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rpmG rpmG nusG nusG rplK rplK rplA rplA rplJ rplJ rplL rplL rpoB rpoB rpoC rpoC SMB88803.1 SMB88803.1 rpsL rpsL rpsG rpsG fusA fusA tuf tuf rpsJ rpsJ rplC rplC rplD rplD rplW rplW rplB rplB rpsS rpsS rplV rplV rpsC rpsC rplP rplP rpmC rpmC rpsQ rpsQ rplN rplN rplX rplX rplE rplE rpsZ rpsZ rpsH rpsH rplF rplF rplR rplR rpsE rpsE rpmD rpmD rplO rplO secY secY adk adk map map SMB88929.1 SMB88929.1 infA infA rpsM rpsM rpsK rpsK rpsD rpsD rpoA rpoA rplQ rplQ rplM rplM rpsI rpsI rplY rplY tig tig rplU rplU rpmA rpmA rpsT rpsT rpsU rpsU rpoZ rpoZ rpmB rpmB rpmF rpmF rpsP rpsP rpsB rpsB tsf tsf nusA nusA rpsO rpsO SMB96726.1 SMB96726.1 SMB97884.1 SMB97884.1 ispH ispH efp efp rplT rplT rpmI rpmI infC infC rplI rplI rpsR rpsR rpsF rpsF rpmE rpmE rpmH rpmH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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rpmGLSU ribosomal protein L33P; InterPro IPR001705:IPR018264; COGs: COG0267 Ribosomal protein L33; KEGG: mta:Moth_2475 50S ribosomal protein L33P; SPTR: 50S ribosomal protein L33; PFAM: ribosomal protein L33; TIGRFAM: ribosomal protein L33; manually curated; Belongs to the bacterial ribosomal protein bL33 family. (49 aa)
nusGTranscription antitermination protein nusG; Participates in transcription elongation, termination and antitermination. (175 aa)
rplKLSU ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (141 aa)
rplALSU ribosomal protein L1P; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (233 aa)
rplJLSU ribosomal protein L10P; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (178 aa)
rplLLSU ribosomal protein L12P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (127 aa)
rpoBDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1150 aa)
rpoCDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1160 aa)
SMB88803.1LSU ribosomal protein L7AE; InterPro IPR000948:IPR004038; COGs: COG1358 Ribosomal protein HS6-type (S12/L30/L7a); KEGG: mta:Moth_2466 50S ribosomal protein L7AE; SPTR: LSU ribosomal protein L7AE; PFAM: ribosomal protein L7Ae/L30e/S12e/Gadd45. (83 aa)
rpsLSSU ribosomal protein S12P; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. (124 aa)
rpsGSSU ribosomal protein S7P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
fusATranslation elongation factor 2 (EF-2/EF-G); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. [...] (692 aa)
tufTranslation elongation factor 1A (EF-1A/EF-Tu); This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (400 aa)
rpsJSSU ribosomal protein S10P; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (103 aa)
rplCLSU ribosomal protein L3P; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (210 aa)
rplDLSU ribosomal protein L4P; Forms part of the polypeptide exit tunnel. (208 aa)
rplWLSU ribosomal protein L23P; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (96 aa)
rplBLSU ribosomal protein L2P; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (274 aa)
rpsSSSU ribosomal protein S19P; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (94 aa)
rplVLSU ribosomal protein L22P; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (112 aa)
rpsCSSU ribosomal protein S3P; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (231 aa)
rplPLSU ribosomal protein L16P; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (144 aa)
rpmCLSU ribosomal protein L29P; InterPro IPR001854:IPR018254; KEGG: mta:Moth_2452 50S ribosomal protein L29; SPTR: 50S ribosomal protein L29; PFAM: ribosomal protein L29; TIGRFAM: ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (70 aa)
rpsQSSU ribosomal protein S17P; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (84 aa)
rplNLSU ribosomal protein L14P; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rplXLSU ribosomal protein L24P; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. (108 aa)
rplELSU ribosomal protein L5P; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (182 aa)
rpsZSSU ribosomal protein S14P; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa)
rpsHSSU ribosomal protein S8P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (131 aa)
rplFLSU ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (187 aa)
rplRLSU ribosomal protein L18P; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (121 aa)
rpsESSU ribosomal protein S5P; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (168 aa)
rpmDLSU ribosomal protein L30P; InterPro IPR005996:IPR000517; COGs: COG1841 Ribosomal protein L30/L7E; KEGG: mta:Moth_2442 50S ribosomal protein L30P; SPTR: 50S ribosomal protein L30; PFAM: ribosomal protein L30; TIGRFAM: ribosomal protein L30. (62 aa)
rplOLSU ribosomal protein L15P; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (146 aa)
secYProtein translocase subunit secY/sec61 alpha; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (420 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa)
mapMethionine aminopeptidase, type I; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. (248 aa)
SMB88929.1KEGG: mta:Moth_2437 hypothetical protein; SPTR: Putative uncharacterized protein. (100 aa)
infABacterial translation initiation factor 1 (bIF-1); One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (72 aa)
rpsMSSU ribosomal protein S13P; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (124 aa)
rpsKSSU ribosomal protein S11P; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (129 aa)
rpsDSSU ribosomal protein S4P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (208 aa)
rpoADNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (313 aa)
rplQInterPro IPR000456; COGs: COG0203 Ribosomal protein L17; KEGG: mta:Moth_2430 50S ribosomal protein L17P; SPTR: 50S ribosomal protein L17; PFAM: ribosomal protein L17; TIGRFAM: ribosomal protein L17. (112 aa)
rplMLSU ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (144 aa)
rpsISSU ribosomal protein S9P; InterPro IPR020574:IPR000754; COGs: COG0103 Ribosomal protein S9; KEGG: mta:Moth_2424 SSU ribosomal protein S9P; SPTR: 30S ribosomal protein S9; PFAM: ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (130 aa)
rplYLSU ribosomal protein L25P; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (227 aa)
tigTrigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. (458 aa)
rplULSU ribosomal protein L21P; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (104 aa)
rpmALSU ribosomal protein L27P; InterPro IPR001684:IPR018261; COGs: COG0211 Ribosomal protein L27; KEGG: tte:TTE0915 50S ribosomal protein L27; SPTR: 50S ribosomal protein L27; PFAM: ribosomal protein L27; TIGRFAM: ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family. (93 aa)
rpsTSSU ribosomal protein S20P; Binds directly to 16S ribosomal RNA. (89 aa)
rpsUSSU ribosomal protein S21P; InterPro IPR001911:IPR018278; KEGG: mta:Moth_0590 30S ribosomal protein S21; SPTR: 30S ribosomal protein S21; PFAM: ribosomal protein S21; TIGRFAM: ribosomal protein S21; Belongs to the bacterial ribosomal protein bS21 family. (58 aa)
rpoZDNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (67 aa)
rpmBInterPro IPR001383; COGs: COG0227 Ribosomal protein L28; KEGG: mta:Moth_0920 50S ribosomal protein L28P; SPTR: 50S ribosomal protein L28; PFAM: ribosomal protein L28; TIGRFAM: ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family. (62 aa)
rpmFInterPro IPR002677; COGs: COG0333 Ribosomal protein L32; KEGG: ribosomal protein L32; SPTR: 50S ribosomal protein L32; PFAM: ribosomal L32p protein; TIGRFAM: ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family. (61 aa)
rpsPSSU ribosomal protein S16P; InterPro IPR000307:IPR020592; COGs: COG0228 Ribosomal protein S16; KEGG: mta:Moth_0967 SSU ribosomal protein S16P; PFAM: ribosomal protein S16; TIGRFAM: ribosomal protein S16; SPTR: 30S ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. (90 aa)
rpsBSSU ribosomal protein S2P; InterPro IPR018130:IPR005706:IPR001865; COGs: COG0052 Ribosomal protein S2; KEGG: mta:Moth_1032 SSU ribosomal protein S2P; SPTR: 30S ribosomal protein S2; PFAM: ribosomal protein S2; TIGRFAM: ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (237 aa)
tsfTranslation elongation factor Ts (EF-Ts); Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (202 aa)
nusANusA antitermination factor; Participates in both transcription termination and antitermination. (356 aa)
rpsOSSU ribosomal protein S15P; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (89 aa)
SMB96726.1InterPro IPR018483:IPR003029; COGs: COG0539 Ribosomal protein S1; KEGG: tte:TTE2040 ribosomal protein S1; SPTR: Ribosomal protein S1; PFAM: RNA binding S1 domain protein. (313 aa)
SMB97884.1Translation elongation factor 2 (EF-2/EF-G); InterProIPR000795:IPR004161:IPR005517:IPR000640:IPR 004540:IPR005225; COGs: COG0480 Translation elongation factors (GTPase); KEGG: mta:Moth_1142 elongation factor G; SPTR: Translation elongation factor 2 (EF-2/EF-G); PFAM: protein synthesis factor GTP-binding; elongation factor Tu domain 2 protein; elongation factor G domain IV; elongation factor G domain-containing protein; TIGRFAM: translation elongation factor G; small GTP-binding protein. (680 aa)
ispH4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (719 aa)
efpTranslation elongation factor P (EF-P); Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. (185 aa)
rplTLSU ribosomal protein L20P; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (121 aa)
rpmILSU ribosomal protein L35P; InterPro IPR018265:IPR001706:IPR021137; KEGG: mta:Moth_1757 50S ribosomal protein L35P; SPTR: 50S ribosomal protein L35; PFAM: Ribosomal protein L35; TIGRFAM: ribosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family. (65 aa)
infCBacterial translation initiation factor 3 (bIF-3); IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. (152 aa)
rplILSU ribosomal protein L9P; Binds to the 23S rRNA. (150 aa)
rpsRSSU ribosomal protein S18P; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (75 aa)
rpsFSSU ribosomal protein S6P; Binds together with S18 to 16S ribosomal RNA. (98 aa)
rpmELSU ribosomal protein L31P; Binds the 23S rRNA. (66 aa)
rpmHLSU ribosomal protein L34P; InterPro IPR020939:IPR000271; KEGG: mta:Moth_0001 50S ribosomal protein L34; SPTR: 50S ribosomal protein L34; PFAM: ribosomal protein L34; TIGRFAM: ribosomal protein L34; manually curated; Belongs to the bacterial ribosomal protein bL34 family. (44 aa)
Your Current Organism:
Thermanaeromonas toyohensis
NCBI taxonomy Id: 698762
Other names: T. toyohensis ToBE, Thermanaeromonas toyohensis DSM 14490, Thermanaeromonas toyohensis ToBE, Thermanaeromonas toyohensis str. ToBE, Thermanaeromonas toyohensis strain ToBE, Thermoanaerobacter sp. ToBE
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