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| | ADU20566.1 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (368 aa) |
| | ADU20581.1 | PFAM: Shikimate dehydrogenase substrate binding domain protein; KEGG: tte:TTE1261 shikimate 5-dehydrogenase. (302 aa) |
| | ADU20594.1 | Uridine kinase; KEGG: btb:BMB171_C2253 uridine kinase. (177 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (211 aa) |
| | rpoA | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (319 aa) |
| | ADU20655.1 | TIGRFAM: seryl-tRNA synthetase; KEGG: apr:Apre_0581 seryl-tRNA synthetase; PFAM: Seryl-tRNA synthetase, class IIa-like; tRNA synthetase class II (G H P and S). (429 aa) |
| | ADU20674.1 | PFAM: CinA domain protein; KEGG: cth:Cthe_1052 competence/damage-inducible protein CinA; Belongs to the CinA family. (187 aa) |
| | thiI | Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (392 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (174 aa) |
| | ADU20710.1 | KEGG: ere:EUBREC_2283 hypothetical protein. (209 aa) |
| | dcd | Deoxycytidine triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (178 aa) |
| | ADU20767.1 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: eel:EUBELI_20139 6-pyruvoyl tetrahydrobiopterin synthase. (140 aa) |
| | queE | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (224 aa) |
| | folE | KEGG: eel:EUBELI_20137 GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase. (186 aa) |
| | queC | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). (228 aa) |
| | queF | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (165 aa) |
| | ADU20791.1 | Phospho-2-dehydro-3-deoxyheptonate aldolase; KEGG: cbk:CLL_A3144 3-deoxy-7-phosphoheptulonate synthase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I/KDSA. (339 aa) |
| | ADU20792.1 | KEGG: gau:GAU_1231 hypothetical protein. (171 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (165 aa) |
| | purC | TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; KEGG: cpy:Cphy_3045 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (239 aa) |
| | ADU20816.1 | KEGG: shi:Shel_06330 amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (473 aa) |
| | purM | TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; KEGG: cce:Ccel_2183 phosphoribosylaminoimidazole synthetase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein. (346 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (208 aa) |
| | purD | TIGRFAM: phosphoribosylamine/glycine ligase; KEGG: cth:Cthe_1245 phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; Belongs to the GARS family. (451 aa) |
| | ADU20828.1 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme formylation region; KEGG: eel:EUBELI_20422 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; SMART: AICARFT/IMPCHase bienzyme formylation region. (393 aa) |
| | ADU20834.1 | PFAM: Inosine monophosphate cyclohydrolase-like; KEGG: ere:EUBREC_1566 hypothetical protein. (238 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. (856 aa) |
| | atpC | ATP synthase F1, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (134 aa) |
| | atpD | ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (468 aa) |
| | atpG | ATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (286 aa) |
| | atpA | ATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (504 aa) |
| | atpH | ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (182 aa) |
| | atpF | ATP synthase F0, B subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (171 aa) |
| | atpE | ATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (86 aa) |
| | atpB | ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (241 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (368 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (409 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (363 aa) |
| | ADU20945.1 | KEGG: rbi:RB2501_13359 putative carbamoyl-phosphate-synthetase. (425 aa) |
| | ADU20947.1 | KEGG: maq:Maqu_2595 putative carbamoyl-phosphate-synthetase. (400 aa) |
| | ADU20963.1 | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (183 aa) |
| | ADU20966.1 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (295 aa) |
| | ADU20968.1 | KEGG: afn:Acfer_0569 nucleotide sugar dehydrogenase; TIGRFAM: nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase. (410 aa) |
| | ADU20991.1 | PFAM: ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; KEGG: shi:Shel_14410 carbamoylphosphate synthase large subunit. (420 aa) |
| | aroQ | 3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (148 aa) |
| | ADU21011.1 | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (310 aa) |
| | ADU21055.1 | PFAM: sigma-70 region 2 domain protein; KEGG: slp:Slip_0393 RNA polymerase, sigma 28 subunit, FliA/WhiG subfamily; Belongs to the sigma-70 factor family. (127 aa) |
| | ADU21089.1 | PFAM: sigma-70 region 4 domain protein; KEGG: bay:RBAM_024040 sporulation sigma factor SigK. (129 aa) |
| | ADU21106.1 | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (147 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (471 aa) |
| | queH | Protein of unknown function DUF208; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (211 aa) |
| | ADU21173.1 | PFAM: carboxyl transferase; KEGG: sna:Snas_0792 carboxyl transferase. (456 aa) |
| | ADU21210.1 | KEGG: dat:HRM2_17350 hypothetical protein. (486 aa) |
| | ADU21226.1 | KEGG: dat:HRM2_17350 hypothetical protein. (543 aa) |
| | ADU21239.1 | DNA primase; Manually curated; KEGG: ere:EUBREC_2705 DNA primase. (197 aa) |
| | ADU21319.1 | KEGG: ate:Athe_1364 von Willebrand factor type A; PFAM: von Willebrand factor type A; SMART: von Willebrand factor type A. (1311 aa) |
| | ADU21381.1 | KEGG: cpf:CPF_0712 ECF subfamily RNA polymerase sigma factor; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein. (566 aa) |
| | ADU21417.1 | KEGG: cbe:Cbei_1302 ECF subfamily RNA polymerase sigma-24 factor; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70 region 4 type 2. (174 aa) |
| | ADU21433.1 | Transketolase central region; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (586 aa) |
| | ADU21463.1 | KEGG: drm:Dred_0041 phosphoribulokinase/uridine kinase. (314 aa) |
| | ADU21490.1 | KEGG: cth:Cthe_0120 RNA polymerase, sigma 28 subunit; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 3 domain protein; sigma-70 region 4 domain protein. (218 aa) |
| | ADU21533.1 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (396 aa) |
| | tgt | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (382 aa) |
| | ADU21590.1 | KEGG: drm:Dred_2232 carbamoyl phosphate synthase large subunit; TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; MGS domain protein; Belongs to the CarB family. (1074 aa) |
| | ADU21592.1 | KEGG: cbe:Cbei_1736 ECF subfamily RNA polymerase sigma-24 factor; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein. (159 aa) |
| | ADU21602.1 | PFAM: cobalamin synthesis protein P47K; cobalamin synthesis CobW domain protein; KEGG: fsu:Fisuc_1189 cobalamin synthesis protein P47K. (370 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa) |
| | ADU21685.1 | TIGRFAM: hypoxanthine phosphoribosyltransferase; KEGG: dhd:Dhaf_1437 hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (184 aa) |
| | ADU21692.1 | PFAM: Prephenate dehydrogenase; KEGG: shi:Shel_10140 prephenate dehydrogenase. (279 aa) |
| | dnaX | DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (532 aa) |
| | coaX | Putative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (254 aa) |
| | ADU21851.1 | TIGRFAM: FolC bifunctional protein; KEGG: cce:Ccel_1447 FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase middle domain protein; Belongs to the folylpolyglutamate synthase family. (423 aa) |
| | ADU21855.1 | KEGG: ctc:CTC01698 putative phosphoenolpyruvate phosphomutase; TIGRFAM: phosphoenolpyruvate phosphomutase; cytidyltransferase-related domain protein; PFAM: cytidylyltransferase. (679 aa) |
| | ADU21858.1 | TIGRFAM: adenosine deaminase; KEGG: hdu:HD0377 adenosine deaminase; PFAM: adenosine/AMP deaminase. (336 aa) |
| | ADU21915.1 | KEGG: dsy:DSY4633 hypothetical protein. (466 aa) |
| | ADU21938.1 | RNA polymerase, sigma-24 subunit, ECF subfamily; KEGG: cdl:CDR20291_3288 hypothetical protein; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein. (162 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (556 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (598 aa) |
| | sigA | RNA polymerase, sigma 70 subunit, RpoD subfamily; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (366 aa) |
| | ADU22026.1 | KEGG: clj:CLJU_c06420 hypothetical protein; PFAM: VWA containing CoxE family protein; SMART: von Willebrand factor type A. (383 aa) |
| | ADU22043.1 | PFAM: adenosine/AMP deaminase; KEGG: bfr:BF3839 putative adenosine deaminase. (502 aa) |
| | ADU22044.1 | KEGG: cbe:Cbei_1736 ECF subfamily RNA polymerase sigma-24 factor; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein. (160 aa) |
| | ADU22048.1 | KEGG: eel:EUBELI_20149 RNA polymerase sigma-70 factor, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein. (185 aa) |
| | ADU22072.1 | KEGG: cpe:CPE0924 metallo-beta-lactamase family protein. (269 aa) |
| | ADU22087.1 | PFAM: pyridoxamine 5'-phosphate oxidase-related FMN-binding; KEGG: cac:CA_C2569 NimC/NimA family protein. (130 aa) |
| | guaA | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (513 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (219 aa) |
| | ADU22133.1 | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (249 aa) |
| | ADU22146.1 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (458 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa) |
| | ADU22153.1 | PFAM: amino acid-binding ACT domain protein; KEGG: cce:Ccel_1723 hypothetical protein; Belongs to the UPF0237 family. (89 aa) |
| | ADU22157.1 | RNA polymerase, sigma 28 subunit, Sig B/F/G subfamily; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (256 aa) |
| | ADU22168.1 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (762 aa) |
| | ADU22170.1 | Coproporphyrinogen dehydrogenase; PFAM: Radical SAM domain protein; KEGG: cth:Cthe_1341 coproporphyrinogen III oxidase; SMART: Elongator protein 3/MiaB/NifB. (489 aa) |
| | ADU22206.1 | KEGG: sti:Sthe_3345 RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2. (187 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (265 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (396 aa) |
| | ADU22213.1 | PFAM: Chorismate mutase, type II; KEGG: hna:Hneap_2059 chorismate mutase. (119 aa) |
| | trpC | KEGG: cce:Ccel_3216 indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (262 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (544 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (491 aa) |
| | ADU22237.1 | TIGRFAM: phosphoribosylformylglycinamidine synthase; KEGG: tjr:TherJR_0822 phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein domain protein. (1237 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa) |
| | cmk | TIGRFAM: cytidylate kinase; PFAM: cytidylate kinase region; phospholipid/glycerol acyltransferase; KEGG: eel:EUBELI_00928 cytidylate kinase; SMART: phospholipid/glycerol acyltransferase. (453 aa) |
| | ADU22281.1 | TIGRFAM: ribose-phosphate pyrophosphokinase; KEGG: cpy:Cphy_0104 phosphoribosylpyrophosphate synthetase; PFAM: phosphoribosyltransferase. (384 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (216 aa) |
| | rpoZ | DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (68 aa) |
| | priA | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (817 aa) |
| | ADU22316.1 | KEGG: bde:BDP_1513 thiamin pyrophosphokinase; TIGRFAM: thiamine pyrophosphokinase; PFAM: Thiamin pyrophosphokinase catalytic domain-containing protein. (208 aa) |
| | ADU22348.1 | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (174 aa) |
| | pyrB | TIGRFAM: aspartate carbamoyltransferase; KEGG: cpf:CPF_1387 aspartate carbamoyltransferase catalytic subunit; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (362 aa) |
| | ADU22356.1 | PFAM: UMUC domain protein DNA-repair protein; KEGG: pru:PRU_0508 ImpB/MucB/SamB family protein. (497 aa) |
| | trpF | KEGG: ere:EUBREC_0263 phosphoribosylanthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); Belongs to the TrpF family. (203 aa) |
| | ADU22370.1 | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (173 aa) |
| | ADU22385.1 | PFAM: protein of unknown function UPF0157; KEGG: sga:GALLO_1321 hypothetical protein. (169 aa) |
| | ADU22388.1 | KEGG: cth:Cthe_1040 DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta. (355 aa) |
| | ADU22417.1 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (274 aa) |
| | ADU22418.1 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (272 aa) |
| | ADU22419.1 | Dihydrofolate reductase region; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (163 aa) |
| | ADU22448.1 | 5-formyltetrahydrofolate cyclo-ligase; KEGG: shi:Shel_24120 5,10-methenyltetrahydrofolate synthetase; TIGRFAM: 5-formyltetrahydrofolate cyclo-ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase. (197 aa) |
| | ADU22451.1 | PFAM: thymidylate kinase; KEGG: cdl:CDR20291_3385 putative thymidylate kinase. (218 aa) |
| | thyX | Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (258 aa) |
| | nadK | ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (287 aa) |
| | dxs | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (616 aa) |
| | nusB | NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (137 aa) |
| | ADU22498.1 | PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; KEGG: cth:Cthe_0373 ferredoxin-NADP(+) reductase subunit alpha. (279 aa) |
| | polC | DNA polymerase III, alpha subunit; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (1500 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (236 aa) |
| | ADU22641.1 | KEGG: gsu:GSU0589 hypothetical protein; TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein. (64 aa) |
| | thiG | Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (257 aa) |
| | ADU22645.1 | PFAM: thiamine monophosphate synthase; KEGG: ere:EUBREC_0222 thiamine-phosphate pyrophosphorylase, putative. (201 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (210 aa) |
| | ADU22647.1 | KEGG: apr:Apre_1397 phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1. (269 aa) |
| | thiC | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (437 aa) |
| | queA | S-adenosylmethionine/tRNA-ribosyltransferase- isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (355 aa) |
| | ADU22743.1 | Hypothetical protein; Manually curated; KEGG: hmo:HM1_2896 primase, putative. (457 aa) |
| | ADU22744.1 | DNA primase; KEGG: ere:EUBREC_2705 DNA primase. (204 aa) |
| | ADU22785.1 | KEGG: mac:MA0739 hypothetical protein. (205 aa) |
| | ADU22810.1 | PFAM: Stress responsive alpha-beta barrel domain-containing protein; KEGG: mmp:MMP0887 stress responsive alpha-beta barrel domain protein. (96 aa) |
| | dacA | Protein of unknown function DUF147; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (293 aa) |
| | ADU22828.1 | Metal dependent phosphohydrolase; KEGG: ctc:CTC01203 HAD superfamily hydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region. (184 aa) |
| | ADU22842.1 | KEGG: ctc:CTC02237 hypothetical protein. (383 aa) |
| | dapF | Carbamoyl-phosphate synthase, large subunit; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. Belongs to the diaminopimelate epimerase family. (1351 aa) |
| | carA | KEGG: ere:EUBREC_0731 carbamoyl phosphate synthase small subunit; TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; Belongs to the CarA family. (363 aa) |
| | ADU22897.1 | TIGRFAM: FolC bifunctional protein; KEGG: cth:Cthe_1384 FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase middle domain protein; Belongs to the folylpolyglutamate synthase family. (427 aa) |
| | ADU22901.1 | PFAM: metal-dependent phosphohydrolase HD sub domain; KEGG: cpy:Cphy_0261 metal dependent phosphohydrolase; SMART: metal-dependent phosphohydrolase HD region. (192 aa) |
| | ADU22979.1 | TIGRFAM: phage/plasmid primase, P4 family; KEGG: hmo:HM1_2896 primase, putative. (558 aa) |
| | ADU22985.1 | DNA primase; Manually curated; KEGG: ere:EUBREC_2705 DNA primase. (195 aa) |
| | ADU22988.1 | KEGG: dat:HRM2_17350 hypothetical protein. (544 aa) |
| | ADU23026.1 | PFAM: metal-dependent phosphohydrolase HD sub domain; KEGG: shi:Shel_05990 hypothetical protein. (143 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (429 aa) |
| | ADU23047.1 | KEGG: cpy:Cphy_0514 ECF subfamily RNA polymerase sigma-24 factor; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2. (184 aa) |
| | nusG | NusG antitermination factor; Participates in transcription elongation, termination and antitermination. (175 aa) |
| | ADU23062.1 | KEGG: bbe:BBR47_58710 hypothetical protein. (338 aa) |
| | ADU23107.1 | PFAM: phosphoribosyltransferase; KEGG: cbe:Cbei_2076 ribose-phosphate pyrophosphokinase. (272 aa) |
| | ADU23108.1 | KEGG: cbe:Cbei_2078 putative nicotinate phosphoribosyltransferase; PFAM: Nicotinate phosphoribosyltransferase-like; Belongs to the NAPRTase family. (506 aa) |
| | ADU23226.1 | Hypothetical protein; KEGG: eel:EUBELI_00026 DNA polymerase. (324 aa) |
| | ADU23241.1 | KEGG: eel:EUBELI_01147 cytidylate kinase. (197 aa) |
| | ADU23292.1 | KEGG: ele:Elen_0590 RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein. (158 aa) |
| | ADU23307.1 | RNA polymerase, sigma-24 subunit, ECF subfamily; KEGG: cbk:CLL_A2662 RNA polymerase sigma factor; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70 region 4 type 2; Belongs to the sigma-70 factor family. ECF subfamily. (179 aa) |
| | pyrC | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (424 aa) |
| | pyrF | TIGRFAM: orotidine 5'-phosphate decarboxylase; KEGG: cce:Ccel_0614 orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (311 aa) |
| | pyrK | Oxidoreductase FAD/NAD(P)-binding domain protein; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (256 aa) |
| | pyrD | Dihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate. (303 aa) |
| | ADU23351.1 | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (480 aa) |
| | ADU23370.1 | PFAM: cobalamin synthesis protein P47K; KEGG: eel:EUBELI_01993 hypothetical protein. (398 aa) |
| | ADU23382.1 | KEGG: ele:Elen_0055 RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein. (167 aa) |
| | rpoC | DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1196 aa) |
| | rpoB | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1301 aa) |
| | ADU23401.1 | KEGG: eel:EUBELI_00461 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: Adenylosuccinate lyase-like; fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (479 aa) |
| | ADU23426.1 | KEGG: drm:Dred_0783 prephenate dehydratase; PFAM: prephenate dehydratase; Chorismate mutase, type II. (370 aa) |
| | ADU23433.1 | KEGG: eel:EUBELI_01147 cytidylate kinase. (209 aa) |
| | nusA | NusA antitermination factor; Participates in both transcription termination and antitermination. (372 aa) |
| | ADU23479.1 | PFAM: GCN5-related N-acetyltransferase; KEGG: eel:EUBELI_01173 hypothetical protein. (151 aa) |
| | ADU23483.1 | Riboflavin biosynthesis protein RibF; KEGG: ere:EUBREC_1939 bifunctional riboflavin kinase/FMN adenylyltransferase; TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: Riboflavin kinase; FAD synthetase; Belongs to the ribF family. (308 aa) |
| | ADU23494.1 | Hypothetical protein; KEGG: bpf:BpOF4_08800 RNA polymerase sigma factor SigW. (920 aa) |
| | murA-2 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (418 aa) |
| | ADU23531.1 | DNA polymerase III, alpha subunit; SMART: phosphoesterase PHP domain protein; TIGRFAM: DNA polymerase III, alpha subunit; KEGG: cth:Cthe_1264 DNA polymerase III DnaE; PFAM: DNA polymerase III alpha subunit; PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type. (1141 aa) |
| | nadD | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (202 aa) |
| | ADU23559.1 | TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; KEGG: hor:Hore_13400 metal dependent phosphohydrolase; SMART: metal-dependent phosphohydrolase HD region. (193 aa) |
| | ADU23586.1 | TIGRFAM: nicotinate-nucleotide pyrophosphorylase; KEGG: csc:Csac_1779 nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. (279 aa) |
| | ADU23589.1 | PFAM: purine or other phosphorylase family 1; KEGG: cpf:CPF_0375 uridine phosphorylase. (263 aa) |
| | ADU23590.1 | KEGG: tva:TVAG_480920 hypothetical protein. (685 aa) |
| | ADU23597.1 | Transcriptional regulator, LuxR family; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; regulatory protein LuxR; KEGG: gtn:GTNG_0089 RNA polymerase factor sigma-70; SMART: regulatory protein LuxR. (195 aa) |
| | ADU23613.1 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (456 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (297 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (290 aa) |
| | ADU23627.1 | PFAM: H+transporting two-sector ATPase C subunit; KEGG: acl:ACL_1172 integral membrane protein. (148 aa) |
| | ADU23629.1 | PFAM: H+transporting two-sector ATPase E subunit; KEGG: afu:AF1163 V-type ATP synthase subunit E. (197 aa) |
| | atpA-2 | H+transporting two-sector ATPase alpha/beta subunit central region; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (589 aa) |
| | atpD-2 | V-type ATPase, D subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (215 aa) |
| | ADU23653.1 | PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: pmo:Pmob_0901 pyridoxamine kinase; Belongs to the pyridoxine kinase family. (286 aa) |
| | cobD | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (329 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (493 aa) |
| | folD | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (283 aa) |
| | ADU23705.1 | KEGG: aoe:Clos_1919 zinc finger CHC2-family protein. (355 aa) |
