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| | AEG58320.1 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: drm:Dred_0615 threonine synthase. (402 aa) |
| | AEG58328.1 | TIGRFAM: D-3-phosphoglycerate dehydrogenase; KEGG: drm:Dred_0014 D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; amino acid-binding ACT domain protein. (526 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (501 aa) |
| | AEG58385.1 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: mrb:Mrub_2461 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein. (314 aa) |
| | AEG58465.1 | KEGG: drm:Dred_0097 threonine dehydratase; TIGRFAM: threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; amino acid-binding ACT domain protein. (404 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (315 aa) |
| | AEG58571.1 | TIGRFAM: serine O-acetyltransferase; KEGG: drm:Dred_0192 serine O-acetyltransferase. (228 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (346 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (406 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (285 aa) |
| | argD | TIGRFAM: acetylornithine and succinylornithine aminotransferase; KEGG: drm:Dred_0274 acetylornithine aminotransferase; PFAM: aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (399 aa) |
| | AEG58649.1 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (313 aa) |
| | argG | TIGRFAM: argininosuccinate synthase; KEGG: drm:Dred_0277 argininosuccinate synthase; PFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (401 aa) |
| | argH | KEGG: drm:Dred_0278 argininosuccinate lyase; TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase. (459 aa) |
| | ilvD | TIGRFAM: dihydroxy-acid dehydratase; KEGG: drm:Dred_0280 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (552 aa) |
| | AEG58654.1 | KEGG: drm:Dred_0281 acetolactate synthase, large subunit, biosynthetic type; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; thiamine pyrophosphate central domain-containing protein. (553 aa) |
| | AEG58655.1 | TIGRFAM: acetolactate synthase, small subunit; KEGG: drm:Dred_0282 acetolactate synthase 3 regulatory subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein. (170 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (330 aa) |
| | AEG58657.1 | KEGG: drm:Dred_0284 acetolactate synthase, large subunit, biosynthetic type; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; thiamine pyrophosphate central domain-containing protein. (553 aa) |
| | leuA-2 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (505 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (420 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (165 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (356 aa) |
| | AEG58662.1 | KEGG: drm:Dred_0289 putative alpha-isopropylmalate/homocitrate synthase family transferase; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: LeuA allosteric (dimerisation) domain-containing protein; pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (530 aa) |
| | AEG58734.1 | PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: drm:Dred_2810 glutamate--ammonia ligase. (432 aa) |
| | AEG58736.1 | Cysteine synthase; KEGG: sat:SYN_00075 cysteinyl-tRNA synthetase; TIGRFAM: cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit. (293 aa) |
| | AEG59015.1 | PFAM: GCN5-related N-acetyltransferase; KEGG: drm:Dred_2898 acetyltransferase; Belongs to the acetyltransferase family. (151 aa) |
| | AEG59017.1 | KEGG: drm:Dred_2896 acetolactate synthase 3 regulatory subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein. (171 aa) |
| | AEG59042.1 | KEGG: drm:Dred_2871 cysteine synthase A; TIGRFAM: cysteine synthase A; cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; Belongs to the cysteine synthase/cystathionine beta- synthase family. (311 aa) |
| | AEG59102.1 | TIGRFAM: asparagine synthase (glutamine-hydrolyzing); KEGG: drm:Dred_2812 asparagine synthase (glutamine-hydrolyzing); PFAM: asparagine synthase; glutamine amidotransferase class-II. (616 aa) |
| | AEG59104.1 | TIGRFAM: glutamine synthetase, type I; KEGG: drm:Dred_2807 glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp. (444 aa) |
| | AEG59105.1 | KEGG: drm:Dred_2806 glutamine synthetase, type I; TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp. (444 aa) |
| | AEG59106.1 | KEGG: drm:Dred_2805 glutamate synthase (ferredoxin); PFAM: glutamine amidotransferase class-II; glutamate synthase; ferredoxin-dependent glutamate synthase; glutamate synthase alpha subunit domain protein. (1536 aa) |
| | AEG59107.1 | KEGG: drm:Dred_2804 glutamate synthases, NADH/NADPH, small subunit; TIGRFAM: glutamate synthase, NADH/NADPH, small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase. (494 aa) |
| | metE | 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (764 aa) |
| | AEG59244.1 | KEGG: drm:Dred_2577 HisJ family histidinol phosphate phosphatase; TIGRFAM: histidinol phosphate phosphatase HisJ family; PFAM: PHP domain protein; Belongs to the PHP hydrolase family. HisK subfamily. (273 aa) |
| | hisZ | histidyl-tRNA synthetase 2; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (401 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (220 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (432 aa) |
| | hisC | KEGG: drm:Dred_2354 histidinol-phosphate aminotransferase; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (361 aa) |
| | hisB | KEGG: drm:Dred_2353 imidazoleglycerol-phosphate dehydratase; PFAM: imidazoleglycerol-phosphate dehydratase. (198 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (203 aa) |
| | hisA | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: drm:Dred_2351 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis protein. (243 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (252 aa) |
| | hisI | phosphoribosyl-ATP diphosphatase; KEGG: drm:Dred_2349 phosphoribosyl-AMP cyclohydrolase; TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphohydrolase-like; In the N-terminal section; belongs to the PRA-CH family. (229 aa) |
| | leuC-2 | Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (418 aa) |
| | leuD-2 | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (169 aa) |
| | AEG59584.1 | TIGRFAM: isocitrate dehydrogenase, NAD-dependent; KEGG: pth:PTH_2517 isocitrate/isopropylmalate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. (332 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (320 aa) |
| | AEG59628.1 | KEGG: drm:Dred_2312 pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; PEP-utilising protein mobile region; Belongs to the pyruvate kinase family. (583 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (507 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (345 aa) |
| | trpC | KEGG: drm:Dred_0251 indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (265 aa) |
| | trpF | KEGG: drm:Dred_0252 phosphoribosylanthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); Belongs to the TrpF family. (211 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (396 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (267 aa) |
| | AEG59812.1 | PFAM: homocysteine S-methyltransferase; dihydropteroate synthase DHPS; Methionine synthase B12-binding module cap domain protein; cobalamin B12-binding domain protein; KEGG: drm:Dred_2207 homocysteine S-methyltransferase. (799 aa) |
| | AEG59917.1 | TIGRFAM: branched-chain amino acid aminotransferase; KEGG: drm:Dred_2144 branched-chain amino acid aminotransferase; PFAM: aminotransferase class IV. (358 aa) |
| | metAA | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (305 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (266 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (340 aa) |
| | AEG60177.1 | KEGG: drm:Dred_1940 aspartate kinase I; TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (411 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (296 aa) |
| | AEG60207.1 | PFAM: aminotransferase class I and II; KEGG: drm:Dred_1913 aminotransferase, class I and II. (388 aa) |
| | AEG60399.1 | TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; KEGG: drm:Dred_0132 glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (341 aa) |
| | pfkA-2 | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (358 aa) |
| | AEG60547.1 | TIGRFAM: ribulose-phosphate 3-epimerase; KEGG: drm:Dred_1716 ribulose-phosphate 3-epimerase; PFAM: ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (219 aa) |
| | AEG60567.1 | PFAM: aminotransferase class I and II; KEGG: drm:Dred_1696 aminotransferase, class I and II. (397 aa) |
| | dapL | LL-diaminopimelate aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (392 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (281 aa) |
| | ilvD-2 | TIGRFAM: dihydroxy-acid dehydratase; KEGG: aar:Acear_1923 dihydroxyacid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (553 aa) |
| | AEG60655.1 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: tpd:Teth39_1970 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding. (331 aa) |
| | AEG60761.1 | PFAM: Methionine synthase vitamin-B12 independent; KEGG: cbe:Cbei_2330 methionine synthase, vitamin-B12 independent. (378 aa) |
| | pheA | KEGG: dau:Daud_1904 prephenate dehydratase; PFAM: prephenate dehydratase; amino acid-binding ACT domain protein. (279 aa) |
| | AEG60867.1 | TIGRFAM: threonine synthase; KEGG: drm:Dred_1379 threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit. (499 aa) |
| | AEG60882.1 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: drm:Dred_1362 pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (318 aa) |
| | ilvD-3 | TIGRFAM: dihydroxy-acid dehydratase; KEGG: ccb:Clocel_0493 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (553 aa) |
| | AEG61044.1 | TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, alpha subunit; KEGG: drm:Dred_1253 L-serine dehydratase, iron-sulfur-dependent, alpha subunit; PFAM: serine dehydratase alpha chain. (294 aa) |
| | AEG61045.1 | TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, beta subunit; KEGG: drm:Dred_1252 L-serine dehydratase, iron-sulfur-dependent, beta subunit; PFAM: serine dehydratase beta chain; amino acid-binding ACT domain protein. (220 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (403 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (366 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (415 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (276 aa) |
| | AEG61140.1 | KEGG: drm:Dred_1167 aspartate kinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (404 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (300 aa) |
| | AEG61142.1 | KEGG: drm:Dred_1165 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; amino acid-binding ACT domain protein. (430 aa) |
| | AEG61143.1 | PFAM: amino acid-binding ACT domain protein; KEGG: drm:Dred_1164 hypothetical protein; Belongs to the UPF0735 family. (148 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (429 aa) |
| | AEG61167.1 | PFAM: Prephenate dehydrogenase; KEGG: drm:Dred_1150 prephenate dehydrogenase. (291 aa) |
| | AEG61168.1 | TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; KEGG: pth:PTH_1622 3-deoxy-7-phosphoheptulonate synthase; PFAM: DAHP synthetase I/KDSA. (340 aa) |
| | AEG61169.1 | PFAM: aminotransferase class I and II; KEGG: drm:Dred_1148 aspartate aminotransferase. (394 aa) |
| | AEG61172.1 | Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis. (122 aa) |
| | lysA-2 | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (446 aa) |
| | AEG61286.1 | Manually curated; TIGRFAM: glutamate synthase (NADPH), homotetrameric; KEGG: drm:Dred_1071 putative oxidoreductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase. (468 aa) |
| | AEG61304.1 | TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; KEGG: dae:Dtox_0904 phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I/KDSA. (337 aa) |
| | aroQ | 3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (149 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (359 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (172 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (387 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (293 aa) |
| | AEG61340.1 | 6-phospho-3-hexuloisomerase; KEGG: rru:Rru_A1367 hexulose-6-phosphate isomerase; PFAM: sugar isomerase (SIS). (185 aa) |
| | AEG61353.1 | TIGRFAM: ketose-bisphosphate aldolase; KEGG: pam:PANA_2380 FbaA; PFAM: ketose-bisphosphate aldolase class-II. (287 aa) |
| | AEG61562.1 | KEGG: drm:Dred_0665 histidinol-phosphatase; TIGRFAM: histidinol phosphate phosphatase HisJ family; PFAM: PHP domain protein; Belongs to the PHP hydrolase family. HisK subfamily. (267 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (408 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa) |
| | gpmI | Phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (516 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa) |
| | pgk | KEGG: drm:Dred_2990 phosphoglycerate kinase; PFAM: phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (393 aa) |
| | AEG61801.1 | TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; KEGG: drm:Dred_2991 glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (346 aa) |
| | AEG61827.1 | PFAM: Transketolase central region; Transketolase domain-containing protein; KEGG: drm:Dred_3074 transketolase, central region. (314 aa) |
| | AEG61828.1 | PFAM: Transketolase domain-containing protein; KEGG: drm:Dred_3075 transketolase domain-containing protein. (272 aa) |
| | metK | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (397 aa) |
| | glyA-2 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa) |
| | AEG61901.1 | TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; KEGG: drm:Dred_3163 RpiB/LacA/LacB family sugar-phosphate isomerase; PFAM: Ribose/galactose isomerase. (156 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (217 aa) |
| | AEG61913.1 | TIGRFAM: fructose-1,6-bisphosphate aldolase, class II; ketose-bisphosphate aldolase; KEGG: drm:Dred_3176 fructose-1,6-bisphosphate aldolase; PFAM: ketose-bisphosphate aldolase class-II. (284 aa) |
| | AEG62010.1 | Arginase; KEGG: dhd:Dhaf_0755 arginase; TIGRFAM: arginase; PFAM: Arginase/agmatinase/formiminoglutamase; Belongs to the arginase family. (299 aa) |
| | pfp | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (384 aa) |
