(13 nodes) The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases. network (Ixodes scapularis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

co-expression

protein homology

Your Input:
	B7P3R5_IXOSC	Suppressor of cytokine signaling-2, putative (Fragment). (171 aa)
	B7P157_IXOSC	Uncharacterized protein. (96 aa)
	B7P8D7_IXOSC	RAS-related protein, putative. (296 aa)
	B7PDS8_IXOSC	Uncharacterized protein. (332 aa)
	B7PHK5_IXOSC	Ankyrin repeat containing protein. (257 aa)
	B7PHT5_IXOSC	Suppressor of cytokine signaling-5, putative. (229 aa)
	B7PLM6_IXOSC	SPRY domain SOCS box-containing protein. (361 aa)
	B7PRR1_IXOSC	Uncharacterized protein. (727 aa)
	B7PTW4_IXOSC	SOCS box SH2 domain-containing protein. (293 aa)
	B7PW93_IXOSC	Ankyrin repeat-containing protein. (497 aa)
	B7Q074_IXOSC	Ankyrin repeatcontaining protein. (184 aa)
	B7Q9T5_IXOSC	SPRY domain SOCS box-containing protein. (423 aa)
	B7QEJ6_IXOSC	ANK_REP_REGION domain-containing protein. (468 aa)

Your Current Organism:

Ixodes scapularis

NCBI taxonomy Id: 6945
Other names: I. scapularis, Ixodes dammini, Ixodes sp. DNAS-303-249710, black-legged tick, blacklegged tick, deer tick, shoulder tick

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B7P3R5_IXOSC	B7PHT5_IXOSC	B7P3R5	B7PHT5	Suppressor of cytokine signaling-2, putative (Fragment).	Suppressor of cytokine signaling-5, putative.	0.847
B7P3R5_IXOSC	B7PTW4_IXOSC	B7P3R5	B7PTW4	Suppressor of cytokine signaling-2, putative (Fragment).	SOCS box SH2 domain-containing protein.	0.667
B7P3R5_IXOSC	B7Q9T5_IXOSC	B7P3R5	B7Q9T5	Suppressor of cytokine signaling-2, putative (Fragment).	SPRY domain SOCS box-containing protein.	0.547
B7PHT5_IXOSC	B7P3R5_IXOSC	B7PHT5	B7P3R5	Suppressor of cytokine signaling-5, putative.	Suppressor of cytokine signaling-2, putative (Fragment).	0.847
B7PHT5_IXOSC	B7PTW4_IXOSC	B7PHT5	B7PTW4	Suppressor of cytokine signaling-5, putative.	SOCS box SH2 domain-containing protein.	0.747
B7PHT5_IXOSC	B7Q9T5_IXOSC	B7PHT5	B7Q9T5	Suppressor of cytokine signaling-5, putative.	SPRY domain SOCS box-containing protein.	0.596
B7PTW4_IXOSC	B7P3R5_IXOSC	B7PTW4	B7P3R5	SOCS box SH2 domain-containing protein.	Suppressor of cytokine signaling-2, putative (Fragment).	0.667
B7PTW4_IXOSC	B7PHT5_IXOSC	B7PTW4	B7PHT5	SOCS box SH2 domain-containing protein.	Suppressor of cytokine signaling-5, putative.	0.747
B7Q9T5_IXOSC	B7P3R5_IXOSC	B7Q9T5	B7P3R5	SPRY domain SOCS box-containing protein.	Suppressor of cytokine signaling-2, putative (Fragment).	0.547
B7Q9T5_IXOSC	B7PHT5_IXOSC	B7Q9T5	B7PHT5	SPRY domain SOCS box-containing protein.	Suppressor of cytokine signaling-5, putative.	0.596