(12 nodes) Ribavirin ADME network (Ixodes scapularis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	B7Q8U6_IXOSC	Adenosine kinase, putative. (348 aa)
	B7PAY2_IXOSC	IMP-GMP specific 5'-nucleotidase, putative (Fragment). (519 aa)
	B7PEV6_IXOSC	Nucleoside transporter, putative (Fragment). (378 aa)
	B7PIA8_IXOSC	Adenosine deaminase, putative. (127 aa)
	B7PJJ3_IXOSC	Adenosine deaminase, putative. (339 aa)
	B7PLE8_IXOSC	IMP-GMP specific 5'-nucleotidase, putative (Fragment). (504 aa)
	B7PMP1_IXOSC	Sodium/nucleoside cotransporter; Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. (440 aa)
	B7Q0I6_IXOSC	5'-nucleotidase domain-containing protein, putative. (334 aa)
	B7QE95_IXOSC	Nucleoside diphosphate kinase. (74 aa)
	B7QGF4_IXOSC	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (174 aa)
	B7QLY6_IXOSC	Nucleoside diphosphate kinase. (152 aa)
	B7QMP3_IXOSC	Purine nucleoside phosphorylase, putative. (102 aa)

Your Current Organism:

Ixodes scapularis

NCBI taxonomy Id: 6945
Other names: I. scapularis, Ixodes dammini, Ixodes sp. DNAS-303-249710, black-legged tick, blacklegged tick, deer tick, shoulder tick

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B7PAY2_IXOSC	B7PJJ3_IXOSC	B7PAY2	B7PJJ3	IMP-GMP specific 5'-nucleotidase, putative (Fragment).	Adenosine deaminase, putative.	0.917
B7PAY2_IXOSC	B7PLE8_IXOSC	B7PAY2	B7PLE8	IMP-GMP specific 5'-nucleotidase, putative (Fragment).	IMP-GMP specific 5'-nucleotidase, putative (Fragment).	0.900
B7PAY2_IXOSC	B7Q0I6_IXOSC	B7PAY2	B7Q0I6	IMP-GMP specific 5'-nucleotidase, putative (Fragment).	5'-nucleotidase domain-containing protein, putative.	0.575
B7PAY2_IXOSC	B7Q8U6_IXOSC	B7PAY2	B7Q8U6	IMP-GMP specific 5'-nucleotidase, putative (Fragment).	Adenosine kinase, putative.	0.905
B7PAY2_IXOSC	B7QGF4_IXOSC	B7PAY2	B7QGF4	IMP-GMP specific 5'-nucleotidase, putative (Fragment).	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	0.902
B7PAY2_IXOSC	B7QMP3_IXOSC	B7PAY2	B7QMP3	IMP-GMP specific 5'-nucleotidase, putative (Fragment).	Purine nucleoside phosphorylase, putative.	0.421
B7PIA8_IXOSC	B7Q8U6_IXOSC	B7PIA8	B7Q8U6	Adenosine deaminase, putative.	Adenosine kinase, putative.	0.759
B7PIA8_IXOSC	B7QGF4_IXOSC	B7PIA8	B7QGF4	Adenosine deaminase, putative.	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	0.449
B7PIA8_IXOSC	B7QMP3_IXOSC	B7PIA8	B7QMP3	Adenosine deaminase, putative.	Purine nucleoside phosphorylase, putative.	0.743
B7PJJ3_IXOSC	B7PAY2_IXOSC	B7PJJ3	B7PAY2	Adenosine deaminase, putative.	IMP-GMP specific 5'-nucleotidase, putative (Fragment).	0.917
B7PJJ3_IXOSC	B7PLE8_IXOSC	B7PJJ3	B7PLE8	Adenosine deaminase, putative.	IMP-GMP specific 5'-nucleotidase, putative (Fragment).	0.917
B7PJJ3_IXOSC	B7Q8U6_IXOSC	B7PJJ3	B7Q8U6	Adenosine deaminase, putative.	Adenosine kinase, putative.	0.974
B7PJJ3_IXOSC	B7QGF4_IXOSC	B7PJJ3	B7QGF4	Adenosine deaminase, putative.	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	0.449
B7PJJ3_IXOSC	B7QMP3_IXOSC	B7PJJ3	B7QMP3	Adenosine deaminase, putative.	Purine nucleoside phosphorylase, putative.	0.743
B7PLE8_IXOSC	B7PAY2_IXOSC	B7PLE8	B7PAY2	IMP-GMP specific 5'-nucleotidase, putative (Fragment).	IMP-GMP specific 5'-nucleotidase, putative (Fragment).	0.900
B7PLE8_IXOSC	B7PJJ3_IXOSC	B7PLE8	B7PJJ3	IMP-GMP specific 5'-nucleotidase, putative (Fragment).	Adenosine deaminase, putative.	0.917
B7PLE8_IXOSC	B7Q0I6_IXOSC	B7PLE8	B7Q0I6	IMP-GMP specific 5'-nucleotidase, putative (Fragment).	5'-nucleotidase domain-containing protein, putative.	0.558
B7PLE8_IXOSC	B7Q8U6_IXOSC	B7PLE8	B7Q8U6	IMP-GMP specific 5'-nucleotidase, putative (Fragment).	Adenosine kinase, putative.	0.905
B7PLE8_IXOSC	B7QGF4_IXOSC	B7PLE8	B7QGF4	IMP-GMP specific 5'-nucleotidase, putative (Fragment).	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	0.902
B7PLE8_IXOSC	B7QMP3_IXOSC	B7PLE8	B7QMP3	IMP-GMP specific 5'-nucleotidase, putative (Fragment).	Purine nucleoside phosphorylase, putative.	0.421