STRINGSTRING
EGW22486.1 EGW22486.1 lpxC lpxC EGW22721.1 EGW22721.1 EGW22935.1 EGW22935.1 EGW22954.1 EGW22954.1 EGW22957.1 EGW22957.1 hldD hldD hldE hldE EGW23016.1 EGW23016.1 EGW23018.1 EGW23018.1 EGW23019.1 EGW23019.1 EGW23020.1 EGW23020.1 EGW23021.1 EGW23021.1 EGW23068.1 EGW23068.1 EGW23069.1 EGW23069.1 EGW23285.1 EGW23285.1 lpxD lpxD EGW23616.1 EGW23616.1 EGW23617.1 EGW23617.1 EGW23672.1 EGW23672.1 ubiB ubiB EGW23809.1 EGW23809.1 kdsA kdsA lpxA lpxA EGW20015.1 EGW20015.1 EGW20092.1 EGW20092.1 rnfE rnfE EGW20324.1 EGW20324.1 EGW20378.1 EGW20378.1 EGW20502.1 EGW20502.1 EGW20754.1 EGW20754.1 EGW20775.1 EGW20775.1 EGW20798.1 EGW20798.1 EGW20882.1 EGW20882.1 EGW20914.1 EGW20914.1 EGW21634.1 EGW21634.1 lpxH lpxH lpxB lpxB EGW21853.1 EGW21853.1 lpxK lpxK kdsB kdsB EGW20963.1 EGW20963.1 EGW21076.1 EGW21076.1 EGW21083.1 EGW21083.1 EGW20614.1 EGW20614.1 EGW20615.1 EGW20615.1 EGW20741.1 EGW20741.1 EGW22300.1 EGW22300.1 EGW22439.1 EGW22439.1 EGW22453.1 EGW22453.1 EGW22455.1 EGW22455.1 EGW22485.1 EGW22485.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EGW22486.1KEGG: rpa:RPA3927 phosphoheptose isomerase. (187 aa)
lpxCUDP-3-O-(3-hydroxymyristoyl) N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (307 aa)
EGW22721.1Phosphoheptose isomerase; Manually curated; KEGG: mca:MCA0183 phosphoheptose isomerase. (195 aa)
EGW22935.1PFAM: Glycosyl transferase, family 2; KEGG: hpy:HP0102 hypothetical protein. (295 aa)
EGW22954.1PFAM: Glycosyl transferase, family 2; KEGG: gur:Gura_3784 glycosyl transferase family protein. (326 aa)
EGW22957.1PFAM: NAD-dependent epimerase/dehydratase; KEGG: gca:Galf_2845 NAD-dependent epimerase/dehydratase. (290 aa)
hldDADP-L-glycero-D-manno-heptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. (314 aa)
hldEBifunctional protein hldE; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (474 aa)
EGW23016.1PFAM: Sugar isomerase (SIS); KEGG: cje:Cj1149c phosphoheptose isomerase. (172 aa)
EGW23018.1PFAM: Glycosyl transferase, family 2; KEGG: rpi:Rpic_2399 glycosyl transferase family 2. (282 aa)
EGW23019.1PFAM: Glycosyl transferase, family 2; KEGG: meh:M301_2022 glycosyl transferase family 2. (248 aa)
EGW23020.1PFAM: Glycosyl transferase, family 25; KEGG: vsp:VS_0190 putative glycosyltransferase. (241 aa)
EGW23021.1Manually curated; TIGRFAM: Lipopolysaccharide heptosyltransferase III, putative; KEGG: bpd:BURPS668_1203 putative lipopolysaccharide heptosyltransferase III; PFAM: Glycosyl transferase, family 9. (367 aa)
EGW23068.1KEGG: ant:Arnit_2252 lipopolysaccharide heptosyltransferase I; TIGRFAM: Lipopolysaccharide heptosyltransferase I; PFAM: Glycosyl transferase, family 9. (334 aa)
EGW23069.1KEGG: meh:M301_2012 lipopolysaccharide heptosyltransferase II; TIGRFAM: Lipopolysaccharide heptosyltransferase II; PFAM: Glycosyl transferase, family 9. (342 aa)
EGW23285.1KEGG: dat:HRM2_37590 glycosyl transferase family protein; manually curated; PFAM: Glycosyl transferase, family 2. (274 aa)
lpxDUDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (346 aa)
EGW23616.1KpsF/GutQ family protein; SMART: Cystathionine beta-synthase, core; TIGRFAM: KpsF/GutQ; KEGG: nwa:Nwat_0300 KpsF/GutQ family protein; PFAM: Sugar isomerase (SIS); Cystathionine beta-synthase, core. (325 aa)
EGW23617.13-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family. (185 aa)
EGW23672.1PFAM: Glycosyl transferase, family 39; KEGG: slt:Slit_1368 glycosyl transferase family 39. (551 aa)
ubiBUbiquinone biosynthesis protein ubiB; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. (516 aa)
EGW23809.1PFAM: Glycosyl transferase, family 2; KEGG: app:CAP2UW1_2822 glycosyl transferase family 2. (229 aa)
kdsA2-dehydro-3-deoxyphosphooctonate aldolase; PFAM: DAHP synthetase I/KDSA; TIGRFAM: 3-deoxy-8-phosphooctulonate synthase; HAMAP: 3-deoxy-8-phosphooctulonate synthase; KEGG: mca:MCA2514 2-dehydro-3-deoxyphosphooctonate aldolase. (277 aa)
lpxAAcyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (256 aa)
EGW20015.1KEGG: maq:Maqu_3491 heat shock protein DnaJ domain-containing protein; PFAM: Heat shock protein DnaJ, N-terminal; SMART: Heat shock protein DnaJ, N-terminal. (163 aa)
EGW20092.1PFAM: O-antigen ligase-related; KEGG: afr:AFE_2896 O-antigen polymerase family protein. (599 aa)
rnfEElectron transport complex protein rnfE; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. (232 aa)
EGW20324.1PFAM: Metallophosphoesterase; KEGG: mag:amb0266 hypothetical protein. (262 aa)
EGW20378.1PFAM: Glycosyl transferase, family 2; KEGG: srm:SRM_00268 glycosyl transferase, family 2. (260 aa)
EGW20502.1Three-deoxy-D-manno-octulosonic-acid transferase domain-containing protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (419 aa)
EGW20754.1PFAM: Glycosyl transferase, family 2; KEGG: ami:Amir_1747 glycosyl transferase family 2. (345 aa)
EGW20775.1PFAM: Protein of unknown function DUF917; KEGG: rce:RC1_3710 hypothetical protein. (437 aa)
EGW20798.1KEGG: mca:MCA2051 D,D-heptose 1,7-bisphosphate phosphatase; TIGRFAM: Histidinol-phosphate phosphatase; HAD-superfamily hydrolase, subfamily IIIA; PFAM: Haloacid dehalogenase-like hydrolase. (183 aa)
EGW20882.1PFAM: ABC-1; KEGG: gca:Galf_2113 ABC-1 domain-containing protein. (554 aa)
EGW20914.1PFAM: ABC-1; KEGG: psl:Psta_3309 ABC-1 domain protein. (516 aa)
EGW21634.1PFAM: RNA-directed DNA polymerase (reverse transcriptase); Group II intron, maturase-specific; KEGG: paa:Paes_0629 RNA-directed DNA polymerase (reverse transcriptase). (405 aa)
lpxHUDP-2,3-diacylglucosamine hydrolase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (241 aa)
lpxBLipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (387 aa)
EGW21853.1PFAM: O-antigen ligase-related; KEGG: meh:M301_2021 O-antigen polymerase. (404 aa)
lpxKTetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (333 aa)
kdsB3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (256 aa)
EGW20963.1KEGG: alv:Alvin_1011 RIO-like kinase; PFAM: RIO-like kinase; SMART: RIO kinase. (280 aa)
EGW21076.1PFAM: O-antigen ligase-related; KEGG: meh:M301_2262 O-antigen polymerase. (463 aa)
EGW21083.1KEGG: meh:M301_2268 ExoV-like protein. (300 aa)
EGW20614.1PFAM: Glycosyl transferase, family 39; KEGG: tbd:Tbd_1534 putative glycosyltransferase. (540 aa)
EGW20615.1PFAM: Lipid A biosynthesis, N-terminal; KEGG: nwi:Nwi_1531 lipid A biosynthesis. (94 aa)
EGW20741.1Acetyltransferase; KEGG: rsh:Rsph17029_3702 acetyltransferase. (213 aa)
EGW22300.1PFAM: Aspartyl/Asparaginyl beta-hydroxylase; KEGG: cak:Caul_3221 aspartyl/asparaginyl beta-hydroxylase. (395 aa)
EGW22439.1TIGRFAM: Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase; KEGG: mca:MCA0397 UDP-N-acetylglucosamine acyltransferase; PFAM: Bacterial transferase hexapeptide repeat. (257 aa)
EGW22453.1PFAM: Protein of unknown function DUF115. (341 aa)
EGW22455.1PFAM: Protein of unknown function DUF115; KEGG: pca:Pcar_1143 hypothetical protein. (838 aa)
EGW22485.1Cytidyltransferase-related domain protein; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (506 aa)
Your Current Organism:
Methylobacter tundripaludum
NCBI taxonomy Id: 697282
Other names: M. tundripaludum SV96, Methylobacter sp. SV96, Methylobacter tundripaludum DSM 17260, Methylobacter tundripaludum SV96, Methylobacter tundripaludum str. SV96, Methylobacter tundripaludum strain SV96
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