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| | EGW23672.1 | PFAM: Glycosyl transferase, family 39; KEGG: slt:Slit_1368 glycosyl transferase family 39. (551 aa) |
| | EGW23686.1 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (723 aa) |
| | purD | Phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; TIGRFAM: Phosphoribosylglycinamide synthetase; HAMAP: Phosphoribosylglycinamide synthetase; KEGG: mca:MCA0361 phosphoribosylamine--glycine ligase; Belongs to the GARS family. (426 aa) |
| | purH | Bifunctional purine biosynthesis protein purH; KEGG: maq:Maqu_3450 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme, formylation region; MGS-like; TIGRFAM: AICARFT/IMPCHase bienzyme; HAMAP: Bifunctional purine biosynthesis protein purH; SMART: AICARFT/IMPCHase bienzyme, formylation region. (535 aa) |
| | EGW23771.1 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (447 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (143 aa) |
| | EGW23852.1 | PFAM: UBA/THIF-type NAD/FAD binding fold; KEGG: vei:Veis_4665 UBA/ThiF-type NAD/FAD binding protein. (585 aa) |
| | EGW23853.1 | KEGG: par:Psyc_1373 hypothetical protein. (396 aa) |
| | accA | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (322 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (543 aa) |
| | ispD | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (230 aa) |
| | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (157 aa) |
| | cmk | TIGRFAM: Cytidylate kinase; HAMAP: Cytidylate kinase; KEGG: mca:MCA1414 cytidylate kinase; PFAM: Cytidylate kinase region. (218 aa) |
| | EGW19754.1 | KEGG: dar:Daro_1894 hypothetical protein. (197 aa) |
| | nadA | Quinolinate synthase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (365 aa) |
| | pyrC | Dihydroorotase, homodimeric type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (343 aa) |
| | lpxA | Acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (256 aa) |
| | fabZ | (3R)-hydroxymyristoyl-(acyl-carrier-protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (147 aa) |
| | EGW19804.1 | PFAM: Flavoprotein; KEGG: gbe:GbCGDNIH1_0764 flavoprotein. (178 aa) |
| | EGW19841.1 | PFAM: Metal-dependent phosphohydrolase, HD region, subdomain; KEGG: hch:HCH_03679 hypothetical protein; SMART: Metal-dependent phosphohydrolase, HD region. (200 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa) |
| | EGW20013.1 | Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (414 aa) |
| | EGW20014.1 | KEGG: mca:MCA2450 molybdopterin-guanine dinucleotide biosynthesis protein MobB; TIGRFAM: Molybdopterin-guanine dinucleotide biosynthesis MobB region; PFAM: Molybdopterin-guanine dinucleotide biosynthesis MobB region. (175 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1289 aa) |
| | carB | TIGRFAM: Carbamoyl phosphate synthase, large subunit, glutamine-dependent; KEGG: mca:MCA1852 carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl phosphate synthetase, large subunit, ATP-binding; Carbamoyl phosphate synthase, large subunit, N-terminal; Carbamoyl phosphate synthetase, large subunit, oligomerisation; MGS-like; Belongs to the CarB family. (1072 aa) |
| | carA | TIGRFAM: Carbamoyl phosphate synthase, small subunit; KEGG: mmw:Mmwyl1_4035 carbamoyl phosphate synthase small subunit; PFAM: Carbamoyl phosphate synthase, small subunit, N-terminal; Glutamine amidotransferase class-I, C-terminal; Belongs to the CarA family. (376 aa) |
| | EGW20101.1 | PFAM: UBA/THIF-type NAD/FAD binding fold; MoeZ/MoeB; KEGG: tgr:Tgr7_0519 UBA/ThiF-type NAD/FAD binding fold protein. (248 aa) |
| | EGW20126.1 | PFAM: Glycosyl transferase, family 2; KEGG: tkm:TK90_0471 glycosyl transferase family 2. (256 aa) |
| | EGW20142.1 | KEGG: nhl:Nhal_3565 adenylate cyclase; PFAM: Adenylate cyclase, class-I. (936 aa) |
| | EGW20175.1 | KEGG: psb:Psyr_0438 phospholipid/glycerol acyltransferase; PFAM: Phospholipid/glycerol acyltransferase; SMART: Phospholipid/glycerol acyltransferase. (264 aa) |
| | EGW20324.1 | PFAM: Metallophosphoesterase; KEGG: mag:amb0266 hypothetical protein. (262 aa) |
| | EGW20346.1 | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate. (337 aa) |
| | EGW20444.1 | PFAM: Phosphoribosyltransferase; KEGG: nhl:Nhal_2865 phosphoribosyltransferase. (179 aa) |
| | EGW20509.1 | SMART: ATPase, AAA+ type, core; TIGRFAM: Flagellar protein export ATPase, FliI; ATPase, type III secretion system, FliI/YscN; KEGG: tgr:Tgr7_1966 flagellar biosynthesis/type III secretory pathway ATPase, FliI/YscN; PFAM: ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain. (454 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (161 aa) |
| | acsA | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (645 aa) |
| | EGW20614.1 | PFAM: Glycosyl transferase, family 39; KEGG: tbd:Tbd_1534 putative glycosyltransferase. (540 aa) |
| | EGW20615.1 | PFAM: Lipid A biosynthesis, N-terminal; KEGG: nwi:Nwi_1531 lipid A biosynthesis. (94 aa) |
| | EGW20616.1 | PFAM: Glycosyl transferase, family 2; KEGG: tbd:Tbd_1536 glycosyltransferase, group 2 family protein. (243 aa) |
| | EGW20681.1 | PFAM: NUDIX hydrolase domain; KEGG: ote:Oter_2376 NUDIX hydrolase. (168 aa) |
| | EGW20741.1 | Acetyltransferase; KEGG: rsh:Rsph17029_3702 acetyltransferase. (213 aa) |
| | EGW20799.1 | KEGG: mca:MCA2052 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative; PFAM: Phospholipid/glycerol acyltransferase; SMART: Phospholipid/glycerol acyltransferase. (248 aa) |
| | folE | PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase; TIGRFAM: GTP cyclohydrolase I; HAMAP: GTP cyclohydrolase I; KEGG: mca:MCA1670 GTP cyclohydrolase I. (180 aa) |
| | purT | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (400 aa) |
| | EGW20852.1 | PFAM: AIR synthase related protein; AIR synthase related protein, C-terminal; KEGG: bvi:Bcep1808_6055 AIR synthase-like protein. (325 aa) |
| | coaX | Putative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (243 aa) |
| | EGW20947.1 | PFAM: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; KEGG: cyt:cce_3339 hypothetical protein. (202 aa) |
| | EGW20990.1 | KEGG: mca:MCA0058 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative; PFAM: Phospholipid/glycerol acyltransferase; SMART: Phospholipid/glycerol acyltransferase. (266 aa) |
| | EGW20991.1 | KEGG: nhl:Nhal_1204 CDP-diacylglycerol/serine O-phosphatidyltransferase; TIGRFAM: CDP-diacylglycerol--serine O-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase. (170 aa) |
| | EGW21043.1 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: azo:azo2654 lactoylglutathione lyase. (156 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (206 aa) |
| | ispG | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (405 aa) |
| | pdxA | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (329 aa) |
| | EGW21272.1 | PFAM: Inositol monophosphatase; KEGG: mca:MCA2609 inositol monophosphatase family protein. (284 aa) |
| | EGW21276.1 | KEGG: mca:MCA2273 CDP-diacylglycerol--serine O-phosphatidyltransferase; TIGRFAM: CDP-diacylglycerol--serine O-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (246 aa) |
| | ispH | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (315 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (334 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (212 aa) |
| | nadK | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (301 aa) |
| | EGW21504.1 | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (443 aa) |
| | EGW21526.1 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (531 aa) |
| | EGW21608.1 | KEGG: nhl:Nhal_2235 ATP synthase gamma subunit C-terminus. (273 aa) |
| | atpA | ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (515 aa) |
| | atpF | ATP synthase subunit b; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (249 aa) |
| | atpE | ATP synthase subunit c; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (88 aa) |
| | atpB | ATP synthase subunit a; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (221 aa) |
| | EGW21614.1 | PFAM: ATPase, F1 complex, delta/epsilon subunit, N-terminal; KEGG: nhl:Nhal_2241 H+transporting two-sector ATPase delta/epsilon subunit. (136 aa) |
| | EGW21616.1 | TIGRFAM: ATPase, F1 complex, beta subunit; HAMAP: ATPase, F1 complex, beta subunit; KEGG: mca:MCA1556 F0F1 ATP synthase subunit beta; PFAM: ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain; ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal; ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal. (464 aa) |
| | EGW21620.1 | PFAM: Phosphoribosyltransferase; KEGG: afu:AF0239 xanthine-guanine phosphoribosyltransferase (GptA-1). (201 aa) |
| | EGW21642.1 | KEGG: app:CAP2UW1_1888 phospholipase D/transphosphatidylase. (530 aa) |
| | lpxH | UDP-2,3-diacylglucosamine hydrolase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (241 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (355 aa) |
| | lpxB | Lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (387 aa) |
| | EGW21701.1 | PFAM: Metallophosphoesterase; KEGG: lic:LIC10391 hypothetical protein. (278 aa) |
| | EGW21852.1 | TIGRFAM: Adenylosuccinate lyase; KEGG: tgr:Tgr7_1849 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (454 aa) |
| | EGW21147.1 | KEGG: tgr:Tgr7_2419 phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1. (262 aa) |
| | EGW21889.1 | CBS domain containing protein; KEGG: mca:MCA1456 magnesium and cobalt efflux protein CorC; PFAM: Cystathionine beta-synthase, core; Transporter-associated region; SMART: Cystathionine beta-synthase, core. (280 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (620 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (171 aa) |
| | EGW21956.1 | KEGG: mca:MCA0818 geranyltranstransferase; PFAM: Polyprenyl synthetase; Belongs to the FPP/GGPP synthase family. (298 aa) |
| | EGW21960.1 | TIGRFAM: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; KEGG: mca:MCA1682 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (187 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (243 aa) |
| | EGW21974.1 | PFAM: Phosphatidate cytidylyltransferase; KEGG: mca:MCA0572 phosphatidate cytidylyltransferase; Belongs to the CDS family. (293 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (394 aa) |
| | EGW21979.1 | KEGG: gca:Galf_0507 CinA domain-containing protein; TIGRFAM: CinA, C-terminal; PFAM: CinA, C-terminal; Belongs to the CinA family. (160 aa) |
| | plsX | Phosphate acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (342 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (223 aa) |
| | psd | Phosphatidylserine decarboxylase proenzyme; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (286 aa) |
| | EGW22050.1 | KEGG: mca:MCA2087 HAD family hydrolase; TIGRFAM: HAD-superfamily hydrolase, subfamily IB, PSPase-like, bacterial; HAD-superfamily hydrolase, subfamily IB, PSPase-like; PFAM: Haloacid dehalogenase-like hydrolase. (228 aa) |
| | accD | Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (320 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (502 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (311 aa) |
| | EGW22108.1 | Phosphatidylglycerophosphatase; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). (168 aa) |
| | EGW22114.1 | Adenylate/guanylate cyclase with Chase sensor; PFAM: CHASE2; Adenylyl cyclase class-3/4/guanylyl cyclase; KEGG: mgm:Mmc1_1858 adenylate/guanylate cyclase; SMART: Adenylyl cyclase class-3/4/guanylyl cyclase. (744 aa) |
| | lpxK | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (333 aa) |
| | nadD | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (210 aa) |
| | EGW22232.1 | PFAM: CDP-alcohol phosphatidyltransferase; KEGG: sun:SUN_1448 phosphatidylglycerophosphate synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (196 aa) |
| | EGW22234.1 | PFAM: Protein of unknown function DUF46; KEGG: mca:MCA0197 hypothetical protein. (167 aa) |
| | EGW22315.1 | PFAM: Molybdopterin binding; KEGG: mca:MCA1092 molybdenum cofactor biosynthesis protein; Belongs to the CinA family. (408 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (241 aa) |
| | EGW22362.1 | KEGG: alv:Alvin_2589 hypothetical protein. (396 aa) |
| | EGW22363.1 | KEGG: pna:Pnap_4658 hypothetical protein. (340 aa) |
| | purM | TIGRFAM: Phosphoribosylformylglycinamidine cyclo-ligase; KEGG: mca:MCA0373 phosphoribosylaminoimidazole synthetase; PFAM: AIR synthase related protein, C-terminal; AIR synthase related protein. (347 aa) |
| | mobA | Molybdopterin-guanine dinucleotide biosynthesis protein A; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (203 aa) |
| | fdhD | Protein fdhD; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (286 aa) |
| | EGW22439.1 | TIGRFAM: Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase; KEGG: mca:MCA0397 UDP-N-acetylglucosamine acyltransferase; PFAM: Bacterial transferase hexapeptide repeat. (257 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (317 aa) |
| | ispE | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (292 aa) |
| | EGW22648.1 | TIGRFAM: HAD-superfamily hydrolase, subfamily IB, PSPase-like, bacterial; HAD-superfamily hydrolase, subfamily IB, PSPase-like; KEGG: eta:ETA_24080 HAD-superfamily hydrolase, subfamily IB. (223 aa) |
| | EGW22665.1 | TIGRFAM: Phosphoribosyl pyrophosphokinase; KEGG: rfr:Rfer_2240 phosphoribosylpyrophosphate synthetase; PFAM: Phosphoribosyltransferase; Belongs to the ribose-phosphate pyrophosphokinase family. (292 aa) |
| | lpxC | UDP-3-O-(3-hydroxymyristoyl) N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (307 aa) |
| | EGW22721.1 | Phosphoheptose isomerase; Manually curated; KEGG: mca:MCA0183 phosphoheptose isomerase. (195 aa) |
| | EGW22725.1 | TIGRFAM: Nicotinate-nucleotide pyrophosphorylase; KEGG: mca:MCA3101 nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. (276 aa) |
| | EGW22730.1 | Riboflavin biosynthesis protein RibF; TIGRFAM: Riboflavin kinase/FAD synthetase; Cytidyltransferase-related; KEGG: saz:Sama_0923 riboflavin biosynthesis protein RibF; PFAM: FAD synthetase; Riboflavin kinase; Belongs to the ribF family. (327 aa) |
| | EGW22771.1 | Dihydroorotase, multifunctional complex type; KEGG: mca:MCA2332 dihydroorotase family protein; TIGRFAM: Dihydroorotase multifunctional complex type; PFAM: Amidohydrolase 1. (424 aa) |
| | pyrB | PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region; TIGRFAM: Aspartate carbamoyltransferase, eukaryotic; HAMAP: Aspartate carbamoyltransferase; KEGG: mca:MCA2333 aspartate carbamoyltransferase catalytic subunit; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (321 aa) |
| | EGW22773.1 | Uracil phosphoribosyltransferase; KEGG: mca:MCA2334 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; PFAM: Phosphoribosyltransferase. (168 aa) |
| | EGW22775.1 | UPF0301 protein yqgE; KEGG: mca:MCA2336 hypothetical protein; HAMAP: Protein of unknown function DUF179; PFAM: Protein of unknown function DUF179; Belongs to the UPF0301 (AlgH) family. (187 aa) |
| | EGW22782.1 | Molybdenum cofactor biosynthesis protein B; May be involved in the biosynthesis of molybdopterin. Belongs to the MoaB/Mog family. (173 aa) |
| | plsY | Glycerol-3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (195 aa) |
| | EGW22802.1 | CTP synthase; KEGG: cko:CKO_01814 hypothetical protein; PFAM: Glutamine amidotransferase class-I, C-terminal. (228 aa) |
| | purC | PFAM: SAICAR synthetase; TIGRFAM: SAICAR synthetase; HAMAP: Phosphoribosylaminoimidazole-succinocarboxamide synthase; KEGG: mca:MCA0021 phosphoribosylaminoimidazole-succinocarboxamide synthase. (297 aa) |
| | EGW22946.1 | PFAM: Glycosyl transferase, family 2; KEGG: ppf:Pput_3929 glycosyl transferase family protein. (323 aa) |
| | nadE | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (536 aa) |
| | EGW22993.1 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (396 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (154 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (528 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (488 aa) |
| | dcd | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (188 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (277 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (204 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (364 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (166 aa) |
| | atpB-2 | ATP synthase subunit a; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (257 aa) |
| | atpE-2 | ATP synthase subunit c; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (95 aa) |
| | atpF-2 | ATP synthase subunit b; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (157 aa) |
| | atpH | ATP synthase subunit delta; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (176 aa) |
| | atpA-2 | ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (513 aa) |
| | atpG | ATP synthase gamma chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (287 aa) |
| | atpD | ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (459 aa) |
| | atpC | ATP synthase epsilon chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. (140 aa) |
| | glmU | Bifunctional protein glmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (488 aa) |
| | EGW23470.1 | PFAM: Bacterial transcriptional activator domain; Tetratricopeptide TPR-4; KEGG: sme:SMa1591 CyaI3 adenylate/guanylate cyclase. (1265 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (214 aa) |
| | thiG | Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (325 aa) |
| | lpxD | UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (346 aa) |
| | moaC | Molybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (160 aa) |
| | EGW23538.1 | PFAM: ThiamineS; KEGG: tgr:Tgr7_2951 molybdopterin converting factor, subunit 1. (77 aa) |
| | EGW23539.1 | PFAM: Molybdopterin biosynthesis MoaE; KEGG: tgr:Tgr7_2952 molybdopterin biosynthesis MoaE protein. (148 aa) |
| | gpsA | KEGG: shn:Shewana3_0054 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; HAMAP: Glycerol-3-phosphate dehydrogenase [NAD(P)+]; PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase, C-terminal; NAD-dependent glycerol-3-phosphate dehydrogenase, N-terminal; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (332 aa) |
| | EGW23574.1 | KEGG: gpb:HDN1F_00940 adenylate cyclase; PFAM: Adenylate cyclase, class-I. (934 aa) |
| | pyrD | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (337 aa) |
| | EGW23613.1 | TIGRFAM: Glycine oxidase ThiO; KEGG: alv:Alvin_1597 FAD dependent oxidoreductase; PFAM: FAD dependent oxidoreductase. (366 aa) |
| | thiC | Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (626 aa) |
| | EGW23633.1 | Diacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (119 aa) |
| | coaE | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (200 aa) |
| | EGW23666.1 | PFAM: Polysaccharide deacetylase; KEGG: slt:Slit_1375 polysaccharide deacetylase. (310 aa) |
| | EGW23669.1 | PFAM: Glycosyl transferase, family 2; KEGG: gca:Galf_0670 glycosyl transferase family 2. (320 aa) |
| | EGW23671.1 | PFAM: Protein of unknown function DUF6, transmembrane; KEGG: rsl:RPSI07_2044 putative small multidrug resistance transmembrane protein. (123 aa) |
