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PH0679 PH0679 PH0678 PH0678 PH0655 PH0655 PH0597 PH0597 PH0572 PH0572 PH1217 PH1217 PH1277 PH1277 PH1387 PH1387 PH1390 PH1390 PH1475 PH1475 PH1516 PH1516 PH1593 PH1593 PH1618 PH1618 PH1720 PH1720 PH1722 PH1722 PH1138 PH1138 PH0520 PH0520 PH0363 PH0363 PH0307 PH0307 PH1994 PH1994 PH1995 PH1995 PH0015 PH0015 PH0181 PH0181 PH1805 PH1805 PH1830 PH1830 PH1083 PH1083 PH1019 PH1019 PH0939 PH0939 PH0765 PH0765 PH0764 PH0764 PH0685 PH0685 PH0684 PH0684 PH0681 PH0681 PH0680 PH0680
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PH0679105aa long hypothetical ferredoxin oxidoreductase delta subunit; Similar to owl:PFPORVOR6 percent identity: 86.667 in 105aa; owl:PFPORVOR9 percent identity: 65.333 in 75aa; PIR:E64333 percent identity: 61.333 in 75aa. motif=4Fe-4S ferredoxins, iron-sulfur binding region signature. (105 aa)
PH0678185aa long hypothetical ferredoxin oxidoreductase gamma subunit; Similar to owl:PFPORVOR5 percent identity: 90.270 in 185aa; PIR:F64333 percent identity: 65.698 in 179aa; owl:TMPMRFDNA2 percent identity: 44.000 in 177aa. (185 aa)
PH0655348aa long hypothetical dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate. Is much less efficient when using NADP(+) instead of NAD(+). To a lesser extent, also catalyzes the oxidation of L-serine and DL-threo-3- phenylserine, but not that of L-allo-threonine, D-threonine and D-allo- threonine and many other L-amino acids. (348 aa)
PH0597376aa long hypothetical dehydrogenase; Similar to owl:BSZ9404317 percent identity: 49.821 in 287aa; Swiss_Prot:P37666 percent identity: 43.750 in 327aa; PIR:A64427 percent identity: 42.633 in 330aa. motif=ATP/GTP-binding site motif A (P-loop); D-isomer specific 2-hydroxyacid dehydrogenases s. (376 aa)
PH0572445aa long hypothetical NADH oxidase; Acts as a coenzyme A disulfide reductase. Specific for CoA disulfide. Shows a slow NAD(P)H oxidase activity in the presence of high concentrations of substrate-level FAD. This demonstrates that it is not likely to act as an NADH oxidase in vivo. (445 aa)
PH1217216aa long hypothetical alkyl hydroperoxide reductase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. (216 aa)
PH1277360aa long hypothetical malate dehydrogenase; Similar to Swiss_Prot:P16142 percent identity: 45.231 in 340aa; PIR:H64477 percent identity: 47.038 in 296aa; owl:ECAE00015710 percent identity: 35.780 in 341aa. (360 aa)
PH1387307aa long hypothetical phosphoglycerate dehydrogenase; Similar to PIR:A64427 percent identity: 55.960 in 305aa; owl:S75016 percent identity: 43.709 in 304aa; owl:CEC31C91 percent identity: 41.391 in 304aa. motif=ATP/GTP-binding site motif A (P-loop); D-isomer specific 2-hydroxyacid dehydrogenases signatures. (307 aa)
PH1390301aa long hypothetical thiamin biosynthesis protein; Catalyzes the NAD(P)H-dependent reduction of ketopantoate into pantoic acid. (301 aa)
PH1475351aa long hypothetical glycerol 1-phaphate dehydrogenase; Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea. Belongs to the glycerol-1-phosphate dehydrogenase family. (351 aa)
PH1516303aa long hypothetical dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. (303 aa)
PH1593422aa long hypothetical glutamate dehydrogenase; Similar to owl:A47410 percent identity: 96.429 in 420aa; Swiss_Prot:P80319 percent identity: 95.952 in 420aa; owl:THCGLUDEHY percent identity: 87.799 in 419aa. motif=glu / Leu / Phe / Val dehydrogenases active site; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (422 aa)
PH1618418aa long hypothetical UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase; Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA). Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (418 aa)
PH1720330aa long hypothetical N-acetyl-gamma-glutamyl-phosphate reductase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (330 aa)
PH1722323aa long hypothetical 3-isopropylmalate dehydrogenase; May play a dual role in glutamate and lysine biosynthesis in vivo. Uses isocitrate and homoisocitrate at near equal efficiency and preferentially uses NAD over NADP. (323 aa)
PH1138618aa long hypothetical indolepyruvate ferredoxin oxidoreductase alpha subunit; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. (618 aa)
PH0520333aa long hypothetical dehydrogenase; Similar to PIR:A64427 percent identity: 38.636 in 317aa; owl:BSZ9404317 percent identity: 36.122 in 268aa; Swiss_Prot:P37666 percent identity: 32.384 in 288aa; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (333 aa)
PH03631291aa long hypothetical ribonucleoside-diphosphate reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (1291 aa)
PH0307486aa long hypothetical inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (486 aa)
PH1994502aa long hypothetical glycine dehydrogenase subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (502 aa)
PH1995449aa long hypothetical glycine dehydrogenase subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (449 aa)
PH0015464aa long hypothetical L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (464 aa)
PH0181393aa long hypothetical protein; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. (393 aa)
PH1805341aa long hypothetical 3-hydroxy-3-methylglutaryl coenzyme A reductase; Converts HMG-CoA to mevalonate. (341 aa)
PH1830334aa long hypothetical glyceraldehyde-3-phosphate dehydrogenase; Similar to Swiss_Prot:P20286 percent identity: 90.719 in 334aa; Swiss_Prot:P10618 percent identity: 56.061 in 334aa; Swiss_Prot:P19315 percent identity: 57.751 in 335aa. motif=glyceraldehyde 3-phosphate dehydrogenase active site. (334 aa)
PH1083137aa long hypothetical protein; Uses electrons from reduced NADP, by way of rubredoxin and an oxidoreductase, to catalyze the reduction of superoxide to hydrogen peroxide; Belongs to the desulfoferrodoxin family. (137 aa)
PH1019607aa long hypothetical aldehyde:ferredoxin oxidoreductase; Similar to owl:PFAOR1 percent identity: 80.629 in 606aa; owl:TLFORPKPF2 percent identity: 39.527 in 620aa; Belongs to the AOR/FOR family. (607 aa)
PH0939430aa long hypothetical ribulose 1,5-bisphosphate carboxylase large subunit; Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase. Belongs to the RuBisCO large chain family. Type III subfamily. (430 aa)
PH0765648aa long hypothetical indolepyruvate ferredoxin oxidoreductase alpha subunit; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. (648 aa)
PH0764202aa long hypothetical indolepyruvate ferredoxin oxidoreductase beta subunit; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. (202 aa)
PH0685334aa long hypothetical ferredoxin oxidoreductase beta subunit; Similar to owl:PFPORVOR11 percent identity: 92.145 in 331aa; PIR:C64333 percent identity: 62.821 in 252aa; owl:PFPORVOR8 percent identity: 55.187 in 257aa. motif=prokaryotic membrane lipoprotein lipid attachment site. (334 aa)
PH0684398aa long hypothetical ferredoxin oxidoreductase alpha-2 subunit; Similar to owl:PFPORVOR10 percent identity:88.101 in 395aa; PIR:D64333 percent identity:57.377 in 373aa; owl:PFPORVOR7 percent identity:51.399 in 396aa. (398 aa)
PH0681314aa long hypothetical ferredoxin oxidoreductase beta subunit; Similar to owl:PFPORVOR8 percent identity: 93.569 in 311aa; PIR:C64333 percent identity: 51.203 in 295aa; owl:PFPORVOR11 percent identity: 56.118 in 253aa. (314 aa)
PH0680397aa long hypothetical ferredoxin oxidoreductase alpha subunit; Similar to owl:PFPORVOR7 percent identity: 90.609 in 394aa; owl:PFPORVOR10 percent identity: 53.093 in 391aa; PIR:D64333 percent identity: 50.806 in 380aa. (397 aa)
Your Current Organism:
Pyrococcus horikoshii
NCBI taxonomy Id: 70601
Other names: P. horikoshii OT3, Pyrococcus horikoshii OT-3, Pyrococcus horikoshii OT3, Pyrococcus horikoshii str. OT3, Pyrococcus shinkaii OT3, Pyrococcus sp. OT3
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