(38 nodes) 4 iron, 4 sulfur cluster binding network (Ixodes scapularis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	B7PEX6_IXOSC	HELICc2 domain-containing protein. (280 aa)
	B7PRQ9_IXOSC	CDK5 regulatory subunit-associated protein, putative (Fragment). (547 aa)
	Q4PM24_IXOSC	Ribosome associated membrane protein 4. (64 aa)
	B7QNT8_IXOSC	Iron-sulfur protein Isa2, putative. (118 aa)
	B7QN38_IXOSC	Flavodoxin-like domain-containing protein. (581 aa)
	B7QKV4_IXOSC	DNA replication helicase DNA2, putative (Fragment). (574 aa)
	B7QGD6_IXOSC	Molybdenum cofactor biosynthesis pathway protein, putative. (143 aa)
	B7QGB3_IXOSC	Uncharacterized protein. (226 aa)
	B7QG38_IXOSC	NADH-plastoquinone oxidoreductase, putative. (162 aa)
	B7QCA1_IXOSC	RNA-binding translational regulator IRP, putative (Fragment). (853 aa)
	B7Q9H1_IXOSC	DNA replication helicase DNA2, putative. (292 aa)
	B7Q9E1_IXOSC	Aconitase, putative. (65 aa)
	B7Q4U2_IXOSC	Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. (326 aa)
	B7Q4K3_IXOSC	NADH:ubiquinone oxidoreductase, NDUFS8/23 kDa subunit, putative (Fragment). (210 aa)
	B7Q4E2_IXOSC	Molybdenum cofactor biosynthesis pathway protein, putative. (381 aa)
	B7Q0G0_IXOSC	Uncharacterized protein. (131 aa)
	B7PZ95_IXOSC	DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (521 aa)
	B7PXP0_IXOSC	Coproporphyrinigen III oxidase, putative (Fragment). (402 aa)
	B7PWM1_IXOSC	DNA primase large subunit, putative. (449 aa)
	B7PW21_IXOSC	DEAD_2 protein domain containing protein. (805 aa)
	B7P2L3_IXOSC	DNA replication helicase DNA2, putative. (207 aa)
	B7P4H9_IXOSC	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (345 aa)
	B7P666_IXOSC	MTTase N-terminal domain-containing protein. (203 aa)
	B7P6B0_IXOSC	Aconitase/homoaconitase, putative (Fragment). (637 aa)
	B7P6B1_IXOSC	NADH-ubiquinone reductase, putative; Belongs to the complex I 75 kDa subunit family. (671 aa)
	B7P6B3_IXOSC	Uncharacterized protein. (446 aa)
	B7PB42_IXOSC	Fe_hyd_lg_C domain-containing protein. (300 aa)
	B7PBH7_IXOSC	NADH-ubiquinone reductase, putative; Belongs to the complex I 75 kDa subunit family. (729 aa)
	B7PCR8_IXOSC	ATPase, nucleotide- binding protein, putative. (205 aa)
	B7PDW8_IXOSC	Molybdenum cofactor biosynthesis pathway protein, putative. (161 aa)
	B7PF36_IXOSC	Uncharacterized protein. (285 aa)
	B7PFI1_IXOSC	Molybdenum cofactor biosynthesis pathway protein, putative. (143 aa)
	B7PGJ4_IXOSC	Aconitase 2, putative (Fragment). (181 aa)
	B7PNG9_IXOSC	Coproporphyrinigen III oxidase, putative (Fragment). (177 aa)
	B7PNX4_IXOSC	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. (477 aa)
	ISCW019144	Anamorsin homolog; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RN [...] (274 aa)
	B7PR51_IXOSC	Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (245 aa)
	B7PRM2_IXOSC	MTTase N-terminal domain-containing protein. (460 aa)

Your Current Organism:

Ixodes scapularis

NCBI taxonomy Id: 6945
Other names: I. scapularis, Ixodes dammini, Ixodes sp. DNAS-303-249710, black-legged tick, blacklegged tick, deer tick, shoulder tick

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B7P2L3_IXOSC	B7PEX6_IXOSC	B7P2L3	B7PEX6	DNA replication helicase DNA2, putative.	HELICc2 domain-containing protein.	0.545
B7P2L3_IXOSC	B7PW21_IXOSC	B7P2L3	B7PW21	DNA replication helicase DNA2, putative.	DEAD_2 protein domain containing protein.	0.545
B7P2L3_IXOSC	B7PWM1_IXOSC	B7P2L3	B7PWM1	DNA replication helicase DNA2, putative.	DNA primase large subunit, putative.	0.601
B7P2L3_IXOSC	B7PZ95_IXOSC	B7P2L3	B7PZ95	DNA replication helicase DNA2, putative.	DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family.	0.601
B7P4H9_IXOSC	B7Q4U2_IXOSC	B7P4H9	B7Q4U2	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.	0.742
B7P666_IXOSC	B7PR51_IXOSC	B7P666	B7PR51	MTTase N-terminal domain-containing protein.	Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	0.419
B7P6B0_IXOSC	B7P6B1_IXOSC	B7P6B0	B7P6B1	Aconitase/homoaconitase, putative (Fragment).	NADH-ubiquinone reductase, putative; Belongs to the complex I 75 kDa subunit family.	0.417
B7P6B0_IXOSC	B7PBH7_IXOSC	B7P6B0	B7PBH7	Aconitase/homoaconitase, putative (Fragment).	NADH-ubiquinone reductase, putative; Belongs to the complex I 75 kDa subunit family.	0.417
B7P6B0_IXOSC	B7PNX4_IXOSC	B7P6B0	B7PNX4	Aconitase/homoaconitase, putative (Fragment).	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain.	0.524
B7P6B0_IXOSC	B7PR51_IXOSC	B7P6B0	B7PR51	Aconitase/homoaconitase, putative (Fragment).	Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	0.438
B7P6B0_IXOSC	B7Q4K3_IXOSC	B7P6B0	B7Q4K3	Aconitase/homoaconitase, putative (Fragment).	NADH:ubiquinone oxidoreductase, NDUFS8/23 kDa subunit, putative (Fragment).	0.485
B7P6B1_IXOSC	B7P6B0_IXOSC	B7P6B1	B7P6B0	NADH-ubiquinone reductase, putative; Belongs to the complex I 75 kDa subunit family.	Aconitase/homoaconitase, putative (Fragment).	0.417
B7P6B1_IXOSC	B7PCR8_IXOSC	B7P6B1	B7PCR8	NADH-ubiquinone reductase, putative; Belongs to the complex I 75 kDa subunit family.	ATPase, nucleotide- binding protein, putative.	0.517
B7P6B1_IXOSC	B7PGJ4_IXOSC	B7P6B1	B7PGJ4	NADH-ubiquinone reductase, putative; Belongs to the complex I 75 kDa subunit family.	Aconitase 2, putative (Fragment).	0.417
B7P6B1_IXOSC	B7PNX4_IXOSC	B7P6B1	B7PNX4	NADH-ubiquinone reductase, putative; Belongs to the complex I 75 kDa subunit family.	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain.	0.999
B7P6B1_IXOSC	B7Q0G0_IXOSC	B7P6B1	B7Q0G0	NADH-ubiquinone reductase, putative; Belongs to the complex I 75 kDa subunit family.	Uncharacterized protein.	0.517
B7P6B1_IXOSC	B7Q4K3_IXOSC	B7P6B1	B7Q4K3	NADH-ubiquinone reductase, putative; Belongs to the complex I 75 kDa subunit family.	NADH:ubiquinone oxidoreductase, NDUFS8/23 kDa subunit, putative (Fragment).	0.999
B7P6B1_IXOSC	B7Q9E1_IXOSC	B7P6B1	B7Q9E1	NADH-ubiquinone reductase, putative; Belongs to the complex I 75 kDa subunit family.	Aconitase, putative.	0.628
B7P6B1_IXOSC	B7QCA1_IXOSC	B7P6B1	B7QCA1	NADH-ubiquinone reductase, putative; Belongs to the complex I 75 kDa subunit family.	RNA-binding translational regulator IRP, putative (Fragment).	0.417
B7P6B1_IXOSC	B7QG38_IXOSC	B7P6B1	B7QG38	NADH-ubiquinone reductase, putative; Belongs to the complex I 75 kDa subunit family.	NADH-plastoquinone oxidoreductase, putative.	0.998