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| | rbsK-2 | Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (309 aa) |
| | AEE95393.1 | Glycerol-1-phosphate dehydrogenase (NAD(P)(+)); COGs: COG0371 Glycerol dehydrogenase; InterPro IPR002658; KEGG: tit:Thit_1700 3-dehydroquinate synthase; PFAM: 3-dehydroquinate synthase; PRIAM: Glycerol-1-phosphate dehydrogenase (NAD(P)(+)); SPTR: 3-dehydroquinate synthase; PFAM: 3-dehydroquinate synthase. (473 aa) |
| | AEE95422.1 | Histidine triad (HIT) protein; COGs: COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolase; InterPro IPR001310; KEGG: hor:Hore_04560 histidine triad (HIT) protein; PFAM: histidine triad (HIT) protein; SPTR: Histidine triad (HIT) protein; PFAM: HIT domain. (91 aa) |
| | AEE95425.1 | Histidine triad (HIT) protein; COGs: COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolase; InterPro IPR001310: IPR019808; KEGG: cbi:CLJ_B2118 HIT family protein; PFAM: histidine triad (HIT) protein; SPTR: Histidine triad (HIT) protein; PFAM: HIT domain. (125 aa) |
| | AEE95426.1 | Type III restriction protein res subunit; COGs: COG1061 DNA or RNA helicase of superfamily II; InterPro IPR014001: IPR001650: IPR014021: IPR006935; KEGG: ctc:CTC00657 DNA/RNA helicase; PFAM: type III restriction protein res subunit; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein; SPTR: DNA/RNA helicase; PFAM: NgoFVII restriction endonuclease; Helicase conserved C-terminal domain; Type III restriction enzyme, res subunit. (864 aa) |
| | AEE95432.1 | Phosphoglycerate mutase; COGs: COG0406 Fructose-2 6-bisphosphatase; InterPro IPR013078; KEGG: ckr:CKR_0654 hypothetical protein; PFAM: Phosphoglycerate mutase; SPTR: Putative uncharacterized protein; PFAM: Phosphoglycerate mutase family; TIGRFAM: alpha-ribazole phosphatase. (198 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (210 aa) |
| | AEE95470.1 | CMP/dCMP deaminase zinc-binding protein; COGs: COG2131 Deoxycytidylate deaminase; InterPro IPR002125: IPR016192: IPR016473; KEGG: chy:CHY_2556 putative ComE operon protein 2; PFAM: CMP/dCMP deaminase zinc-binding; SPTR: Putative comE operon protein 2; PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region. (170 aa) |
| | AEE95472.1 | COGs: COG0191 Fructose/tagatose bisphosphate aldolase; InterPro IPR000771: IPR011289; KEGG: chy:CHY_0128 fructose-1,6-bisphosphate aldolase; PFAM: ketose-bisphosphate aldolase class-II; PRIAM: Tagatose-bisphosphate aldolase; SPTR: Fructose-1,6-bisphosphate aldolase, class II; TIGRFAM: fructose-1,6-bisphosphate aldolase, class II; ketose-bisphosphate aldolase; PFAM: Fructose-bisphosphate aldolase class-II; TIGRFAM: ketose-bisphosphate aldolases; class II aldolase, tagatose bisphosphate family; fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist. (283 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (216 aa) |
| | fabZ | 3-hydroxyacyl-(acyl-carrier-protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (144 aa) |
| | AEE95517.1 | COGs: COG0232 dGTP triphosphohydrolase; InterPro IPR003607: IPR006261: IPR006674; KEGG: cth:Cthe_0897 deoxyguanosinetriphosphate triphosphohydrolase-like protein; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region; SPTR: Putative deoxyguanosinetriphosphate triphosphohydrolase; TIGRFAM: deoxyguanosinetriphosphate triphosphohydrolase; PFAM: HD domain; TIGRFAM: deoxyguanosinetriphosphate triphosphohydrolase, putative; Belongs to the dGTPase family. Type 2 subfamily. (331 aa) |
| | AEE95570.1 | Hypothetical protein; COGs: COG1044 UDP-3-O-(3-hydroxymyristoyl); InterPro IPR018357: IPR001451; KEGG: ckr:CKR_2805 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Bacterial transferase hexapeptide (three repeats). (248 aa) |
| | AEE95576.1 | Sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; COGs: COG1044 UDP-3-O-(3-hydroxymyristoyl); InterPro IPR020019: IPR001451; KEGG: bpf:BpOF4_06570 acetyltransferase; PFAM: transferase hexapeptide repeat containing protein; SPTR: Acetyltransferase; TIGRFAM: sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; TIGRFAM: sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family. (209 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (212 aa) |
| | atpC | ATP synthase F1 subcomplex epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (139 aa) |
| | atpD | ATP synthase F1 subcomplex beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (472 aa) |
| | atpG | ATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (292 aa) |
| | atpA | ATP synthase F1 subcomplex alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (512 aa) |
| | atpH | ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (184 aa) |
| | atpF | ATP synthase F0, B subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (160 aa) |
| | atpE | ATP synthase F0 subcomplex C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (71 aa) |
| | atpB | ATP synthase F0 subcomplex A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (222 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (427 aa) |
| | mcsB | ATP:guanido phosphotransferase; Catalyzes the specific phosphorylation of arginine residues in proteins. (342 aa) |
| | AEE95656.1 | KEGG: cth:Cthe_1784 hypothetical protein; SPTR: Putative uncharacterized protein. (133 aa) |
| | nadE | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (548 aa) |
| | ldh | L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (312 aa) |
| | AEE95731.1 | Thioesterase superfamily protein; COGs: COG1607 Acyl-CoA hydrolase; InterPro IPR006683; KEGG: cth:Cthe_2687 thioesterase superfamily protein; PFAM: thioesterase superfamily protein; SPTR: Thioesterase superfamily; PFAM: Thioesterase superfamily. (164 aa) |
| | AEE95820.1 | COGs: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; InterPro IPR005904: IPR000836; KEGG: drm:Dred_2376 hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; PRIAM: Hypoxanthine phosphoribosyltransferase; SPTR: Hypoxanthine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain; TIGRFAM: hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (178 aa) |
| | atpE-2 | H+transporting two-sector ATPase E subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (202 aa) |
| | AEE95832.1 | COGs: COG1436 H+-ATPase subunit F; InterPro IPR008218; KEGG: tmt:Tmath_2244 vacuolar H+transporting two-sector ATPase F subunit; PFAM: Vacuolar H+transporting two-sector ATPase F subunit; SPTR: Vacuolar H+transporting two-sector ATPase F subunit; PFAM: ATP synthase (F/14-kDa) subunit. (107 aa) |
| | atpB-2 | H+transporting two-sector ATPase alpha/beta subunit central region; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit. (464 aa) |
| | atpD-2 | V-type ATPase, D subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (213 aa) |
| | AEE95866.1 | COGs: COG0015 Adenylosuccinate lyase; InterPro IPR000362: IPR004769: IPR019468: IPR020557: IPR 013838; KEGG: cth:Cthe_0741 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase-like; fumarate lyase; SPTR: Adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: Lyase; Adenylosuccinate lyase C-terminus; TIGRFAM: adenylosuccinate lyase. (476 aa) |
| | nadD | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (205 aa) |
| | AEE95911.1 | Metal dependent phosphohydrolase; COGs: COG1713 HD superfamily hydrolase involved in NAD metabolism; InterPro IPR003607: IPR005249: IPR006674; KEGG: tte:TTE0919 HD superfamily hydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region; SPTR: Metal dependent phosphohydrolase; PFAM: HD domain; TIGRFAM: putative HD superfamily hydrolase of NAD metabolism; uncharacterized domain HDIG. (192 aa) |
| | AEE95920.1 | Histidine triad (HIT) protein; COGs: COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolase; InterPro IPR001310: IPR019808; KEGG: tpd:Teth39_1375 histidine triad (HIT) protein; PFAM: histidine triad (HIT) protein; SPTR: Histidine triad (HIT) protein; PFAM: HIT domain. (114 aa) |
| | AEE95948.1 | 1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase; COGs: COG1691 NCAIR mutase (PurE)-related protein; InterPro IPR000031; KEGG: cce:Ccel_2205 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase; PFAM: 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase; SPTR: 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase; PFAM: AIR carboxylase. (249 aa) |
| | folD | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (630 aa) |
| | nadK | ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (291 aa) |
| | AEE96000.1 | MazG family protein; COGs: COG3956 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain; InterPro IPR011551: IPR004518; KEGG: cbb:CLD_0948 MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; SPTR: MazG family protein; TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase domain; TIGRFAM: MazG family protein. (261 aa) |
| | cinA | Competence/damage-inducible protein cinA; COGs: COG1058 nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA; InterPro IPR008135: IPR008136: IPR001453; KEGG: cth:Cthe_1052 competence/damage-inducible protein CinA; PFAM: CinA domain protein; molybdopterin binding domain; SPTR: Competence/damage-inducible protein CinA; TIGRFAM: competence/damage-inducible protein CinA; PFAM: Probable molybdopterin binding domain; Competence-damaged protein; TIGRFAM: competence/damage-inducible protein CinA N-terminal domain; competence/damage-inducible protein CinA C-terminal dom [...] (413 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (396 aa) |
| | AEE96021.1 | COGs: COG0191 Fructose/tagatose bisphosphate aldolase; InterPro IPR000771; KEGG: pam:PANA_2380 FbaA; PFAM: ketose-bisphosphate aldolase class-II; PRIAM: Tagatose-bisphosphate aldolase; SPTR: Putative uncharacterized protein; TIGRFAM: ketose-bisphosphate aldolase; PFAM: Fructose-bisphosphate aldolase class-II; TIGRFAM: ketose-bisphosphate aldolases. (354 aa) |
| | ackA-2 | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa) |
| | AEE96053.1 | Type III secretion system ATPase, FliI/YscN; COGs: COG1157 Flagellar biosynthesis/type III secretory pathway ATPase; InterPro IPR003593: IPR005714: IPR004100: IPR000194: IPR 020003; KEGG: cce:Ccel_2048 ATPase FliI/YscN; PFAM: H+transporting two-sector ATPase alpha/beta subunit central region; H+transporting two-sector ATPase alpha/beta subunit domain protein; SMART: AAA ATPase; SPTR: ATPase, FliI/YscN family; TIGRFAM: ATPase, FliI/YscN family; PFAM: ATP synthase alpha/beta family, beta-barrel domain; ATP synthase alpha/beta family, nucleotide-binding domain; TIGRFAM: ATPase FliI/YscN f [...] (435 aa) |
| | AEE96097.1 | Oxidoreductase FAD/NAD(P)-binding domain protein; COGs: COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductase; InterPro IPR017927: IPR001221: IPR012165: IPR008333: IPR 001433: IPR019480; KEGG: chy:CHY_0934 hydrogenase, gamma subunit; PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; SPTR: Hydrogenase, gamma subunit; PFAM: Oxidoreductase FAD-binding domain; Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase [...] (285 aa) |
| | AEE96112.1 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (199 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (174 aa) |
| | AEE96128.1 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (719 aa) |
| | AEE96145.1 | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; COGs: COG0558 Phosphatidylglycerophosphate synthase; InterPro IPR004570: IPR000462; KEGG: tte:TTE1376 phosphatidylglycerophosphate synthase; PFAM: CDP-alcohol phosphatidyltransferase; SPTR: Phosphatidylglycerophosphate synthase; TIGRFAM: CDP-diacylglycerol/glycerol-3-phosphate 3-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; TIGRFAM: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (177 aa) |
| | surE | 5'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (257 aa) |
| | AEE96149.1 | Phosphoglycerate mutase; COGs: COG0406 Fructose-2 6-bisphosphatase; InterPro IPR013078: IPR001345; KEGG: tte:TTE1346 phosphoglycerate mutase/fructose-2,6-bisphosphatase; PFAM: Phosphoglycerate mutase; SPTR: Phosphoglycerate mutase/fructose-2,6-bisphosphatase; manually curated; PFAM: Phosphoglycerate mutase family. (201 aa) |
| | AEE96161.1 | Sodium pump decarboxylase, gamma subunit; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation; Belongs to the OadG family. (122 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (204 aa) |
| | AEE96179.1 | Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (403 aa) |
| | AEE96189.1 | COGs: COG0036 Pentose-5-phosphate-3-epimerase; InterPro IPR000056: IPR010916; KEGG: amt:Amet_2777 ribulose-phosphate 3-epimerase; PFAM: ribulose-phosphate 3-epimerase; PRIAM: Ribulose-phosphate 3-epimerase; SPTR: Ribulose-phosphate 3-epimerase; TIGRFAM: ribulose-phosphate 3-epimerase; PFAM: Ribulose-phosphate 3 epimerase family; TIGRFAM: ribulose-phosphate 3-epimerase. (222 aa) |
| | AEE96190.1 | COGs: COG1564 Thiamine pyrophosphokinase; InterPro IPR007371: IPR006282; KEGG: tte:TTE1497 thiamine pyrophosphokinase; PFAM: Thiamin pyrophosphokinase catalytic domain-containing protein; SPTR: Thiamine pyrophosphokinase; TIGRFAM: thiamine pyrophosphokinase; PFAM: Thiamin pyrophosphokinase, vitamin B1 binding domain; Thiamin pyrophosphokinase, catalytic domain; TIGRFAM: thiamine pyrophosphokinase. (209 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (162 aa) |
| | glmU | Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (461 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (317 aa) |
| | nadE-2 | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (312 aa) |
| | AEE96237.1 | Riboflavin biosynthesis protein RibF; COGs: COG0196 FAD synthase; InterPro IPR002606: IPR015864: IPR015865; KEGG: tpd:Teth39_1205 bifunctional riboflavin kinase/FMN adenylyltransferase; PFAM: FAD synthetase; Riboflavin kinase; SPTR: Riboflavin biosynthesis protein RibF; TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: Riboflavin kinase; FAD synthetase; TIGRFAM: riboflavin kinase/FMN adenylyltransferase; Belongs to the ribF family. (323 aa) |
| | plsX | Phosphate:acyl-(acyl carrier protein) acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (339 aa) |
| | AEE96338.1 | COGs: COG0157 Nicotinate-nucleotide pyrophosphorylase; InterPro IPR002638: IPR004393; KEGG: cth:Cthe_2354 nicotinate-nucleotide pyrophosphorylase [carboxylating]; PFAM: Quinolinate phosphoribosyl transferase; PRIAM: Nicotinate-nucleotide diphosphorylase (carboxylating); SPTR: Nicotinate-nucleotide pyrophosphorylase; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase, C-terminal domain; Quinolinate phosphoribosyl transferase, N-terminal domain; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. (280 aa) |
| | nadA | Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (301 aa) |
| | folE | COGs: COG0302 GTP cyclohydrolase I; InterPro IPR020602: IPR018234: IPR001474; KEGG: tjr:TherJR_1931 GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase; PRIAM: GTP cyclohydrolase I; SPTR: GTP cyclohydrolase 1; TIGRFAM: GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I. (186 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (198 aa) |
| | AEE96502.1 | Glyoxalase/bleomycin resistance protein/dioxygenase; InterPro IPR004360; KEGG: lbr:LVIS_2160 lactoylglutathione lyase related lyase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; SPTR: Putative uncharacterized protein; PFAM: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily. (132 aa) |
| | AEE96503.1 | COGs: COG0191 Fructose/tagatose bisphosphate aldolase; InterPro IPR000771; KEGG: tmt:Tmath_0177 fructose-1,6-bisphosphate aldolase, class II; PFAM: ketose-bisphosphate aldolase class-II; PRIAM: Tagatose-bisphosphate aldolase; SPTR: Putative uncharacterized protein; TIGRFAM: ketose-bisphosphate aldolase; PFAM: Fructose-bisphosphate aldolase class-II; TIGRFAM: ketose-bisphosphate aldolases. (284 aa) |
| | tmk-2 | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (240 aa) |
| | tmk-3 | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (231 aa) |
| | AEE96570.1 | COGs: COG0191 Fructose/tagatose bisphosphate aldolase; InterPro IPR000771; KEGG: ate:Athe_2390 ketose-bisphosphate aldolase; PFAM: ketose-bisphosphate aldolase class-II; PRIAM: Tagatose-bisphosphate aldolase; SPTR: Ketose-bisphosphate aldolase; TIGRFAM: ketose-bisphosphate aldolase; PFAM: Fructose-bisphosphate aldolase class-II; TIGRFAM: ketose-bisphosphate aldolases. (280 aa) |
| | AEE96591.1 | COGs: COG0469 Pyruvate kinase; InterPro IPR015793: IPR015794: IPR008279: IPR018209: IPR 001697; KEGG: tte:TTE1815 pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; PEP-utilising protein mobile region; SPTR: Pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase, barrel domain; PEP-utilising enzyme, mobile domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family. (583 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (193 aa) |
| | pyrD | Dihydroorotate oxidase B, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. (304 aa) |
| | AEE96613.1 | Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulfur cluster binding domain protein; COGs: COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductase; InterPro IPR001433: IPR019480: IPR012165: IPR017927; KEGG: cth:Cthe_0948 dihydroorotate oxidase B, electron transfer subunit; PFAM: Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; oxidoreductase FAD/NAD(P)-binding domain protein; SPTR: Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; PFAM: Iron-sulfur cluster bindi [...] (260 aa) |
| | carB | COGs: COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); InterPro IPR005481: IPR005479: IPR005480: IPR011607: IPR 005483: IPR011761: IPR006275; KEGG: cth:Cthe_0949 carbamoyl phosphate synthase large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; MGS domain protein; SPTR: Carbamoyl-phosphate synthase large subunit; TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; MG [...] (1080 aa) |
| | pyrF | COGs: COG0284 Orotidine-5'-phosphate decarboxylase; InterPro IPR001754: IPR018089: IPR011995; KEGG: cth:Cthe_0951 orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase; PRIAM: Orotidine-5'-phosphate decarboxylase; SPTR: Orotidine 5'-phosphate decarboxylase; TIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase / HUMPS family; TIGRFAM: orotidine 5'-phosphate decarboxylase, subfamily 2; Belongs to the OMP decarboxylase family. Type 2 subfamily. (313 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (438 aa) |
| | pyrB | COGs: COG0540 Aspartate carbamoyltransferase catalytic chain; InterPro IPR006132: IPR006131: IPR002082: IPR006130; KEGG: cce:Ccel_0612 aspartate carbamoyltransferase catalytic subunit; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; SPTR: Aspartate carbamoyltransferase; TIGRFAM: aspartate carbamoyltransferase; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; TIGRFAM: ornithine carbamoyltransferase; aspar [...] (316 aa) |
| | deoB | Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (389 aa) |
| | AEE96647.1 | NUDIX hydrolase; InterPro IPR000086: IPR020084; KEGG: tpd:Teth39_1115 NUDIX hydrolase; PFAM: NUDIX hydrolase; SPTR: NUDIX hydrolase; PFAM: NUDIX domain. (178 aa) |
| | AEE96652.1 | Thiamin pyrophosphokinase catalytic domain-containing protein; COGs: COG4825 Uncharacterized membrane-anchored protein; InterPro IPR007371; KEGG: tte:TTE1305 hypothetical protein; PFAM: Thiamin pyrophosphokinase catalytic domain-containing protein; SPTR: Putative uncharacterized protein; PFAM: Thiamine pyrophosphokinase C terminal. (372 aa) |
| | coaX | Pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (255 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa) |
| | gpmI | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (513 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (249 aa) |
| | pgk | COGs: COG0126 3-phosphoglycerate kinase; InterPro IPR001576: IPR015911; KEGG: tte:TTE1761 phosphoglycerate kinase; PFAM: phosphoglycerate kinase; PRIAM: Phosphoglycerate kinase; SPTR: Phosphoglycerate kinase; PFAM: Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (395 aa) |
| | AEE96687.1 | ATPase; KEGG: cth:Cthe_0434 ATPase; SPTR: ATPase. (362 aa) |
| | AEE96689.1 | KEGG: tmt:Tmath_2131 molybdopterin-guanine dinucleotide biosynthesis protein A-like protein; SPTR: Molybdopterin-guanine dinucleotide biosynthesis protein A-like protein; PFAM: Uncharacterized protein family UPF0007. (252 aa) |
| | ispDF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF). (396 aa) |
| | carA | COGs: COG0505 Carbamoylphosphate synthase small subunit; InterPro IPR001317: IPR011702: IPR006220: IPR017926: IPR 002474: IPR000991: IPR006274; KEGG: cce:Ccel_2913 carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; SPTR: Carbamoyl-phosphate synthase, small subunit; TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I; TIGRFAM: carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (355 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (533 aa) |
| | AEE96755.1 | Protein of unknown function DUF201; COGs: COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); InterPro IPR011761: IPR003806; KEGG: cbk:CLL_A0824 carbamoyl phosphate synthase-like protein; PFAM: protein of unknown function DUF201; SPTR: ATP domain protein; PFAM: ATP-grasp domain. (329 aa) |
| | cmk | COGs: COG0283 Cytidylate kinase; InterPro IPR003136: IPR000623: IPR011994; KEGG: cth:Cthe_0712 cytidylate kinase; PFAM: cytidylate kinase region; shikimate kinase; SPTR: Cytidylate kinase; TIGRFAM: cytidylate kinase; PFAM: Cytidylate kinase; Adenylate kinase; TIGRFAM: cytidylate kinase. (225 aa) |
| | purD | COGs: COG0151 Phosphoribosylamine-glycine ligase; InterPro IPR020559: IPR011761: IPR000115: IPR020562: IPR 020561: IPR020560; KEGG: cth:Cthe_1245 phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; PRIAM: Phosphoribosylamine--glycine ligase; SPTR: Phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine/glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; P [...] (416 aa) |
| | purH | IMP cyclohydrolase; COGs: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); InterPro IPR013982: IPR011607: IPR002695; KEGG: cth:Cthe_1246 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein; PRIAM: Phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme formylation region; SPTR: Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarbox [...] (514 aa) |
| | purN | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (207 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase; COGs: COG0150 Phosphoribosylaminoimidazole (AIR) synthetase; InterPro IPR000728: IPR010918: IPR004733; KEGG: cce:Ccel_2183 phosphoribosylaminoimidazole synthetase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; PRIAM: Phosphoribosylformylglycinamidine cyclo-ligase; SPTR: Phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: phosphoribosylaminoi [...] (335 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (491 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase subunit II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (735 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (236 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (82 aa) |
| | purC | COGs: COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; InterPro IPR018236: IPR001636; KEGG: ate:Athe_1452 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; PRIAM: Phosphoribosylaminoimidazolesuccinocarboxamide synthase; SPTR: Phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase. (236 aa) |
| | purE | 5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (165 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (511 aa) |
| | AEE96833.1 | Maf protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (192 aa) |
| | AEE96843.1 | COGs: COG1488 Nicotinic acid phosphoribosyltransferase; InterPro IPR002638: IPR000056; KEGG: tmt:Tmath_0853 quinolinate phosphoribosyl transferase; PFAM: Quinolinate phosphoribosyl transferase; ribulose-phosphate 3-epimerase; SPTR: Quinolinate phosphoribosyl transferase; PFAM: Quinolinate phosphoribosyl transferase, C-terminal domain; Quinolinate phosphoribosyl transferase, N-terminal domain; Belongs to the NAPRTase family. (344 aa) |
| | ispH | Hydroxymethylbutenyl pyrophosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (718 aa) |
| | AEE96852.1 | 1-phosphofructokinase; COGs: COG1105 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB); InterPro IPR011611: IPR017583; KEGG: cbt:CLH_2876 1-phosphofructokinase; PFAM: PfkB domain protein; SPTR: 1-phosphofructokinase; TIGRFAM: 1-phosphofructokinase; PFAM: pfkB family carbohydrate kinase; TIGRFAM: tagatose-6-phosphate kinase; 1-phosphofructokinase; hexose kinase, 1-phosphofructokinase family; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. (311 aa) |
| | AEE96854.1 | COGs: COG0191 Fructose/tagatose bisphosphate aldolase; InterPro IPR000771: IPR011289; KEGG: chy:CHY_0128 fructose-1,6-bisphosphate aldolase; PFAM: ketose-bisphosphate aldolase class-II; PRIAM: Tagatose-bisphosphate aldolase; SPTR: Fructose-1,6-bisphosphate aldolase, class II; TIGRFAM: fructose-1,6-bisphosphate aldolase, class II; ketose-bisphosphate aldolase; PFAM: Fructose-bisphosphate aldolase class-II; TIGRFAM: ketose-bisphosphate aldolases; class II aldolase, tagatose bisphosphate family; fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist. (287 aa) |
| | AEE97874.1 | Transaldolase; COGs: COG0176 Transaldolase; InterPro IPR001585; KEGG: pac:PPA0454 transaldolase; PFAM: Transaldolase; SPTR: Putative uncharacterized protein; PFAM: Transaldolase. (358 aa) |
| | AEE96855.1 | COGs: COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase; InterPro IPR002123: IPR004552; KEGG: tit:Thit_1146 1-acyl-sn-glycerol-3-phosphate acyltransferase; PFAM: phospholipid/glycerol acyltransferase; SMART: phospholipid/glycerol acyltransferase; SPTR: 1-acyl-sn-glycerol-3-phosphate acyltransferase; TIGRFAM: 1-acyl-sn-glycerol-3-phosphate acyltransferase; PFAM: Acyltransferase; TIGRFAM: 1-acyl-sn-glycerol-3-phosphate acyltransferases; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (195 aa) |
| | AEE96872.1 | CDP-alcohol phosphatidyltransferase; COGs: COG0558 Phosphatidylglycerophosphate synthase; InterPro IPR000462: IPR004570; KEGG: tex:Teth514_2221 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; SPTR: CDP-alcohol phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; TIGRFAM: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (169 aa) |
| | thiI | Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (390 aa) |
| | ackA-3 | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (401 aa) |
| | AEE96881.1 | COGs: COG0280 Phosphotransacetylase; InterPro IPR002505: IPR004614: IPR012147; KEGG: tte:TTE1482 phosphotransacetylase; PFAM: phosphate acetyl/butaryl transferase; PRIAM: Phosphate acetyltransferase; SPTR: Phosphotransacetylase; TIGRFAM: phosphate acetyltransferase; PFAM: Phosphate acetyl/butaryl transferase; TIGRFAM: phosphate acetyltransferase. (328 aa) |
| | AEE96946.1 | ROK family protein; COGs: COG1940 Transcriptional regulator/sugar kinase; InterPro IPR000600; KEGG: tte:TTE0090 transcriptional regulator; PFAM: ROK family protein; SPTR: Transcriptional regulator; PFAM: ROK family; TIGRFAM: ROK family protein (putative glucokinase). (306 aa) |
| | AEE96948.1 | COGs: COG0036 Pentose-5-phosphate-3-epimerase; InterPro IPR000056; KEGG: gme:Gmet_0067 ribulose-5-phosphate 3-epimerase; PFAM: ribulose-phosphate 3-epimerase; PRIAM: Ribulose-phosphate 3-epimerase; SPTR: Ribulose-phosphate 3-epimerase; TIGRFAM: ribulose-phosphate 3-epimerase; PFAM: Ribulose-phosphate 3 epimerase family; TIGRFAM: ribulose-phosphate 3-epimerase. (224 aa) |
| | deoC | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (232 aa) |
| | AEE97011.1 | Glucokinase, ROK family; COGs: COG1940 Transcriptional regulator/sugar kinase; InterPro IPR000600: IPR004654; KEGG: tte:TTE1961 transcriptional regulator; PFAM: ROK family protein; SPTR: Transcriptional regulator; TIGRFAM: glucokinase, ROK family; PFAM: ROK family; TIGRFAM: ROK family protein (putative glucokinase). (319 aa) |
| | dacA | Protein of unknown function DUF147; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (286 aa) |
| | nnrE | Carbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...] (515 aa) |
| | plsY | Acyl-phosphate glycerol-3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (198 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (325 aa) |
| | ispG | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (350 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (386 aa) |
| | AEE97085.1 | Phosphatidate cytidylyltransferase; COGs: COG0575 CDP-diglyceride synthetase; InterPro IPR000374; KEGG: cno:NT01CX_2144 phosphatidate cytidylyltransferase; PFAM: phosphatidate cytidylyltransferase; SPTR: Phosphatidate cytidylyltransferase; PFAM: Cytidylyltransferase family. (268 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (235 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (488 aa) |
| | AEE97198.1 | ROK family protein; COGs: COG1940 Transcriptional regulator/sugar kinase; InterPro IPR000600; KEGG: tte:TTE0761 transcriptional regulator; PFAM: ROK family protein; SPTR: Transcriptional regulator; PFAM: ROK family; TIGRFAM: ROK family protein (putative glucokinase). (321 aa) |
| | AEE97210.1 | COGs: COG0191 Fructose/tagatose bisphosphate aldolase; InterPro IPR000771; KEGG: adg:Adeg_0056 fructose-1,6-bisphosphate aldolase, class II; PFAM: ketose-bisphosphate aldolase class-II; PRIAM: 5-dehydro-2-deoxyphosphogluconate aldolase; SPTR: Fructose-1,6-bisphosphate aldolase, class II; TIGRFAM: ketose-bisphosphate aldolase; PFAM: Fructose-bisphosphate aldolase class-II; TIGRFAM: ketose-bisphosphate aldolases. (312 aa) |
| | thiE | Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (207 aa) |
| | AEE97220.1 | KEGG: ant:Arnit_3051 hypothetical protein; SPTR: Putative uncharacterized protein. (144 aa) |
| | thiM | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (267 aa) |
| | thiC | Hydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (426 aa) |
| | AEE97253.1 | KEGG: tmt:Tmath_2131 molybdopterin-guanine dinucleotide biosynthesis protein A-like protein; SPTR: Molybdopterin-guanine dinucleotide biosynthesis protein A-like protein; PFAM: Uncharacterized protein family UPF0007. (253 aa) |
| | ispE | 4-diphosphocytidyl-2C-methyl-D-erythritolkinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (291 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (211 aa) |
| | thyX | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (229 aa) |
| | AEE97418.1 | Sulfide dehydrogenase (flavoprotein) subunit SudB; COGs: COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductase; InterPro IPR001433: IPR019480: IPR017927: IPR012165; KEGG: cth:Cthe_0373 ferredoxin-NADP(+) reductase subunit alpha; PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; SPTR: Ferredoxin-NADP(+) reductase subunit alpha; PFAM: Oxidoreductase FAD-binding domain; Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B; Oxidoreductase NAD-binding domain. (281 aa) |
| | pdxS | Pyridoxal phosphate synthase yaaD subunit; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (293 aa) |
| | pdxT | Pyridoxal phosphate synthase yaaE subunit; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (194 aa) |
| | pfp | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (390 aa) |
| | araB | L-ribulokinase; COGs: COG1069 Ribulose kinase; InterPro IPR018484: IPR018485: IPR018483: IPR005929; KEGG: tit:Thit_1703 L-ribulokinase; PFAM: Carbohydrate kinase, FGGY-like; SPTR: Ribulokinase; TIGRFAM: L-ribulokinase; PFAM: FGGY family of carbohydrate kinases, N-terminal domain; FGGY family of carbohydrate kinases, C-terminal domain; TIGRFAM: L-ribulokinase. (555 aa) |
| | glpK | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. (495 aa) |
| | rbsK | Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (309 aa) |
| | AEE97609.1 | KEGG: tte:TTE2019 hypothetical protein; SPTR: Putative uncharacterized protein. (180 aa) |
| | AEE97666.1 | Ribose-phosphate pyrophosphokinase; COGs: COG0462 Phosphoribosylpyrophosphate synthetase; InterPro IPR000836: IPR005946; KEGG: eel:EUBELI_01922 phosphoribosylpyrophosphate synthetase; PFAM: phosphoribosyltransferase; SPTR: Ribose-phosphate pyrophosphokinase; TIGRFAM: ribose-phosphate pyrophosphokinase; PFAM: Phosphoribosyl transferase domain; TIGRFAM: ribose-phosphate pyrophosphokinase. (366 aa) |
| | AEE97739.1 | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. (497 aa) |
| | AEE97749.1 | InterPro IPR004360; KEGG: cce:Ccel_3377 glyoxalase/bleomycin resistance protein/dioxygenase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; SPTR: Glyoxalase/bleomycin resistance protein/dioxygenase; PFAM: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily. (125 aa) |
| | AEE97843.1 | COGs: COG0191 Fructose/tagatose bisphosphate aldolase; InterPro IPR000771; KEGG: tit:Thit_1576 ketose-bisphosphate aldolase; PFAM: ketose-bisphosphate aldolase class-II; PRIAM: Tagatose-bisphosphate aldolase; SPTR: Ketose-bisphosphate aldolase; TIGRFAM: ketose-bisphosphate aldolase; PFAM: Fructose-bisphosphate aldolase class-II; TIGRFAM: ketose-bisphosphate aldolases. (282 aa) |
| | AEE97852.1 | 1-phosphofructokinase; COGs: COG1105 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB); InterPro IPR011611: IPR002173: IPR017583; KEGG: csc:Csac_2441 ribokinase-like domain-containing protein; PFAM: PfkB domain protein; SPTR: PfkB domain protein; TIGRFAM: 1-phosphofructokinase; PFAM: pfkB family carbohydrate kinase; TIGRFAM: 1-phosphofructokinase; hexose kinase, 1-phosphofructokinase family; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. (318 aa) |
