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| | cobT | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (344 aa) |
| | pdxA | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (329 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (334 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (212 aa) |
| | fliA | RNA polymerase, sigma 28 subunit, FliA/WhiG; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes; Belongs to the sigma-70 factor family. FliA subfamily. (237 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (322 aa) |
| | bioF | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (389 aa) |
| | EGW21375.1 | Carboxylesterase; KEGG: mca:MCA1127 BioH protein; PFAM: Alpha/beta hydrolase fold-1. (287 aa) |
| | bioC | Biotin biosynthesis protein BioC; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (257 aa) |
| | bioD | Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (219 aa) |
| | ftsY | Signal recognition particle-docking protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. (664 aa) |
| | rpoH | RNA polymerase, sigma 32 subunit, RpoH; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. (285 aa) |
| | nadK | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (301 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (421 aa) |
| | EGW21504.1 | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (443 aa) |
| | EGW21526.1 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (531 aa) |
| | EGW21533.1 | PFAM: 6-pyruvoyl tetrahydropterin synthase-related; KEGG: mca:MCA2527 6-pyruvoyl tetrahydropterin synthase, putative. (134 aa) |
| | EGW21581.1 | KEGG: drt:Dret_1630 hypothetical protein. (93 aa) |
| | EGW21608.1 | KEGG: nhl:Nhal_2235 ATP synthase gamma subunit C-terminus. (273 aa) |
| | atpA | ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (515 aa) |
| | atpF | ATP synthase subunit b; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (249 aa) |
| | atpE | ATP synthase subunit c; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (88 aa) |
| | atpB | ATP synthase subunit a; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (221 aa) |
| | EGW21614.1 | PFAM: ATPase, F1 complex, delta/epsilon subunit, N-terminal; KEGG: nhl:Nhal_2241 H+transporting two-sector ATPase delta/epsilon subunit. (136 aa) |
| | EGW21616.1 | TIGRFAM: ATPase, F1 complex, beta subunit; HAMAP: ATPase, F1 complex, beta subunit; KEGG: mca:MCA1556 F0F1 ATP synthase subunit beta; PFAM: ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain; ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal; ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal. (464 aa) |
| | EGW21619.1 | KEGG: pin:Ping_3062 helix-hairpin-helix DNA-binding, class 1. (297 aa) |
| | EGW21620.1 | PFAM: Phosphoribosyltransferase; KEGG: afu:AF0239 xanthine-guanine phosphoribosyltransferase (GptA-1). (201 aa) |
| | EGW21634.1 | PFAM: RNA-directed DNA polymerase (reverse transcriptase); Group II intron, maturase-specific; KEGG: paa:Paes_0629 RNA-directed DNA polymerase (reverse transcriptase). (405 aa) |
| | EGW21638.1 | KEGG: nwa:Nwat_0083 hypothetical protein. (205 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (355 aa) |
| | EGW21852.1 | TIGRFAM: Adenylosuccinate lyase; KEGG: tgr:Tgr7_1849 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (454 aa) |
| | EGW21855.1 | KEGG: mca:MCA1870 riboflavin biosynthesis protein RibD domain-containing protein. (280 aa) |
| | EGW21857.1 | KEGG: ftn:FTN_1444 ornithine cyclodeaminase; PFAM: Ornithine cyclodeaminase/mu-crystallin. (336 aa) |
| | EGW21858.1 | KEGG: nhl:Nhal_3591 transcriptional coactivator/pterin dehydratase; HAMAP: pterin-4-alpha-carbinolamine dehydratase; PFAM: Transcriptional coactivator/pterin dehydratase. (111 aa) |
| | EGW21865.1 | PFAM: Protein of unknown function DUF336; KEGG: mrd:Mrad2831_4389 hypothetical protein. (144 aa) |
| | EGW21889.1 | CBS domain containing protein; KEGG: mca:MCA1456 magnesium and cobalt efflux protein CorC; PFAM: Cystathionine beta-synthase, core; Transporter-associated region; SMART: Cystathionine beta-synthase, core. (280 aa) |
| | EGW21890.1 | PFAM: Transcriptional coactivator/pterin dehydratase; KEGG: nhl:Nhal_0016 transcriptional coactivator/pterin dehydratase. (127 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (620 aa) |
| | EGW21919.1 | KEGG: nmu:Nmul_A2560 radical SAM family protein; TIGRFAM: Hopanoid biosynthesis associated radical SAM protein HpnH; PFAM: Radical SAM. (369 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (171 aa) |
| | EGW21930.1 | KEGG: gca:Galf_1632 uroporphyrinogen decarboxylase (URO-D); Belongs to the uroporphyrinogen decarboxylase family. (342 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (243 aa) |
| | EGW21979.1 | KEGG: gca:Galf_0507 CinA domain-containing protein; TIGRFAM: CinA, C-terminal; PFAM: CinA, C-terminal; Belongs to the CinA family. (160 aa) |
| | hemF | Coproporphyrinogen-III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (304 aa) |
| | EGW22031.1 | TIGRFAM: Aminodeoxychorismate lyase, class IV; KEGG: noc:Noc_1662 aminotransferase, class IV; PFAM: Aminotransferase, class IV; overlaps another CDS with the same product name. (283 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (223 aa) |
| | EGW22034.1 | TIGRFAM: DNA polymerase III, delta prime subunit; KEGG: mca:MCA1995 DNA polymerase III, delta prime subunit. (352 aa) |
| | queF | NADPH-dependent 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (129 aa) |
| | trpF | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: mca:MCA2496 N-(5'phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (210 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (400 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (267 aa) |
| | accD | Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (320 aa) |
| | EGW22093.1 | FolC bifunctional protein; TIGRFAM: Folylpolyglutamate synthetase; KEGG: mca:MCA2492 folylpolyglutamate synthase/dihydrofolate synthase; PFAM: Mur ligase, central; Mur ligase, C-terminal. (423 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (502 aa) |
| | EGW22102.1 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (361 aa) |
| | EGW22103.1 | Riboflavin synthase, alpha subunit; TIGRFAM: Lumazine-binding protein; KEGG: tgr:Tgr7_1560 riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein. (218 aa) |
| | ribB | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (367 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. (158 aa) |
| | nusB | NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (144 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (311 aa) |
| | EGW22114.1 | Adenylate/guanylate cyclase with Chase sensor; PFAM: CHASE2; Adenylyl cyclase class-3/4/guanylyl cyclase; KEGG: mgm:Mmc1_1858 adenylate/guanylate cyclase; SMART: Adenylyl cyclase class-3/4/guanylyl cyclase. (744 aa) |
| | EGW22142.1 | KEGG: nhl:Nhal_0978 hypothetical protein. (803 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (418 aa) |
| | nadD | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (210 aa) |
| | kdsB | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (256 aa) |
| | EGW22242.1 | PFAM: BolA-like protein; KEGG: mca:MCA1644 BolA protein; Belongs to the BolA/IbaG family. (92 aa) |
| | hemE | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (355 aa) |
| | EGW22309.1 | PFAM: Putative cell wall binding repeat; KEGG: mrb:Mrub_2772 bifunctional DNA primase/polymerase. (660 aa) |
| | EGW22315.1 | PFAM: Molybdopterin binding; KEGG: mca:MCA1092 molybdenum cofactor biosynthesis protein; Belongs to the CinA family. (408 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (241 aa) |
| | pdxJ | Pyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (248 aa) |
| | EGW22333.1 | cob(I)alamin adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (178 aa) |
| | EGW22362.1 | KEGG: alv:Alvin_2589 hypothetical protein. (396 aa) |
| | EGW22363.1 | KEGG: pna:Pnap_4658 hypothetical protein. (340 aa) |
| | purM | TIGRFAM: Phosphoribosylformylglycinamidine cyclo-ligase; KEGG: mca:MCA0373 phosphoribosylaminoimidazole synthetase; PFAM: AIR synthase related protein, C-terminal; AIR synthase related protein. (347 aa) |
| | cysG | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. (464 aa) |
| | mobA | Molybdopterin-guanine dinucleotide biosynthesis protein A; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (203 aa) |
| | fdhD | Protein fdhD; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (286 aa) |
| | EGW22466.1 | dTDP-glucose 4,6-dehydratase; KEGG: pap:PSPA7_1970 NAD-dependent epimerase/dehydratase; PFAM: NAD-dependent epimerase/dehydratase. (326 aa) |
| | EGW22471.1 | PFAM: Radical SAM; KEGG: mag:amb0046 Fe-S oxidoreductase. (371 aa) |
| | EGW22482.1 | PFAM: Radical SAM; KEGG: geo:Geob_0662 radical SAM domain protein. (464 aa) |
| | EGW22485.1 | Cytidyltransferase-related domain protein; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (506 aa) |
| | EGW22487.1 | UDP-glucose 4-epimerase; KEGG: mgm:Mmc1_1063 NAD-dependent epimerase/dehydratase; PFAM: NAD-dependent epimerase/dehydratase. (328 aa) |
| | EGW22488.1 | PFAM: Radical SAM; KEGG: gca:Galf_1100 radical SAM domain-containing protein. (366 aa) |
| | EGW22490.1 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (463 aa) |
| | rpoA | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (337 aa) |
| | rpoC | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1397 aa) |
| | rpoB | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1364 aa) |
| | nusG | NusG antitermination factor; Participates in transcription elongation, termination and antitermination. (177 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (317 aa) |
| | hemA | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (419 aa) |
| | EGW22557.1 | TIGRFAM: 3-hexulose-6-phosphate synthase; KEGG: mca:MCA3049 hexulose-6-phosphate synthase; PFAM: Orotidine 5'-phosphate decarboxylase, core. (213 aa) |
| | lipA | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (320 aa) |
| | EGW22634.1 | TIGRFAM: Glutamine amidotransferase of anthranilate synthase; KEGG: prw:PsycPRwf_1153 glutamine amidotransferase of anthranilate synthase; PFAM: Glutamine amidotransferase class-I, C-terminal. (214 aa) |
| | EGW22635.1 | KEGG: abm:ABSDF3336 anthranilate synthase component I; PFAM: Chorismate binding, C-terminal; Trp repressor; Anthranilate synthase component I, N-terminal. (567 aa) |
| | EGW22665.1 | TIGRFAM: Phosphoribosyl pyrophosphokinase; KEGG: rfr:Rfer_2240 phosphoribosylpyrophosphate synthetase; PFAM: Phosphoribosyltransferase; Belongs to the ribose-phosphate pyrophosphokinase family. (292 aa) |
| | EGW22713.1 | KEGG: neu:NE0547 ECF subfamily RNA polymerase sigma factor; TIGRFAM: RNA polymerase sigma-70; PFAM: RNA polymerase sigma factor 70, region 4 type 2; RNA polymerase sigma-70 region 2. (167 aa) |
| | EGW22725.1 | TIGRFAM: Nicotinate-nucleotide pyrophosphorylase; KEGG: mca:MCA3101 nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. (276 aa) |
| | EGW22730.1 | Riboflavin biosynthesis protein RibF; TIGRFAM: Riboflavin kinase/FAD synthetase; Cytidyltransferase-related; KEGG: saz:Sama_0923 riboflavin biosynthesis protein RibF; PFAM: FAD synthetase; Riboflavin kinase; Belongs to the ribF family. (327 aa) |
| | priA | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (743 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (275 aa) |
| | EGW22771.1 | Dihydroorotase, multifunctional complex type; KEGG: mca:MCA2332 dihydroorotase family protein; TIGRFAM: Dihydroorotase multifunctional complex type; PFAM: Amidohydrolase 1. (424 aa) |
| | pyrB | PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region; TIGRFAM: Aspartate carbamoyltransferase, eukaryotic; HAMAP: Aspartate carbamoyltransferase; KEGG: mca:MCA2333 aspartate carbamoyltransferase catalytic subunit; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (321 aa) |
| | EGW22773.1 | Uracil phosphoribosyltransferase; KEGG: mca:MCA2334 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; PFAM: Phosphoribosyltransferase. (168 aa) |
| | EGW22775.1 | UPF0301 protein yqgE; KEGG: mca:MCA2336 hypothetical protein; HAMAP: Protein of unknown function DUF179; PFAM: Protein of unknown function DUF179; Belongs to the UPF0301 (AlgH) family. (187 aa) |
| | EGW22782.1 | Molybdenum cofactor biosynthesis protein B; May be involved in the biosynthesis of molybdopterin. Belongs to the MoaB/Mog family. (173 aa) |
| | EGW22786.1 | KEGG: mca:MCA2987 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; TIGRFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; PFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK. (166 aa) |
| | EGW22787.1 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (119 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (592 aa) |
| | rpoD | RNA polymerase, sigma 70 subunit, RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (602 aa) |
| | bioA | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (450 aa) |
| | EGW22802.1 | CTP synthase; KEGG: cko:CKO_01814 hypothetical protein; PFAM: Glutamine amidotransferase class-I, C-terminal. (228 aa) |
| | purC | PFAM: SAICAR synthetase; TIGRFAM: SAICAR synthetase; HAMAP: Phosphoribosylaminoimidazole-succinocarboxamide synthase; KEGG: mca:MCA0021 phosphoribosylaminoimidazole-succinocarboxamide synthase. (297 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (373 aa) |
| | EGW22910.1 | KEGG: hse:Hsero_2645 oxygen-insensitive nitroreductase; TIGRFAM: Cob(II)yrinic acid a,c-diamide reductase; PFAM: Nitroreductase-like. (217 aa) |
| | cobS | Cobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (301 aa) |
| | EGW22914.1 | PFAM: Aminotransferase, class I/II; KEGG: sua:Saut_0088 class I/II aminotransferase. (339 aa) |
| | cobQ | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (483 aa) |
| | cobD | Cobalamin biosynthesis protein cbiB; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (298 aa) |
| | EGW22918.1 | Cobalbumin biosynthesis protein; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (165 aa) |
| | EGW22944.1 | WxcM-like domain-containing protein; PFAM: WxcM-like, C-terminal; Bacterial transferase hexapeptide repeat; KEGG: ppf:Pput_3930 WxcM domain-containing protein. (315 aa) |
| | EGW22950.1 | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (181 aa) |
| | EGW22952.1 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (300 aa) |
| | EGW22957.1 | PFAM: NAD-dependent epimerase/dehydratase; KEGG: gca:Galf_2845 NAD-dependent epimerase/dehydratase. (290 aa) |
| | EGW22960.1 | TIGRFAM: CDP-glucose 4,6-dehydratase; KEGG: gca:Galf_2849 CDP-glucose 4,6-dehydratase; PFAM: NAD-dependent epimerase/dehydratase. (369 aa) |
| | fcl | GDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (319 aa) |
| | EGW22964.1 | TIGRFAM: Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; KEGG: aeh:Mlg_0100 mannose-1-phosphate guanylyltransferase (GDP); PFAM: Mannose-6-phosphate isomerase, type II, C-terminal; Nucleotidyl transferase; Belongs to the mannose-6-phosphate isomerase type 2 family. (500 aa) |
| | EGW22981.1 | ATPase; KEGG: syf:Synpcc7942_0181 ATPase. (430 aa) |
| | nadE | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (536 aa) |
| | EGW22993.1 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (396 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (154 aa) |
| | hldD | ADP-L-glycero-D-manno-heptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. (314 aa) |
| | hldE | Bifunctional protein hldE; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (474 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (528 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (488 aa) |
| | dcd | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (188 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (418 aa) |
| | EGW23090.1 | Von Willebrand factor type A; KEGG: mca:MCA3086 TPR domain-containing protein; PFAM: von Willebrand factor, type A; Tetratricopeptide TPR-1; SMART: von Willebrand factor, type A; Tetratricopeptide repeat; overlaps another CDS with the same product name. (600 aa) |
| | EGW23091.1 | Von Willebrand factor type A; KEGG: mca:MCA3085 BatB protein, putative; PFAM: von Willebrand factor, type A; SMART: von Willebrand factor, type A; overlaps another CDS with the same product name. (326 aa) |
| | EGW23113.1 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (366 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (277 aa) |
| | EGW23156.1 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (163 aa) |
| | apaG | KEGG: tgr:Tgr7_2722 ApaG domain protein; HAMAP: Protein ApaG; PFAM: ApaG. (125 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (338 aa) |
| | trpC | KEGG: psp:PSPPH_0674 indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (266 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (204 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (364 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (166 aa) |
| | hemL | Glutamate-1-semialdehyde 2,1-aminomutase; PFAM: Aminotransferase class-III; TIGRFAM: Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase; HAMAP: Glutamate-1-semialdehyde 2,1-aminomutase; KEGG: alv:Alvin_0103 glutamate-1-semialdehyde-2,1-aminomutase. (426 aa) |
| | ribA | GTP cyclohydrolase-2; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. (202 aa) |
| | atpB-2 | ATP synthase subunit a; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (257 aa) |
| | atpE-2 | ATP synthase subunit c; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (95 aa) |
| | atpF-2 | ATP synthase subunit b; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (157 aa) |
| | atpH | ATP synthase subunit delta; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (176 aa) |
| | atpA-2 | ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (513 aa) |
| | atpG | ATP synthase gamma chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (287 aa) |
| | atpD | ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (459 aa) |
| | atpC | ATP synthase epsilon chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. (140 aa) |
| | glmU | Bifunctional protein glmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (488 aa) |
| | EGW23336.1 | KEGG: gca:Galf_1712 beta-lactamase domain-containing protein. (293 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (930 aa) |
| | EGW23340.1 | TIGRFAM: Nucleotide sugar dehydrogenase; KEGG: mca:MCA2487 UDP-glucose 6-dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase, N-terminal; UDP-glucose/GDP-mannose dehydrogenase, dimerisation; UDP-glucose/GDP-mannose dehydrogenase, C-terminal. (439 aa) |
| | dinB | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (367 aa) |
| | EGW23393.1 | PFAM: RecF/RecN/SMC protein, N-terminal; KEGG: gca:Galf_0891 SMC domain-containing protein. (385 aa) |
| | EGW23467.1 | KEGG: xau:Xaut_2777 ECF subfamily RNA polymerase sigma-24 factor; TIGRFAM: RNA polymerase sigma-70; PFAM: RNA polymerase sigma-70 region 2; RNA polymerase sigma factor 70, region 4 type 2. (172 aa) |
| | EGW23470.1 | PFAM: Bacterial transcriptional activator domain; Tetratricopeptide TPR-4; KEGG: sme:SMa1591 CyaI3 adenylate/guanylate cyclase. (1265 aa) |
| | EGW23491.1 | PFAM: Protein of unknown function DUF336; KEGG: pfl:PFL_1702 GlcG protein. (142 aa) |
| | EGW23500.1 | TIGRFAM: Glutamine amidotransferase of anthranilate synthase; KEGG: mca:MCA2585 anthranilate synthase component II; PFAM: Glutamine amidotransferase class-I, C-terminal. (212 aa) |
| | EGW23501.1 | PFAM: Anthranilate synthase component I, N-terminal; KEGG: mca:MCA2584 anthranilate synthase component I. (124 aa) |
| | EGW23507.1 | Oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (379 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (214 aa) |
| | thiG | Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (325 aa) |
| | moaC | Molybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (160 aa) |
| | EGW23538.1 | PFAM: ThiamineS; KEGG: tgr:Tgr7_2951 molybdopterin converting factor, subunit 1. (77 aa) |
| | EGW23539.1 | PFAM: Molybdopterin biosynthesis MoaE; KEGG: tgr:Tgr7_2952 molybdopterin biosynthesis MoaE protein. (148 aa) |
| | EGW23564.1 | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (492 aa) |
| | EGW23574.1 | KEGG: gpb:HDN1F_00940 adenylate cyclase; PFAM: Adenylate cyclase, class-I. (934 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (313 aa) |
| | EGW23577.1 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (256 aa) |
| | EGW23578.1 | hemX domain protein; PFAM: HemX; KEGG: mca:MCA3061 bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase. (439 aa) |
| | EGW23579.1 | HemY domain protein; PFAM: HemY, N-terminal; KEGG: mca:MCA3062 HemY protein, putative. (410 aa) |
| | EGW23596.1 | TIGRFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; KEGG: mca:MCA2313 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK. (167 aa) |
| | pyrD | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (337 aa) |
| | EGW23613.1 | TIGRFAM: Glycine oxidase ThiO; KEGG: alv:Alvin_1597 FAD dependent oxidoreductase; PFAM: FAD dependent oxidoreductase. (366 aa) |
| | EGW23621.1 | RNA polymerase, sigma 54 subunit, RpoN; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (481 aa) |
| | thiC | Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (626 aa) |
| | coaE | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (200 aa) |
| | EGW23662.1 | PFAM: DNA polymerase III chi subunit, HolC; KEGG: nhl:Nhal_3009 DNA polymerase III chi subunit HolC. (160 aa) |
| | EGW23667.1 | PFAM: NAD-dependent epimerase/dehydratase; KEGG: cvi:CV_0747 NAD-dependent epimerase/dehydratase family protein. (351 aa) |
| | EGW23678.1 | Porphobilinogen synthase; KEGG: mca:MCA2793 delta-aminolevulinic acid dehydratase; PFAM: Tetrapyrrole biosynthesis, porphobilinogen synthase; Belongs to the ALAD family. (334 aa) |
| | EGW23686.1 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (723 aa) |
| | rpoZ | DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (81 aa) |
| | EGW23723.1 | TIGRFAM: Oxygen-independent coproporphyrinogen III oxidase HemN; PFAM: HemN, C-terminal; Radical SAM; KEGG: tcx:Tcr_0501 coproporphyrinogen III oxidase; SMART: Elongator protein 3/MiaB/NifB; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (460 aa) |
| | purD | Phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; TIGRFAM: Phosphoribosylglycinamide synthetase; HAMAP: Phosphoribosylglycinamide synthetase; KEGG: mca:MCA0361 phosphoribosylamine--glycine ligase; Belongs to the GARS family. (426 aa) |
| | purH | Bifunctional purine biosynthesis protein purH; KEGG: maq:Maqu_3450 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme, formylation region; MGS-like; TIGRFAM: AICARFT/IMPCHase bienzyme; HAMAP: Bifunctional purine biosynthesis protein purH; SMART: AICARFT/IMPCHase bienzyme, formylation region. (535 aa) |
| | EGW23771.1 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (447 aa) |
| | EGW23799.1 | KEGG: RNA polymerase, sigma 70 subunit, RpoD subfamily; TIGRFAM: RNA polymerase sigma-70; PFAM: RNA polymerase sigma-70 region 4; RNA polymerase sigma-70 region 2; Belongs to the sigma-70 factor family. (391 aa) |
| | EGW23823.1 | TIGRFAM: DNA polymerase III, delta subunit; KEGG: cja:CJA_0452 DNA polymerase III subunit delta; PFAM: DNA polymerase III, delta. (337 aa) |
| | tgt | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (371 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (143 aa) |
| | EGW23852.1 | PFAM: UBA/THIF-type NAD/FAD binding fold; KEGG: vei:Veis_4665 UBA/ThiF-type NAD/FAD binding protein. (585 aa) |
| | EGW23853.1 | KEGG: par:Psyc_1373 hypothetical protein. (396 aa) |
| | accA | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (322 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (543 aa) |
| | EGW19664.1 | PFAM: CobB/CobQ-like glutamine amidotransferase; Cobyrinic acid a,c-diamide synthase; KEGG: mca:MCA2290 cobyrinic acid a,c-diamide synthase. (432 aa) |
| | EGW19666.1 | precorrin-3B C17-methyltransferase; KEGG: hse:Hsero_2649 bifunctional precorrin-3 methyltransferase/precorrin-6x reductase oxidoreductase; TIGRFAM: Cobalamin (vitamin B12) biosynthesis CobJ/CibH, precorrin-3B C17-methyltransferase, core; Cobalamin (vitamin B12) biosynthesis CobK/CbiJ, precorrin-6x reductase; PFAM: Cobalamin (vitamin B12) biosynthesis CobK/CbiJ, precorrin-6x reductase; Tetrapyrrole methylase. (533 aa) |
| | EGW19667.1 | PFAM: Cobalamin (vitamin B12) biosynthesis CbiG, core; KEGG: ddr:Deide_2p01620 cobalamin biosynthesis protein CbiG. (254 aa) |
| | EGW19668.1 | Precorrin-4 C11-methyltransferase; TIGRFAM: Cobalamin (vitamin B12) biosynthesis CobM/CbiF, precorrin-4 C11-methyltransferase, core; KEGG: hse:Hsero_2651 precorrin-4 C11-methyltransferase; PFAM: Tetrapyrrole methylase. (259 aa) |
| | EGW19669.1 | KEGG: rso:RSp0621 precorrin-2 C20-methyltransferase protein; TIGRFAM: Cobalamin (vitamin B12) biosynthesis CobI/CbiL, precorrin-2 C20-methyltransferase, core; PFAM: Tetrapyrrole methylase. (244 aa) |
| | cbiD | cobalt-precorrin-6A synthase (deacetylating); Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (377 aa) |
| | EGW19671.1 | KEGG: hse:Hsero_2654 precorrin-8X methylmutase; PFAM: Cobalamin (vitamin B12) biosynthesis CobH/CbiC, precorrin-8X methylmutase, core; Cobalamin (vitamin B12) biosynthesis CbiX. (525 aa) |
| | EGW19672.1 | Precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; KEGG: hse:Hsero_2655 precorrin-6y methylase methyltransferase; TIGRFAM: Cobalamin (vitamin B12) biosynthesis CbiE, precorrin-6Y methyltransferase, core; PFAM: Tetrapyrrole methylase. (239 aa) |
| | EGW19673.1 | Magnesium chelatase; PFAM: von Willebrand factor, type A; Magnesium chelatase, ChlI subunit; KEGG: hse:Hsero_2656 Mg-chelatase subunit ChlI protein; SMART: von Willebrand factor, type A; ATPase, AAA+ type, core. (629 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (359 aa) |
| | cmk | TIGRFAM: Cytidylate kinase; HAMAP: Cytidylate kinase; KEGG: mca:MCA1414 cytidylate kinase; PFAM: Cytidylate kinase region. (218 aa) |
| | EGW19754.1 | KEGG: dar:Daro_1894 hypothetical protein. (197 aa) |
| | nadA | Quinolinate synthase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (365 aa) |
| | pyrC | Dihydroorotase, homodimeric type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (343 aa) |
| | EGW19788.1 | PFAM: Cytochrome oxidase assembly; KEGG: mca:MCA1778 cytochrome oxidase assembly protein. (322 aa) |
| | EGW19803.1 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (303 aa) |
| | EGW19804.1 | PFAM: Flavoprotein; KEGG: gbe:GbCGDNIH1_0764 flavoprotein. (178 aa) |
| | EGW19805.1 | PFAM: Dihydropteroate synthase, DHPS; KEGG: mca:MCA1245 pterin-binding domain-containing protein. (462 aa) |
| | EGW19807.1 | Response regulator receiver protein; KEGG: mca:MCA1243 hypothetical protein; PFAM: Signal transduction response regulator, receiver region; Protein of unknown function DUF556; SMART: Signal transduction response regulator, receiver region. (347 aa) |
| | EGW19841.1 | PFAM: Metal-dependent phosphohydrolase, HD region, subdomain; KEGG: hch:HCH_03679 hypothetical protein; SMART: Metal-dependent phosphohydrolase, HD region. (200 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa) |
| | EGW19870.1 | ApbE family lipoprotein; Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein. Belongs to the ApbE family. (359 aa) |
| | EGW19887.1 | PFAM: HI0933-like protein; KEGG: scl:sce5178 hypothetical protein. (455 aa) |
| | EGW19942.1 | 8-amino-7-oxononanoate synthase; KEGG: gfo:GFO_1376 class-I/II aminotransferase; PFAM: Aminotransferase, class I/II. (414 aa) |
| | dnaX | DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (540 aa) |
| | EGW20013.1 | Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (414 aa) |
| | EGW20014.1 | KEGG: mca:MCA2450 molybdopterin-guanine dinucleotide biosynthesis protein MobB; TIGRFAM: Molybdopterin-guanine dinucleotide biosynthesis MobB region; PFAM: Molybdopterin-guanine dinucleotide biosynthesis MobB region. (175 aa) |
| | rpoS | RNA polymerase, sigma 70 subunit, RpoD subfamily; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. (342 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1289 aa) |
| | dnaQ | DNA polymerase III, epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (241 aa) |
| | carB | TIGRFAM: Carbamoyl phosphate synthase, large subunit, glutamine-dependent; KEGG: mca:MCA1852 carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl phosphate synthetase, large subunit, ATP-binding; Carbamoyl phosphate synthase, large subunit, N-terminal; Carbamoyl phosphate synthetase, large subunit, oligomerisation; MGS-like; Belongs to the CarB family. (1072 aa) |
| | carA | TIGRFAM: Carbamoyl phosphate synthase, small subunit; KEGG: mmw:Mmwyl1_4035 carbamoyl phosphate synthase small subunit; PFAM: Carbamoyl phosphate synthase, small subunit, N-terminal; Glutamine amidotransferase class-I, C-terminal; Belongs to the CarA family. (376 aa) |
| | EGW20101.1 | PFAM: UBA/THIF-type NAD/FAD binding fold; MoeZ/MoeB; KEGG: tgr:Tgr7_0519 UBA/ThiF-type NAD/FAD binding fold protein. (248 aa) |
| | pqqB | Coenzyme PQQ synthesis protein B; May be involved in the transport of PQQ or its precursor to the periplasm; Belongs to the PqqB family. (303 aa) |
| | pqqC | Pyrroloquinoline-quinone synthase; Ring cyclization and eight-electron oxidation of 3a-(2-amino- 2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9- dicarboxylic-acid to PQQ. (242 aa) |
| | EGW20106.1 | TIGRFAM: coenzyme PQQ biosynthesis protein PqqD; KEGG: mca:MCA1448 pyrroloquinoline quinone biosynthesis protein PqqD. (90 aa) |
| | pqqE | Coenzyme PQQ synthesis protein E; Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ). (375 aa) |
| | EGW20118.1 | KEGG: dar:Daro_3269 AsnC family transcriptional regulator. (152 aa) |
| | EGW20119.1 | KEGG: tbd:Tbd_0074 AsnC family transcriptional regulator; overlaps another CDS with the same product name. (165 aa) |
| | EGW20120.1 | SMART: Transcription regulator, AsnC-type; KEGG: tbd:Tbd_0073 AsnC family transcriptional regulator; overlaps another CDS with the same product name. (147 aa) |
| | EGW20121.1 | SMART: Transcription regulator, AsnC-type; KEGG: tbd:Tbd_0072 AsnC family transcriptional regulator. (184 aa) |
| | EGW20122.1 | KEGG: dar:Daro_3261 radical SAM family protein; PFAM: Radical SAM; SMART: Elongator protein 3/MiaB/NifB. (378 aa) |
| | EGW20142.1 | KEGG: nhl:Nhal_3565 adenylate cyclase; PFAM: Adenylate cyclase, class-I. (936 aa) |
| | EGW20346.1 | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate. (337 aa) |
| | EGW20364.1 | PFAM: Aldo/keto reductase; KEGG: mca:MCA0485 aldo/keto reductase family oxidoreductase. (282 aa) |
| | queC | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (225 aa) |
| | queE | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (213 aa) |
| | EGW20444.1 | PFAM: Phosphoribosyltransferase; KEGG: nhl:Nhal_2865 phosphoribosyltransferase. (179 aa) |
| | EGW20445.1 | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. (242 aa) |
| | EGW20509.1 | SMART: ATPase, AAA+ type, core; TIGRFAM: Flagellar protein export ATPase, FliI; ATPase, type III secretion system, FliI/YscN; KEGG: tgr:Tgr7_1966 flagellar biosynthesis/type III secretory pathway ATPase, FliI/YscN; PFAM: ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain. (454 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (161 aa) |
| | acsA | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (645 aa) |
| | EGW20609.1 | RNA polymerase, sigma 32 subunit, RpoH; KEGG: nde:NIDE0990 RNA polymerase sigma factor RpoD (sigma-70); TIGRFAM: RNA polymerase sigma-70; PFAM: RNA polymerase sigma-70 region 4; RNA polymerase sigma-70 region 2; RNA polymerase sigma-70 region 3. (448 aa) |
| | serS | Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (423 aa) |
| | EGW20701.1 | DNA polymerase III, alpha subunit; SMART: Polymerase/histidinol phosphatase, N-terminal; TIGRFAM: DNA polymerase III, alpha subunit; KEGG: mca:MCA1286 DNA polymerase III, alpha subunit; PFAM: Bacterial DNA polymerase III, alpha subunit; PHP, C-terminal; Nucleic acid binding, OB-fold, tRNA/helicase-type. (1164 aa) |
| | EGW20752.1 | Hypothetical protein; KEGG: app:CAP2UW1_0858 nucleotide sugar dehydrogenase. (87 aa) |
| | EGW20793.1 | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: cytosine deaminase. (150 aa) |
| | folE | PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase; TIGRFAM: GTP cyclohydrolase I; HAMAP: GTP cyclohydrolase I; KEGG: mca:MCA1670 GTP cyclohydrolase I. (180 aa) |
| | hemH | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (322 aa) |
| | purT | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (400 aa) |
| | EGW20852.1 | PFAM: AIR synthase related protein; AIR synthase related protein, C-terminal; KEGG: bvi:Bcep1808_6055 AIR synthase-like protein. (325 aa) |
| | EGW20855.1 | PFAM: Radical SAM; KEGG: noc:Noc_0590 radical SAM domain-containing protein. (323 aa) |
| | EGW20862.1 | RNA polymerase, sigma-24 subunit, ECF subfamily; KEGG: tmz:Tmz1t_2737 RNA polymerase sigma factor; TIGRFAM: RNA polymerase sigma-24 related; RNA polymerase sigma-70; PFAM: RNA polymerase sigma-70 region 2; RNA polymerase sigma factor 70, region 4 type 2; Belongs to the sigma-70 factor family. ECF subfamily. (198 aa) |
| | EGW20890.1 | Putative anti-sigma regulatory factor, serine/threonine protein kinase; PFAM: ATP-binding region, ATPase-like; KEGG: mca:MCA1685 anti-sigma B factor. (141 aa) |
| | EGW20905.1 | KEGG: mca:MCA1820 hypothetical protein; TIGRFAM: Conserved hypothetical protein CHP02096; PFAM: Protein of unknown function DUF1486. (135 aa) |
| | queA | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (339 aa) |
| | coaX | Putative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (243 aa) |
| | birA | biotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. (332 aa) |
| | cyoE | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (295 aa) |
| | EGW20937.1 | PFAM: Glycosyl transferase, family 3, N-terminal; KEGG: hch:HCH_02544 hypothetical protein. (342 aa) |
| | EGW20947.1 | PFAM: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; KEGG: cyt:cce_3339 hypothetical protein. (202 aa) |
| | EGW21022.1 | KEGG: sat:SYN_00564 L-threonine 3-dehydrogenase; PFAM: NAD-dependent epimerase/dehydratase. (310 aa) |
| | EGW21023.1 | 8-amino-7-oxononanoate synthase; KEGG: sat:SYN_00565 2-amino-3-ketobutyrate coenzyme A ligase; PFAM: Aminotransferase, class I/II. (407 aa) |
| | EGW21043.1 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: azo:azo2654 lactoylglutathione lyase. (156 aa) |
| | nusA | NusA antitermination factor; Participates in both transcription termination and antitermination. (505 aa) |
| | EGW21099.1 | TIGRFAM: Para-aminobenzoate synthase, component I; KEGG: mca:MCA2870 para-aminobenzoate synthase, component I; PFAM: Chorismate binding, C-terminal; Anthranilate synthase component I, N-terminal. (462 aa) |
| | EGW21123.1 | KEGG: pen:PSEEN4768 ECF subfamily RNA polymerase sigma factor; TIGRFAM: RNA polymerase sigma-70; PFAM: RNA polymerase sigma factor 70, region 4 type 2; RNA polymerase sigma-70 region 2. (170 aa) |
| | EGW21131.1 | PFAM: Cobalamin (vitamin B12) biosynthesis CbiX; KEGG: ant:Arnit_0389 cobalamin (vitamin B12) biosynthesis protein CbiX. (122 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (206 aa) |
| | EGW21147.1 | KEGG: tgr:Tgr7_2419 phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1. (262 aa) |
| | EGW21171.1 | KEGG: mca:MCA1258 hypothetical protein; TIGRFAM: Conserved hypothetical protein CHP00701; PFAM: Uncharacterised protein family UPF0093. (141 aa) |
| | queG | Iron-sulfur cluster binding protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (361 aa) |
| | EGW21197.1 | KEGG: rba:RB5405 5-formyltetrahydrofolate cyclo-ligase; TIGRFAM: 5-formyltetrahydrofolate cyclo-ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (202 aa) |
