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infC infC ALA96530.1 ALA96530.1 gyrB gyrB gyrA gyrA ALA94690.1 ALA94690.1 mraY mraY murD murD murG murG murC murC murB murB ftsZ ftsZ ALA94702.1 ALA94702.1 rpsG rpsG fusA fusA rplW rplW rpsS rpsS rplV rplV ALA94750.1 ALA94750.1 priA priA ALA94821.1 ALA94821.1 ALA94836.1 ALA94836.1 ALA94837.1 ALA94837.1 recG recG rpsK rpsK ruvB ruvB rsfS rsfS ALA94880.1 ALA94880.1 ALA94882.1 ALA94882.1 ALA96567.1 ALA96567.1 sepF sepF ALA95035.1 ALA95035.1 ALA95036.1 ALA95036.1 era era ALA95168.1 ALA95168.1 murA murA ALA95283.1 ALA95283.1 ALA95316.1 ALA95316.1 fusA-2 fusA-2 rplT rplT rimP rimP topA topA mltG mltG ALA95523.1 ALA95523.1 ALA95526.1 ALA95526.1 mscL mscL murJ murJ ALA95614.1 ALA95614.1 prfB prfB ALA95671.1 ALA95671.1 ALA95682.1 ALA95682.1 ALA95763.1 ALA95763.1 ALA96674.1 ALA96674.1 ALA95865.1 ALA95865.1 ALA96681.1 ALA96681.1 smc smc ALA95941.1 ALA95941.1 ALA95951.1 ALA95951.1 cas2 cas2 cas1 cas1 ALA96006.1 ALA96006.1 ALA96026.1 ALA96026.1 prfA prfA ALA96105.1 ALA96105.1 engB engB ALA96107.1 ALA96107.1 frr frr ALA96141.1 ALA96141.1 rlpA rlpA murE murE ALA96293.1 ALA96293.1 der der ALA96318.1 ALA96318.1 ALA96362.1 ALA96362.1 murI murI ruvA ruvA ALA96374.1 ALA96374.1 ddl ddl ALA96385.1 ALA96385.1 ALA96412.1 ALA96412.1 uppP uppP ALA96459.1 ALA96459.1 ALA96460.1 ALA96460.1 spoVG spoVG mfd mfd ALA94652.1 ALA94652.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
infCTranslation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. (163 aa)
ALA96530.1Single-stranded DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (306 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (660 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (825 aa)
ALA94690.1UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. (472 aa)
mraYphospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (362 aa)
murDUDP-N-acetylmuramoylalanine ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (456 aa)
murGUDP-diphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (349 aa)
murCUDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (447 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (285 aa)
ftsZCell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (395 aa)
ALA94702.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (159 aa)
rpsG30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
fusAElongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (692 aa)
rplW50S ribosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (94 aa)
rpsS30S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (92 aa)
rplV50S ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (111 aa)
ALA94750.1Peptidoglycan glycosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (666 aa)
priAPrimosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (736 aa)
ALA94821.1Nitrogen fixation protein NifU; Derived by automated computational analysis using gene prediction method: Protein Homology. (145 aa)
ALA94836.1SufBD protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (375 aa)
ALA94837.1Fe-S cluster assembly protein SufB; Derived by automated computational analysis using gene prediction method: Protein Homology. (471 aa)
recGATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (692 aa)
rpsK30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (129 aa)
ruvBATP-dependent DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (349 aa)
rsfSRibosome-associated protein IOJAP; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. (120 aa)
ALA94880.1Penicillin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (679 aa)
ALA94882.1RNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (112 aa)
ALA96567.1Hypothetical protein; Provides the (R)-glutamate required for cell wall biosynthesis. (210 aa)
sepFCell division protein SepF; Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA. (167 aa)
ALA95035.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (920 aa)
ALA95036.1DNA helicase UvrD; Derived by automated computational analysis using gene prediction method: Protein Homology. (1061 aa)
eraGTPase Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. (299 aa)
ALA95168.1Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology. (382 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (422 aa)
ALA95283.1DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (483 aa)
ALA95316.1Helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (823 aa)
fusA-2Elongation factor G; EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; Derived by automated computational analysis using gene prediction method: Protein Homology. (661 aa)
rplT50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (114 aa)
rimPRibosome maturation protein RimP; Required for maturation of 30S ribosomal subunits. Belongs to the RimP family. (161 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (809 aa)
mltGAminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family. (316 aa)
ALA95523.1GTP-binding protein TypA; Derived by automated computational analysis using gene prediction method: Protein Homology. (604 aa)
ALA95526.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (572 aa)
mscLLarge-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. (133 aa)
murJHypothetical protein; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (499 aa)
ALA95614.1Esterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (244 aa)
prfBPeptide chain release factor 2; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. (332 aa)
ALA95671.1Cobyrinic acid a,c-diamide synthase; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (264 aa)
ALA95682.1AAA family ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (732 aa)
ALA95763.1RNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (80 aa)
ALA96674.1Helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1050 aa)
ALA95865.1ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (330 aa)
ALA96681.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (432 aa)
smcChromosome segregation protein SMC; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1176 aa)
ALA95941.1Rod shape-determining protein RodA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SEDS family. (367 aa)
ALA95951.1Organic solvent tolerance protein OstA; Derived by automated computational analysis using gene prediction method: Protein Homology. (791 aa)
cas2CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (92 aa)
cas1CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (330 aa)
ALA96006.1CRISPR-associated protein Cas3; Derived by automated computational analysis using gene prediction method: Protein Homology. (805 aa)
ALA96026.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (214 aa)
prfAPeptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (359 aa)
ALA96105.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (186 aa)
engBGTP-binding protein; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. (199 aa)
ALA96107.1Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (264 aa)
frrRibosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. (185 aa)
ALA96141.1Magnesium chelatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (511 aa)
rlpAHypothetical protein; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (132 aa)
murEUDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (508 aa)
ALA96293.1Cytochrome C biogenesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (212 aa)
derGTP-binding protein Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. (439 aa)
ALA96318.1Organic solvent tolerance protein OstA; Derived by automated computational analysis using gene prediction method: Protein Homology. (1228 aa)
ALA96362.1D-alanyl-D-alanine carboxypeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S11 family. (392 aa)
murIGlutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (261 aa)
ruvAATP-dependent DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (213 aa)
ALA96374.1Glutaredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (416 aa)
ddlD-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (308 aa)
ALA96385.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (690 aa)
ALA96412.1ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (405 aa)
uppPUDP pyrophosphate phosphatase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (274 aa)
ALA96459.1Relaxase; Derived by automated computational analysis using gene prediction method: Protein Homology. (368 aa)
ALA96460.1Reticulocyte-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (95 aa)
spoVGSeptation protein spoVG; Could be involved in septation. (91 aa)
mfdTranscription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1022 aa)
ALA94652.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (232 aa)
Your Current Organism:
Leptotrichia
NCBI taxonomy Id: 712357
Other names: L. sp. oral taxon 212, Leptotrichia sp. oral taxon 212
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