(42 nodes) Defense response to Gram-negative bacterium network (Ixodes scapularis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	B7QHE0_IXOSC	Laminin beta 1 chain, putative. (2084 aa)
	B7QI42_IXOSC	Beclin, putative. (443 aa)
	Q4VRW2_IXOSC	Protective antigen 4D8. (184 aa)
	B7PSE2_IXOSC	Histone acetyltransferase type B catalytic subunit. (411 aa)
	B7P2P5_IXOSC	CA domain-containing protein. (117 aa)
	B7P310_IXOSC	Dehydrogenase, putative. (411 aa)
	B7P4F5_IXOSC	Sumo ligase, putative. (263 aa)
	B7P5Y3_IXOSC	Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (826 aa)
	B7P7P1_IXOSC	Tnf receptor associated factor, putative. (324 aa)
	B7P7S5_IXOSC	Asparaginase, putative (Fragment). (377 aa)
	B7P8W6_IXOSC	Protocadherin fat, putative. (2933 aa)
	B7PAT7_IXOSC	Protein transport protein Sec31A, putative (Fragment). (1184 aa)
	B7PIR6_IXOSC	Protein phosphatase 1 regulatory subunit, putative (Fragment). (125 aa)
	B7PIR9_IXOSC	Spaetzle domain-containing protein. (244 aa)
	B7PL56_IXOSC	Nuclear factor nf-kappa-B P105 subunit, putative. (349 aa)
	B7PLL7_IXOSC	Sumo ligase, putative (Fragment). (480 aa)
	B7PLS5_IXOSC	Cadherin, putative. (1123 aa)
	B7PMJ5_IXOSC	Programmed cell death, putative. (119 aa)
	B7PNB5_IXOSC	Activin_recp domain-containing protein. (141 aa)
	B7PNZ7_IXOSC	S-adenosylmethionine decarboxylase, putative (Fragment). (384 aa)
	B7PQK3_IXOSC	Williams-beuren syndrome critical region protein, putative (Fragment); Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (445 aa)
	B7PRR0_IXOSC	DNA repair and recombination protein RAD54B, putative. (614 aa)
	B7PT81_IXOSC	Ubiquitin protein ligase; Belongs to the ubiquitin-conjugating enzyme family. (168 aa)
	B7PTF4_IXOSC	Uncharacterized protein. (205 aa)
	B7PUY4_IXOSC	Sumo ligase, putative. (143 aa)
	B7PVI0_IXOSC	Chain A, solution structure Of The Ibr Domain Of The RING finger protein 31 protein, putative. (138 aa)
	B7Q0J3_IXOSC	p15-2B protein, Putative. (143 aa)
	B7Q195_IXOSC	Developmental orphan receptor, putative. (431 aa)
	B7Q3J7_IXOSC	Ubiquitin specific protease, putative; Belongs to the peptidase C19 family. (1324 aa)
	B7Q8I1_IXOSC	Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (573 aa)
	B7Q8N1_IXOSC	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (308 aa)
	B7Q8P0_IXOSC	Myotubularinrelated protein. (710 aa)
	B7Q9L2_IXOSC	Nucleolar protein c7c, putative (Fragment). (804 aa)
	B7QCK3_IXOSC	Translation elongation factor EF-1 alpha/Tu, putative. (697 aa)
	B7QDN8_IXOSC	Sptzle 1B, putative. (191 aa)
	B7QF22_IXOSC	NAV2 protein, putative. (706 aa)
	B7QF25_IXOSC	Mucin-21, putative. (505 aa)
	B7QF27_IXOSC	Uncharacterized protein. (317 aa)
	B7QFC1_IXOSC	Spatzle alternatively spliced isoform 11.27, putative. (155 aa)
	B7QGL7_IXOSC	DUF4203 domain-containing protein. (326 aa)
	B7QGZ6_IXOSC	Sumo ligase, putative. (223 aa)
	B7QH06_IXOSC	WD-repeat protein, putative (Fragment). (358 aa)

Your Current Organism:

Ixodes scapularis

NCBI taxonomy Id: 6945
Other names: I. scapularis, Ixodes dammini, Ixodes sp. DNAS-303-249710, black-legged tick, blacklegged tick, deer tick, shoulder tick

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B7P7P1_IXOSC	B7PL56_IXOSC	B7P7P1	B7PL56	Tnf receptor associated factor, putative.	Nuclear factor nf-kappa-B P105 subunit, putative.	0.412
B7PL56_IXOSC	B7P7P1_IXOSC	B7PL56	B7P7P1	Nuclear factor nf-kappa-B P105 subunit, putative.	Tnf receptor associated factor, putative.	0.412
B7PL56_IXOSC	B7QFC1_IXOSC	B7PL56	B7QFC1	Nuclear factor nf-kappa-B P105 subunit, putative.	Spatzle alternatively spliced isoform 11.27, putative.	0.462
B7PL56_IXOSC	B7QGL7_IXOSC	B7PL56	B7QGL7	Nuclear factor nf-kappa-B P105 subunit, putative.	DUF4203 domain-containing protein.	0.612
B7PMJ5_IXOSC	B7QI42_IXOSC	B7PMJ5	B7QI42	Programmed cell death, putative.	Beclin, putative.	0.551
B7QFC1_IXOSC	B7PL56_IXOSC	B7QFC1	B7PL56	Spatzle alternatively spliced isoform 11.27, putative.	Nuclear factor nf-kappa-B P105 subunit, putative.	0.462
B7QGL7_IXOSC	B7PL56_IXOSC	B7QGL7	B7PL56	DUF4203 domain-containing protein.	Nuclear factor nf-kappa-B P105 subunit, putative.	0.612
B7QI42_IXOSC	B7PMJ5_IXOSC	B7QI42	B7PMJ5	Beclin, putative.	Programmed cell death, putative.	0.551