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PH0022 PH0022 PH0113 PH0113 PH0119 PH0119 PH0124 PH0124 PH0132 PH0132 PH0155 PH0155 PH0157 PH0157 PH0186 PH0186 PH0194 PH0194 PH0197 PH0197 PH0201 PH0201 PH0203 PH0203 PH0274 PH0274 PH0284 PH0284 PH0329 PH0329 PH0505 PH0505 PH0507 PH0507 PH0541 PH0541 PH0556 PH0556 PH0567 PH0567 PH0687 PH0687 PH0756 PH0756 PH0791 PH0791 PH0792 PH0792 PH0800 PH0800 PH0810 PH0810 PH0811 PH0811 PH0820 PH0820 PH0833 PH0833 PH0859 PH0859 PH0882 PH0882 PH0913 PH0913 PH0929 PH0929 PH1110 PH1110 PH1123 PH1123 PH1188 PH1188 PH1230 PH1230 PH1235 PH1235 PH1278 PH1278 PH1350 PH1350 PH1366 PH1366 PH1384 PH1384 PH1412 PH1412 PH1413 PH1413 PH1490 PH1490 PH1507 PH1507 PH1532 PH1532 PH1653 PH1653 PH1669 PH1669 PH1694 PH1694 PH1713 PH1713 PH1735 PH1735 PH1736 PH1736 PH1804 PH1804 PH1815 PH1815 PH1840 PH1840 PH1849 PH1849 PH1958 PH1958 PH1959 PH1959
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PH0022373aa long hypothetical sugar-binding transport ATP-binding protein; Similar to owl:D8302640 percent identity: 48.753 in 366aa; owl:S76829 percent identity: 49.307 in 364aa; owl:SLU12007 percent identity: 55.185 in 270aa. motif=ABC transporters family signature; ATP/GTP-binding site motif A (P-loop). (373 aa)
PH0113468aa long hypothetical replication factor C subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. (468 aa)
PH0119228aa long hypothetical DNA repair protein; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange (By similarity). (228 aa)
PH0124437aa long hypothetical protein; Involved in regulation of DNA replication. (437 aa)
PH0132260aa long hypothetical transport protein; Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity). (260 aa)
PH0155317aa long hypothetical protein; Similar to PIR:B64511 percent identity: 41.026 in 209aa; PIR:C64511 percent identity: 55.455 in 114aa. motif=ATP/GTP-binding site motif A (P-loop). (317 aa)
PH0157345aa long hypothetical transport-ATP binding protein; Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Sulfate/tungstate importer (TC 3.A.1.6) family. (345 aa)
PH0186251aa long hypothetical protein; Similar to PIR:F64469 percent identity: 41.026 in 239aa; owl:S76478 percent identity: 37.021 in 243aa; owl:S76850 percent identity: 35.193 in 240aa. motif=ATP/GTP-binding site motif A (P-loop). (251 aa)
PH0194375aa long hypothetical multiple sugar-binding transport ATP-binding protein; Similar to owl:D8302640 percent identity: 57.025 in 372aa; Swiss_Prot:Q00752 percent identity: 53.846 in 383aa; owl:MLU1518037 percent identity: 57.680 in 329aa. motif=ABC transporters family signature; ATP/GTP-binding site motif A (P-loop). (375 aa)
PH0197361aa long hypothetical protein; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA. (361 aa)
PH0201399aa long hypothetical 26S protease regulatory subunit; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding a [...] (399 aa)
PH0203362aa long hypothetical maltose/maltodextrin transport ATP-binding protein; Similar to owl:D8302640 percent identity: 50.704 in 288aa; owl:RZAE0000893 percent identity: 44.126 in 353aa; owl:S76829 percent identity: 49.796 in 245aa. motif=ABC transporters family signature; ATP/GTP-binding site motif A (P-loop). (362 aa)
PH0274317aa long hypothetical protein; May have GTPase activity. May also bind and hydrolyze ATP. May function as chaperone (By similarity). (317 aa)
PH0284252aa long hypothetical protein; Similar to PIR:F64469 percent identity: 74.370 in 239aa. motif=ATP/GTP-binding site motif A (P-loop); Belongs to the UPF0273 family. (252 aa)
PH0329317aa long hypothetical protein; Similar to owl:BSU511154 percent identity:51.342 in 303aa; PIR:S75782 percent identity:49.823 in 286aa; PIR:S74593 percent identity:41.751 in 297aa. (317 aa)
PH0505324aa long hypothetical oligopeptide transport ATP-binding protein AppF; Similar to Swiss_Prot:P42065 percent identity: 45.763 in 302aa; Swiss_Prot:P26905 percent identity: 43.269 in 319aa; owl:RSPNGR2342 percent identity: 40.064 in 318aa. motif=ABC transporters family signature; ATP/GTP-binding site motif A (P-loop). (324 aa)
PH0507321aa long hypothetical oligopeptide transport ATP-binding protein AppF; Similar to Swiss_Prot:P42065 percent identity: 44.898 in 299aa; owl:RSPNGR2343 percent identity: 41.924 in 295aa; Swiss_Prot:P45094 percent identity: 38.488 in 295aa. motif=ABC transporters family signature; ATP/GTP-binding site motif A (P-loop). (321 aa)
PH0541321aa long hypothetical protein; Similar to PIR:A64507 percent identity: 44.340 in 350aa; PIR:B64309 percent identity: 45.455 in 242aa; PIR:G64354 percent identity: 43.802 in 254aa. motif=ATP/GTP-binding site motif A (P-loop); Belongs to the archaeal ATPase family. (321 aa)
PH0556232aa long hypothetical protein; Similar to PIR:C64412 percent identity: 43.043 in 230aa; owl:MVU970405 percent identity: 43.556 in 225aa. motif=ATP/GTP-binding site motif A (P-loop). (232 aa)
PH0567453aa long hypothetical protein; Similar to PIR:C64504 percent identity: 40.000 in 424aa. motif=ATP/GTP-binding site motif A (P-loop). (453 aa)
PH0687840aa long hypothetical cell division control protein (transitional endoplasmic reticulum ATPase); Similar to PIR:C64444 percent identity: 68.554 in 760aa; Swiss_Prot:Q07590 percent identity: 62.391 in 771aa; owl:TAU78072 percent identity: 61.891 in 761aa. motif=AAA-protein family signature; ATP/GTP-binding site motif A (P-loop). (840 aa)
PH0756357aa long hypothetical sugar transport ATP-binding protein; Similar to owl:S76829 percent identity: 55.830 in 286aa; Swiss_Prot:P10907 percent identity: 47.025 in 358aa; owl:RZAE0000893 percent identity: 46.307 in 360aa. motif=ABC transporters family signature; ATP/GTP-binding site motif A (P-loop). (357 aa)
PH0791241aa long hypothetical iron (III) dicitrate transport ATP-binding protein; Similar to PIR:A64311 percent identity:39.419 in 252aa; Swiss_Prot:P15031 percent identity:38.350 in 219aa. motif=ATP/GTP-binding site motif A (P-loop). (241 aa)
PH0792172aa long hypothetical protein; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family. (172 aa)
PH08001624aa long hypothetical reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity); In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily. (1624 aa)
PH0810327aa long hypothetical oligopeptide transport ATP-binding protein APPD; Similar to owl:RSPNGR2342 percent identity: 43.689 in 317aa; Swiss_Prot:P37314 percent identity: 40.256 in 317aa; Swiss_Prot:P45052 percent identity: 39.228 in 317aa. motif=ABC transporters family signature; ATP/GTP-binding site motif A (P-loop). (327 aa)
PH0811323aa long hypothetical oligopeptide transport ATP-binding protein APPF; Similar to Swiss_Prot:P42065 percent identity: 47.484 in 326aa; owl:RSPNGR2343 percent identity: 45.714 in 320aa; owl:BACSPO0K6 percent identity: 50.598 in 254aa. motif=ABC transporters family signature; ATP/GTP-binding site motif A (P-loop); prenyl gr. (323 aa)
PH0820312aa long hypothetical ATP-binding protein; Similar to owl:SS100KBFR62 percent identity: 41.391 in 308aa. motif=ABC transporters family signature; ATP/GTP-binding site motif A (P-loop). (312 aa)
PH0833483aa long hypothetical protein; Similar to owl:S76850 percent identity: 29.909 in 450aa; owl:S76478 percent identity: 29.909 in 453aa; owl:S75060 percent identity: 31.096 in 462aa. motif=ATP/GTP-binding site motif A (P-loop). (483 aa)
PH0859590aa long hypothetical transport protein; Similar to PIR:G64389 percent identity: 61.921 in 596aa; owl:S63672 percent identity: 48.048 in 594aa; PIR:S58091 percent identity: 50.000 in 599aa. motif=4Fe-4S ferredoxins, iron-sulfur binding region signature; ABC transporters family signature; ATP/. (590 aa)
PH0882237aa long hypothetical ABC transporter ATP-binding protein; Similar to PIR:C64304 percent identity: 50.230 in 225aa; owl:ECAE00039920 percent identity:33.486 in 222aa. motif=ABC transporters family signature; ATP/GTP-binding site motif A (P-loop). (237 aa)
PH0913324aa long hypothetical resistance ATP-binding protein; Similar to owl:SS100KBFR62 percent identity: 45.833 in 317aa; owl:SAU435372 percent identity: 38.926 in 303aa; PIR:S32908 percent identity: 47.368 in 229aa. motif=ABC transporters family signature; ATP/GTP-binding site motif A (P-loop). (324 aa)
PH0929879aa long hypothetical purine NTPase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. (879 aa)
PH11101352aa long hypothetical ATP-dependent helicase LHR; Similar to PIR:G64336 percent identity:59.481 in 515aa; owl:SS56KBFR9 percent identity:49.126 in 526aa; owl:MTCY7135 percent identity:40.068 in 300aa. (1352 aa)
PH1123605aa long hypothetical protein; Similar to PIR:D64491 percent identity: 55.201 in 612aa; PIR:S28724 percent identity: 50.251 in 612aa. motif=ATP/GTP-binding site motif A (P-loop). (605 aa)
PH1188484aa long hypothetical protein; motif=ATP/GTP-binding site motif A (P-loop). (484 aa)
PH1230253aa long hypothetical ATP-binding transport protein; Similar to PIR:S76626 percent identity:42.202 in 219aa; Swiss_Prot:P46903 percent identity:32.877 in 220aa; Swiss_Prot:P55339 percent identity:35.443 in 239aa. motif=ATP/GTP-binding site motif A (P-loop). (253 aa)
PH1235250aa long hypothetical ferrichrome transport ATP-binding protein; Similar to PIR:A64311 percent identity: 46.862 in 241aa. motif=ABC transporters family signature; ATP/GTP-binding site motif A (P-loop). (250 aa)
PH1278363aa long hypothetical protein; Similar to Swiss_Prot:P52917 percent identity: 45.778 in 232aa; Swiss_Prot:Q09803 percent identity: 42.478 in 233aa; Swiss_Prot:P46467 percent identity: 43.556 in 233aa. motif=ATP/GTP-binding site motif A (P-loop). (363 aa)
PH1350330aa long hypothetical ATP-binding transport protein; Similar to Swiss_Prot:P37009 percent identity: 51.653 in 244aa; owl:AB00168470 percent identity: 51.502 in 235aa; Swiss_Prot:P14788 percent identity: 53.165 in 239aa. motif=ABC transporters family signature; ATP/GTP-binding site motif A (P-loop). (330 aa)
PH1366308aa long hypothetical ATP-binding transport protein; Similar to owl:D785084 percent identity: 40.367 in 218aa; Swiss_Prot:P54592 percent identity: 42.361 in 297aa. motif=ABC transporters family signature; ATP/GTP-binding site motif A (P-loop). (308 aa)
PH1384247aa long hypothetical ATP-dependent transporter YCF16; Similar to Swiss_Prot:P48255 percent identity: 48.511 in 243aa; Swiss_Prot:P51241 percent identity: 48.936 in 243aa; owl:D908119 percent identity: 45.957 in 243aa. motif=ABC transporters family signature; ATP/GTP-binding site motif A (P-loop). (247 aa)
PH1412329aa long hypothetical dipeptide transport ATP-binding protein dppD; Similar to owl:RSPNGR2342 percent identity: 52.077 in 321aa; Swiss_Prot:P26905 percent identity: 51.735 in 324aa; Swiss_Prot:P42064 percent identity: 49.211 in 322aa. motif=ABC transporters family signature; ATP/GTP-binding site motif A (P-loop); preny. (329 aa)
PH1413329aa long hypothetical dipeptide transport ATP-binding protein dppF; Similar to Swiss_Prot:P42065 percent identity: 53.605 in 326aa; owl:BACSPO0K6 percent identity: 61.943 in 250aa; owl:BACSPO0K5 percent identity: 61.943 in 250aa. motif=ABC transporters family signature; ATP/GTP-binding site motif A (P-loop). (329 aa)
PH1490222aa long hypothetical transport protein; Similar to PIR:S42931 percent identity:29.949 in 204aa; PIR:S42927 percent identity:30.457 in 204aa. motif=ABC transporters family signature; ATP/GTP-binding site motif A (P-loop). (222 aa)
PH1507633aa long hypothetical protein; motif=ATP/GTP-binding site motif A (P-loop). (633 aa)
PH1532226aa long hypothetical ATP-binding transport protein; Similar to Swiss_Prot:P46903 percent identity:38.182 in 221aa. motif=ATP/GTP-binding site motif A (P-loop). (226 aa)
PH1653260aa long hypothetical ABC transporter; Similar to owl:AF00822022 percent identity:30.172 in 234aa; owl:TPU552142 percent identity:32.759 in 234aa; PIR:S61910 percent identity:34.348 in 233aa. motif=ABC transporters family signature; ATP/GTP-binding site motif A (P-loop). (260 aa)
PH1669326aa long hypothetical signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). (326 aa)
PH1694445aa long hypothetical signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. (445 aa)
PH1713498aa long hypothetical sugar transport ATP-binding protein; Similar to owl:BSZ939374 percent identity: 43.585 in 496aa; owl:BSZ929534 percent identity: 37.295 in 497aa; Swiss_Prot:P44884 percent identity: 35.669 in 477aa. motif=ABC transporters family signature; ATP/GTP-binding site motif A (P-loop). (498 aa)
PH1735582aa long hypothetical ABC transporter ATP-binding protein; Similar to Swiss_Prot:P54719 percent identity: 36.445 in 559aa; owl:TTU509513 percent identity: 33.919 in 572aa; owl:BSZ820444 percent identity: 33.624 in 583aa. motif=ABC transporters family signature; ATP/GTP-binding site motif A (P-loop). (582 aa)
PH1736580aa long hypothetical ABC transporter ATP-binding protein; Similar to owl:TTU509512 percent identity: 33.452 in 563aa. motif=ABC transporters family signature; ATP/GTP-binding site motif A (P-loop). (580 aa)
PH1804441aa long hypothetical protein; Similar to owl:AB002406 percent identity: 49.883 in 443aa; PIR:S52698 percent identity: 48.219 in 435aa; PIR:S61029 percent identity: 45.564 in 431aa. motif=ATP/GTP-binding site motif A (P-loop). (441 aa)
PH1815284aa long hypothetical cobalt transport ATP-binding protein; Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity). (284 aa)
PH1840798aa long hypothetical transitional endoplasmic reticulum ATPase; Similar to PIR:C64444 percent identity: 70.579 in 736aa; Swiss_Prot:Q07590 percent identity: 62.185 in 778aa; owl:TAU78072 percent identity: 59.097 in 799aa. motif=AAA-protein family signature; ATP/GTP-binding site motif A (P-loop). (798 aa)
PH1849318aa long hypothetical ATP-binding transport protein; Similar to owl:SS100KBFR62 percent identity: 43.299 in 297aa; owl:D785084 percent identity: 41.463 in 297aa; Swiss_Prot:P46903 percent identity: 42.326 in 216aa. motif=ATP/GTP-binding site motif A (P-loop). (318 aa)
PH1958335aa long hypothetical oligopeptide transport ATP-binding protein appF; Similar to Swiss_Prot:P42065 percent identity: 46.563 in 328aa; owl:BACSPO0K6 percent identity: 50.617 in 245aa; Swiss_Prot:P24137 percent identity: 50.617 in 245aa. motif=ABC transporters family signature; ATP/GTP-binding site motif A (P-loop). (335 aa)
PH1959322aa long hypothetical oligopeptide transport ATP-binding protein appD; Similar to Swiss_Prot:P42064 percent identity: 47.604 in 317aa; Swiss_Prot:P04285 percent identity: 49.832 in 301aa; Swiss_Prot:P24136 percent identity: 50.000 in 321aa. motif=ABC transporters family signature; ATP/GTP-binding site motif A (P-loop); pr. (322 aa)
Your Current Organism:
Pyrococcus horikoshii
NCBI taxonomy Id: 70601
Other names: P. horikoshii OT3, Pyrococcus horikoshii OT-3, Pyrococcus horikoshii OT3, Pyrococcus horikoshii str. OT3, Pyrococcus shinkaii OT3, Pyrococcus sp. OT3
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