STRINGSTRING
PH0112 PH0112 PH0113 PH0113 PH0118 PH0118 PH0119 PH0119 PH0120 PH0120 PH0121 PH0121 PH0123 PH0123 PH0124 PH0124 PH0195 PH0195 PH0196 PH0196 PHS020 PHS020 PH0606 PH0606 PH0622 PH0622 PH0665 PH0665 PH1415 PH1415 PH1622 PH1622 PH1650 PH1650 PH1893 PH1893 PHS055 PHS055 PH1896 PH1896 PH1947 PH1947
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PH0112855aa long hypothetical replication factor C subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. (855 aa)
PH0113468aa long hypothetical replication factor C subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. (468 aa)
PH0118115aa long hypothetical protein. (115 aa)
PH0119228aa long hypothetical DNA repair protein; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange (By similarity). (228 aa)
PH0120211aa long hypothetical protein; Similar to PIR:B64445 percent identity:34.483 in 186aa; Belongs to the UPF0173 family. (211 aa)
PH01211434aa long hypothetical protein; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity). (1434 aa)
PH0123622aa long hypothetical protein; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity); Belongs to the DNA polymerase delta/II small subunit family. (622 aa)
PH0124437aa long hypothetical protein; Involved in regulation of DNA replication. (437 aa)
PH0195346aa long hypothetical protein; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synth [...] (346 aa)
PH0196397aa long hypothetical protein; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. (397 aa)
PHS02097aa long hypothetical protein; Similar to PIR:H64330 percent identity:36.047 in 88aa; Swiss_Prot:P18248 percent identity:20.588 in 68aa. (97 aa)
PH06061108aa long hypothetical cell division control protein; Similar to Swiss_Prot:P30665 percent identity:41.538 in 331aa. motif=ATP/GTP-binding site motif A (P-loop); protein splicing signature; Belongs to the MCM family. (1108 aa)
PH0622686aa long hypothetical DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand [...] (686 aa)
PH0665249aa long hypothetical proliferating-cell nuclear antigen; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. (249 aa)
PH1415343aa long hypothetical 5' nuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] (343 aa)
PH1622559aa long hypothetical DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (559 aa)
PH1650220aa long hypothetical ribonuclease H II; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (220 aa)
PH1893361aa long hypothetical protein; Similar to PIR:F64444 percent identity:33.486 in 240aa. (361 aa)
PHS05590aa long hypothetical DNA excision repair protein; Similar to PIR:H64487 percent identity:53.488 in 86aa; GENPEPT:U74491 percent identity:29.577 in 71aa; Swiss_Prot:P07903 percent identity:30.986 in 71aa. (90 aa)
PH1896650aa long hypothetical ATP-dependent RNA helicase; Similar to PIR:H64487 percent identity: 42.424 in 695aa. (650 aa)
PH19471235aa long hypothetical DNA-directed DNA polymerase; Similar to PIR:S68593 percent identity: 75.831 in 1312aa; Swiss_Prot:P30317 percent identity: 67.133 in 1082aa; owl:PYWKODPOL percent identity: 75.792 in 1671aa. motif=DNA polymerase family B signature; protein splicing signature; Belongs to the DNA polymerase type-B family. (1235 aa)
Your Current Organism:
Pyrococcus horikoshii
NCBI taxonomy Id: 70601
Other names: P. horikoshii OT3, Pyrococcus horikoshii OT-3, Pyrococcus horikoshii OT3, Pyrococcus horikoshii str. OT3, Pyrococcus shinkaii OT3, Pyrococcus sp. OT3
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