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G7K_4648-t1 G7K_4648-t1 G7K_4559-t1 G7K_4559-t1 G7K_4032-t1 G7K_4032-t1 G7K_4472-t1 G7K_4472-t1 G7K_4337-t1 G7K_4337-t1 G7K_3936-t1 G7K_3936-t1 PIM1 PIM1 PIF1 PIF1 G7K_3936-t2 G7K_3936-t2 G7K_4006-t1 G7K_4006-t1 G7K_3725-t1 G7K_3725-t1 G7K_3807-t1 G7K_3807-t1 G7K_3376-t2 G7K_3376-t2 G7K_3742-t1 G7K_3742-t1 G7K_3683-t1 G7K_3683-t1 G7K_3504-t1 G7K_3504-t1 G7K_3499-t1 G7K_3499-t1 G7K_3068-t1 G7K_3068-t1 G7K_3436-t1 G7K_3436-t1 G7K_3431-t1 G7K_3431-t1 G7K_3269-t1 G7K_3269-t1 G7K_3376-t1 G7K_3376-t1 G7K_3112-t1 G7K_3112-t1 G7K_3135-t1 G7K_3135-t1 G7K_3158-t1 G7K_3158-t1 G7K_2803-t1 G7K_2803-t1 G7K_2380-t1 G7K_2380-t1 G7K_2589-t1 G7K_2589-t1 G7K_2544-t1 G7K_2544-t1 G7K_2591-t1 G7K_2591-t1 G7K_2542-t1 G7K_2542-t1 G7K_2421-t1 G7K_2421-t1 G7K_2363-t1 G7K_2363-t1 G7K_2359-t1 G7K_2359-t1 G7K_2362-t1 G7K_2362-t1 G7K_2307-t1 G7K_2307-t1 G7K_2172-t1 G7K_2172-t1 G7K_2232-t1 G7K_2232-t1 G7K_2057-t1 G7K_2057-t1 G7K_2104-t1 G7K_2104-t1 G7K_1687-t2 G7K_1687-t2 G7K_1994-t1 G7K_1994-t1 G7K_1657-t1 G7K_1657-t1 G7K_1987-t1 G7K_1987-t1 G7K_1948-t1 G7K_1948-t1 G7K_1687-t1 G7K_1687-t1 G7K_1641-t1 G7K_1641-t1 G7K_1517-t1 G7K_1517-t1 G7K_1083-t1 G7K_1083-t1 G7K_1406-t1 G7K_1406-t1 G7K_1517-t2 G7K_1517-t2 G7K_1433-t1 G7K_1433-t1 G7K_0886-t1 G7K_0886-t1 MCM7 MCM7 G7K_1157-t1 G7K_1157-t1 G7K_1110-t1 G7K_1110-t1 G7K_1075-t1 G7K_1075-t1 G7K_1022-t1 G7K_1022-t1 G7K_0812-t1 G7K_0812-t1 G7K_0687-t1 G7K_0687-t1 G7K_0369-t1 G7K_0369-t1 G7K_0491-t1 G7K_0491-t1 G7K_0571-t1 G7K_0571-t1 G7K_0441-t1 G7K_0441-t1 G7K_0435-t1 G7K_0435-t1 G7K_0289-t1 G7K_0289-t1 G7K_0359-t1 G7K_0359-t1 G7K_0057-t1 G7K_0057-t1 G7K_0040-t1 G7K_0040-t1 G7K_6789-t1 G7K_6789-t1 G7K_6647-t1 G7K_6647-t1 G7K_6412-t1 G7K_6412-t1 G7K_6192-t1 G7K_6192-t1 G7K_5868-t1 G7K_5868-t1 G7K_6019-t1 G7K_6019-t1 G7K_5791-t1 G7K_5791-t1 G7K_5792-t1 G7K_5792-t1 G7K_5517-t1 G7K_5517-t1 G7K_5172-t1 G7K_5172-t1 G7K_5592-t1 G7K_5592-t1 G7K_5417-t1 G7K_5417-t1 G7K_4896-t1 G7K_4896-t1 G7K_5260-t1 G7K_5260-t1 G7K_5230-t1 G7K_5230-t1 G7K_5220-t1 G7K_5220-t1 G7K_4699-t1 G7K_4699-t1 G7K_5032-t1 G7K_5032-t1 G7K_4818-t1 G7K_4818-t1 G7K_4767-t1 G7K_4767-t1 G7K_4677-t1 G7K_4677-t1 G7K_4299-t1 G7K_4299-t1 G7K_4668-t1 G7K_4668-t1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
G7K_4648-t1Zn(2)-C6 fungal-type domain-containing protein. (636 aa)
G7K_4559-t1Uncharacterized protein. (937 aa)
G7K_4032-t1Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (604 aa)
G7K_4472-t1Homeobox domain-containing protein. (228 aa)
G7K_4337-t1Uncharacterized protein. (223 aa)
G7K_3936-t1Uncharacterized protein. (1170 aa)
PIM1Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. (1158 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (951 aa)
G7K_3936-t2Uncharacterized protein. (1223 aa)
G7K_4006-t1Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (171 aa)
G7K_3725-t1Uncharacterized protein. (1252 aa)
G7K_3807-t1DNA polymerase. (1132 aa)
G7K_3376-t2DNA helicase; Belongs to the MCM family. (1830 aa)
G7K_3742-t1Zn(2)-C6 fungal-type domain-containing protein. (847 aa)
G7K_3683-t1Zn(2)-C6 fungal-type domain-containing protein. (1859 aa)
G7K_3504-t1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (767 aa)
G7K_3499-t1Homeobox domain-containing protein. (717 aa)
G7K_3068-t1Zn(2)-C6 fungal-type domain-containing protein. (831 aa)
G7K_3436-t1DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1246 aa)
G7K_3431-t1Zn(2)-C6 fungal-type domain-containing protein. (758 aa)
G7K_3269-t1NDT80 domain-containing protein. (619 aa)
G7K_3376-t1DNA helicase; Belongs to the MCM family. (1810 aa)
G7K_3112-t1Zn(2)-C6 fungal-type domain-containing protein. (1004 aa)
G7K_3135-t1Zn(2)-C6 fungal-type domain-containing protein. (831 aa)
G7K_3158-t1Uncharacterized protein. (435 aa)
G7K_2803-t1Uncharacterized protein. (1007 aa)
G7K_2380-t1Response regulatory domain-containing protein. (693 aa)
G7K_2589-t1Uncharacterized protein. (741 aa)
G7K_2544-t1Zn(2)-C6 fungal-type domain-containing protein. (855 aa)
G7K_2591-t1DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (645 aa)
G7K_2542-t1Zn(2)-C6 fungal-type domain-containing protein. (973 aa)
G7K_2421-t1Histone H2B; Belongs to the histone H2B family. (195 aa)
G7K_2363-t1Histone H2B; Belongs to the histone H2B family. (175 aa)
G7K_2359-t1H15 domain-containing protein. (288 aa)
G7K_2362-t1Histone H2A; Belongs to the histone H2A family. (202 aa)
G7K_2307-t1Zn(2)-C6 fungal-type domain-containing protein. (856 aa)
G7K_2172-t1DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (468 aa)
G7K_2232-t1Zn(2)-C6 fungal-type domain-containing protein. (1030 aa)
G7K_2057-t1Homeobox domain-containing protein. (926 aa)
G7K_2104-t1Zn(2)-C6 fungal-type domain-containing protein. (837 aa)
G7K_1687-t2Zn(2)-C6 fungal-type domain-containing protein. (1054 aa)
G7K_1994-t1HSF_DOMAIN domain-containing protein. (576 aa)
G7K_1657-t1Uncharacterized protein. (912 aa)
G7K_1987-t1MADS-box domain-containing protein. (281 aa)
G7K_1948-t1Zn(2)-C6 fungal-type domain-containing protein. (732 aa)
G7K_1687-t1Zn(2)-C6 fungal-type domain-containing protein. (1052 aa)
G7K_1641-t1DNA helicase; Belongs to the MCM family. (834 aa)
G7K_1517-t1Zn(2)-C6 fungal-type domain-containing protein. (1035 aa)
G7K_1083-t1DNA helicase; Belongs to the MCM family. (1614 aa)
G7K_1406-t1Zn(2)-C6 fungal-type domain-containing protein. (562 aa)
G7K_1517-t2Zn(2)-C6 fungal-type domain-containing protein. (1036 aa)
G7K_1433-t1Uncharacterized protein. (766 aa)
G7K_0886-t1HMG box domain-containing protein. (564 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (1043 aa)
G7K_1157-t1NmrA domain-containing protein; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (805 aa)
G7K_1110-t1Zn(2)-C6 fungal-type domain-containing protein. (772 aa)
G7K_1075-t1DNA polymerase. (1610 aa)
G7K_1022-t1HMG box domain-containing protein. (250 aa)
G7K_0812-t1MADS-box domain-containing protein. (550 aa)
G7K_0687-t1DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2222 aa)
G7K_0369-t1Zn(2)-C6 fungal-type domain-containing protein. (640 aa)
G7K_0491-t1Histone H2A; Belongs to the histone H2A family. (252 aa)
G7K_0571-t1Uncharacterized protein. (705 aa)
G7K_0441-t1HSF_DOMAIN domain-containing protein. (509 aa)
G7K_0435-t1Zn(2)-C6 fungal-type domain-containing protein. (1128 aa)
G7K_0289-t1DNA helicase; Belongs to the MCM family. (873 aa)
G7K_0359-t1Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit; Belongs to the HSF family. (973 aa)
G7K_0057-t1DNA polymerase. (1257 aa)
G7K_0040-t1Homeobox domain-containing protein. (819 aa)
G7K_6789-t1Homeobox domain-containing protein. (537 aa)
G7K_6647-t1DNA_MISMATCH_REPAIR_2 domain-containing protein; Component of the post-replicative DNA mismatch repair system (MMR). (921 aa)
G7K_6412-t1DNA helicase; Belongs to the MCM family. (928 aa)
G7K_6192-t1Uncharacterized protein. (804 aa)
G7K_5868-t1Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (624 aa)
G7K_6019-t1Fungal_trans domain-containing protein. (1184 aa)
G7K_5791-t1MADS-box domain-containing protein. (599 aa)
G7K_5792-t1Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (320 aa)
G7K_5517-t1Zn(2)-C6 fungal-type domain-containing protein. (962 aa)
G7K_5172-t1Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (295 aa)
G7K_5592-t1Zn(2)-C6 fungal-type domain-containing protein. (1109 aa)
G7K_5417-t1Zn(2)-C6 fungal-type domain-containing protein. (784 aa)
G7K_4896-t1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (868 aa)
G7K_5260-t1DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (349 aa)
G7K_5230-t1Zn(2)-C6 fungal-type domain-containing protein. (860 aa)
G7K_5220-t1Uncharacterized protein. (423 aa)
G7K_4699-t1Histone H3; Belongs to the histone H3 family. (137 aa)
G7K_5032-t1Homeobox domain-containing protein. (631 aa)
G7K_4818-t1Zn(2)-C6 fungal-type domain-containing protein. (740 aa)
G7K_4767-t1HMG box domain-containing protein. (679 aa)
G7K_4677-t1Fork-head domain-containing protein. (619 aa)
G7K_4299-t1Zn(2)-C6 fungal-type domain-containing protein. (898 aa)
G7K_4668-t1Fork-head domain-containing protein. (596 aa)
Your Current Organism:
Saitoella complicata
NCBI taxonomy Id: 698492
Other names: S. complicata NRRL Y-17804, Saitoella complicata CBS 7301, Saitoella complicata CCRC 22490, Saitoella complicata IAM 12963, Saitoella complicata JCM 7358, Saitoella complicata NBRC 10748, Saitoella complicata NRRL Y-17804
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