STRINGSTRING
PH1137 PH1137 PH1019 PH1019 PH0819 PH0819 PH0765 PH0765 PH0685 PH0685 PH0682 PH0682 PH0679 PH0679 PH0635 PH0635 PH1726 PH1726 PH0300 PH0300 PH0240 PH0240 PH0196 PH0196 PH0013 PH0013 PH0114 PH0114 PH1875 PH1875 PH1498 PH1498 PH1449 PH1449 PH1705 PH1705 PH1259 PH1259 PH1138 PH1138 PH1105 PH1105
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PH1137407aa long hypothetical RNA methyltransferase; Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (407 aa)
PH1019607aa long hypothetical aldehyde:ferredoxin oxidoreductase; Similar to owl:PFAOR1 percent identity: 80.629 in 606aa; owl:TLFORPKPF2 percent identity: 39.527 in 620aa; Belongs to the AOR/FOR family. (607 aa)
PH0819459aa long hypothetical methyltransferase; Similar to Swiss_Prot:P26168 percent identity: 29.216 in 437aa; PIR:S75722 percent identity: 24.480 in 442aa. (459 aa)
PH0765648aa long hypothetical indolepyruvate ferredoxin oxidoreductase alpha subunit; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. (648 aa)
PH0685334aa long hypothetical ferredoxin oxidoreductase beta subunit; Similar to owl:PFPORVOR11 percent identity: 92.145 in 331aa; PIR:C64333 percent identity: 62.821 in 252aa; owl:PFPORVOR8 percent identity: 55.187 in 257aa. motif=prokaryotic membrane lipoprotein lipid attachment site. (334 aa)
PH0682108aa long hypothetical ferredoxin oxidoreductase delta subunit; Similar to owl:PFPORVOR9 percent identity: 95.238 in 105aa; owl:PFPORVOR6 percent identity: 62.667 in 75aa; PIR:E64333 percent identity: 58.824 in 85aa. motif=4Fe-4S ferredoxins, iron-sulfur binding region signature. (108 aa)
PH0679105aa long hypothetical ferredoxin oxidoreductase delta subunit; Similar to owl:PFPORVOR6 percent identity: 86.667 in 105aa; owl:PFPORVOR9 percent identity: 65.333 in 75aa; PIR:E64333 percent identity: 61.333 in 75aa. motif=4Fe-4S ferredoxins, iron-sulfur binding region signature. (105 aa)
PH0635254aa long hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (254 aa)
PH1726380aa long hypothetical isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (380 aa)
PH0300310aa long hypothetical protein; Catalyzes the ATP-dependent 2-thiolation of 5-methyluridine residue at position 54 in the T loop of tRNAs, leading to 5-methyl-2- thiouridine (m(5)s(2)U or s(2)T). This modification allows thermal stabilization of tRNAs in thermophilic microorganisms, and is required for cell growth at high temperatures (By similarity). Can use free sulfide as sulfur source in vitro, which may be also the sulfur source in vivo ; Belongs to the TtcA family. TtuA subfamily. (310 aa)
PH0240449aa long hypothetical amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (449 aa)
PH0196397aa long hypothetical protein; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. (397 aa)
PH0013300aa long hypothetical quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (300 aa)
PH0114316aa long hypothetical molybdenum cofactor biosynthesis protein; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. (316 aa)
PH1875432aa long hypothetical protein; Catalyzes the methylthiolation of N6- threonylcarbamoyladenosine (t(6)A), leading to the formation of 2- methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. (432 aa)
PH1498222aa long hypothetical endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (222 aa)
PH1449195aa long hypothetical NADH-ubiquinone oxidoreductase subunit; Similar to Swiss_Prot:P52766 percent identity:48.485 in 133aa; Swiss_Prot:P06410 percent identity:45.926 in 136aa; Swiss_Prot:P06409 percent identity:48.485 in 133aa; Belongs to the complex I 20 kDa subunit family. (195 aa)
PH1705342aa long hypothetical protein; Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe); Belongs to the TYW1 family. (342 aa)
PH1259412aa long hypothetical protein; Catalyzes the formation of 5-methyl-uridine at position equivalent to 747 (m5U747) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (412 aa)
PH1138618aa long hypothetical indolepyruvate ferredoxin oxidoreductase alpha subunit; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. (618 aa)
PH1105342aa long hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). (342 aa)
Your Current Organism:
Pyrococcus horikoshii
NCBI taxonomy Id: 70601
Other names: P. horikoshii OT3, Pyrococcus horikoshii OT-3, Pyrococcus horikoshii OT3, Pyrococcus horikoshii str. OT3, Pyrococcus shinkaii OT3, Pyrococcus sp. OT3
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.