(27 nodes) Nonhomologous End-Joining (NHEJ) network (Ixodes scapularis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	B7QI11_IXOSC	DNA ligase IV, putative (Fragment); Belongs to the ATP-dependent DNA ligase family. (817 aa)
	B7P4T3_IXOSC	FHA domaincontaining protein. (314 aa)
	B7PA39_IXOSC	mDNApk3', putative; Belongs to the PI3/PI4-kinase family. (239 aa)
	B7PA40_IXOSC	Protein kinase, DNAactivated, catalytic polypeptide; Belongs to the PI3/PI4-kinase family. (256 aa)
	B7PA41_IXOSC	NUC194 domaincontaining protein. (1206 aa)
	B7PA43_IXOSC	DNAdependent protein kinase catalytic subunit isoform 7 family protein. (500 aa)
	B7PA44_IXOSC	Uncharacterized protein. (488 aa)
	B7PBX9_IXOSC	Uncharacterized protein. (166 aa)
	B7PC76_IXOSC	Uncharacterized protein. (107 aa)
	B7PEV9_IXOSC	RING-type domain-containing protein. (206 aa)
	B7PIM4_IXOSC	ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. (687 aa)
	B7PQK8_IXOSC	Histone H2B, putative; Belongs to the histone H2B family. (68 aa)
	B7PRG3_IXOSC	Tyrosyl-DNA phosphodiesterase, putative. (624 aa)
	B7PSB6_IXOSC	C6.1A, putative (Fragment). (262 aa)
	B7PWX5_IXOSC	Uncharacterized protein. (211 aa)
	B7PZJ2_IXOSC	Reverse transcriptase domain-containing protein. (241 aa)
	B7Q1G6_IXOSC	Endo/exonuclease/phosphatase domain-containing protein. (383 aa)
	B7QAA2_IXOSC	Histone H2B, putative; Belongs to the histone H2B family. (66 aa)
	B7QCD9_IXOSC	Uncharacterized protein. (375 aa)
	B7QCE0_IXOSC	Uncharacterized protein. (883 aa)
	B7QFM1_IXOSC	DNA cross-link repair protein pso2/snm1, putative. (248 aa)
	B7QJH1_IXOSC	Endo/exonuclease/phosphatase domain-containing protein. (284 aa)
	B7QKM7_IXOSC	Protein BRE, putative. (371 aa)
	B7QLH2_IXOSC	Ankyrin repeat-containing protein (Fragment). (139 aa)
	B7QNT6_IXOSC	Uncharacterized protein. (410 aa)
	Q4PM63_IXOSC	Histone H2B; Belongs to the histone H2B family. (124 aa)
	Q4PM69_IXOSC	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)

Your Current Organism:

Ixodes scapularis

NCBI taxonomy Id: 6945
Other names: I. scapularis, Ixodes dammini, Ixodes sp. DNAS-303-249710, black-legged tick, blacklegged tick, deer tick, shoulder tick

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B7P4T3_IXOSC	B7PA39_IXOSC	B7P4T3	B7PA39	FHA domaincontaining protein.	mDNApk3', putative; Belongs to the PI3/PI4-kinase family.	0.440
B7P4T3_IXOSC	B7PA40_IXOSC	B7P4T3	B7PA40	FHA domaincontaining protein.	Protein kinase, DNAactivated, catalytic polypeptide; Belongs to the PI3/PI4-kinase family.	0.440
B7P4T3_IXOSC	B7PA41_IXOSC	B7P4T3	B7PA41	FHA domaincontaining protein.	NUC194 domaincontaining protein.	0.440
B7P4T3_IXOSC	B7PA43_IXOSC	B7P4T3	B7PA43	FHA domaincontaining protein.	DNAdependent protein kinase catalytic subunit isoform 7 family protein.	0.440
B7P4T3_IXOSC	B7PA44_IXOSC	B7P4T3	B7PA44	FHA domaincontaining protein.	Uncharacterized protein.	0.440
B7P4T3_IXOSC	B7PC76_IXOSC	B7P4T3	B7PC76	FHA domaincontaining protein.	Uncharacterized protein.	0.474
B7P4T3_IXOSC	B7PEV9_IXOSC	B7P4T3	B7PEV9	FHA domaincontaining protein.	RING-type domain-containing protein.	0.849
B7P4T3_IXOSC	B7PIM4_IXOSC	B7P4T3	B7PIM4	FHA domaincontaining protein.	ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase.	0.474
B7P4T3_IXOSC	B7PSB6_IXOSC	B7P4T3	B7PSB6	FHA domaincontaining protein.	C6.1A, putative (Fragment).	0.632
B7P4T3_IXOSC	B7PWX5_IXOSC	B7P4T3	B7PWX5	FHA domaincontaining protein.	Uncharacterized protein.	0.575
B7P4T3_IXOSC	B7PZJ2_IXOSC	B7P4T3	B7PZJ2	FHA domaincontaining protein.	Reverse transcriptase domain-containing protein.	0.809
B7P4T3_IXOSC	B7QCD9_IXOSC	B7P4T3	B7QCD9	FHA domaincontaining protein.	Uncharacterized protein.	0.465
B7P4T3_IXOSC	B7QCE0_IXOSC	B7P4T3	B7QCE0	FHA domaincontaining protein.	Uncharacterized protein.	0.465
B7P4T3_IXOSC	B7QFM1_IXOSC	B7P4T3	B7QFM1	FHA domaincontaining protein.	DNA cross-link repair protein pso2/snm1, putative.	0.597
B7P4T3_IXOSC	B7QKM7_IXOSC	B7P4T3	B7QKM7	FHA domaincontaining protein.	Protein BRE, putative.	0.516
B7P4T3_IXOSC	B7QLH2_IXOSC	B7P4T3	B7QLH2	FHA domaincontaining protein.	Ankyrin repeat-containing protein (Fragment).	0.598
B7P4T3_IXOSC	Q4PM69_IXOSC	B7P4T3	Q4PM69	FHA domaincontaining protein.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.424
B7PA39_IXOSC	B7P4T3_IXOSC	B7PA39	B7P4T3	mDNApk3', putative; Belongs to the PI3/PI4-kinase family.	FHA domaincontaining protein.	0.440
B7PA39_IXOSC	B7PA40_IXOSC	B7PA39	B7PA40	mDNApk3', putative; Belongs to the PI3/PI4-kinase family.	Protein kinase, DNAactivated, catalytic polypeptide; Belongs to the PI3/PI4-kinase family.	0.950
B7PA39_IXOSC	B7PA41_IXOSC	B7PA39	B7PA41	mDNApk3', putative; Belongs to the PI3/PI4-kinase family.	NUC194 domaincontaining protein.	0.944