node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADU20676.1 | ADU21422.1 | Rumal_0114 | Rumal_0895 | Cysteine desulfurase; KEGG: cth:Cthe_1064 aminotransferase, class V; PFAM: aminotransferase class V. | Cysteine desulfurase; KEGG: cpy:Cphy_0181 aminotransferase class V; PFAM: aminotransferase class V. | 0.923 |
ADU20676.1 | iscS | Rumal_0114 | Rumal_1709 | Cysteine desulfurase; KEGG: cth:Cthe_1064 aminotransferase, class V; PFAM: aminotransferase class V. | Cysteine desulfurase NifS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.918 |
ADU20676.1 | mnmA | Rumal_0114 | Rumal_1710 | Cysteine desulfurase; KEGG: cth:Cthe_1064 aminotransferase, class V; PFAM: aminotransferase class V. | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. | 0.574 |
ADU20676.1 | thiI | Rumal_0114 | Rumal_0113 | Cysteine desulfurase; KEGG: cth:Cthe_1064 aminotransferase, class V; PFAM: aminotransferase class V. | Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.983 |
ADU21094.1 | bioB | Rumal_0545 | Rumal_1686 | Radical SAM domain protein; KEGG: cth:Cthe_1839 biotin synthase; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.900 |
ADU21422.1 | ADU20676.1 | Rumal_0895 | Rumal_0114 | Cysteine desulfurase; KEGG: cpy:Cphy_0181 aminotransferase class V; PFAM: aminotransferase class V. | Cysteine desulfurase; KEGG: cth:Cthe_1064 aminotransferase, class V; PFAM: aminotransferase class V. | 0.923 |
ADU21422.1 | iscS | Rumal_0895 | Rumal_1709 | Cysteine desulfurase; KEGG: cpy:Cphy_0181 aminotransferase class V; PFAM: aminotransferase class V. | Cysteine desulfurase NifS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.918 |
ADU21422.1 | mnmA | Rumal_0895 | Rumal_1710 | Cysteine desulfurase; KEGG: cpy:Cphy_0181 aminotransferase class V; PFAM: aminotransferase class V. | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. | 0.543 |
ADU21422.1 | thiI | Rumal_0895 | Rumal_0113 | Cysteine desulfurase; KEGG: cpy:Cphy_0181 aminotransferase class V; PFAM: aminotransferase class V. | Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.956 |
bioB | ADU21094.1 | Rumal_1686 | Rumal_0545 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Radical SAM domain protein; KEGG: cth:Cthe_1839 biotin synthase; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. | 0.900 |
iscS | ADU20676.1 | Rumal_1709 | Rumal_0114 | Cysteine desulfurase NifS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | Cysteine desulfurase; KEGG: cth:Cthe_1064 aminotransferase, class V; PFAM: aminotransferase class V. | 0.918 |
iscS | ADU21422.1 | Rumal_1709 | Rumal_0895 | Cysteine desulfurase NifS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | Cysteine desulfurase; KEGG: cpy:Cphy_0181 aminotransferase class V; PFAM: aminotransferase class V. | 0.918 |
iscS | mnmA | Rumal_1709 | Rumal_1710 | Cysteine desulfurase NifS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. | 0.882 |
iscS | thiI | Rumal_1709 | Rumal_0113 | Cysteine desulfurase NifS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.955 |
mnmA | ADU20676.1 | Rumal_1710 | Rumal_0114 | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. | Cysteine desulfurase; KEGG: cth:Cthe_1064 aminotransferase, class V; PFAM: aminotransferase class V. | 0.574 |
mnmA | ADU21422.1 | Rumal_1710 | Rumal_0895 | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. | Cysteine desulfurase; KEGG: cpy:Cphy_0181 aminotransferase class V; PFAM: aminotransferase class V. | 0.543 |
mnmA | iscS | Rumal_1710 | Rumal_1709 | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. | Cysteine desulfurase NifS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.882 |
thiG | thiI | Rumal_2157 | Rumal_0113 | Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. | Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.929 |
thiI | ADU20676.1 | Rumal_0113 | Rumal_0114 | Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | Cysteine desulfurase; KEGG: cth:Cthe_1064 aminotransferase, class V; PFAM: aminotransferase class V. | 0.983 |
thiI | ADU21422.1 | Rumal_0113 | Rumal_0895 | Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | Cysteine desulfurase; KEGG: cpy:Cphy_0181 aminotransferase class V; PFAM: aminotransferase class V. | 0.956 |