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AEV70680.1 AEV70680.1 AEV70687.1 AEV70687.1 AEV71062.1 AEV71062.1 AEV71063.1 AEV71063.1 AEV71297.1 AEV71297.1 gpmA gpmA ackA ackA AEV71893.1 AEV71893.1 AEV71937.1 AEV71937.1 AEV72678.1 AEV72678.1 AEV72679.1 AEV72679.1 AEV72680.1 AEV72680.1 acsA acsA AEV72995.1 AEV72995.1 serC serC AEV73490.1 AEV73490.1 AEV73570.1 AEV73570.1 AEV73580.1 AEV73580.1 AEV73581.1 AEV73581.1 AEV73582.1 AEV73582.1 AEV73589.1 AEV73589.1 AEV73590.1 AEV73590.1 AEV73591.1 AEV73591.1 AEV73592.1 AEV73592.1 AEV73593.1 AEV73593.1 AEV73594.1 AEV73594.1 acsA-2 acsA-2 eno eno glyA glyA AEV74058.1 AEV74058.1 AEV74163.1 AEV74163.1 mdh mdh AEV74268.1 AEV74268.1 AEV74406.1 AEV74406.1 AEV75114.1 AEV75114.1 ppc ppc fbiD fbiD AEV76382.1 AEV76382.1 pfkA pfkA AEV76435.1 AEV76435.1 AEV76638.1 AEV76638.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AEV70680.1Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (798 aa)
AEV70687.1PFAM: pfkB family carbohydrate kinase; TIGRFAM: hexose kinase, 1-phosphofructokinase family. (317 aa)
AEV71062.1LPPG:FO 2-phospho-L-lactate transferase; PFAM: Uncharacterised protein family UPF0052; TIGRFAM: LPPG:FO 2-phospho-L-lactate transferase. (346 aa)
AEV71063.1PFAM: F420-0:Gamma-glutamyl ligase; Nitroreductase family; TIGRFAM: F420 biosynthesis protein FbiB, C-terminal domain; F420-0:gamma-glutamyl ligase. (446 aa)
AEV71297.1Phosphoglycerate dehydrogenase-like oxidoreductase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (318 aa)
gpmAPhosphoglycerate mutase, BPG-dependent, family 1; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (248 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (380 aa)
AEV71893.1Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (690 aa)
AEV71937.1Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (345 aa)
AEV72678.1PFAM: Conserved region in glutamate synthase; Belongs to the glutamate synthase family. (434 aa)
AEV72679.1Glutamate synthase family protein; PFAM: GXGXG motif. (223 aa)
AEV72680.1PFAM: Glutamine amidotransferases class-II. (292 aa)
acsAacetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (654 aa)
AEV72995.1Oxidoreductase, Rxyl_3153 family; PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase; TIGRFAM: oxidoreductase, Rxyl_3153 family. (378 aa)
serCPhosphoserine aminotransferase, putative; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (370 aa)
AEV73490.1Hypothetical protein; PFAM: (2R)-phospho-3-sulfolactate synthase (ComA). (257 aa)
AEV73570.1Alcohol dehydrogenase, class IV; PFAM: Iron-containing alcohol dehydrogenase. (430 aa)
AEV73580.1PFAM: Ammonia monooxygenase/methane monooxygenase, subunit C; TIGRFAM: methane monooxygenase/ammonia monooxygenase, subunit C. (293 aa)
AEV73581.1PFAM: Ammonia monooxygenase; TIGRFAM: methane monooxygenase/ammonia monooxygenase, subunit A. (259 aa)
AEV73582.1PFAM: Monooxygenase subunit B protein. (422 aa)
AEV73589.1YHS domain-containing protein; PFAM: YHS domain; Methane/Phenol/Toluene Hydroxylase. (531 aa)
AEV73590.1PFAM: Methane/Phenol/Toluene Hydroxylase. (407 aa)
AEV73591.1PFAM: MmoB/DmpM family. (173 aa)
AEV73592.1Hypothetical protein. (62 aa)
AEV73593.12-polyprenylphenol hydroxylase-like oxidoreductase; PFAM: 2Fe-2S iron-sulfur cluster binding domain; Oxidoreductase FAD-binding domain; Oxidoreductase NAD-binding domain. (347 aa)
AEV73594.1PFAM: Methane monooxygenase, hydrolase gamma chain. (188 aa)
acsA-2acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (649 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa)
glyAGlycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (490 aa)
AEV74058.1Fructose-1,6-bisphosphatase, class II; PFAM: Bacterial fructose-1,6-bisphosphatase, glpX-encoded; TIGRFAM: fructose-1,6-bisphosphatase, class II. (342 aa)
AEV74163.1Radical SAM domain protein, CofH subfamily; PFAM: Radical SAM superfamily; TIGRFAM: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit; radical SAM domain protein, CofH subfamily; 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofG subunit. (878 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
AEV74268.1Anaerobic dehydrogenase, typically selenocysteine-containing; PFAM: Molybdopterin oxidoreductase; Molydopterin dinucleotide binding domain; Molybdopterin oxidoreductase Fe4S4 domain; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (719 aa)
AEV74406.1PFAM: Luciferase-like monooxygenase; TIGRFAM: F420-dependent oxidoreductase, MSMEG_4879 family. (313 aa)
AEV75114.1PFAM: Fructose-bisphosphate aldolase class-I. (294 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (929 aa)
fbiD2-phospho-L-lactate guanylyltransferase; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor. (217 aa)
AEV76382.1PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; ACT domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; TIGRFAM: D-3-phosphoglycerate dehydrogenase. (528 aa)
pfkAPhosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (343 aa)
AEV76435.1Phosphoserine phosphatase SerB; PFAM: ACT domain; haloacid dehalogenase-like hydrolase; TIGRFAM: Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; phosphoserine phosphatase SerB. (427 aa)
AEV76638.1Phosphoglycerate dehydrogenase-like oxidoreductase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (358 aa)
Your Current Organism:
Mycolicibacterium rhodesiae NBB3
NCBI taxonomy Id: 710685
Other names: M. rhodesiae NBB3, Mycobacterium rhodesiae NBB3
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