STRINGSTRING
pckA pckA ALA94663.1 ALA94663.1 ALA94664.1 ALA94664.1 ALA94665.1 ALA94665.1 ALA94666.1 ALA94666.1 ALA94667.1 ALA94667.1 ALA94687.1 ALA94687.1 ALA96544.1 ALA96544.1 ALA94763.1 ALA94763.1 ALA94764.1 ALA94764.1 gpmA gpmA pflD pflD ALA94842.1 ALA94842.1 eno eno pdxT pdxT pdxS pdxS ALA94938.1 ALA94938.1 ALA94980.1 ALA94980.1 ppc ppc prs prs ALA95010.1 ALA95010.1 tpiA tpiA ALA95083.1 ALA95083.1 ALA95094.1 ALA95094.1 ALA95095.1 ALA95095.1 ALA95096.1 ALA95096.1 ALA95097.1 ALA95097.1 ALA95098.1 ALA95098.1 ALA96592.1 ALA96592.1 ALA95204.1 ALA95204.1 ALA95211.1 ALA95211.1 fabV fabV ALA95370.1 ALA95370.1 ALA95428.1 ALA95428.1 ALA95440.1 ALA95440.1 ALA95487.1 ALA95487.1 fabH fabH ALA95547.1 ALA95547.1 acpP acpP ALA95549.1 ALA95549.1 ALA95606.1 ALA95606.1 ALA95616.1 ALA95616.1 ALA95670.1 ALA95670.1 fabZ fabZ rbsK rbsK fbp fbp ALA96666.1 ALA96666.1 pfkA pfkA ALA95762.1 ALA95762.1 ALA95767.1 ALA95767.1 ALA95772.1 ALA95772.1 adhP adhP deoB deoB deoC deoC ALA95918.1 ALA95918.1 ALA95919.1 ALA95919.1 ALA95920.1 ALA95920.1 ALA95935.1 ALA95935.1 accA accA accD accD ALA95942.1 ALA95942.1 ilvC ilvC leuB leuB leuD leuD leuC leuC ALA95966.1 ALA95966.1 leuA leuA ALA95979.1 ALA95979.1 ALA95980.1 ALA95980.1 ilvD ilvD ALA96011.1 ALA96011.1 ALA96012.1 ALA96012.1 pflA pflA ALA96016.1 ALA96016.1 ALA96057.1 ALA96057.1 gpmI gpmI ALA96140.1 ALA96140.1 ALA96147.1 ALA96147.1 ALA96148.1 ALA96148.1 ALA96152.1 ALA96152.1 ALA96153.1 ALA96153.1 ALA96180.1 ALA96180.1 ALA96191.1 ALA96191.1 ALA96194.1 ALA96194.1 ALA96265.1 ALA96265.1 ALA96288.1 ALA96288.1 ackA ackA ALA96300.1 ALA96300.1 pgk pgk pgi pgi prs-2 prs-2 ALA96475.1 ALA96475.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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pckAPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (527 aa)
ALA94663.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (178 aa)
ALA94664.1Converts oxaloacetate to phosphoenolpyruvate using ATP as an energy source; Derived by automated computational analysis using gene prediction method: Protein Homology. (460 aa)
ALA94665.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (117 aa)
ALA94666.1Oxaloacetate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (124 aa)
ALA94667.1glutaconyl-CoA decarboxylase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (372 aa)
ALA94687.1Glyceraldehyde-3-phosphate dehydrogenase; NAD-dependent; catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; active during glycolysis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa)
ALA96544.1NADH:ubiquinone oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (583 aa)
ALA94763.1NADH dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (614 aa)
ALA94764.1NADH dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (159 aa)
gpmAPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (229 aa)
pflDFormate acetyltransferase; Involved in production of D-lactate from glucose under microaerobic conditions; cytoplasmic protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (764 aa)
ALA94842.1Pyruvate-flavodoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1179 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (439 aa)
pdxTGlutamine amidotransferase; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (197 aa)
pdxSPyridoxal biosynthesis lyase PdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (289 aa)
ALA94938.1Phosphoglucomutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (572 aa)
ALA94980.1Pyruvate phosphate dikinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (852 aa)
ppcHypothetical protein; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (880 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (330 aa)
ALA95010.1Pyridine nucleotide-disulfide oxidoreductase; Involved in disulfide oxidoreductase activity and electron transport; Derived by automated computational analysis using gene prediction method: Protein Homology. (457 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa)
ALA95083.1Fructokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (293 aa)
ALA95094.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (321 aa)
ALA95095.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (332 aa)
ALA95096.1Dihydrolipoamide acetyltransferase; Unlike PdhC proteins from other organisms, some Mycoplasma lack an N-terminal lipoyl domain; in Mycoplasma hyopneumonia the PdhD proteins contains the lipoyl domain; Derived by automated computational analysis using gene prediction method: Protein Homology. (344 aa)
ALA95097.1Dihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (583 aa)
ALA95098.1Lipoate--protein ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (331 aa)
ALA96592.1Mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (404 aa)
ALA95204.1Nucleoside-diphosphate sugar epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (279 aa)
ALA95211.1Branched-chain amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (310 aa)
fabVtrans-2-enoyl-CoA reductase; Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon- carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP); Belongs to the TER reductase family. (397 aa)
ALA95370.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (494 aa)
ALA95428.1Selenate reductase subunit YgfK; Derived by automated computational analysis using gene prediction method: Protein Homology. (1011 aa)
ALA95440.12-polyprenylphenol hydroxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (784 aa)
ALA95487.1NUDIX hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (163 aa)
fabH3-oxoacyl-ACP synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (325 aa)
ALA95547.1Malonyl CoA-ACP transacylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (305 aa)
acpPAcyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (74 aa)
ALA95549.13-oxoacyl-ACP synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (411 aa)
ALA95606.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (480 aa)
ALA95616.13-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (530 aa)
ALA95670.12-hydroxyacid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (346 aa)
fabZ3-hydroxyacyl-ACP dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (141 aa)
rbsKRibokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (305 aa)
fbpClass 3; catalyzes the formation of fructose 6-phosphate from fructose-1,6-bisphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (645 aa)
ALA96666.1Pyruvate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pyruvate kinase family. (471 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (320 aa)
ALA95762.1Ribose 5-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (144 aa)
ALA95767.1Ribulose phosphate epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribulose-phosphate 3-epimerase family. (211 aa)
ALA95772.1Fructose-bisphosphate aldolase; Catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (328 aa)
adhPEthanol-active dehydrogenase/acetaldehyde-active reductase; Similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; Derived by automated computational analysis using gene prediction method: Protein Homology. (351 aa)
deoBPhosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (391 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (221 aa)
ALA95918.1Citrate synthase; Catalyzes the formation of citrate from acetyl-CoA and oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. (442 aa)
ALA95919.1Isocitrate dehydrogenase; Catalyzes the formation of 2-oxoglutarate from isocitrate; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)
ALA95920.1Aconitate hydratase; Catalyzes the conversion of citrate to isocitrate; Derived by automated computational analysis using gene prediction method: Protein Homology. (643 aa)
ALA95935.1AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (825 aa)
accAacetyl-CoA carboxyl transferase; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (318 aa)
accDacetyl-CoA carboxyl transferase; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (283 aa)
ALA95942.1Peptidase M16; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase M16 family. (404 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (336 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (352 aa)
leuDIsopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (191 aa)
leuCIsopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (472 aa)
ALA95966.13-oxoacyl-ACP synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (309 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (503 aa)
ALA95979.1Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (162 aa)
ALA95980.1Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (572 aa)
ilvDDihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (554 aa)
ALA96011.1Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (308 aa)
ALA96012.1Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (269 aa)
pflAPyruvate formate lyase-activating enzyme 1; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (242 aa)
ALA96016.1Formate acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (743 aa)
ALA96057.1Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (324 aa)
gpmIPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (513 aa)
ALA96140.1Alpha/beta hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (291 aa)
ALA96147.1acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (447 aa)
ALA96148.1Biotin attachment protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (133 aa)
ALA96152.1Glyceraldehyde-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (472 aa)
ALA96153.1Lysophospholipase; Derived by automated computational analysis using gene prediction method: Protein Homology. (298 aa)
ALA96180.1Short-chain dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (236 aa)
ALA96191.1Alpha/beta hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (520 aa)
ALA96194.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (377 aa)
ALA96265.1acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (158 aa)
ALA96288.1Mannose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (318 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa)
ALA96300.1Phosphotransacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (335 aa)
pgkPhosphoglycerate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate kinase family. (408 aa)
pgiGlucose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GPI family. (451 aa)
prs-2Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (327 aa)
ALA96475.1Phosphoglucomutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (572 aa)
Your Current Organism:
Leptotrichia
NCBI taxonomy Id: 712357
Other names: L. sp. oral taxon 212, Leptotrichia sp. oral taxon 212
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