(59 nodes) Signaling by NTRKs network (Ixodes scapularis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	B7P0R2_IXOSC	C. elegans sem-5, putative. (211 aa)
	B7P1J6_IXOSC	GTPase Rho, putative. (228 aa)
	B7P6L3_IXOSC	Uncharacterized protein. (756 aa)
	B7P6Y3_IXOSC	MAP kinase-activated protein kinase, putative; Belongs to the protein kinase superfamily. (467 aa)
	B7P723_IXOSC	Uncharacterized protein. (137 aa)
	B7P8X6_IXOSC	Cdc42 protein, putative (Fragment). (238 aa)
	B7P9R7_IXOSC	Venom nerve growth factor, putative (Fragment). (70 aa)
	B7P9Z2_IXOSC	AP-2 complex subunit alpha-1, putative. (861 aa)
	B7PA24_IXOSC	Protein phosphatase 2A regulatory subunit A, putative. (597 aa)
	B7PA82_IXOSC	Ras, putative (Fragment). (120 aa)
	B7PAU9_IXOSC	BHLH domain-containing protein. (171 aa)
	B7PC09_IXOSC	NCD2 domain-containing protein. (250 aa)
	B7PDG7_IXOSC	Factor for adipocyte differentiation, putative. (1062 aa)
	B7PE64_IXOSC	BHLH domain-containing protein. (271 aa)
	B7PEY0_IXOSC	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (940 aa)
	B7PH64_IXOSC	Cdc42 protein, putative. (201 aa)
	B7PH65_IXOSC	GTPase Rho, putative (Fragment). (205 aa)
	B7PH66_IXOSC	GTPase Rho, putative. (192 aa)
	B7PJ92_IXOSC	Ankyrin repeat-containing protein. (858 aa)
	B7PKK5_IXOSC	GTPase Rho, putative. (82 aa)
	B7PLQ0_IXOSC	Chromodomain helicase DNA binding protein, putative. (1882 aa)
	B7PP73_IXOSC	Mitogen-activated protein kinase kinase MKK4, putative (Fragment); Belongs to the protein kinase superfamily. (385 aa)
	B7PQ59_IXOSC	Ras GTP exchange factor, son of sevenless, putative (Fragment). (1034 aa)
	B7PT02_IXOSC	Pyst2, putative. (394 aa)
	B7PUK8_IXOSC	Clathrin heavy chain, putative (Fragment). (1616 aa)
	B7PV86_IXOSC	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (213 aa)
	B7PVG3_IXOSC	Protein phosphatase 2A regulatory subunit A, putative (Fragment). (871 aa)
	B7PW65_IXOSC	Ngfi-A binding protein, putative. (157 aa)
	B7Q054_IXOSC	Lysophosphatidic acid acyltransferase endophilin, putative. (350 aa)
	B7Q192_IXOSC	CSD_1 domain-containing protein. (348 aa)
	B7Q194_IXOSC	BHLH domain-containing protein. (115 aa)
	B7Q199_IXOSC	RAS protein, putative (Fragment). (192 aa)
	B7Q1P4_IXOSC	Shc transforming protein, putative (Fragment). (461 aa)
	B7Q2F1_IXOSC	Dual specificty phosphatase, putative; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (292 aa)
	B7Q2J4_IXOSC	Uncharacterized protein. (195 aa)
	B7Q4T8_IXOSC	SP-RING-type domain-containing protein. (851 aa)
	B7Q548_IXOSC	Phosphoinositide-3-kinase, regulatory subunit, putative. (427 aa)
	B7Q6K8_IXOSC	Phosphatidylinositol 3-kinase catalytic subunit, putative; Belongs to the PI3/PI4-kinase family. (491 aa)
	B7Q6V9_IXOSC	AP complex subunit beta. (938 aa)
	B7Q826_IXOSC	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
	B7Q903_IXOSC	Pole hole family protein. (667 aa)
	B7Q914_IXOSC	Clathrin-adaptor protein, putative (Fragment); Belongs to the adaptor complexes medium subunit family. (436 aa)
	B7QAX3_IXOSC	Tyrosine-protein kinase receptor. (711 aa)
	B7QBB8_IXOSC	Ribosomal protein kinase, putative. (639 aa)
	B7QCS4_IXOSC	Dynein light chain. (106 aa)
	B7QE44_IXOSC	C-AMP-responsive-element binding protein omega, putative (Fragment). (308 aa)
	B7QEH4_IXOSC	Uncharacterized protein. (1061 aa)
	B7QEY1_IXOSC	Helix-loop-helix protein, putative. (215 aa)
	B7QFX4_IXOSC	Mitogen-activated protein kinase. (359 aa)
	B7QGQ3_IXOSC	143-3 isoform A isoform 2 family protein; Belongs to the 14-3-3 family. (101 aa)
	B7QGT5_IXOSC	RAS, putative. (200 aa)
	B7QGY5_IXOSC	Serine/threonine-protein phosphatase. (311 aa)
	B7QIB0_IXOSC	DNA-binding protein inhibitor, putative. (197 aa)
	B7QIB7_IXOSC	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (384 aa)
	B7QJF5_IXOSC	Phosphatidylinositol 3-kinase catalytic subunit, putative (Fragment); Belongs to the PI3/PI4-kinase family. (617 aa)
	B7QLS3_IXOSC	Uncharacterized protein. (273 aa)
	B7QLS4_IXOSC	Bis(5'nucleosyl)-tetraphosphatase (symmetrical), putative. (146 aa)
	B7QNH3_IXOSC	Protein kinase, putative. (676 aa)
	B7QNT5_IXOSC	HEAT repeatcontaining protein. (156 aa)

Your Current Organism:

Ixodes scapularis

NCBI taxonomy Id: 6945
Other names: I. scapularis, Ixodes dammini, Ixodes sp. DNAS-303-249710, black-legged tick, blacklegged tick, deer tick, shoulder tick

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B7P0R2_IXOSC	B7P9Z2_IXOSC	B7P0R2	B7P9Z2	C. elegans sem-5, putative.	AP-2 complex subunit alpha-1, putative.	0.406
B7P0R2_IXOSC	B7PA82_IXOSC	B7P0R2	B7PA82	C. elegans sem-5, putative.	Ras, putative (Fragment).	0.761
B7P0R2_IXOSC	B7PEY0_IXOSC	B7P0R2	B7PEY0	C. elegans sem-5, putative.	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.406
B7P0R2_IXOSC	B7PP73_IXOSC	B7P0R2	B7PP73	C. elegans sem-5, putative.	Mitogen-activated protein kinase kinase MKK4, putative (Fragment); Belongs to the protein kinase superfamily.	0.635
B7P0R2_IXOSC	B7PQ59_IXOSC	B7P0R2	B7PQ59	C. elegans sem-5, putative.	Ras GTP exchange factor, son of sevenless, putative (Fragment).	0.999
B7P0R2_IXOSC	B7PUK8_IXOSC	B7P0R2	B7PUK8	C. elegans sem-5, putative.	Clathrin heavy chain, putative (Fragment).	0.689
B7P0R2_IXOSC	B7PV86_IXOSC	B7P0R2	B7PV86	C. elegans sem-5, putative.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.616
B7P0R2_IXOSC	B7Q054_IXOSC	B7P0R2	B7Q054	C. elegans sem-5, putative.	Lysophosphatidic acid acyltransferase endophilin, putative.	0.626
B7P0R2_IXOSC	B7Q192_IXOSC	B7P0R2	B7Q192	C. elegans sem-5, putative.	CSD_1 domain-containing protein.	0.754
B7P0R2_IXOSC	B7Q199_IXOSC	B7P0R2	B7Q199	C. elegans sem-5, putative.	RAS protein, putative (Fragment).	0.675
B7P0R2_IXOSC	B7Q1P4_IXOSC	B7P0R2	B7Q1P4	C. elegans sem-5, putative.	Shc transforming protein, putative (Fragment).	0.983
B7P0R2_IXOSC	B7Q2J4_IXOSC	B7P0R2	B7Q2J4	C. elegans sem-5, putative.	Uncharacterized protein.	0.675
B7P0R2_IXOSC	B7Q4T8_IXOSC	B7P0R2	B7Q4T8	C. elegans sem-5, putative.	SP-RING-type domain-containing protein.	0.957
B7P0R2_IXOSC	B7Q548_IXOSC	B7P0R2	B7Q548	C. elegans sem-5, putative.	Phosphoinositide-3-kinase, regulatory subunit, putative.	0.896
B7P0R2_IXOSC	B7Q6K8_IXOSC	B7P0R2	B7Q6K8	C. elegans sem-5, putative.	Phosphatidylinositol 3-kinase catalytic subunit, putative; Belongs to the PI3/PI4-kinase family.	0.682
B7P0R2_IXOSC	B7Q6V9_IXOSC	B7P0R2	B7Q6V9	C. elegans sem-5, putative.	AP complex subunit beta.	0.612
B7P0R2_IXOSC	B7Q826_IXOSC	B7P0R2	B7Q826	C. elegans sem-5, putative.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.637
B7P0R2_IXOSC	B7Q903_IXOSC	B7P0R2	B7Q903	C. elegans sem-5, putative.	Pole hole family protein.	0.729
B7P0R2_IXOSC	B7Q914_IXOSC	B7P0R2	B7Q914	C. elegans sem-5, putative.	Clathrin-adaptor protein, putative (Fragment); Belongs to the adaptor complexes medium subunit family.	0.710
B7P0R2_IXOSC	B7QAX3_IXOSC	B7P0R2	B7QAX3	C. elegans sem-5, putative.	Tyrosine-protein kinase receptor.	0.583