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gltX gltX leuA leuA leuC leuC leuD leuD leuB leuB lysC lysC ispB ispB sucC sucC ilvE ilvE grpE grpE lpdA lpdA ADM89944.1 ADM89944.1 argC argC argD argD argB argB argE argE aroK aroK tilS tilS tal tal lysA lysA aroC aroC menA menA thrC thrC thrB thrB thrA thrA sucD sucD korA korA dapA dapA dapB dapB aroE aroE lpdA-2 lpdA-2 sucA sucA sucB sucB aroG aroG pheA pheA asd asd aroA aroA aspC aspC pdhB pdhB fbaA fbaA ubiE ubiE dapF dapF argH argH acoA acoA pdhC pdhC pfkA pfkA gapA gapA ADM90074.1 ADM90074.1 ilvA ilvA ilvC ilvC ilvB ilvB ilvD ilvD korB korB aroB aroB aroD aroD acpP acpP prsA prsA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
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textmining
co-expression
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gltXglutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (490 aa)
leuA2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (382 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (469 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (195 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. (362 aa)
lysCPutative aspartate kinase; Belongs to the aspartokinase family. (345 aa)
ispBPolyprenyl synthetase; Belongs to the FPP/GGPP synthase family. (326 aa)
sucCsuccinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (392 aa)
ilvEBranched-chain amino acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (349 aa)
grpEHeat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] (160 aa)
lpdADihydrolipoamide dehydrogenase. (467 aa)
ADM89944.1Putative argininosuccinate synthase/acetyltransferase activity of N-acetylglutamate synthase; ArgG/ArgA. (578 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (323 aa)
argDAcetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (381 aa)
argBAcetylglutamate kinase. (257 aa)
argEAcetylornithine deacetylase. (357 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (161 aa)
tilSPutative tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. (432 aa)
talPutative translaldolase. (197 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (402 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (352 aa)
menA1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. (290 aa)
thrCThreonine synthase. (434 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (310 aa)
thrAAspartokinase/homoserine dehydrogenase. (818 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (291 aa)
korA2-oxoglutarate ferredoxin oxidoreductase alpha subunit. (579 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (237 aa)
dapBDihydrodipicolinate reductase; Belongs to the DapB family. (237 aa)
aroEPutative shikimate 5-dehydrogenase. (250 aa)
lpdA-2Dihydrolipoamide dehydrogenase. (464 aa)
sucA2-oxoglutarate dehydrogenase, E1 component. (896 aa)
sucB2-oxoglutarate dehydrogenase, E2 component. (371 aa)
aroGPutative phospho-2-dehydro-3-deoxyheptonate aldolase/chorismate mutase. (348 aa)
pheAPutative prephenate dehydratase. (277 aa)
asdAspartate semialdehyde dehydrogenase; Belongs to the aspartate-semialdehyde dehydrogenase family. (329 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (417 aa)
aspCAspartate aminotransferase. (393 aa)
pdhBPyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (326 aa)
fbaAFructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (355 aa)
ubiEUbiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). (240 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (259 aa)
argHArgininosuccinate lyase. (451 aa)
acoAPyruvate dehydrogenase E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (324 aa)
pdhCDihydrolipoamide acyltransferase E2 component. (385 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (325 aa)
gapAGlyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa)
ADM90074.1Conserved hypothetical protein. (146 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (417 aa)
ilvCKetol-acid reductoisomerase. (344 aa)
ilvBAcetolactate synthase large subunit. (561 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (560 aa)
korB2-oxoglutarate ferredoxin oxidoreductase beta subunit. (315 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (358 aa)
aroD3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (138 aa)
acpPAcyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (82 aa)
prsARibose-phosphate pyrophosphokinase. (279 aa)
Your Current Organism:
Sulcia muelleri CARI
NCBI taxonomy Id: 706194
Other names: C. Sulcia muelleri CARI, Candidatus Sulcia muelleri CARI, Candidatus Sulcia muelleri str. CARI, Candidatus Sulcia muelleri strain CARI
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