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AEG58320.1 AEG58320.1 AEG58465.1 AEG58465.1 AEG58571.1 AEG58571.1 argC argC argJ argJ argB argB argD argD argG argG argH argH AEG58736.1 AEG58736.1 AEG59015.1 AEG59015.1 AEG59042.1 AEG59042.1 AEG59102.1 AEG59102.1 metE metE AEG59811.1 AEG59811.1 AEG59812.1 AEG59812.1 AEG59830.1 AEG59830.1 ahcY ahcY AEG60091.1 AEG60091.1 AEG60092.1 AEG60092.1 metAA metAA dapB dapB asd asd AEG60177.1 AEG60177.1 dapA dapA AEG60207.1 AEG60207.1 AEG60417.1 AEG60417.1 AEG60567.1 AEG60567.1 dapL dapL dapF dapF AEG60761.1 AEG60761.1 pheA pheA AEG60867.1 AEG60867.1 AEG60882.1 AEG60882.1 AEG60906.1 AEG60906.1 AEG61044.1 AEG61044.1 AEG61045.1 AEG61045.1 lysA lysA proB proB proA proA proC proC AEG61140.1 AEG61140.1 thrB thrB AEG61142.1 AEG61142.1 AEG61169.1 AEG61169.1 lysA-2 lysA-2 metK metK rocD rocD AEG62010.1 AEG62010.1 purA purA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
AEG58320.1PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: drm:Dred_0615 threonine synthase. (402 aa)
AEG58465.1KEGG: drm:Dred_0097 threonine dehydratase; TIGRFAM: threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; amino acid-binding ACT domain protein. (404 aa)
AEG58571.1TIGRFAM: serine O-acetyltransferase; KEGG: drm:Dred_0192 serine O-acetyltransferase. (228 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (346 aa)
argJArginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (406 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (285 aa)
argDTIGRFAM: acetylornithine and succinylornithine aminotransferase; KEGG: drm:Dred_0274 acetylornithine aminotransferase; PFAM: aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (399 aa)
argGTIGRFAM: argininosuccinate synthase; KEGG: drm:Dred_0277 argininosuccinate synthase; PFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (401 aa)
argHKEGG: drm:Dred_0278 argininosuccinate lyase; TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase. (459 aa)
AEG58736.1Cysteine synthase; KEGG: sat:SYN_00075 cysteinyl-tRNA synthetase; TIGRFAM: cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit. (293 aa)
AEG59015.1PFAM: GCN5-related N-acetyltransferase; KEGG: drm:Dred_2898 acetyltransferase; Belongs to the acetyltransferase family. (151 aa)
AEG59042.1KEGG: drm:Dred_2871 cysteine synthase A; TIGRFAM: cysteine synthase A; cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; Belongs to the cysteine synthase/cystathionine beta- synthase family. (311 aa)
AEG59102.1TIGRFAM: asparagine synthase (glutamine-hydrolyzing); KEGG: drm:Dred_2812 asparagine synthase (glutamine-hydrolyzing); PFAM: asparagine synthase; glutamine amidotransferase class-II. (616 aa)
metE5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (764 aa)
AEG59811.1PFAM: Vitamin B12 dependent methionine synthase activation region; KEGG: drm:Dred_2208 vitamin B12 dependent methionine synthase, activation region. (230 aa)
AEG59812.1PFAM: homocysteine S-methyltransferase; dihydropteroate synthase DHPS; Methionine synthase B12-binding module cap domain protein; cobalamin B12-binding domain protein; KEGG: drm:Dred_2207 homocysteine S-methyltransferase. (799 aa)
AEG59830.1TIGRFAM: 5,10-methylenetetrahydrofolate reductase; KEGG: drm:Dred_2192 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (288 aa)
ahcYAdenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (418 aa)
AEG60091.1Hypothetical protein. (56 aa)
AEG60092.1TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; KEGG: hmo:HM1_0096 O-acetylhomoserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. (427 aa)
metAAHomoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (305 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (266 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (340 aa)
AEG60177.1KEGG: drm:Dred_1940 aspartate kinase I; TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (411 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (296 aa)
AEG60207.1PFAM: aminotransferase class I and II; KEGG: drm:Dred_1913 aminotransferase, class I and II. (388 aa)
AEG60417.1KEGG: afn:Acfer_0135 lysine decarboxylase; PFAM: Orn/DAP/Arg decarboxylase 2; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (388 aa)
AEG60567.1PFAM: aminotransferase class I and II; KEGG: drm:Dred_1696 aminotransferase, class I and II. (397 aa)
dapLLL-diaminopimelate aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (392 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (281 aa)
AEG60761.1PFAM: Methionine synthase vitamin-B12 independent; KEGG: cbe:Cbei_2330 methionine synthase, vitamin-B12 independent. (378 aa)
pheAKEGG: dau:Daud_1904 prephenate dehydratase; PFAM: prephenate dehydratase; amino acid-binding ACT domain protein. (279 aa)
AEG60867.1TIGRFAM: threonine synthase; KEGG: drm:Dred_1379 threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit. (499 aa)
AEG60882.1PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: drm:Dred_1362 pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (318 aa)
AEG60906.1PFAM: AIG2 family protein; KEGG: dre:100149204 si:ch211-149a19.5. (236 aa)
AEG61044.1TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, alpha subunit; KEGG: drm:Dred_1253 L-serine dehydratase, iron-sulfur-dependent, alpha subunit; PFAM: serine dehydratase alpha chain. (294 aa)
AEG61045.1TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, beta subunit; KEGG: drm:Dred_1252 L-serine dehydratase, iron-sulfur-dependent, beta subunit; PFAM: serine dehydratase beta chain; amino acid-binding ACT domain protein. (220 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (403 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (366 aa)
proAGamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (415 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (276 aa)
AEG61140.1KEGG: drm:Dred_1167 aspartate kinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (404 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (300 aa)
AEG61142.1KEGG: drm:Dred_1165 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; amino acid-binding ACT domain protein. (430 aa)
AEG61169.1PFAM: aminotransferase class I and II; KEGG: drm:Dred_1148 aspartate aminotransferase. (394 aa)
lysA-2Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (446 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (397 aa)
rocDOrnithine aminotransferase; Catalyzes the interconversion of ornithine to glutamate semialdehyde. (396 aa)
AEG62010.1Arginase; KEGG: dhd:Dhaf_0755 arginase; TIGRFAM: arginase; PFAM: Arginase/agmatinase/formiminoglutamase; Belongs to the arginase family. (299 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (428 aa)
Your Current Organism:
Desulfotomaculum ruminis
NCBI taxonomy Id: 696281
Other names: D. ruminis DSM 2154, Desulfotomaculum ruminis ATCC 23193, Desulfotomaculum ruminis DL, Desulfotomaculum ruminis DSM 2154, Desulfotomaculum ruminis str. DSM 2154, Desulfotomaculum ruminis strain DSM 2154
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