STRINGSTRING
PH0636 PH0636 PH0735 PH0735 PH0823 PH0823 PH0965 PH0965 PH0993 PH0993 PH1011 PH1011 PH1065 PH1065 PH1102 PH1102 PH1257 PH1257 PH1313 PH1313 PH1347 PH1347 PH1441 PH1441 PH1478 PH1478 PH1540 PH1540 PH1608 PH1608 PH1680 PH1680 PH1686 PH1686 PH1786 PH1786 PH1911 PH1911 PH1914 PH1914 PH0182 PH0182 PH0224 PH0224 PH0268 PH0268 PH0276 PH0276 PH0300 PH0300 PH0314 PH0314 PH0375 PH0375 PH0464 PH0464 PH0624 PH0624 PH1921 PH1921 PH0085 PH0085 PH1943 PH1943 PH1968 PH1968
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PH0636476aa long hypothetical cysteinyl-tRNA synthetase; Similar to Swiss_Prot:Q06752 percent identity: 48.707 in 473aa; Swiss_Prot:P43816 percent identity: 50.000 in 472aa; Swiss_Prot:P21888 percent identity: 48.904 in 474aa. (476 aa)
PH0735148aa long hypothetical protein; Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme. (148 aa)
PH0823170aa long hypothetical protein; Similar to PIR:A64372 percent identity: 41.333 in 157aa. (170 aa)
PH0965967aa long hypothetical leucyl-tRNA synthetase; Similar to PIR:A64379 percent identity: 53.987 in 980aa; owl:F21M12 percent identity: 36.017 in 737aa; Swiss_Prot:Q09996 percent identity: 34.910 in 766aa. motif=aminoacyl-transfer RNA synthetases class-I signature. (967 aa)
PH0993723aa long hypothetical methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (723 aa)
PH1011375aa long hypothetical tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily. (375 aa)
PH10651066aa long hypothetical isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1066 aa)
PH1102480aa long hypothetical asparagine synthetase; Similar to PIR:C64439 percent identity: 45.304 in 190aa. (480 aa)
PH1257227aa long hypothetical protein; Similar to owl:B64371 percent identity: 58.986 in 218aa. (227 aa)
PH1313307aa long hypothetical protein; Similar to PIR:C64416 percent identity: 39.381 in 231aa. (307 aa)
PH1347308aa long hypothetical GMP synthase; Catalyzes the synthesis of GMP from XMP. (308 aa)
PH1441428aa long hypothetical protein. (428 aa)
PH1478629aa long hypothetical arginyl-tRNA synthetase; Similar to PIR:F64329 percent identity: 40.975 in 639aa; Swiss_Prot:P43832 percent identity: 40.000 in 192aa. motif=aminoacyl-transfer RNA synthetases class-I signature. (629 aa)
PH1540208aa long hypothetical protein. (208 aa)
PH1608295aa long hypothetical protein; Similar to PIR:G64426 percent identity:30.980 in 273aa. (295 aa)
PH1680320aa long hypothetical protein; Similar to PIR:E64444 percent identity: 40.203 in 305aa; PIR:E64484 percent identity: 37.500 in 311aa; owl:S71668 percent identity: 37.008 in 260aa. (320 aa)
PH1686570aa long hypothetical glutaminyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (570 aa)
PH1786201aa long hypothetical protein; Similar to PIR:C64416 percent identity: 50.521 in 194aa. (201 aa)
PH1911204aa long hypothetical protein. (204 aa)
PH1914149aa long hypothetical protein; Similar to PIR:A64372 percent identity:29.730 in 152aa. motif=ATP/GTP-binding site motif A (P-loop). (149 aa)
PH0182257aa long hypothetical NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (257 aa)
PH0224523aa long hypothetical lysyl-tRNA synthetase; Similar to PIR:C64367 percent identity: 40.971 in 535aa. motif=aminoacyl-transfer RNA synthetases class-I signature. (523 aa)
PH0268630aa long hypothetical protein; Similar to PIR:B64308 percent identity: 40.959 in 474aa; PIR:E64421 percent identity: 37.209 in 269aa. motif=4Fe-4S ferredoxins, iron-sulfur binding region signature. (630 aa)
PH0276206aa long hypothetical protein; Similar to PIR:B64386 percent identity: 52.284 in 200aa. (206 aa)
PH0300310aa long hypothetical protein; Catalyzes the ATP-dependent 2-thiolation of 5-methyluridine residue at position 54 in the T loop of tRNAs, leading to 5-methyl-2- thiouridine (m(5)s(2)U or s(2)T). This modification allows thermal stabilization of tRNAs in thermophilic microorganisms, and is required for cell growth at high temperatures (By similarity). Can use free sulfide as sulfur source in vitro, which may be also the sulfur source in vivo ; Belongs to the TtcA family. TtuA subfamily. (310 aa)
PH0314896aa long hypothetical valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily. (896 aa)
PH0375221aa long hypothetical protein; Similar to PIR:B64371 percent identity:29.000 in 210aa. (221 aa)
PH0464186aa long hypothetical protein; Similar to PIR:E64367 percent identity: 59.756 in 166aa. (186 aa)
PH0624177aa long hypothetical protein; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the eukaryotic CoaD family. (177 aa)
PH1921301aa long hypothetical tryptophanyl-tRNA synthetase; Similar to owl:S51901 percent identity: 49.296 in 298aa; Swiss_Prot:Q09692 percent identity: 48.352 in 286aa; Swiss_Prot:P23381 percent identity: 46.831 in 301aa; Belongs to the class-I aminoacyl-tRNA synthetase family. (301 aa)
PH0085269aa long hypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (269 aa)
PH1943243aa long hypothetical protein; Motif=mitochondrial energy transfer proteins signature; myb DNA-binding domain repeat signatures. (243 aa)
PH1968273aa long hypothetical protein; Similar to PIR:F64499 percent identity: 48.302 in 273aa. (273 aa)
Your Current Organism:
Pyrococcus horikoshii
NCBI taxonomy Id: 70601
Other names: P. horikoshii OT3, Pyrococcus horikoshii OT-3, Pyrococcus horikoshii OT3, Pyrococcus horikoshii str. OT3, Pyrococcus shinkaii OT3, Pyrococcus sp. OT3
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