(41 nodes) Positive regulation of secretion network (Ixodes scapularis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

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protein homology

Your Input:
	B7PZ70_IXOSC	RAS-related protein, putative. (126 aa)
	Q4PLZ4_IXOSC	Endothelial monocyte-activating protein II-like. (309 aa)
	B7QNA3_IXOSC	Metalloprotease, putative. (109 aa)
	B7QLI1_IXOSC	Vacuolar sorting protein, putative (Fragment). (738 aa)
	B7QKP6_IXOSC	Type 3 inositol 1,4,5-trisphosphate receptor, putative. (2569 aa)
	B7QK26_IXOSC	Salivary metalloprotease, putative. (259 aa)
	B7QIN6_IXOSC	Sorting nexin 9 variant, putative (Fragment). (160 aa)
	B7QHS0_IXOSC	Flotillin, putative; Belongs to the band 7/mec-2 family. Flotillin subfamily. (399 aa)
	B7QFJ7_IXOSC	Metalloprotease, putative (Fragment). (128 aa)
	B7QF57_IXOSC	Autophagy protein 5; Involved in autophagic vesicle formation. (194 aa)
	B7QD66_IXOSC	Fmp27_GFWDK domain-containing protein. (1345 aa)
	B7QBW7_IXOSC	Integral membrane protein GPR177-B, putative (Fragment). (526 aa)
	B7Q9Y5_IXOSC	Sorting nexin, putative. (369 aa)
	B7Q8Q8_IXOSC	CUB domain-containing protein. (251 aa)
	B7Q7Z1_IXOSC	Codakine isoform, putative (Fragment). (231 aa)
	B7Q7Z0_IXOSC	Serine protease family protein. (187 aa)
	B7Q4I4_IXOSC	Metalloprotease, putative. (119 aa)
	B7Q4I3_IXOSC	Metalloprotease, putative (Fragment). (395 aa)
	B7Q2C1_IXOSC	Metalloprotease, putative. (291 aa)
	B7Q1Z1_IXOSC	Ca2+-dependent activator protein for secretion 2 isoform A, putative. (1355 aa)
	B7Q163_IXOSC	RAB-3 GTPase-activating protein catalytic subunit, putative. (475 aa)
	B7Q159_IXOSC	RAB-3GAP1 protein, putative (Fragment). (258 aa)
	B7PZS8_IXOSC	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (510 aa)
	B7P710_IXOSC	Sorting nexin, putative. (166 aa)
	B7PAK9_IXOSC	Rho GTPase-activating protein RICH2, putative. (824 aa)
	B7PBH8_IXOSC	Uncharacterized protein. (791 aa)
	B7PBS6_IXOSC	CUB domaincontaining protein. (506 aa)
	B7PBS7_IXOSC	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (445 aa)
	B7PC18_IXOSC	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (589 aa)
	B7PCX5_IXOSC	Hepatocyte growth factor-regulated tyrosine kinase substrate, putative. (392 aa)
	B7PGD2_IXOSC	Tyrosine protein phosphatase non-receptor type, putative. (1400 aa)
	B7PGV5_IXOSC	PDZ/DHR/GLGF domaincontaining protein. (1104 aa)
	B7PH72_IXOSC	Uncharacterized protein. (813 aa)
	B7PK70_IXOSC	Vacuolar membrane protein pep18, putative. (911 aa)
	B7PL65_IXOSC	DUF4203 domain-containing protein. (443 aa)
	B7PN32_IXOSC	Basic helix-loop-helix protein mist1, putative. (181 aa)
	B7PP60_IXOSC	Peptidase, S54 (rhomboid) family protein. (453 aa)
	B7PPK2_IXOSC	Munc13-4, putative. (1075 aa)
	B7PPP9_IXOSC	Adiponectin receptor, putative (Fragment). (248 aa)
	B7PTJ6_IXOSC	Metalloprotease, putative. (225 aa)
	B7PWY7_IXOSC	RAB-23, putative. (233 aa)

Your Current Organism:

Ixodes scapularis

NCBI taxonomy Id: 6945
Other names: I. scapularis, Ixodes dammini, Ixodes sp. DNAS-303-249710, black-legged tick, blacklegged tick, deer tick, shoulder tick

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B7P710_IXOSC	B7PCX5_IXOSC	B7P710	B7PCX5	Sorting nexin, putative.	Hepatocyte growth factor-regulated tyrosine kinase substrate, putative.	0.729
B7P710_IXOSC	B7Q9Y5_IXOSC	B7P710	B7Q9Y5	Sorting nexin, putative.	Sorting nexin, putative.	0.654
B7P710_IXOSC	B7QBW7_IXOSC	B7P710	B7QBW7	Sorting nexin, putative.	Integral membrane protein GPR177-B, putative (Fragment).	0.858
B7P710_IXOSC	B7QIN6_IXOSC	B7P710	B7QIN6	Sorting nexin, putative.	Sorting nexin 9 variant, putative (Fragment).	0.563
B7P710_IXOSC	B7QLI1_IXOSC	B7P710	B7QLI1	Sorting nexin, putative.	Vacuolar sorting protein, putative (Fragment).	0.992
B7PBH8_IXOSC	B7PBS7_IXOSC	B7PBH8	B7PBS7	Uncharacterized protein.	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	0.650
B7PBH8_IXOSC	B7PZS8_IXOSC	B7PBH8	B7PZS8	Uncharacterized protein.	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	0.650
B7PBS7_IXOSC	B7PBH8_IXOSC	B7PBS7	B7PBH8	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	Uncharacterized protein.	0.650
B7PBS7_IXOSC	B7PZS8_IXOSC	B7PBS7	B7PZS8	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	0.901
B7PCX5_IXOSC	B7P710_IXOSC	B7PCX5	B7P710	Hepatocyte growth factor-regulated tyrosine kinase substrate, putative.	Sorting nexin, putative.	0.729
B7PCX5_IXOSC	B7PGD2_IXOSC	B7PCX5	B7PGD2	Hepatocyte growth factor-regulated tyrosine kinase substrate, putative.	Tyrosine protein phosphatase non-receptor type, putative.	0.751
B7PCX5_IXOSC	B7QHS0_IXOSC	B7PCX5	B7QHS0	Hepatocyte growth factor-regulated tyrosine kinase substrate, putative.	Flotillin, putative; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.535
B7PCX5_IXOSC	B7QLI1_IXOSC	B7PCX5	B7QLI1	Hepatocyte growth factor-regulated tyrosine kinase substrate, putative.	Vacuolar sorting protein, putative (Fragment).	0.668
B7PGD2_IXOSC	B7PCX5_IXOSC	B7PGD2	B7PCX5	Tyrosine protein phosphatase non-receptor type, putative.	Hepatocyte growth factor-regulated tyrosine kinase substrate, putative.	0.751
B7PK70_IXOSC	B7QLI1_IXOSC	B7PK70	B7QLI1	Vacuolar membrane protein pep18, putative.	Vacuolar sorting protein, putative (Fragment).	0.606
B7PPK2_IXOSC	B7PZ70_IXOSC	B7PPK2	B7PZ70	Munc13-4, putative.	RAS-related protein, putative.	0.465
B7PZ70_IXOSC	B7PPK2_IXOSC	B7PZ70	B7PPK2	RAS-related protein, putative.	Munc13-4, putative.	0.465
B7PZS8_IXOSC	B7PBH8_IXOSC	B7PZS8	B7PBH8	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	Uncharacterized protein.	0.650
B7PZS8_IXOSC	B7PBS7_IXOSC	B7PZS8	B7PBS7	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	0.901
B7Q159_IXOSC	B7Q163_IXOSC	B7Q159	B7Q163	RAB-3GAP1 protein, putative (Fragment).	RAB-3 GTPase-activating protein catalytic subunit, putative.	0.938