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surE surE pyrD pyrD pyrK pyrK carB carB carA carA pyrC pyrC pyrB pyrB pyrG pyrG upp upp pyrR pyrR AME03011.1 AME03011.1 deoD deoD ndk ndk AME03521.1 AME03521.1 AME03577.1 AME03577.1 AME03950.1 AME03950.1 AME04167.1 AME04167.1 deoD-2 deoD-2 AME04227.1 AME04227.1 pyrF pyrF pyrE pyrE AME04474.1 AME04474.1 cmk cmk AME04587.1 AME04587.1 pyrH pyrH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
surEAcid phosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (253 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (310 aa)
pyrKDihydroorotate dehydrogenase; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (261 aa)
carBCarbamoyl phosphate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarB family. (1075 aa)
carACarbamoyl-phosphate synthase small subunit; Catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; Derived by automated computational analysis using gene prediction method: Protein Homology. (357 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (430 aa)
pyrBAspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (315 aa)
pyrGCTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (535 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (218 aa)
pyrRTranscriptional regulator; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. (182 aa)
AME03011.1Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (150 aa)
deoDPurine-nucleoside phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (235 aa)
ndkNucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (137 aa)
AME03521.1Anaerobic ribonucleoside triphosphate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (754 aa)
AME03577.1Cytidine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (158 aa)
AME03950.1Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (140 aa)
AME04167.1Thymidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (231 aa)
deoD-2Purine-nucleoside phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (236 aa)
AME04227.1Pyrimidine-nucleoside phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (440 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (237 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (191 aa)
AME04474.1Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (212 aa)
cmkCytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (217 aa)
AME04587.1AAA family ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (540 aa)
pyrHUMP kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (241 aa)
Your Current Organism:
Selenomonas
NCBI taxonomy Id: 713030
Other names: S. sp. oral taxon 136, Selenomonas sp. oral taxon 136
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