(21 nodes) Terpenoid backbone biosynthesis network (Saprolegnia parasitica)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	SPRG_18431	Uncharacterized protein. (183 aa)
	SPRG_14352	Nudix hydrolase domain-containing protein. (227 aa)
	SPRG_13991	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (408 aa)
	SPRG_15224	Uncharacterized protein. (477 aa)
	SPRG_11795	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (409 aa)
	SPRG_21275	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (225 aa)
	SPRG_14908	Prenylcys_lyase domain-containing protein. (462 aa)
	SPRG_14098	Uncharacterized protein. (476 aa)
	SPRG_10991	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (350 aa)
	SPRG_09165	COesterase domain-containing protein. (279 aa)
	SPRG_06894	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (295 aa)
	SPRG_10771	Uncharacterized protein. (300 aa)
	SPRG_03870	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (368 aa)
	SPRG_06153	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (431 aa)
	SPRG_05716	Protein-S-isoprenylcysteine O-methyltransferase. (237 aa)
	SPRG_01888	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (453 aa)
	SPRG_05623	Uncharacterized protein. (295 aa)
	SPRG_05647	Mevalonate kinase. (377 aa)
	SPRG_01272	3-hydroxy-3-methylglutaryl coenzyme A reductase. (397 aa)
	SPRG_00258	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (408 aa)
	SPRG_00725	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding. (416 aa)

Your Current Organism:

Saprolegnia parasitica

NCBI taxonomy Id: 695850
Other names: S. parasitica CBS 223.65, Saprolegnia parasitica CBS 223.65

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SPRG_00258	SPRG_03870	A0A067CY22	A0A067CL82	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.	0.657
SPRG_00258	SPRG_05647	A0A067CY22	A0A067CT61	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Mevalonate kinase.	0.758
SPRG_00258	SPRG_10991	A0A067CY22	A0A067C844	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.453
SPRG_00258	SPRG_11795	A0A067CY22	A0A067BWM4	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.902
SPRG_00258	SPRG_14352	A0A067CY22	A0A067BPH8	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Nudix hydrolase domain-containing protein.	0.488
SPRG_00258	SPRG_21275	A0A067CY22	A0A067BXN3	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.906
SPRG_00725	SPRG_01888	A0A067D6N9	A0A067CRD7	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family.	0.949
SPRG_00725	SPRG_05623	A0A067D6N9	A0A067CT44	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	Uncharacterized protein.	0.997
SPRG_00725	SPRG_05716	A0A067D6N9	A0A067CQM9	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	Protein-S-isoprenylcysteine O-methyltransferase.	0.513
SPRG_00725	SPRG_06894	A0A067D6N9	A0A067CA41	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.942
SPRG_00725	SPRG_10771	A0A067D6N9	A0A067CAK5	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	Uncharacterized protein.	0.980
SPRG_00725	SPRG_10991	A0A067D6N9	A0A067C844	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.947
SPRG_00725	SPRG_14908	A0A067D6N9	A0A067BZ78	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	Prenylcys_lyase domain-containing protein.	0.513
SPRG_00725	SPRG_18431	A0A067D6N9	A0A067BCE5	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	Uncharacterized protein.	0.900
SPRG_01272	SPRG_03870	A0A067CTZ6	A0A067CL82	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.	0.541
SPRG_01272	SPRG_05647	A0A067CTZ6	A0A067CT61	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Mevalonate kinase.	0.979
SPRG_01272	SPRG_06153	A0A067CTZ6	A0A067CQL5	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.407
SPRG_01272	SPRG_06894	A0A067CTZ6	A0A067CA41	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.550
SPRG_01272	SPRG_10991	A0A067CTZ6	A0A067C844	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.572
SPRG_01272	SPRG_14098	A0A067CTZ6	A0A067C233	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Uncharacterized protein.	0.425