(21 nodes) Inactivation of APC/C via direct inhibition of the APC/C complex, and The WD repeat Cdc20/Fizzy family network (Saprolegnia parasitica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SPRG_18488	WD_REPEATS_REGION domain-containing protein. (139 aa)
	SPRG_17025	Uncharacterized protein. (1019 aa)
	SPRG_13457	WD_REPEATS_REGION domain-containing protein. (630 aa)
	SPRG_13406	WD_REPEATS_REGION domain-containing protein. (330 aa)
	SPRG_13376	Uncharacterized protein. (743 aa)
	SPRG_14896	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (201 aa)
	SPRG_11712	Uncharacterized protein. (561 aa)
	SPRG_22263	Uncharacterized protein. (765 aa)
	SPRG_11649	Uncharacterized protein. (702 aa)
	SPRG_20641	TPR_REGION domain-containing protein. (556 aa)
	SPRG_20918	Ribonuclease HI. (154 aa)
	SPRG_10188	Uncharacterized protein. (544 aa)
	SPRG_09929	WD_REPEATS_REGION domain-containing protein. (543 aa)
	SPRG_05703	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (175 aa)
	SPRG_09747	BUB protein kinase. (360 aa)
	SPRG_19777	Uncharacterized protein. (218 aa)
	SPRG_04234	Alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (860 aa)
	SPRG_00695	TPR_REGION domain-containing protein. (627 aa)
	SPRG_00198	CULLIN_2 domain-containing protein; Belongs to the cullin family. (673 aa)
	SPRG_01620	Anaphase-promoting complex subunit 11. (86 aa)
	SPRG_00339	NEK protein kinase. (447 aa)

Your Current Organism:

Saprolegnia parasitica

NCBI taxonomy Id: 695850
Other names: S. parasitica CBS 223.65, Saprolegnia parasitica CBS 223.65

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SPRG_00198	SPRG_00339	A0A067CXC3	A0A067D907	CULLIN_2 domain-containing protein; Belongs to the cullin family.	NEK protein kinase.	0.950
SPRG_00198	SPRG_00695	A0A067CXC3	A0A067CVV8	CULLIN_2 domain-containing protein; Belongs to the cullin family.	TPR_REGION domain-containing protein.	0.999
SPRG_00198	SPRG_01620	A0A067CXC3	A0A067D3W6	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Anaphase-promoting complex subunit 11.	0.999
SPRG_00198	SPRG_04234	A0A067CXC3	A0A067CKM2	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family.	0.963
SPRG_00198	SPRG_05703	A0A067CXC3	A0A067CDF0	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	0.965
SPRG_00198	SPRG_09747	A0A067CXC3	A0A067CDW5	CULLIN_2 domain-containing protein; Belongs to the cullin family.	BUB protein kinase.	0.962
SPRG_00198	SPRG_09929	A0A067CXC3	A0A067CBV8	CULLIN_2 domain-containing protein; Belongs to the cullin family.	WD_REPEATS_REGION domain-containing protein.	0.841
SPRG_00198	SPRG_10188	A0A067CXC3	A0A067C686	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Uncharacterized protein.	0.998
SPRG_00198	SPRG_11649	A0A067CXC3	A0A067C2G7	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Uncharacterized protein.	0.999
SPRG_00198	SPRG_11712	A0A067CXC3	A0A067C086	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Uncharacterized protein.	0.983
SPRG_00198	SPRG_13376	A0A067CXC3	A0A067BXI3	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Uncharacterized protein.	0.999
SPRG_00198	SPRG_13406	A0A067CXC3	A0A067BQW9	CULLIN_2 domain-containing protein; Belongs to the cullin family.	WD_REPEATS_REGION domain-containing protein.	0.660
SPRG_00198	SPRG_13457	A0A067CXC3	A0A067BPP6	CULLIN_2 domain-containing protein; Belongs to the cullin family.	WD_REPEATS_REGION domain-containing protein.	0.841
SPRG_00198	SPRG_14896	A0A067CXC3	A0A067BZY2	CULLIN_2 domain-containing protein; Belongs to the cullin family.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.997
SPRG_00198	SPRG_17025	A0A067CXC3	A0A067BGN3	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Uncharacterized protein.	0.979
SPRG_00198	SPRG_18488	A0A067CXC3	A0A067BCX5	CULLIN_2 domain-containing protein; Belongs to the cullin family.	WD_REPEATS_REGION domain-containing protein.	0.660
SPRG_00198	SPRG_19777	A0A067CXC3	A0A067CIA7	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Uncharacterized protein.	0.965
SPRG_00198	SPRG_20641	A0A067CXC3	A0A067C4R4	CULLIN_2 domain-containing protein; Belongs to the cullin family.	TPR_REGION domain-containing protein.	0.999
SPRG_00198	SPRG_20918	A0A067CXC3	A0A067C5G2	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Ribonuclease HI.	0.979
SPRG_00198	SPRG_22263	A0A067CXC3	A0A067C097	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Uncharacterized protein.	0.979