STRINGSTRING
ruvC ruvC rnpA rnpA ALA94689.1 ALA94689.1 ALA94690.1 ALA94690.1 ALA94742.1 ALA94742.1 ALA94744.1 ALA94744.1 ALA96541.1 ALA96541.1 ALA94776.1 ALA94776.1 ALA94825.1 ALA94825.1 ALA94849.1 ALA94849.1 ileS ileS ALA94863.1 ALA94863.1 ALA94871.1 ALA94871.1 rnj rnj ALA94903.1 ALA94903.1 ALA94905.1 ALA94905.1 ALA96568.1 ALA96568.1 ALA94971.1 ALA94971.1 mutS2 mutS2 ALA94991.1 ALA94991.1 valS valS ALA95035.1 ALA95035.1 ALA95101.1 ALA95101.1 ALA95107.1 ALA95107.1 ALA95110.1 ALA95110.1 uvrB uvrB ALA95134.1 ALA95134.1 pth pth ALA96474.1 ALA96474.1 ALA96749.1 ALA96749.1 rnr rnr ALA96376.1 ALA96376.1 ALA96320.1 ALA96320.1 ALA96319.1 ALA96319.1 ALA96315.1 ALA96315.1 ALA96284.1 ALA96284.1 ALA96734.1 ALA96734.1 ALA96172.1 ALA96172.1 proS proS ALA96718.1 ALA96718.1 ALA96149.1 ALA96149.1 xseB xseB ALA96084.1 ALA96084.1 nth nth ALA96064.1 ALA96064.1 ALA96055.1 ALA96055.1 ALA96033.1 ALA96033.1 ALA96026.1 ALA96026.1 ALA96019.1 ALA96019.1 ALA96010.1 ALA96010.1 ALA96005.1 ALA96005.1 cas1 cas1 cas2 cas2 ALA95996.1 ALA95996.1 ALA95968.1 ALA95968.1 alaS alaS ALA95948.1 ALA95948.1 rph rph ALA95886.1 ALA95886.1 ALA96688.1 ALA96688.1 polC polC uvrC uvrC rny rny ALA96677.1 ALA96677.1 uvrA uvrA dtd dtd ALA95783.1 ALA95783.1 ALA96668.1 ALA96668.1 nfo nfo ALA95744.1 ALA95744.1 fbp fbp ALA95672.1 ALA95672.1 ALA95603.1 ALA95603.1 ALA96646.1 ALA96646.1 pnp pnp rnc rnc ALA95517.1 ALA95517.1 ALA95486.1 ALA95486.1 ALA95484.1 ALA95484.1 ALA95465.1 ALA95465.1 ALA95458.1 ALA95458.1 ALA95385.1 ALA95385.1 ALA95371.1 ALA95371.1 rnmV rnmV ybeY ybeY leuS leuS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ruvCHolliday junction resolvase; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (189 aa)
rnpARibonuclease P; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (108 aa)
ALA94689.1D,D-heptose 1,7-bisphosphate phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (190 aa)
ALA94690.1UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. (472 aa)
ALA94742.1Haloacid dehalogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (213 aa)
ALA94744.1Restriction endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (488 aa)
ALA96541.1Deoxyribonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (333 aa)
ALA94776.1Phosphoglycerate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate mutase family. (215 aa)
ALA94825.1Histidinol phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PHP hydrolase family. HisK subfamily. (265 aa)
ALA94849.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (668 aa)
ileSisoleucine--tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (931 aa)
ALA94863.1Haloacid dehalogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (270 aa)
ALA94871.1Acid phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (242 aa)
rnjRibonuclease J; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. (624 aa)
ALA94903.1Haloacid dehalogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (267 aa)
ALA94905.1Haloacid dehalogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (271 aa)
ALA96568.1Histidinol phosphate phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PHP hydrolase family. HisK subfamily. (285 aa)
ALA94971.1Phosphoglycerate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (203 aa)
mutS2DNA mismatch repair protein MutS; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (779 aa)
ALA94991.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (220 aa)
valSvalyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (883 aa)
ALA95035.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (920 aa)
ALA95101.1Acetyl xylan esterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (320 aa)
ALA95107.1CRISPR-associated protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (232 aa)
ALA95110.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (134 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (657 aa)
ALA95134.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (217 aa)
pthpeptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. (188 aa)
ALA96474.1Protein tyrosine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. (154 aa)
ALA96749.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (481 aa)
rnrRibonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. (714 aa)
ALA96376.1Hydrolase TatD; Derived by automated computational analysis using gene prediction method: Protein Homology. (253 aa)
ALA96320.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (219 aa)
ALA96319.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0310 family. (133 aa)
ALA96315.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (130 aa)
ALA96284.1Toxin HicA; Derived by automated computational analysis using gene prediction method: Protein Homology. (63 aa)
ALA96734.1Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (711 aa)
ALA96172.1Single-stranded DNA exonuclease RecJ; Derived by automated computational analysis using gene prediction method: Protein Homology. (958 aa)
proSprolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (570 aa)
ALA96718.1Haloacid dehalogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (263 aa)
ALA96149.1DNA polymerase III subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (1157 aa)
xseBExodeoxyribonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (73 aa)
ALA96084.1Haloacid dehalogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (272 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (233 aa)
ALA96064.1Addiction module protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (85 aa)
ALA96055.1cysteinyl-tRNA(Pro) deacylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. (163 aa)
ALA96033.13-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (164 aa)
ALA96026.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (214 aa)
ALA96019.1Lipase; Derived by automated computational analysis using gene prediction method: Protein Homology. (265 aa)
ALA96010.1CRISPR-associated protein Cas6; Derived by automated computational analysis using gene prediction method: Protein Homology. (242 aa)
ALA96005.1CRISPR-associated protein Cas4; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Belongs to the CRISPR-associated exonuclease Cas4 family. (162 aa)
cas1CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (330 aa)
cas2CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (92 aa)
ALA95996.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (229 aa)
ALA95968.1Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (274 aa)
alaSalanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (870 aa)
ALA95948.1Holliday junction resolvase; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. (138 aa)
rphRibonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (221 aa)
ALA95886.1Fis family transcriptional regulator; May nick specific sequences that contain T:G mispairs resulting from m5C-deamination. (165 aa)
ALA96688.1prolyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (162 aa)
polCDNA polymerase III; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (1436 aa)
uvrCDNA helicase UvrC; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (593 aa)
rnyRibonuclease; Endoribonuclease that initiates mRNA decay. Belongs to the RNase Y family. (524 aa)
ALA96677.1Metallophosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (259 aa)
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (941 aa)
dtdtyrosyl-tRNA deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (145 aa)
ALA95783.1Restriction endonuclease subunit R; Derived by automated computational analysis using gene prediction method: Protein Homology. (1027 aa)
ALA96668.1Thioesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (130 aa)
nfoEndonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (302 aa)
ALA95744.13',5'-cyclic-nucleotide phosphodiesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (325 aa)
fbpClass 3; catalyzes the formation of fructose 6-phosphate from fructose-1,6-bisphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (645 aa)
ALA95672.1DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (374 aa)
ALA95603.1DNA polymerase III; Derived by automated computational analysis using gene prediction method: Protein Homology. (196 aa)
ALA96646.1Deoxyguanosinetriphosphate triphosphohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (489 aa)
pnpPolynucleotide phosphorylase/polyadenylase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (714 aa)
rncRibonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. (234 aa)
ALA95517.1Haloacid dehalogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (271 aa)
ALA95486.1Histidinol phosphate phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PHP hydrolase family. HisK subfamily. (256 aa)
ALA95484.1Beta-lactamase; Derived by automated computational analysis using gene prediction method: Protein Homology. (206 aa)
ALA95465.1Histidinol phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PHP hydrolase family. HisK subfamily. (286 aa)
ALA95458.1Recombination protein RecJ; Derived by automated computational analysis using gene prediction method: Protein Homology. (558 aa)
ALA95385.1Serine/threonine protein phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (768 aa)
ALA95371.1Haloacid dehalogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (245 aa)
rnmVDNA primase; Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step. (183 aa)
ybeYrRNA maturation factor; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (154 aa)
leuSleucyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I aminoacyl-tRNA synthetase family. (895 aa)
Your Current Organism:
Leptotrichia
NCBI taxonomy Id: 712357
Other names: L. sp. oral taxon 212, Leptotrichia sp. oral taxon 212
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