STRINGSTRING
kbl kbl phnW phnW ADO46521.1 ADO46521.1 arnB arnB ADO46563.1 ADO46563.1 argD argD ADO46831.1 ADO46831.1 patA patA ADO46918.1 ADO46918.1 ADO47017.1 ADO47017.1 ADO47055.1 ADO47055.1 gcvP gcvP ADO47189.1 ADO47189.1 ADO47343.1 ADO47343.1 ADO47463.1 ADO47463.1 glyA glyA iscS iscS ADO47625.1 ADO47625.1 ADO47700.1 ADO47700.1 hisC hisC ADO47994.1 ADO47994.1 ADO48285.1 ADO48285.1 sufS sufS ADO48462.1 ADO48462.1 ADO48480.1 ADO48480.1 ADO48640.1 ADO48640.1 tnaA tnaA argD-2 argD-2 ADO49105.1 ADO49105.1 serC serC ADO49167.1 ADO49167.1 bioF bioF bioA bioA ADO49370.1 ADO49370.1 ADO49432.1 ADO49432.1 ADO49763.1 ADO49763.1 ADO49792.1 ADO49792.1 hemL hemL ADO50048.1 ADO50048.1 ADO50285.1 ADO50285.1 ADO50349.1 ADO50349.1 wecE wecE ADO50565.1 ADO50565.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
kbl2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (398 aa)
phnW2-aminoethylphosphonate/pyruvate transaminase; Involved in phosphonate degradation; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily. (367 aa)
ADO46521.12,4-diaminobutyrate 4-transaminase; KEGG: pct:PC1_2060 diaminobutyrate--2-oxoglutarate aminotransferase; TIGRFAM: 2,4-diaminobutyrate 4-transaminase; PFAM: aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (460 aa)
arnBDegT/DnrJ/EryC1/StrS aminotransferase; Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily. (379 aa)
ADO46563.1KEGG: ent:Ent638_3864 4-aminobutyrate aminotransferase; TIGRFAM: 4-aminobutyrate aminotransferase; PFAM: aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (421 aa)
argDSuccinylornithine transaminase family; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (407 aa)
ADO46831.1PFAM: aminotransferase class I and II; KEGG: cko:CKO_04539 hypothetical protein. (392 aa)
patAPutrescine aminotransferase; Catalyzes the aminotransferase reaction from putrescine to 2- oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. This is the first step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate (gamma-aminobutyrate or GABA) via 4- aminobutanal. Also functions as a cadaverine transaminase in a a L- lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. (459 aa)
ADO46918.1PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: enc:ECL_02361 cystathionine gamma-lyase. (382 aa)
ADO47017.1KEGG: cko:CKO_04402 cystathionine beta-lyase; TIGRFAM: cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. (395 aa)
ADO47055.1KEGG: enc:ECL_04303 ornithine decarboxylase; PFAM: Orn/Lys/Arg decarboxylase major region; Orn/Lys/Arg decarboxylase domain protein. (711 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (957 aa)
ADO47189.1PFAM: aminotransferase class V; KEGG: enc:ECL_04136 cysteine sulfinate desulfinase. (401 aa)
ADO47343.1PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: ect:ECIAI39_2453 cystathionine gamma-synthase (CGS) (O-succinylhomoserine (thiol)-lyase). (408 aa)
ADO47463.1KEGG: kva:Kvar_3879 lysine decarboxylase; PFAM: Orn/Lys/Arg decarboxylase major region; Orn/Lys/Arg decarboxylase domain protein. (714 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
iscSCysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. (404 aa)
ADO47625.1PFAM: aminotransferase class I and II; KEGG: enc:ECL_03723 aminotransferase. (401 aa)
ADO47700.1PFAM: aminotransferase class I and II; KEGG: enc:ECL_03634 putative aminotransferase. (404 aa)
hisCKEGG: ent:Ent638_2633 histidinol-phosphate aminotransferase; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (353 aa)
ADO47994.1KEGG: xne:XNC1_1146 threonine-phosphate decarboxylase (L-threonine-O-3-phosphate decarboxylase); TIGRFAM: L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II. (370 aa)
ADO48285.1KEGG: pmr:PMI0626 cystathionine beta-lyase; TIGRFAM: cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. (390 aa)
sufSCysteine desulfurase, SufS subfamily; Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L- selenocysteine. Selenocysteine lyase activity is however unsure in vivo. (406 aa)
ADO48462.1PFAM: aminotransferase class I and II; KEGG: kpn:KPN_01511 bifunctional PLP-dependent beta-cystathionase; repressor of maltose regulon through interaction with MalT. (390 aa)
ADO48480.1PFAM: aminotransferase class I and II; KEGG: enc:ECL_02037 putative aminotransferase. (389 aa)
ADO48640.1Transcriptional regulator, GntR family with aminotransferase domain; KEGG: kpn:KPN_01929 transcription regulator GntR; PFAM: regulatory protein GntR HTH; aminotransferase class I and II; SMART: regulatory protein GntR HTH. (481 aa)
tnaATIGRFAM: tryptophanase; KEGG: sfv:SFV_3805 tryptophanase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase. (471 aa)
argD-2Succinylornithine transaminase family; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (406 aa)
ADO49105.1Aspartate transaminase; KEGG: esa:ESA_02414 aromatic amino acid aminotransferase; PFAM: aminotransferase class I and II. (396 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (362 aa)
ADO49167.1KEGG: ent:Ent638_1386 L-threonine aldolase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase. (333 aa)
bioF8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (384 aa)
bioAAdenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (435 aa)
ADO49370.1KEGG: cko:CKO_02469 ornithine decarboxylase; PFAM: Orn/Lys/Arg decarboxylase major region; Orn/Lys/Arg decarboxylase domain protein. (732 aa)
ADO49432.1PFAM: aminotransferase class I and II; KEGG: kva:Kvar_3722 aminotransferase class I and II. (386 aa)
ADO49763.1KEGG: kpu:KP1_1410 lysine decarboxylase 1; PFAM: Orn/Lys/Arg decarboxylase major region; Orn/Lys/Arg decarboxylase domain protein. (714 aa)
ADO49792.1Lysine decarboxylase; KEGG: cko:CKO_03180 hypothetical protein; PFAM: Orn/Lys/Arg decarboxylase major region; Orn/Lys/Arg decarboxylase domain protein. (712 aa)
hemLKEGG: kva:Kvar_4212 glutamate-1-semialdehyde-2,1-aminomutase; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III. (426 aa)
ADO50048.1Transcriptional regulator, GntR family with aminotransferase domain; KEGG: kpu:KP1_0709 putative aminotransferase; PFAM: regulatory protein GntR HTH; aminotransferase class I and II; SMART: regulatory protein GntR HTH. (470 aa)
ADO50285.1KEGG: sew:SeSA_A4551 biodegradative arginine decarboxylase; PFAM: Orn/Lys/Arg decarboxylase major region; Orn/Lys/Arg decarboxylase domain protein. (755 aa)
ADO50349.1Aromatic-amino-acid transaminase; KEGG: enc:ECL_00312 aromatic amino acid aminotransferase; PFAM: aminotransferase class I and II. (397 aa)
wecETDP-4-keto-6-deoxy-D-glucose transaminase; Catalyzes the synthesis of dTDP-4-amino-4,6-dideoxy-D- galactose (dTDP-Fuc4N) from dTDP-4-keto-6-deoxy-D-glucose (dTDP-D- Glc4O) and L-glutamate; Belongs to the DegT/DnrJ/EryC1 family. (376 aa)
ADO50565.1O-succinylhomoserine (thiol)-lyase; KEGG: cro:ROD_38041 cystathionine gamma-synthase; TIGRFAM: O-succinylhomoserine (thiol)-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. (386 aa)
Your Current Organism:
Enterobacter lignolyticus
NCBI taxonomy Id: 701347
Other names: Enterobacter lignolyticus SCF1, [. lignolyticus SCF1, [Enterobacter] lignolyticus SCF1
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.