(39 nodes) DNA duplex unwinding network (Saprolegnia parasitica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SPRG_01797	Uncharacterized protein. (135 aa)
	SPRG_18023	Uncharacterized protein. (217 aa)
	SPRG_21993	Helicase ATP-binding domain-containing protein. (414 aa)
	SPRG_17872	SF4 helicase domain-containing protein. (170 aa)
	SPRG_21836	ATP-dependent DNA helicase; Belongs to the helicase family. (271 aa)
	SPRG_15354	MCM domain-containing protein; Belongs to the MCM family. (844 aa)
	SPRG_15063	DNA helicase; Belongs to the MCM family. (915 aa)
	SPRG_11316	HD domain-containing protein. (238 aa)
	SPRG_16173	SF4 helicase domain-containing protein. (507 aa)
	SPRG_09971	Uncharacterized protein. (949 aa)
	SPRG_12082	RuvB-like helicase; Belongs to the RuvB family. (447 aa)
	SPRG_11271	Uncharacterized protein. (799 aa)
	SPRG_10832	DNA helicase; Belongs to the MCM family. (713 aa)
	SPRG_11368	DNA helicase; Belongs to the MCM family. (983 aa)
	SPRG_13186	MCM domain-containing protein; Belongs to the MCM family. (694 aa)
	SPRG_13157	Uncharacterized protein. (1082 aa)
	SPRG_22285	Uncharacterized protein. (963 aa)
	SPRG_10010	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (536 aa)
	SPRG_20614	ATP-dependent DNA helicase; Belongs to the helicase family. (563 aa)
	SPRG_07102	MCM domain-containing protein; Belongs to the MCM family. (787 aa)
	SPRG_10631	FHA domain-containing protein. (593 aa)
	SPRG_10445	VWFA domain-containing protein. (729 aa)
	SPRG_08149	Helicase ATP-binding domain-containing protein. (907 aa)
	SPRG_06502	Helicase ATP-binding domain-containing protein. (838 aa)
	SPRG_08328	Uncharacterized protein. (524 aa)
	SPRG_05932	Helicase ATP-binding domain-containing protein. (779 aa)
	SPRG_20323	RuvB-like helicase. (420 aa)
	SPRG_02383	ATP-dependent DNA helicase; Belongs to the helicase family. (120 aa)
	SPRG_19987	Helicase ATP-binding domain-containing protein. (671 aa)
	SPRG_03584	AAA domain-containing protein. (466 aa)
	SPRG_01897	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (601 aa)
	SPRG_02052	MCM domain-containing protein; Belongs to the MCM family. (807 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (870 aa)
	SPRG_01798	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (806 aa)
	SPRG_19723	AN1-type domain-containing protein. (931 aa)
	SPRG_05048	Uncharacterized protein. (1947 aa)
	SPRG_01137	Uncharacterized protein. (1323 aa)
	SPRG_00320	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (432 aa)
	SPRG_19108	SAP domain-containing protein. (613 aa)

Your Current Organism:

Saprolegnia parasitica

NCBI taxonomy Id: 695850
Other names: S. parasitica CBS 223.65, Saprolegnia parasitica CBS 223.65

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MCM7	SPRG_02052	A0A067CT48	A0A067CRY5	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	MCM domain-containing protein; Belongs to the MCM family.	0.999
MCM7	SPRG_07102	A0A067CT48	A0A067CAN9	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	MCM domain-containing protein; Belongs to the MCM family.	0.996
MCM7	SPRG_10832	A0A067CT48	A0A067BZT3	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	SPRG_11368	A0A067CT48	A0A067BZX9	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	SPRG_13186	A0A067CT48	A0A067C4P8	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	MCM domain-containing protein; Belongs to the MCM family.	0.995
MCM7	SPRG_15063	A0A067CT48	A0A067BND2	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.997
MCM7	SPRG_15354	A0A067CT48	A0A067BLS4	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	MCM domain-containing protein; Belongs to the MCM family.	0.997
SPRG_00320	SPRG_01137	A0A067CY79	A0A067CX41	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	Uncharacterized protein.	0.798
SPRG_00320	SPRG_03584	A0A067CY79	A0A067CR25	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	AAA domain-containing protein.	0.556
SPRG_00320	SPRG_05932	A0A067CY79	A0A067CJL8	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	Helicase ATP-binding domain-containing protein.	0.482
SPRG_00320	SPRG_06502	A0A067CY79	A0A067CDT3	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	Helicase ATP-binding domain-containing protein.	0.471
SPRG_00320	SPRG_08149	A0A067CY79	A0A067CCE9	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	Helicase ATP-binding domain-containing protein.	0.519
SPRG_00320	SPRG_10445	A0A067CY79	A0A067CC18	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	VWFA domain-containing protein.	0.642
SPRG_00320	SPRG_10631	A0A067CY79	A0A067CBP6	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	FHA domain-containing protein.	0.586
SPRG_00320	SPRG_10832	A0A067CY79	A0A067BZT3	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	DNA helicase; Belongs to the MCM family.	0.459
SPRG_00320	SPRG_19108	A0A067CY79	A0A067CYG2	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	SAP domain-containing protein.	0.738
SPRG_00320	SPRG_19987	A0A067CY79	A0A067CQI1	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	Helicase ATP-binding domain-containing protein.	0.519
SPRG_00320	SPRG_21993	A0A067CY79	A0A067BE28	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	Helicase ATP-binding domain-containing protein.	0.519
SPRG_00320	SPRG_22285	A0A067CY79	A0A067C8Q5	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	Uncharacterized protein.	0.843
SPRG_01137	SPRG_00320	A0A067CX41	A0A067CY79	Uncharacterized protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.798