(10 nodes) PIN-like domain superfamily network (Saprolegnia parasitica)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SPRG_05104	Uncharacterized protein. (510 aa)
	SPRG_13682	53EXOc domain-containing protein. (356 aa)
	SPRG_13988	Uncharacterized protein. (1668 aa)
	SPRG_08796	Uncharacterized protein. (1013 aa)
	SPRG_08289	Uncharacterized protein. (380 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (393 aa)
	SPRG_06432	53EXOc domain-containing protein. (369 aa)
	SPRG_03635	Uncharacterized protein. (677 aa)
	SPRG_22081	Uncharacterized protein. (227 aa)
	SPRG_01346	rRNA-processing protein FCF1. (197 aa)

Your Current Organism:

Saprolegnia parasitica

NCBI taxonomy Id: 695850
Other names: S. parasitica CBS 223.65, Saprolegnia parasitica CBS 223.65

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FEN1	SPRG_03635	A0A067CJ19	A0A067CY65	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.797
FEN1	SPRG_05104	A0A067CJ19	A0A067CIP6	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.797
FEN1	SPRG_06432	A0A067CJ19	A0A067CPW2	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	53EXOc domain-containing protein.	0.752
FEN1	SPRG_08289	A0A067CJ19	A0A067CIV1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.797
FEN1	SPRG_08796	A0A067CJ19	A0A067CGA7	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.618
FEN1	SPRG_13682	A0A067CJ19	A0A067BS80	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	53EXOc domain-containing protein.	0.752
SPRG_01346	SPRG_13988	A0A067D4Y6	A0A067BUE5	rRNA-processing protein FCF1.	Uncharacterized protein.	0.608
SPRG_01346	SPRG_22081	A0A067D4Y6	A0A067CYH4	rRNA-processing protein FCF1.	Uncharacterized protein.	0.841
SPRG_03635	FEN1	A0A067CY65	A0A067CJ19	Uncharacterized protein.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.797
SPRG_03635	SPRG_05104	A0A067CY65	A0A067CIP6	Uncharacterized protein.	Uncharacterized protein.	0.913
SPRG_03635	SPRG_06432	A0A067CY65	A0A067CPW2	Uncharacterized protein.	53EXOc domain-containing protein.	0.621
SPRG_03635	SPRG_08289	A0A067CY65	A0A067CIV1	Uncharacterized protein.	Uncharacterized protein.	0.914
SPRG_03635	SPRG_13682	A0A067CY65	A0A067BS80	Uncharacterized protein.	53EXOc domain-containing protein.	0.621
SPRG_05104	FEN1	A0A067CIP6	A0A067CJ19	Uncharacterized protein.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.797
SPRG_05104	SPRG_03635	A0A067CIP6	A0A067CY65	Uncharacterized protein.	Uncharacterized protein.	0.913
SPRG_05104	SPRG_06432	A0A067CIP6	A0A067CPW2	Uncharacterized protein.	53EXOc domain-containing protein.	0.621
SPRG_05104	SPRG_08289	A0A067CIP6	A0A067CIV1	Uncharacterized protein.	Uncharacterized protein.	0.907
SPRG_05104	SPRG_13682	A0A067CIP6	A0A067BS80	Uncharacterized protein.	53EXOc domain-containing protein.	0.621
SPRG_06432	FEN1	A0A067CPW2	A0A067CJ19	53EXOc domain-containing protein.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.752
SPRG_06432	SPRG_03635	A0A067CPW2	A0A067CY65	53EXOc domain-containing protein.	Uncharacterized protein.	0.621