitin-protein ligase.	0.693
B7P0R2_IXOSC	B7PWV3_IXOSC	B7P0R2	B7PWV3	C. elegans sem-5, putative.	E3 ubiquitin ligase, putative.	0.987
B7P0R2_IXOSC	B7Q1G0_IXOSC	B7P0R2	B7Q1G0	C. elegans sem-5, putative.	Variant sh3 domaincontaining protein.	0.774
B7P0R2_IXOSC	B7Q8Q0_IXOSC	B7P0R2	B7Q8Q0	C. elegans sem-5, putative.	Ubiquitin protein ligase, putative.	0.478
B7P6Q5_IXOSC	B7PWS6_IXOSC	B7P6Q5	B7PWS6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.936
B7PEM1_IXOSC	B7PWS6_IXOSC	B7PEM1	B7PWS6	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.618
B7PMB5_IXOSC	B7Q1G0_IXOSC	B7PMB5	B7Q1G0	Phosphatidylinositol-binding clathrin assembly protein, putative.	Variant sh3 domaincontaining protein.	0.831
B7PMB5_IXOSC	B7QI66_IXOSC	B7PMB5	B7QI66	Phosphatidylinositol-binding clathrin assembly protein, putative.	Ldl receptor adaptor protein, putative.	0.465
B7PWH7_IXOSC	B7P0R2_IXOSC	B7PWH7	B7P0R2	E3 ubiquitin-protein ligase.	C. elegans sem-5, putative.	0.693
B7PWH7_IXOSC	B7PWV3_IXOSC	B7PWH7	B7PWV3	E3 ubiquitin-protein ligase.	E3 ubiquitin ligase, putative.	0.930
B7PWS6_IXOSC	B7P6Q5_IXOSC	B7PWS6	B7P6Q5	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.936
B7PWS6_IXOSC	B7PEM1_IXOSC	B7PWS6	B7PEM1	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.618
B7PWS6_IXOSC	B7Q7G5_IXOSC	B7PWS6	B7Q7G5	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Protein kinase C alpha binding protein, putative.	0.602
B7PWV3_IXOSC	B7P0R2_IXOSC	B7PWV3	B7P0R2	E3 ubiquitin ligase, putative.	C. elegans sem-5, putative.	0.987
B7PWV3_IXOSC	B7PWH7_IXOSC	B7PWV3	B7PWH7	E3 ubiquitin ligase, putative.	E3 ubiquitin-protein ligase.	0.930
B7PWV3_IXOSC	B7Q1G0_IXOSC	B7PWV3	B7Q1G0	E3 ubiquitin ligase, putative.	Variant sh3 domaincontaining protein.	0.952
B7PWV3_IXOSC	B7QI66_IXOSC	B7PWV3	B7QI66	E3 ubiquitin ligase, putative.	Ldl receptor adaptor protein, putative.	0.539
B7Q1G0_IXOSC	B7P0R2_IXOSC	B7Q1G0	B7P0R2	Variant sh3 domaincontaining protein.	C. elegans sem-5, putative.	0.774
B7Q1G0_IXOSC	B7PMB5_IXOSC	B7Q1G0	B7PMB5	Variant sh3 domaincontaining protein.	Phosphatidylinositol-binding clathrin assembly protein, putative.	0.831
B7Q1G0_IXOSC	B7PWV3_IXOSC	B7Q1G0	B7PWV3	Variant sh3 domaincontaining protein.	E3 ubiquitin ligase, putative.	0.952