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G7K_2591-t1 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (645 aa) | ||||
G7K_2158-t1 | Replication factor C subunit 1. (1025 aa) | ||||
G7K_2341-t1 | Protein kinase domain-containing protein. (1086 aa) | ||||
G7K_2036-t1 | ERCC4 domain-containing protein. (611 aa) | ||||
G7K_2417-t1 | FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (563 aa) | ||||
G7K_2298-t1 | Helicase ATP-binding domain-containing protein. (1337 aa) | ||||
G7K_2172-t1 | DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (468 aa) | ||||
G7K_2147-t1 | AAA domain-containing protein. (358 aa) | ||||
G7K_2158-t2 | Replication factor C subunit 1. (1029 aa) | ||||
G7K_1898-t1 | Uncharacterized protein. (331 aa) | ||||
G7K_1705-t1 | Uncharacterized protein. (1118 aa) | ||||
G7K_1641-t1 | DNA helicase; Belongs to the MCM family. (834 aa) | ||||
G7K_1083-t1 | DNA helicase; Belongs to the MCM family. (1614 aa) | ||||
G7K_1479-t1 | Uncharacterized protein. (713 aa) | ||||
G7K_1043-t1 | Uncharacterized protein. (499 aa) | ||||
G7K_1249-t1 | UvrD_C_2 domain-containing protein. (965 aa) | ||||
MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (1043 aa) | ||||
G7K_1222-t1 | Uncharacterized protein. (900 aa) | ||||
G7K_1051-t1 | RPA_C domain-containing protein. (283 aa) | ||||
G7K_1075-t1 | DNA polymerase. (1610 aa) | ||||
G7K_1040-t1 | AAA_23 domain-containing protein. (1309 aa) | ||||
G7K_0906-t1 | Uncharacterized protein. (1620 aa) | ||||
G7K_0687-t1 | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2222 aa) | ||||
G7K_0844-t1 | Uncharacterized protein. (767 aa) | ||||
G7K_0553-t1 | WD_REPEATS_REGION domain-containing protein. (812 aa) | ||||
G7K_0533-t1 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (200 aa) | ||||
G7K_0638-t1 | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (332 aa) | ||||
G7K_0070-t1 | DNA ligase. (963 aa) | ||||
G7K_0534-t1 | Uncharacterized protein. (1022 aa) | ||||
G7K_0289-t1 | DNA helicase; Belongs to the MCM family. (873 aa) | ||||
G7K_0238-t1 | C2H2-type domain-containing protein. (326 aa) | ||||
G7K_0198-t1 | ORC_WH_C domain-containing protein. (789 aa) | ||||
G7K_0194-t1 | Uncharacterized protein. (469 aa) | ||||
G7K_0070-t2 | DNA ligase. (969 aa) | ||||
G7K_0113-t1 | Uncharacterized protein. (393 aa) | ||||
G7K_0057-t1 | DNA polymerase. (1257 aa) | ||||
G7K_0043-t1 | Uncharacterized protein. (655 aa) | ||||
G7K_0028-t1 | RNase H domain-containing protein. (382 aa) | ||||
G7K_5864-t1 | HD_domain domain-containing protein. (276 aa) | ||||
G7K_2672-t1 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (856 aa) | ||||
FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (1294 aa) | ||||
G7K_2375-t1 | Uncharacterized protein. (645 aa) | ||||
G7K_2684-t1 | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (407 aa) | ||||
G7K_2887-t1 | Uncharacterized protein. (643 aa) | ||||
G7K_2930-t1 | DNA ligase. (813 aa) | ||||
G7K_2980-t1 | Uncharacterized protein. (1152 aa) | ||||
G7K_3085-t1 | Uncharacterized protein. (1550 aa) | ||||
G7K_3099-t1 | Uncharacterized protein. (1286 aa) | ||||
G7K_2753-t1 | DNA ligase. (905 aa) | ||||
G7K_3149-t1 | Uncharacterized protein. (436 aa) | ||||
SLX1 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (560 aa) | ||||
G7K_3376-t1 | DNA helicase; Belongs to the MCM family. (1810 aa) | ||||
G7K_3465-t1 | UmuC domain-containing protein. (680 aa) | ||||
G7K_3504-t1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (767 aa) | ||||
G7K_3082-t1 | AAA domain-containing protein. (897 aa) | ||||
G7K_3390-t1 | DNA_LIGASE_A3 domain-containing protein. (924 aa) | ||||
G7K_3584-t1 | CBFD_NFYB_HMF domain-containing protein. (222 aa) | ||||
G7K_3632-t1 | Uncharacterized protein. (762 aa) | ||||
G7K_3376-t2 | DNA helicase; Belongs to the MCM family. (1830 aa) | ||||
G7K_3807-t1 | DNA polymerase. (1132 aa) | ||||
G7K_3408-t1 | Uncharacterized protein. (927 aa) | ||||
G7K_3670-t1 | Uncharacterized protein. (196 aa) | ||||
G7K_3585-t1 | SLD3 domain-containing protein. (737 aa) | ||||
G7K_4026-t1 | CBFD_NFYB_HMF domain-containing protein. (102 aa) | ||||
PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (951 aa) | ||||
G7K_4169-t1 | Uncharacterized protein. (137 aa) | ||||
G7K_4184-t1 | POLAc domain-containing protein. (1175 aa) | ||||
G7K_4042-t1 | DNA_pol_E_B domain-containing protein. (830 aa) | ||||
G7K_3863-t1 | Uncharacterized protein. (1458 aa) | ||||
G7K_4399-t1 | WD_REPEATS_REGION domain-containing protein. (457 aa) | ||||
G7K_4463-t1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (706 aa) | ||||
G7K_4032-t1 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (604 aa) | ||||
G7K_4466-t1 | AAA domain-containing protein. (348 aa) | ||||
G7K_4572-t1 | Chromosome segregation in meiosis protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (277 aa) | ||||
G7K_4160-t1 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (641 aa) | ||||
G7K_4549-t1 | AAA domain-containing protein. (665 aa) | ||||
G7K_4672-t1 | Uncharacterized protein. (142 aa) | ||||
G7K_4304-t1 | Uncharacterized protein. (925 aa) | ||||
G7K_4682-t1 | Uncharacterized protein. (850 aa) | ||||
G7K_4762-t1 | Uncharacterized protein. (655 aa) | ||||
G7K_4791-t1 | Uncharacterized protein. (489 aa) | ||||
G7K_4855-t1 | Rtf2 domain-containing protein. (269 aa) | ||||
G7K_4463-t2 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (711 aa) | ||||
G7K_4589-t1 | Uncharacterized protein. (459 aa) | ||||
G7K_5094-t1 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (523 aa) | ||||
G7K_5159-t1 | Sld5 domain-containing protein. (179 aa) | ||||
G7K_4768-t1 | Ubiquitin-like domain-containing protein. (713 aa) | ||||
G7K_5260-t1 | DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (349 aa) | ||||
G7K_4896-t1 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (868 aa) | ||||
G7K_5340-t1 | AAA domain-containing protein. (457 aa) | ||||
G7K_4911-t1 | Uncharacterized protein. (2285 aa) | ||||
G7K_5332-t1 | CPSF_A domain-containing protein. (1250 aa) | ||||
G7K_5394-t1 | Uncharacterized protein. (1009 aa) | ||||
G7K_5108-t1 | Uncharacterized protein. (308 aa) | ||||
G7K_5653-t1 | Zn(2)-C6 fungal-type domain-containing protein. (822 aa) | ||||
G7K_5737-t1 | ERCC4 domain-containing protein. (626 aa) | ||||
G7K_5672-t1 | Ku domain-containing protein. (626 aa) | ||||
G7K_5792-t1 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (320 aa) | ||||
G7K_5467-t1 | Cell division control protein; Belongs to the CDC6/cdc18 family. (483 aa) | ||||
G7K_6020-t1 | AAA domain-containing protein. (378 aa) | ||||
G7K_2213-t1 | Uncharacterized protein. (1233 aa) | ||||
G7K_6220-t1 | Uncharacterized protein. (1011 aa) | ||||
G7K_5808-t1 | Vezatin domain-containing protein. (676 aa) | ||||
G7K_6432-t1 | Zf-primase domain-containing protein. (656 aa) | ||||
G7K_6412-t1 | DNA helicase; Belongs to the MCM family. (928 aa) | ||||
G7K_6299-t1 | Uncharacterized protein. (311 aa) | ||||
G7K_6142-t1 | Uncharacterized protein. (972 aa) | ||||
G7K_6682-t1 | Uncharacterized protein; Belongs to the MT-A70-like family. (997 aa) | ||||
G7K_6622-t1 | Uncharacterized protein. (2153 aa) | ||||
G7K_6566-t1 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (239 aa) | ||||
G7K_6799-t1 | WD_REPEATS_REGION domain-containing protein. (564 aa) |