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| | mnmE | tRNA modification GTPase trmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. (459 aa) |
| | cysS | cysteinyl-tRNA synthetase; InterPro IPR002308:IPR015803:IPR015273; COGs: COG0215 Cysteinyl-tRNA synthetase; KEGG: mta:Moth_2484 cysteinyl-tRNA synthetase; SPTR: Cysteinyl-tRNA synthetase; PFAM: Cysteinyl-tRNA synthetase class Ia; Cysteinyl-tRNA synthetase class Ia DALR; TIGRFAM: cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (489 aa) |
| | SMB88567.1 | 23S rRNA (guanosine2251-2'-O)-methyltransferase; InterPro IPR004441:IPR013123:IPR001537; COGs: COG0566 rRNA methylase; KEGG: mta:Moth_2481 RNA methyltransferase TrmH, group 3; SPTR: RNA methyltransferase TrmH, group 3; PFAM: tRNA/rRNA methyltransferase (SpoU); RNA 2-O ribose methyltransferase substrate binding; TIGRFAM: RNA methyltransferase, TrmH family, group 3; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (256 aa) |
| | SMB88572.1 | RNA polymerase, sigma 30 subunit, SigH; InterProIPR014218:IPR014284:IPR016371:IPR000792:IPR 000943:IPR007627:IPR013249; COGs: COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog; KEGG: mta:Moth_2479 RNA polymerase factor sigma-70; SPTR: RNA polymerase, sigma-24 subunit, ECF subfamily; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; TIGRFAM: RNA polymerase sigma-H factor; RNA polymerase sigma factor, sigma-70 family. (214 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (427 aa) |
| | rpmG | LSU ribosomal protein L33P; InterPro IPR001705:IPR018264; COGs: COG0267 Ribosomal protein L33; KEGG: mta:Moth_2475 50S ribosomal protein L33P; SPTR: 50S ribosomal protein L33; PFAM: ribosomal protein L33; TIGRFAM: ribosomal protein L33; manually curated; Belongs to the bacterial ribosomal protein bL33 family. (49 aa) |
| | nusG | Transcription antitermination protein nusG; Participates in transcription elongation, termination and antitermination. (175 aa) |
| | rplK | LSU ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (141 aa) |
| | rplA | LSU ribosomal protein L1P; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (233 aa) |
| | rplJ | LSU ribosomal protein L10P; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (178 aa) |
| | rplL | LSU ribosomal protein L12P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (127 aa) |
| | rpoB | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1150 aa) |
| | rpoC | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1160 aa) |
| | SMB88803.1 | LSU ribosomal protein L7AE; InterPro IPR000948:IPR004038; COGs: COG1358 Ribosomal protein HS6-type (S12/L30/L7a); KEGG: mta:Moth_2466 50S ribosomal protein L7AE; SPTR: LSU ribosomal protein L7AE; PFAM: ribosomal protein L7Ae/L30e/S12e/Gadd45. (83 aa) |
| | rpsL | SSU ribosomal protein S12P; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. (124 aa) |
| | rpsG | SSU ribosomal protein S7P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa) |
| | fusA | Translation elongation factor 2 (EF-2/EF-G); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. [...] (692 aa) |
| | tuf | Translation elongation factor 1A (EF-1A/EF-Tu); This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (400 aa) |
| | rpsJ | SSU ribosomal protein S10P; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (103 aa) |
| | rplC | LSU ribosomal protein L3P; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (210 aa) |
| | rplD | LSU ribosomal protein L4P; Forms part of the polypeptide exit tunnel. (208 aa) |
| | rplW | LSU ribosomal protein L23P; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (96 aa) |
| | rplB | LSU ribosomal protein L2P; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (274 aa) |
| | rpsS | SSU ribosomal protein S19P; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (94 aa) |
| | rplV | LSU ribosomal protein L22P; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (112 aa) |
| | rpsC | SSU ribosomal protein S3P; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (231 aa) |
| | rplP | LSU ribosomal protein L16P; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (144 aa) |
| | rpmC | LSU ribosomal protein L29P; InterPro IPR001854:IPR018254; KEGG: mta:Moth_2452 50S ribosomal protein L29; SPTR: 50S ribosomal protein L29; PFAM: ribosomal protein L29; TIGRFAM: ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (70 aa) |
| | rpsQ | SSU ribosomal protein S17P; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (84 aa) |
| | rplN | LSU ribosomal protein L14P; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa) |
| | rplX | LSU ribosomal protein L24P; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. (108 aa) |
| | rplE | LSU ribosomal protein L5P; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (182 aa) |
| | rpsZ | SSU ribosomal protein S14P; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa) |
| | rpsH | SSU ribosomal protein S8P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (131 aa) |
| | rplF | LSU ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (187 aa) |
| | rplR | LSU ribosomal protein L18P; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (121 aa) |
| | rpsE | SSU ribosomal protein S5P; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (168 aa) |
| | rpmD | LSU ribosomal protein L30P; InterPro IPR005996:IPR000517; COGs: COG1841 Ribosomal protein L30/L7E; KEGG: mta:Moth_2442 50S ribosomal protein L30P; SPTR: 50S ribosomal protein L30; PFAM: ribosomal protein L30; TIGRFAM: ribosomal protein L30. (62 aa) |
| | rplO | LSU ribosomal protein L15P; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (146 aa) |
| | SMB88929.1 | KEGG: mta:Moth_2437 hypothetical protein; SPTR: Putative uncharacterized protein. (100 aa) |
| | infA | Bacterial translation initiation factor 1 (bIF-1); One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (72 aa) |
| | rpsM | SSU ribosomal protein S13P; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (124 aa) |
| | rpsK | SSU ribosomal protein S11P; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (129 aa) |
| | rpsD | SSU ribosomal protein S4P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (208 aa) |
| | rpoA | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (313 aa) |
| | rplQ | InterPro IPR000456; COGs: COG0203 Ribosomal protein L17; KEGG: mta:Moth_2430 50S ribosomal protein L17P; SPTR: 50S ribosomal protein L17; PFAM: ribosomal protein L17; TIGRFAM: ribosomal protein L17. (112 aa) |
| | truA | tRNA pseudouridine38-40 synthase; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (246 aa) |
| | rplM | LSU ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (144 aa) |
| | rpsI | SSU ribosomal protein S9P; InterPro IPR020574:IPR000754; COGs: COG0103 Ribosomal protein S9; KEGG: mta:Moth_2424 SSU ribosomal protein S9P; SPTR: 30S ribosomal protein S9; PFAM: ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (130 aa) |
| | rlmH | 23S rRNA (pseudouridine1915-N3)-methyltransferase; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. (154 aa) |
| | fmt | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (309 aa) |
| | rsmI | 16S rRNA (cytidine1402-2'-O)-methyltransferase; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (276 aa) |
| | metG | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (640 aa) |
| | rsmA | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (295 aa) |
| | rplY | LSU ribosomal protein L25P; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (227 aa) |
| | pth | peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. (187 aa) |
| | SMB89506.1 | Sigma-70, region 4; InterPro IPR000792:IPR013249; KEGG: mta:Moth_0090 sigma-24 (FecI-like); SPTR: Sigma-24 (FecI-like); PFAM: Sigma-70 region 4 type 2. (74 aa) |
| | SMB89601.1 | RNA polymerase, sigma-24 subunit, RpoE; InterPro IPR014284:IPR000838:IPR007627:IPR013249; COGs: COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog; KEGG: mta:Moth_2362 sigma-24 (FecI-like); SPTR: RNA polymerase sigma factor; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; Belongs to the sigma-70 factor family. ECF subfamily. (208 aa) |
| | SMB89873.1 | RNA polymerase sigma-70 factor, ECF subfamily; InterPro IPR014284:IPR007627:IPR013249; COGs: COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog; KEGG: dau:Daud_2125 ECF subfamily RNA polymerase sigma-24 factor; SPTR: RNA polymerase sigma factor; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; TIGRFAM: RNA polymerase sigma factor, sigma-70 family. (227 aa) |
| | SMB90200.1 | Methyltransferase, FkbM family; InterPro IPR013216; KEGG: mta:Moth_1645 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Methyltransferase type 11. (295 aa) |
| | SMB90348.1 | NOL1/NOP2/sun family putative RNA methylase; InterPro IPR018314:IPR001678; COGs: COG0144 tRNA and rRNA cytosine-C5-methylase; KEGG: adg:Adeg_1267 Fmu (Sun) domain protein; SPTR: Fmu (Sun) domain protein; PFAM: Fmu (Sun) domain protein. (484 aa) |
| | SMB91049.1 | tRNA threonylcarbamoyladenosine biosynthesis protein TsaE; InterPro IPR003442; COGs: COG0802 ATPase or kinase; KEGG: mta:Moth_2160 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Uncharacterised protein family UPF0079, ATPase. (152 aa) |
| | SMB91055.1 | tRNA threonylcarbamoyladenosine biosynthesis protein TsaB; InterPro IPR000905; COGs: COG1214 Inactive homolog of metal-dependent protease putative molecular chaperone; KEGG: mta:Moth_2159 peptidase M22, glycoprotease; SPTR: Peptidase M22, glycoprotease; PFAM: peptidase M22 glycoprotease. (228 aa) |
| | SMB91061.1 | [SSU ribosomal protein S18P]-alanine acetyltransferase; Acetylates the N-terminal alanine of ribosomal protein S18. (148 aa) |
| | tsaD | O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (336 aa) |
| | SMB91152.1 | InterPro IPR002646:IPR006674:IPR006675; COGs: COG0617 tRNA nucleotidyltransferase/poly(A) polymerase; KEGG: tde:TDE1033 polyA polymerase family protein; SPTR: PolyA polymerase family protein; PFAM: Polynucleotide adenylyltransferase region; metal-dependent phosphohydrolase HD sub domain; TIGRFAM: metal dependent phophohydrolase. (457 aa) |
| | thiI | Thiamine biosynthesis protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (384 aa) |
| | SMB91526.1 | RNA polymerase, sigma 54 subunit, RpoN/SigL; InterPro IPR000394:IPR007046:IPR007634; COGs: COG1508 DNA-directed RNA polymerase specialized sigma subunit sigma54 homolog; KEGG: mta:Moth_0261 sigma-54 (RpoN); SPTR: Sigma-54 (RpoN); PFAM: sigma-54 DNA-binding domain protein; sigma-54 factor core-binding region; sigma-54 factor; TIGRFAM: RNA polymerase sigma-54 factor, RpoN. (465 aa) |
| | smpB | SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...] (154 aa) |
| | SMB91802.1 | TusA-related sulfurtransferase; KEGG: pai:PAE2602 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: SirA-like domain-containing protein; InterPro IPR013838:IPR001455; Belongs to the sulfur carrier protein TusA family. (84 aa) |
| | SMB91839.1 | Ribonuclease BN, tRNA processing enzyme; COGs: COG1234 Metal-dependent hydrolase of the beta-lactamase superfamily III; KEGG: metal-dependent hydrolase; SPTR: Putative uncharacterized protein. (244 aa) |
| | SMB92484.1 | Epoxyqueuosine reductase; Contains selenocysteine; InterPro IPR017896:IPR004155:IPR013542:IPR017900; COGs: COG1600 Uncharacterized Fe-S protein; KEGG: mta:Moth_0507 4Fe-4S ferredoxin, iron-sulfur binding; SPTR: 4Fe-4S ferredoxin, iron-sulfur binding; PFAM: domain of unknown function DUF1730; PBS lyase HEAT domain protein repeat-containing protein; manually curated. (366 aa) |
| | rph | RNAse PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (249 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (888 aa) |
| | hypA | Hydrogenase-3 nickel incorporation protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (113 aa) |
| | rplU | LSU ribosomal protein L21P; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (104 aa) |
| | rpmA | LSU ribosomal protein L27P; InterPro IPR001684:IPR018261; COGs: COG0211 Ribosomal protein L27; KEGG: tte:TTE0915 50S ribosomal protein L27; SPTR: 50S ribosomal protein L27; PFAM: ribosomal protein L27; TIGRFAM: ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family. (93 aa) |
| | leuS | leucyl-tRNA synthetase; InterPro IPR015413:IPR013155:IPR002302:IPR001412; COGs: COG0495 Leucyl-tRNA synthetase; KEGG: mta:Moth_0568 leucyl-tRNA synthetase; SPTR: Leucyl-tRNA synthetase; PFAM: tRNA synthetase valyl/leucyl anticodon-binding; tRNA synthetase class I (M); TIGRFAM: leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (831 aa) |
| | rpsT | SSU ribosomal protein S20P; Binds directly to 16S ribosomal RNA. (89 aa) |
| | lepA | GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (599 aa) |
| | SMB92920.1 | 16S rRNA (uracil1498-N3)-methyltransferase; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. (252 aa) |
| | SMB92931.1 | Threonylcarbamoyladenosine tRNA methylthiotransferase MtaB; InterProIPR002792:IPR013848:IPR006638:IPR007197:IPR 005839:IPR006467:IPR020612; COGs: COG0621 2-methylthioadenine synthetase; KEGG: mta:Moth_0588 MiaB-like tRNA modifying enzyme; SPTR: MiaB-like tRNA modifying enzyme; SMART: Elongator protein 3/MiaB/NifB; PFAM: protein of unknown function UPF0004; Radical SAM domain protein; deoxyribonuclease/rho motif-related TRAM; TIGRFAM: RNA modification enzyme, MiaB family; MiaB-like tRNA modifying enzyme. (434 aa) |
| | rpsU | SSU ribosomal protein S21P; InterPro IPR001911:IPR018278; KEGG: mta:Moth_0590 30S ribosomal protein S21; SPTR: 30S ribosomal protein S21; PFAM: ribosomal protein S21; TIGRFAM: ribosomal protein S21; Belongs to the bacterial ribosomal protein bS21 family. (58 aa) |
| | ybeY | Probable rRNA maturation factor; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (156 aa) |
| | glyQ | InterPro IPR006194:IPR002310; COGs: COG0752 Glycyl-tRNA synthetase alpha subunit; KEGG: mta:Moth_0603 glycyl-tRNA synthetase subunit alpha; SPTR: Glycyl-tRNA synthetase alpha subunit; PFAM: glycyl-tRNA synthetase alpha subunit; PRIAM: Glycine--tRNA ligase; TIGRFAM: glycyl-tRNA synthetase, alpha subunit. (331 aa) |
| | rpmH | LSU ribosomal protein L34P; InterPro IPR020939:IPR000271; KEGG: mta:Moth_0001 50S ribosomal protein L34; SPTR: 50S ribosomal protein L34; PFAM: ribosomal protein L34; TIGRFAM: ribosomal protein L34; manually curated; Belongs to the bacterial ribosomal protein bL34 family. (44 aa) |
| | glyS | glycyl-tRNA synthetase beta chain; InterPro IPR006194:IPR015944:IPR002311:IPR008909; COGs: COG0751 Glycyl-tRNA synthetase beta subunit; KEGG: mta:Moth_0604 glycyl-tRNA synthetase, beta subunit; SPTR: Glycyl-tRNA synthetase beta subunit; PFAM: glycyl-tRNA synthetase beta subunit; DALR anticodon binding domain protein; PRIAM: Glycine--tRNA ligase; TIGRFAM: glycyl-tRNA synthetase, beta subunit. (696 aa) |
| | sigA | RNA polymerase primary sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (363 aa) |
| | hypA-2 | Hydrogenase nickel incorporation protein HypA/HybF; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (116 aa) |
| | SMB93127.1 | Hydrogenase nickel incorporation protein HypB; InterPro IPR012202:IPR003495:IPR004392; COGs: COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; KEGG: mta:Moth_2180 hydrogenase accessory protein HypB; SPTR: Hydrogenase accessory protein HypB; PFAM: cobalamin synthesis protein P47K; TIGRFAM: hydrogenase accessory protein HypB. (224 aa) |
| | SMB93130.1 | tRNA (adenine22-N1)-methyltransferase; InterPro IPR006901:IPR000408; COGs: COG2384 SAM-dependent methyltransferase; KEGG: mta:Moth_0625 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: protein of unknown function DUF633. (242 aa) |
| | SMB93488.1 | tRNA pseudouridine13 synthase; InterPro IPR011760:IPR001656; COGs: COG0585 conserved hypothetical protein; KEGG: mta:Moth_1745 pseudouridylate synthase; SPTR: Pseudouridylate synthase; PFAM: tRNA pseudouridine synthase D TruD. (388 aa) |
| | SMB93515.1 | TusA-related sulfurtransferase; InterPro IPR001455; KEGG: mta:Moth_0447 SirA-like; SPTR: SirA-like; PFAM: SirA-like domain-containing protein; Belongs to the sulfur carrier protein TusA family. (75 aa) |
| | SMB94093.1 | RNA polymerase, sigma 28 subunit, SigD/FliA/WhiG; InterProIPR014284:IPR012845:IPR007627:IPR007624:IPR 007630:IPR000943; COGs: COG1191 DNA-directed RNA polymerase specialized sigma subunit; KEGG: mta:Moth_0794 sigma 28 (flagella/sporulation); SPTR: RNA polymerase sigma factor; PFAM: sigma-70 region 4 domain protein; sigma-70 region 2 domain protein; sigma-70 region 3 domain protein; TIGRFAM: RNA polymerase sigma factor, FliA/WhiG family; RNA polymerase sigma factor, sigma-70 family. (252 aa) |
| | SMB94227.1 | InterPro IPR013027:IPR001327; KEGG: mta:Moth_0819 glucose-inhibited division protein A; SPTR: Glucose-inhibited division protein A; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase. (427 aa) |
| | rsmH | 16S rRNA (cytosine1402-N4)-methyltransferase; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (302 aa) |
| | SMB94389.1 | RNA polymerase, sigma 29 subunit, SigE; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (241 aa) |
| | SMB94393.1 | RNA polymerase, sigma subunit, RpsG/SigG; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (257 aa) |
| | ileS | Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (940 aa) |
| | SMB94463.1 | Ribosomal large subunit pseudouridine synthase D; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (304 aa) |
| | pyrR | Pyrimidine operon attenuation protein / uracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. (185 aa) |
| | SMB94539.1 | InterPro IPR008616:IPR008532; COGs: COG1293 RNA-binding protein homologous to eukaryotic snRNP; KEGG: mta:Moth_0886 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Fibronectin-binding A domain protein; protein of unknown function DUF814. (602 aa) |
| | SMB94566.1 | TIGR00255 family protein; InterPro IPR005229:IPR013527:IPR013551; COGs: COG1561 Uncharacterized stress-induced protein; KEGG: mta:Moth_0890 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: YicC-like domain-containing protein; domain of unknown function DUF1732. (293 aa) |
| | rnpA | Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (122 aa) |
| | rpoZ | DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (67 aa) |
| | def | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (155 aa) |
| | fmt-2 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (314 aa) |
| | SMB94623.1 | 16S rRNA (cytosine967-C5)-methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. (452 aa) |
| | rlmN | 23S rRNA (adenine2503-C2)-methyltransferase; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (380 aa) |
| | rpmB | InterPro IPR001383; COGs: COG0227 Ribosomal protein L28; KEGG: mta:Moth_0920 50S ribosomal protein L28P; SPTR: 50S ribosomal protein L28; PFAM: ribosomal protein L28; TIGRFAM: ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family. (62 aa) |
| | SMB94763.1 | 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD; InterPro IPR004398:IPR002052; COGs: COG0742 N6-adenine-specific methylase; KEGG: adg:Adeg_0116 methyltransferase; SPTR: Methyltransferase; PFAM: Conserved hypothetical protein CHP00095; TIGRFAM: methyltransferase. (186 aa) |
| | rpmF | InterPro IPR002677; COGs: COG0333 Ribosomal protein L32; KEGG: ribosomal protein L32; SPTR: 50S ribosomal protein L32; PFAM: ribosomal L32p protein; TIGRFAM: ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family. (61 aa) |
| | rnc | RNAse III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. (236 aa) |
| | lipB | Lipoyl(octanoyl) transferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (213 aa) |
| | rpsP | SSU ribosomal protein S16P; InterPro IPR000307:IPR020592; COGs: COG0228 Ribosomal protein S16; KEGG: mta:Moth_0967 SSU ribosomal protein S16P; PFAM: ribosomal protein S16; TIGRFAM: ribosomal protein S16; SPTR: 30S ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. (90 aa) |
| | rimM | 16S rRNA processing protein RimM; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. (170 aa) |
| | trmD | tRNA (Guanine37-N(1)-) methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. (249 aa) |
| | rplS | LSU ribosomal protein L19P; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (113 aa) |
| | SMB95341.1 | Signal peptidase I Serine peptidase. MEROPS family S26A; InterPro IPR000223:IPR019759:IPR019758; COGs: COG0681 Signal peptidase I; KEGG: mta:Moth_0972 signal peptidase I; SPTR: Signal peptidase I. Serine peptidase. MEROPS family S26A; PFAM: Peptidase S24/S26A/S26B, conserved region; PRIAM: Signal peptidase I; TIGRFAM: signal peptidase I; Belongs to the peptidase S26 family. (185 aa) |
| | SMB95424.1 | Ribonuclease J; InterPro IPR011108; COGs: COG0595 hydrolase of the metallo-beta-lactamase superfamily; KEGG: dau:Daud_0808 beta-lactamase domain-containing protein; SPTR: Beta-lactamase domain protein; PFAM: RNA-metabolising metallo-beta-lactamase. (522 aa) |
| | trmFO | methylenetetrahydrofolate--tRNA-(uracil-5-)- methyltransferase; Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs; Belongs to the MnmG family. TrmFO subfamily. (438 aa) |
| | rpsB | SSU ribosomal protein S2P; InterPro IPR018130:IPR005706:IPR001865; COGs: COG0052 Ribosomal protein S2; KEGG: mta:Moth_1032 SSU ribosomal protein S2P; SPTR: 30S ribosomal protein S2; PFAM: ribosomal protein S2; TIGRFAM: ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (237 aa) |
| | tsf | Translation elongation factor Ts (EF-Ts); Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (202 aa) |
| | frr | Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. (185 aa) |
| | proS | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (577 aa) |
| | nusA | NusA antitermination factor; Participates in both transcription termination and antitermination. (356 aa) |
| | infB | Bacterial translation initiation factor 2 (bIF-2); One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (867 aa) |
| | rbfA | Ribosome-binding factor A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. (115 aa) |
| | truB | tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. (308 aa) |
| | rpsO | SSU ribosomal protein S15P; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (89 aa) |
| | pnp | Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (739 aa) |
| | rnj | Ribonuclease J; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. (554 aa) |
| | SMB96187.1 | Ribonuclease BN, tRNA processing enzyme; COGs: COG1234 Metal-dependent hydrolase of the beta-lactamase superfamily III; KEGG: adg:Adeg_0700 beta-lactamase domain protein; SPTR: Beta-lactamase domain protein. (275 aa) |
| | rnc-2 | RNAse III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. (250 aa) |
| | SMB96648.1 | Sigma-70 region 2; InterPro IPR007627; KEGG: aac:Aaci_1081 RNA polymerase, sigma 28 subunit, FliA/WhiG subfamily; SPTR: RNA polymerase, sigma 28 subunit, FliA/WhiG subfamily; PFAM: sigma-70 region 2 domain protein; Belongs to the sigma-70 factor family. (159 aa) |
| | SMB96695.1 | RNA polymerase, sigma-24 subunit, RpoE; InterPro IPR000838:IPR014284:IPR007627:IPR013249; COGs: COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog; SPTR: RNA polymerase sigma factor; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; KEGG: mta:Moth_2362 sigma-24 (FecI-like); Belongs to the sigma-70 factor family. ECF subfamily. (207 aa) |
| | SMB96726.1 | InterPro IPR018483:IPR003029; COGs: COG0539 Ribosomal protein S1; KEGG: tte:TTE2040 ribosomal protein S1; SPTR: Ribosomal protein S1; PFAM: RNA binding S1 domain protein. (313 aa) |
| | rimO | SSU ribosomal protein S12P methylthiotransferase; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (446 aa) |
| | miaB | tRNA-i(6)A37 thiotransferase enzyme MiaB; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (439 aa) |
| | miaA | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (325 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (483 aa) |
| | SMB97884.1 | Translation elongation factor 2 (EF-2/EF-G); InterProIPR000795:IPR004161:IPR005517:IPR000640:IPR 004540:IPR005225; COGs: COG0480 Translation elongation factors (GTPase); KEGG: mta:Moth_1142 elongation factor G; SPTR: Translation elongation factor 2 (EF-2/EF-G); PFAM: protein synthesis factor GTP-binding; elongation factor Tu domain 2 protein; elongation factor G domain IV; elongation factor G domain-containing protein; TIGRFAM: translation elongation factor G; small GTP-binding protein. (680 aa) |
| | SMB97990.1 | Hypothetical protein; KEGG: eck:EC55989_3265 helicase; SPTR: Helicase. (108 aa) |
| | SMB97998.1 | Phosphoribosyl 1,2-cyclic phosphodiesterase; COGs: COG1235 Metal-dependent hydrolase of the beta-lactamase superfamily I; KEGG: amt:Amet_2603 hypothetical protein; SPTR: Gp51. (238 aa) |
| | SMB98109.1 | TIGR00269 family protein; InterPro IPR012089:IPR011063; COGs: COG0037 ATPase of the PP-loop superfamily protein implicated in cell cycle control; KEGG: PP-loop domain protein; SPTR: PP-loop domain protein; PFAM: PP-loop domain protein; Belongs to the TtcA family. (302 aa) |
| | SMB98364.1 | Ribosomal large subunit pseudouridine synthase B; InterPro IPR000748:IPR002942:IPR006145:IPR018496; COGs: COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthase; KEGG: mta:Moth_1352 ribosomal large subunit pseudouridine synthase B; SPTR: Pseudouridine synthase; SMART: RNA-binding S4 domain protein; PFAM: pseudouridine synthase; RNA-binding S4 domain protein; Belongs to the pseudouridine synthase RsuA family. (241 aa) |
| | SMB98381.1 | Lipoate-protein ligase A; InterPro IPR004143:IPR002829; COGs: COG0095 Lipoate-protein ligase A; KEGG: mta:Moth_0443 biotin/lipoate A/B protein ligase; SPTR: Biotin/lipoate A/B protein ligase; PFAM: protein of unknown function DUF116; biotin/lipoate A/B protein ligase. (528 aa) |
| | SMB98450.1 | tryptophanyl-tRNA synthetase; InterPro IPR002306:IPR002305:IPR001412; COGs: COG0180 Tryptophanyl-tRNA synthetase; KEGG: tryptophanyl-tRNA synthetase; SPTR: Tryptophanyl-tRNA synthetase; PFAM: aminoacyl-tRNA synthetase class Ib; PRIAM: Tryptophan--tRNA ligase; TIGRFAM: tryptophanyl-tRNA synthetase. (329 aa) |
| | SMB98535.1 | RNA polymerase, sigma subunit, RpoX/SigF; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (255 aa) |
| | SMB98574.1 | N6-L-threonylcarbamoyladenine synthase; InterPro IPR000905:IPR017861; COGs: COG0533 Metal-dependent protease with possible chaperone activity; KEGG: mta:Moth_1520 O-sialoglycoprotein endopeptidase; SPTR: O-sialoglycoprotein endopeptidase; PFAM: peptidase M22 glycoprotease. (317 aa) |
| | nusB | NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (140 aa) |
| | efp | Translation elongation factor P (EF-P); Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. (185 aa) |
| | SMB98631.1 | InterPro IPR007630:IPR000943; KEGG: RNA polymerase, sigma 28 subunit, FliA/WhiG subfamily; SPTR: RNA polymerase sigma factor; PFAM: sigma-70 region 4 domain protein; COGs: COG1191 DNA-directed RNA polymerase specialized sigma subunit. (183 aa) |
| | SMB98664.1 | InterPro IPR000943:IPR007627; KEGG: mta:Moth_1582 sporulation sigma factor SigK; SPTR: RNA polymerase sigma factor; PFAM: sigma-70 region 2 domain protein; COGs: COG1191 DNA-directed RNA polymerase specialized sigma subunit. (116 aa) |
| | SMB98690.1 | tRNA 2-thiouridine synthesizing protein E; KEGG: mta:Moth_1631 putative sulfite reductase subunit protein; SPTR: Putative sulfite reductase subunit protein. (84 aa) |
| | SMB98691.1 | tRNA 2-thiouridine synthesizing protein E; InterPro IPR007453; COGs: COG2920 Dissimilatory sulfite reductase (desulfoviridin) gamma subunit; KEGG: mta:Moth_1632 DsrC-like protein; SPTR: DsrC-like protein; PFAM: DsrC family protein; TIGRFAM: sulfur relay protein, TusE/DsrC/DsvC family. (105 aa) |
| | SMB98709.1 | Sulfurtransferase TusA; InterPro IPR001455; KEGG: SirA family protein; SPTR: Similar to response regulator sirA; PFAM: SirA-like domain-containing protein; Belongs to the sulfur carrier protein TusA family. (79 aa) |
| | SMB98717.1 | Putative holliday junction resolvase; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. (141 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (889 aa) |
| | SMB98739.1 | STE24 endopeptidase; InterPro IPR001202:IPR001915; COGs: COG0501 Zn-dependent protease with chaperone function; KEGG: mta:Moth_1231 STE24 endopeptidase; SPTR: Ste24 endopeptidase; PFAM: peptidase M48 Ste24p; PRIAM: Ste24 endopeptidase. (420 aa) |
| | mnmA | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (371 aa) |
| | aspS | aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (606 aa) |
| | hisS | histidyl-tRNA synthetase; InterProIPR006195:IPR015807:IPR004516:IPR002314:IPR 004154; COGs: COG0124 Histidyl-tRNA synthetase; KEGG: mta:Moth_1677 histidyl-tRNA synthetase; SPTR: Histidyl-tRNA synthetase; PFAM: tRNA synthetase class II (G H P and S); Anticodon-binding domain protein; PRIAM: Histidine--tRNA ligase; TIGRFAM: histidyl-tRNA synthetase. (423 aa) |
| | tgt | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] (378 aa) |
| | sigI | RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; Belongs to the sigma-70 factor family. SigI subfamily. (237 aa) |
| | hypA-3 | Hydrogenase nickel incorporation protein HypA/HybF; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (120 aa) |
| | SMB98889.1 | Hydrogenase nickel incorporation protein HypB; InterPro IPR004827:IPR004392:IPR012202:IPR003495; COGs: COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; KEGG: dau:Daud_1648 hydrogenase accessory protein HypB; SPTR: Hydrogenase accessory protein HypB; PFAM: cobalamin synthesis protein P47K; TIGRFAM: hydrogenase accessory protein HypB. (230 aa) |
| | SMB98891.1 | Hydrogenase expression/formation protein HypC; InterPro IPR019812:IPR001109; COGs: COG0298 Hydrogenase maturation factor; KEGG: adg:Adeg_2008 hydrogenase assembly chaperone HypC/HupF; SPTR: Hydrogenase assembly chaperone hypC/hupF; PFAM: hydrogenase expression/formation protein (HUPF/HYPC); TIGRFAM: hydrogenase assembly chaperone hypC/hupF. (79 aa) |
| | SMB98892.1 | Hydrogenase expression/formation protein HypD; InterPro IPR002780; COGs: COG0409 Hydrogenase maturation factor; KEGG: adg:Adeg_2007 hydrogenase formation HypD protein; SPTR: Hydrogenase formation HypD protein; PFAM: hydrogenase formation HypD protein; TIGRFAM: hydrogenase expression/formation protein HypD. (369 aa) |
| | SMB98893.1 | Hydrogenase maturation protein, carbamoyl dehydratase HypE; InterPro IPR011854:IPR000728:IPR010918; COGs: COG0309 Hydrogenase maturation factor; KEGG: adg:Adeg_2006 hydrogenase expression/formation protein HypE; SPTR: Hydrogenase expression/formation protein HypE; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; TIGRFAM: hydrogenase expression/formation protein HypE. (343 aa) |
| | tyrS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. (404 aa) |
| | SMB98943.1 | Protein of unknown function; KEGG: mta:Moth_1855 hypothetical protein; SPTR: Putative uncharacterized protein. (143 aa) |
| | pheT | phenylalanyl-tRNA synthetase beta subunit; InterProIPR002547:IPR005121:IPR004532:IPR005146:IPR 005147; COGs: COG0072 Phenylalanyl-tRNA synthetase beta subunit; KEGG: mta:Moth_1750 phenylalanyl-tRNA synthetase beta subunit; SPTR: Phenylalanyl-tRNA synthetase beta chain; PFAM: B3/4 domain protein; t-RNA-binding domain-containing protein; tRNA synthetase B5; ferredoxin-fold anticodon-binding; PRIAM: Phenylalanine--tRNA ligase; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit. (807 aa) |
| | pheS | phenylalanyl-tRNA synthetase, alpha subunit; InterPro IPR006195:IPR004529:IPR004188:IPR002319; COGs: COG0016 Phenylalanyl-tRNA synthetase alpha subunit; KEGG: mta:Moth_1751 phenylalanyl-tRNA synthetase, alpha subunit; SPTR: Phenylalanyl-tRNA synthetase alpha chain; PFAM: phenylalanyl-tRNA synthetase class IIc; aminoacyl tRNA synthetase class II domain protein; TIGRFAM: phenylalanyl-tRNA synthetase, alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (342 aa) |
| | SMB98964.1 | RNA methyltransferase, TrmH family; InterPro IPR013123:IPR001537; COGs: COG0566 rRNA methylase; KEGG: mta:Moth_1753 tRNA/rRNA methyltransferase (SpoU); SPTR: tRNA/rRNA methyltransferase (SpoU); PFAM: tRNA/rRNA methyltransferase (SpoU); RNA 2-O ribose methyltransferase substrate binding; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (256 aa) |
| | rplT | LSU ribosomal protein L20P; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (121 aa) |
| | rpmI | LSU ribosomal protein L35P; InterPro IPR018265:IPR001706:IPR021137; KEGG: mta:Moth_1757 50S ribosomal protein L35P; SPTR: 50S ribosomal protein L35; PFAM: Ribosomal protein L35; TIGRFAM: ribosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family. (65 aa) |
| | infC | Bacterial translation initiation factor 3 (bIF-3); IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. (152 aa) |
| | thrS | threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). (634 aa) |
| | lipA | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (287 aa) |
| | SMB99009.1 | tRNA (adenine57-N1/adenine58-N1)-methyltransferase; Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA. (257 aa) |
| | rtcB | tRNA-splicing ligase RtcB; InterPro IPR001233; COGs: COG1690 conserved hypothetical protein; KEGG: protein of unknown function UPF0027; SPTR: Putative uncharacterized protein; PFAM: protein of unknown function UPF0027; Belongs to the RtcB family. (478 aa) |
| | SMB99154.1 | InterPro IPR000824; KEGG: mta:Moth_1870 transcription attenuation protein MtrB; SPTR: Tryptophan RNA-binding attenuator protein; PFAM: tryptophan RNA-binding attenuator protein. (76 aa) |
| | SMB99244.1 | tRNA (cytidine/uridine-2'-O-)-methyltransferase; Could methylate the ribose at the nucleotide 34 wobble position in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily. (154 aa) |
| | SMB99268.1 | Hypothetical protein; InterPro IPR003675; KEGG: mta:Moth_1913 abortive infection protein; SPTR: Abortive infection protein; PFAM: Abortive infection protein. (235 aa) |
| | SMB99274.1 | COGs: COG3330 conserved hypothetical protein; KEGG: mta:Moth_1914 hypothetical protein; SPTR: Putative uncharacterized protein. (198 aa) |
| | SMB99331.1 | COGs: COG1600 Uncharacterized Fe-S protein; KEGG: dau:Daud_0137 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein; SPTR: 4Fe-4S ferredoxin, iron-sulfur binding domain protein. (268 aa) |
| | SMB99366.1 | RNA polymerase sigma-70 factor, ECF subfamily; InterPro IPR000838:IPR007627:IPR013249:IPR014284; COGs: COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog; KEGG: sth:STH907 RNA polymerase factor sigma C; SPTR: RNA polymerase sigma factor; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; Belongs to the sigma-70 factor family. ECF subfamily. (181 aa) |
| | SMB99441.1 | Lipoate-protein ligase A; InterPro IPR004143; COGs: COG0095 Lipoate-protein ligase A; KEGG: mta:Moth_1939 biotin/lipoate A/B protein ligase; SPTR: Biotin/lipoate A/B protein ligase; PFAM: biotin/lipoate A/B protein ligase. (272 aa) |
| | SMB99540.1 | Acylphosphatase; InterPro IPR017968:IPR001792:IPR020456; COGs: COG1254 Acylphosphatase; KEGG: mta:Moth_1216 acylphosphatase; SPTR: Acylphosphatase; PFAM: acylphosphatase. (93 aa) |
| | gatB | aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (476 aa) |
| | gatA | aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (484 aa) |
| | gatC | aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (94 aa) |
| | SMB99652.1 | tRNA 2-thiouridine synthesizing protein A; InterPro IPR001455; KEGG: mta:Moth_1439 SirA-like; SPTR: SirA-like; PFAM: SirA-like domain-containing protein; Belongs to the sulfur carrier protein TusA family. (72 aa) |
| | SMB99894.1 | TusA-related sulfurtransferase; InterPro IPR001455; KEGG: fpl:Ferp_2460 SirA family protein; SPTR: SirA family protein; PFAM: SirA-like domain-containing protein; Belongs to the sulfur carrier protein TusA family. (80 aa) |
| | lysS | lysyl-tRNA synthetase, class II; InterProIPR004365:IPR004364:IPR018149:IPR006195:IPR 002313; COGs: COG1190 Lysyl-tRNA synthetase (class II); KEGG: mta:Moth_0152 lysyl-tRNA synthetase; SPTR: Lysyl-tRNA synthetase; PFAM: tRNA synthetase class II (D K and N); nucleic acid binding OB-fold tRNA/helicase-type; TIGRFAM: lysyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (487 aa) |
| | SMB99981.1 | tRNA-U20-dihydrouridine synthase; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (334 aa) |
| | birA | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. (328 aa) |
| | SMB99987.1 | tRNA(Ile)-lysidine synthase TilS/MesJ; InterPro IPR011063:IPR012089; COGs: COG0037 ATPase of the PP-loop superfamily protein implicated in cell cycle control; KEGG: pth:PTH_2665 ATPase; SPTR: Predicted ATPase; PFAM: PP-loop domain protein; Belongs to the TtcA family. (251 aa) |
| | rplI | LSU ribosomal protein L9P; Binds to the 23S rRNA. (150 aa) |
| | rpsR | SSU ribosomal protein S18P; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (75 aa) |
| | rpsF | SSU ribosomal protein S6P; Binds together with S18 to 16S ribosomal RNA. (98 aa) |
| | SMC00042.1 | Selenium metabolism protein YedF; InterPro IPR001455:IPR019870; KEGG: mta:Moth_0124 SirA-like; SPTR: SirA-like; PFAM: SirA-like domain-containing protein; TIGRFAM: selenium metabolism protein YedF; Belongs to the sulfur carrier protein TusA family. (193 aa) |
| | SMC00060.1 | 23S rRNA (uracil1939-C5)-methyltransferase; InterPro IPR010280:IPR002792:IPR007848:IPR001566; COGs: COG2265 SAM-dependent methyltransferase related to tRNA (uracil-5-)-methyltransferase; KEGG: afn:Acfer_1736 RNA methyltransferase, TrmA family; PFAM: deoxyribonuclease/rho motif-related TRAM; methyltransferase small; TIGRFAM: RNA methyltransferase, TrmA family; SPTR: RNA methyltransferase, TrmA family; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (444 aa) |
| | tilS | tRNA(Ile)-lysidine synthase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (461 aa) |
| | SMC00113.1 | Translation factor SUA5; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. (356 aa) |
| | prfA | Bacterial peptide chain release factor 1 (bRF-1); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (355 aa) |
| | rpmE | LSU ribosomal protein L31P; Binds the 23S rRNA. (66 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (500 aa) |
| | argS | arginyl-tRNA synthetase; InterProIPR001412:IPR005148:IPR015945:IPR008909:IPR 001278; COGs: COG0018 Arginyl-tRNA synthetase; KEGG: mta:Moth_2410 arginyl-tRNA synthetase; SPTR: Arginyl-tRNA synthetase; PFAM: Arginyl-tRNA synthetase, class Ic, core; arginyl tRNA synthetase domain protein; DALR anticodon binding domain protein; PRIAM: Arginine--tRNA ligase; TIGRFAM: arginyl-tRNA synthetase. (560 aa) |
| | SMC00150.1 | Selenocysteine-specific translation elongation factor SelB; InterProIPR000795:IPR004161:IPR015190:IPR015191:IPR 005225:IPR004535; COGs: COG3276 Selenocysteine-specific translation elongation factor; KEGG: mta:Moth_2503 selenocysteine-specific translation elongation factor SelB; SPTR: Selenocysteine-specific translation elongation factor SelB; PFAM: protein synthesis factor GTP-binding; elongation factor Tu domain 2 protein; Elongation factor SelB winged helix 2; Elongation factor SelB winged helix 3; TIGRFAM: selenocysteine-specific translation elongation factor; small GTP-binding protein. (639 aa) |
| | selA | L-seryl-tRNA(Sec) selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. (467 aa) |
| | larC | Hypothetical protein; Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes. Belongs to the LarC family. (414 aa) |
| | rsmG | 16S rRNA (guanine527-N7)-methyltransferase; Specifically methylates the N7 position of a guanine in 16S rRNA; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family. (242 aa) |
| | mnmG | tRNA uridine 5-carboxymethylaminomethyl modification enzyme; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34; Belongs to the MnmG family. (633 aa) |
